-
1
-
-
77953429959
-
Clinical development of combination strategies in immunotherapy: are we ready for more than one investigational product in an early clinical trial?
-
Perez-Gracia, J.L., Berraondo, P., Martinez-Forero, I., Alfaro, C., Suarez, N., Gurpide, A., Sangro, B., Hervas-Stubbs, S., Ochoa, C., Melero, J.A. and Melero, I. (2009) Clinical development of combination strategies in immunotherapy: are we ready for more than one investigational product in an early clinical trial? Immunotherapy, 1, 845-853.
-
(2009)
Immunotherapy
, vol.1
, pp. 845-853
-
-
Perez-Gracia, J.L.1
Berraondo, P.2
Martinez-Forero, I.3
Alfaro, C.4
Suarez, N.5
Gurpide, A.6
Sangro, B.7
Hervas-Stubbs, S.8
Ochoa, C.9
Melero, J.A.10
Melero, I.11
-
2
-
-
41149097574
-
Adoptive cell transfer: a clinical path to effective cancer immunotherapy
-
Rosenberg, S.A., Restifo, N.P., Yang, J.C., Morgan, R.A. and Dudley, M.E. (2008) Adoptive cell transfer: a clinical path to effective cancer immunotherapy. Nat. Rev. Cancer, 8, 299-308.
-
(2008)
Nat. Rev. Cancer
, vol.8
, pp. 299-308
-
-
Rosenberg, S.A.1
Restifo, N.P.2
Yang, J.C.3
Morgan, R.A.4
Dudley, M.E.5
-
3
-
-
34247881794
-
Improving T cell therapy for cancer
-
Leen, A.M., Rooney, C.M. and Foster, A.E. (2007) Improving T cell therapy for cancer. Annu. Rev. Immunol., 25, 243-265.
-
(2007)
Annu. Rev. Immunol.
, vol.25
, pp. 243-265
-
-
Leen, A.M.1
Rooney, C.M.2
Foster, A.E.3
-
4
-
-
77951058615
-
Effective and long-term control of EBV PTLD after transfer of peptide-selected T cells
-
Moosmann, A., Bigalke, I., Tischer, J., Schirrmann, L., Kasten, J., Tippmer, S., Leeping, M., Prevalsek, D., Jaeger, G., Ledderose, G. et al. (2010) Effective and long-term control of EBV PTLD after transfer of peptide-selected T cells. Blood, 115, 2960-2970.
-
(2010)
Blood
, vol.115
, pp. 2960-2970
-
-
Moosmann, A.1
Bigalke, I.2
Tischer, J.3
Schirrmann, L.4
Kasten, J.5
Tippmer, S.6
Leeping, M.7
Prevalsek, D.8
Jaeger, G.9
Ledderose, G.10
-
5
-
-
20144388509
-
Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer
-
Miller, J.S., Soignier, Y., Panoskaltsis-Mortari, A., McNearney, S.A., Yun, G.H., Fautsch, S.K., McKenna, D., Le, C., Defor, T.E., Burns, L.J. et al. (2005) Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer. Blood, 105, 3051-3057.
-
(2005)
Blood
, vol.105
, pp. 3051-3057
-
-
Miller, J.S.1
Soignier, Y.2
Panoskaltsis-Mortari, A.3
McNearney, S.A.4
Yun, G.H.5
Fautsch, S.K.6
McKenna, D.7
Le, C.8
Defor, T.E.9
Burns, L.J.10
-
7
-
-
53549087527
-
How tumours escape mass destruction
-
Stewart, T.J. and Abrams, S.I. (2008) How tumours escape mass destruction. Oncogene, 27, 5894-5903.
-
(2008)
Oncogene
, vol.27
, pp. 5894-5903
-
-
Stewart, T.J.1
Abrams, S.I.2
-
8
-
-
0036566184
-
Adapting a transforming growth factor beta-related tumor protection strategy to enhance antitumor immunity
-
Bollard, C.M., Rössig, C., Calonge, M.J., Huls, M.H., Wagner, H., Massague, J., Brenner, M.K., Heslop, H.E. and Rooney, C.M. (2002) Adapting a transforming growth factor beta-related tumor protection strategy to enhance antitumor immunity. Blood, 99, 3179-3187.
-
(2002)
Blood
, vol.99
, pp. 3179-3187
-
-
Bollard, C.M.1
Rössig, C.2
Calonge, M.J.3
Huls, M.H.4
Wagner, H.5
Massague, J.6
Brenner, M.K.7
Heslop, H.E.8
Rooney, C.M.9
-
9
-
-
77952484156
-
Genetic redirection of T cells for cancer therapy
-
Westwood, J.A. and Kershaw, M.H. (2010) Genetic redirection of T cells for cancer therapy. J. Leukoc. Biol., 87, 791-803.
-
(2010)
J. Leukoc. Biol.
, vol.87
, pp. 791-803
-
-
Westwood, J.A.1
Kershaw, M.H.2
-
10
-
-
67650638846
-
T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model
-
Di Stasi, A., De Angelis, B., Rooney, C.M., Zhang, L., Mahendravada, A., Foster, A.E., Heslop, H.E., Brenner, M.K., Dotti, G. and Savoldo, B. (2009) T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model. Blood, 113, 6392-6402.
-
(2009)
Blood
, vol.113
, pp. 6392-6402
-
-
Di Stasi, A.1
De Angelis, B.2
Rooney, C.M.3
Zhang, L.4
Mahendravada, A.5
Foster, A.E.6
Heslop, H.E.7
Brenner, M.K.8
Dotti, G.9
Savoldo, B.10
-
11
-
-
73449085640
-
Generation of Epstein-Barr virus-specific cytotoxic T lymphocytes resistant to the immunosuppressive drug tacrolimus (FK506)
-
De Angelis, B., Dotti, G., Quintarelli, C., Huye, L.E., Zhang, L., Zhang, M., Pane, F., Heslop, H.E., Brenner, M.K., Rooney, C.M. and Savoldo, B. (2009) Generation of Epstein-Barr virus-specific cytotoxic T lymphocytes resistant to the immunosuppressive drug tacrolimus (FK506). Blood, 114, 4784-4791.
-
(2009)
Blood
, vol.114
, pp. 4784-4791
-
-
De Angelis, B.1
Dotti, G.2
Quintarelli, C.3
Huye, L.E.4
Zhang, L.5
Zhang, M.6
Pane, F.7
Heslop, H.E.8
Brenner, M.K.9
Rooney, C.M.10
Savoldo, B.11
-
12
-
-
33749624177
-
Cancer regression in patients after transfer of genetically engineered lymphocytes
-
Morgan, R.A., Dudley, M.E., Wunderlich, J.R., Hughes, M.S., Yang, J.C., Sherry, R.M., Royal, R.E., Topalian, S.L., Kammula, U.S., Restifo, N.P. et al. (2006) Cancer regression in patients after transfer of genetically engineered lymphocytes. Science, 314, 126-129.
-
(2006)
Science
, vol.314
, pp. 126-129
-
-
Morgan, R.A.1
Dudley, M.E.2
Wunderlich, J.R.3
Hughes, M.S.4
Yang, J.C.5
Sherry, R.M.6
Royal, R.E.7
Topalian, S.L.8
Kammula, U.S.9
Restifo, N.P.10
-
13
-
-
78650636797
-
Genetic modification of T cells. Biol. Blood Marrow Transplant
-
Bonini, C., Brenner, M.K., Heslop, H.E. and Morgan, R.A. (2011) Genetic modification of T cells. Biol. Blood Marrow Transplant. J. Am. Soc. Blood Marrow Transplant., 17, S15-S20.
-
(2011)
J. Am. Soc. Blood Marrow Transplant.
, vol.17
-
-
Bonini, C.1
Brenner, M.K.2
Heslop, H.E.3
Morgan, R.A.4
-
14
-
-
70149114880
-
Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen
-
Johnson, L.A., Morgan, R.A., Dudley, M.E., Cassard, L., Yang, J.C., Hughes, M.S., Kammula, U.S., Royal, R.E., Sherry, R.M., Wunderlich, J.R. et al. (2009) Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen. Blood, 114, 535-546.
-
(2009)
Blood
, vol.114
, pp. 535-546
-
-
Johnson, L.A.1
Morgan, R.A.2
Dudley, M.E.3
Cassard, L.4
Yang, J.C.5
Hughes, M.S.6
Kammula, U.S.7
Royal, R.E.8
Sherry, R.M.9
Wunderlich, J.R.10
-
15
-
-
79952187823
-
T cells targeting carcinoembryonic antigen can mediate regression of metastatic colorectal cancer but induce severe transient colitis
-
doi:10.1038/mt.2010.272
-
Parkhurst, M.R., Yang, J.C., Langan, R.C., Dudley, M.E., Nathan, D.N., Feldman, S.A., Davis, J.L., Morgan, R.A., Merino, M.J., Sherry, R.M. et al. (2010) T cells targeting carcinoembryonic antigen can mediate regression of metastatic colorectal cancer but induce severe transient colitis. Mol. Ther., doi:10.1038/mt.2010.272.
-
(2010)
Mol. Ther.
-
-
Parkhurst, M.R.1
Yang, J.C.2
Langan, R.C.3
Dudley, M.E.4
Nathan, D.N.5
Feldman, S.A.6
Davis, J.L.7
Morgan, R.A.8
Merino, M.J.9
Sherry, R.M.10
-
16
-
-
77952236875
-
Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy
-
(1p following 570)
-
Bendle, G.M., Linnemann, C., Hooijkaas, A.I., Bies, L., de Witte, M.A., Jorritsma, A., Kaiser, A.D.M., Pouw, N., Debets, R., Kieback, E. et al. (2010) Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy. Nat. Med., 16, 565-570 (1p following 570).
-
(2010)
Nat. Med.
, vol.16
, pp. 565-570
-
-
Bendle, G.M.1
Linnemann, C.2
Hooijkaas, A.I.3
Bies, L.4
de Witte, M.A.5
Jorritsma, A.6
Kaiser, A.D.M.7
Pouw, N.8
Debets, R.9
Kieback, E.10
-
17
-
-
77957577506
-
Of mice, not men: no evidence for graft-versus-host disease in humans receiving T-cell receptor-transduced autologous T cells
-
Rosenberg, S.A. (2010) Of mice, not men: no evidence for graft-versus-host disease in humans receiving T-cell receptor-transduced autologous T cells. Mol. Ther., 18, 1744-1745.
-
(2010)
Mol. Ther.
, vol.18
, pp. 1744-1745
-
-
Rosenberg, S.A.1
-
18
-
-
0028879071
-
A spacer region between the single chain antibody- and the CD3 zeta-chain domain of chimeric T cell receptor components is required for efficient ligand binding and signaling activity
-
Moritz, D. and Groner, B. (1995) A spacer region between the single chain antibody- and the CD3 zeta-chain domain of chimeric T cell receptor components is required for efficient ligand binding and signaling activity. Gene Ther., 2, 539-546.
-
(1995)
Gene Ther
, vol.2
, pp. 539-546
-
-
Moritz, D.1
Groner, B.2
-
19
-
-
65249101637
-
The promise and potential pitfalls of chimeric antigen receptors
-
Sadelain, M., Brentjens, R. and Rivière, I. (2009) The promise and potential pitfalls of chimeric antigen receptors. Curr. Opin. Immunol., 21, 215-223.
-
(2009)
Curr. Opin. Immunol.
, vol.21
, pp. 215-223
-
-
Sadelain, M.1
Brentjens, R.2
Rivière, I.3
-
20
-
-
33846215917
-
Antibody constructs in cancer therapy: protein engineering strategies to improve exposure in solid tumors
-
Beckman, R.A., Weiner, L.M. and Davis, H.M. (2007) Antibody constructs in cancer therapy: protein engineering strategies to improve exposure in solid tumors. Cancer, 109, 170-179.
-
(2007)
Cancer
, vol.109
, pp. 170-179
-
-
Beckman, R.A.1
Weiner, L.M.2
Davis, H.M.3
-
21
-
-
0030014521
-
Single chain Ig/gamma gene-redirected human T lymphocytes produce cytokines, specifically lyse tumor cells, and recycle lytic capacity
-
Weijtens, M.E., Willemsen, R.A., Valerio, D., Stam, K. and Bolhuis, R.L. (1996) Single chain Ig/gamma gene-redirected human T lymphocytes produce cytokines, specifically lyse tumor cells, and recycle lytic capacity. J. Immunol., 157, 836-843.
-
(1996)
J. Immunol.
, vol.157
, pp. 836-843
-
-
Weijtens, M.E.1
Willemsen, R.A.2
Valerio, D.3
Stam, K.4
Bolhuis, R.L.5
-
22
-
-
55549145071
-
Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma
-
Pule, M.A., Savoldo, B., Myers, G.D., Rossig, C., Russell, H.V., Dotti, G., Huls, M.H., Liu, E., Gee, A.P., Mei, Z. et al. (2008) Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma. Nat. Med., 14, 1264-1270.
-
(2008)
Nat. Med.
, vol.14
, pp. 1264-1270
-
-
Pule, M.A.1
Savoldo, B.2
Myers, G.D.3
Rossig, C.4
Russell, H.V.5
Dotti, G.6
Huls, M.H.7
Liu, E.8
Gee, A.P.9
Mei, Z.10
-
23
-
-
0035889157
-
Integrated src kinase and costimulatory activity enhances signal transduction through single-chain chimeric receptors in T lymphocytes
-
Geiger, T.L., Nguyen, P., Leitenberg, D. and Flavell, R.A. (2001) Integrated src kinase and costimulatory activity enhances signal transduction through single-chain chimeric receptors in T lymphocytes. Blood, 98, 2364-2371.
-
(2001)
Blood
, vol.98
, pp. 2364-2371
-
-
Geiger, T.L.1
Nguyen, P.2
Leitenberg, D.3
Flavell, R.A.4
-
24
-
-
27744566329
-
A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells
-
Pulè, M.A., Straathof, K.C., Dotti, G., Heslop, H.E., Rooney, C.M. and Brenner, M.K. (2005) A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells. Mol. Ther., 12, 933-941.
-
(2005)
Mol. Ther.
, vol.12
, pp. 933-941
-
-
Pulè, M.A.1
Straathof, K.C.2
Dotti, G.3
Heslop, H.E.4
Rooney, C.M.5
Brenner, M.K.6
-
25
-
-
34848842554
-
Genetically targeted T cells eradicate systemic acute lymphoblastic leukemia xenografts
-
Brentjens, R.J., Santos, E., Nikhamin, Y., Yeh, R., Matsushita, M., La Perle, K., Quintás-Cardama, A., Larson, S.M. and Sadelain, M. (2007) Genetically targeted T cells eradicate systemic acute lymphoblastic leukemia xenografts. Clin. Cancer Res., 13, 5426-5435.
-
(2007)
Clin. Cancer Res.
, vol.13
, pp. 5426-5435
-
-
Brentjens, R.J.1
Santos, E.2
Nikhamin, Y.3
Yeh, R.4
Matsushita, M.5
La Perle, K.6
Quintás-Cardama, A.7
Larson, S.M.8
Sadelain, M.9
-
26
-
-
70349852616
-
Immunotherapy for osteosarcoma: genetic modification of T cells overcomes low levels of tumor antigen expression
-
Ahmed, N., Salsman, V.S., Yvon, E., Louis, C.U., Perlaky, L., Wels, W.S., Dishop, M.K., Kleinerman, E.E., Pule, M., Rooney, C.M., Heslop, H.E. and Gottschalk, S. (2009) Immunotherapy for osteosarcoma: genetic modification of T cells overcomes low levels of tumor antigen expression. Mol. Ther., 17, 1779-1787.
-
(2009)
Mol. Ther.
, vol.17
, pp. 1779-1787
-
-
Ahmed, N.1
Salsman, V.S.2
Yvon, E.3
Louis, C.U.4
Perlaky, L.5
Wels, W.S.6
Dishop, M.K.7
Kleinerman, E.E.8
Pule, M.9
Rooney, C.M.10
Heslop, H.E.11
Gottschalk, S.12
-
27
-
-
79952146504
-
CARs on track in the clinic
-
Kohn, D.B., Dotti, G., Brentjens, R., Savoldo, B., Jensen, M., Cooper, L.J., June, C.H., Rosenberg, S., Sadelain, M. and Heslop, H.E. (2011) CARs on track in the clinic.Mol. Ther. J. Am. Soc. Gene Ther., 19, 432-438.
-
(2011)
Mol. Ther. J. Am. Soc. Gene Ther.
, vol.19
, pp. 432-438
-
-
Kohn, D.B.1
Dotti, G.2
Brentjens, R.3
Savoldo, B.4
Jensen, M.5
Cooper, L.J.6
June, C.H.7
Rosenberg, S.8
Sadelain, M.9
Heslop, H.E.10
-
28
-
-
78549278144
-
Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19
-
Kochenderfer, J.N., Wilson, W.H., Janik, J.E., Dudley, M.E., Stetler-Stevenson, M., Feldman, S.A., Maric, I., Raffeld, M., Nathan, D.N., Lanier, B.J., Morgan, R.A. and Rosenberg, S.A. (2010) Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19. Blood, 116, 4099-4102.
-
(2010)
Blood
, vol.116
, pp. 4099-4102
-
-
Kochenderfer, J.N.1
Wilson, W.H.2
Janik, J.E.3
Dudley, M.E.4
Stetler-Stevenson, M.5
Feldman, S.A.6
Maric, I.7
Raffeld, M.8
Nathan, D.N.9
Lanier, B.J.10
Morgan, R.A.11
Rosenberg, S.A.12
-
29
-
-
77956535599
-
Redirecting T-cell specificity by introducing a tumor-specific chimeric antigen receptor
-
Jena, B., Dotti, G. and Cooper, L.J.N. (2010) Redirecting T-cell specificity by introducing a tumor-specific chimeric antigen receptor. Blood, 116, 1035-1044.
-
(2010)
Blood
, vol.116
, pp. 1035-1044
-
-
Jena, B.1
Dotti, G.2
Cooper, L.J.N.3
-
30
-
-
77950501752
-
Safer CARS
-
Heslop, H.E. (2010) Safer CARS. Mol. Ther., 18, 661-662.
-
(2010)
Mol. Ther.
, vol.18
, pp. 661-662
-
-
Heslop, H.E.1
-
31
-
-
77950475517
-
Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2
-
Morgan, R.A., Yang, J.C., Kitano, M., Dudley, M.E., Laurencot, C.M. and Rosenberg, S.A. (2010) Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2. Mol. Ther., 18, 843-851.
-
(2010)
Mol. Ther.
, vol.18
, pp. 843-851
-
-
Morgan, R.A.1
Yang, J.C.2
Kitano, M.3
Dudley, M.E.4
Laurencot, C.M.5
Rosenberg, S.A.6
-
32
-
-
77950480974
-
Treatment of chronic lymphocytic leukemia with genetically targeted autologous T cells: case report of an unforeseen adverse event in a phase I clinical trial
-
Brentjens, R., Yeh, R., Bernal, Y., Riviere, I. and Sadelain, M. (2010) Treatment of chronic lymphocytic leukemia with genetically targeted autologous T cells: case report of an unforeseen adverse event in a phase I clinical trial. Mol. Ther., 18, 666-668.
-
(2010)
Mol. Ther.
, vol.18
, pp. 666-668
-
-
Brentjens, R.1
Yeh, R.2
Bernal, Y.3
Riviere, I.4
Sadelain, M.5
-
33
-
-
77951257237
-
Therapy of relapsed leukemia after allogeneic hematopoietic cell transplantation with T cells specific for minor histocompatibility antigens
-
Warren, E.H., Fujii, N., Akatsuka, Y., Chaney, C.N., Mito, J.K., Loeb, K.R., Gooley, T.A., Brown, M.L., Koo, K.K.W., Rosinski, K.V. et al. (2010) Therapy of relapsed leukemia after allogeneic hematopoietic cell transplantation with T cells specific for minor histocompatibility antigens. Blood, 115, 3869-3878.
-
(2010)
Blood
, vol.115
, pp. 3869-3878
-
-
Warren, E.H.1
Fujii, N.2
Akatsuka, Y.3
Chaney, C.N.4
Mito, J.K.5
Loeb, K.R.6
Gooley, T.A.7
Brown, M.L.8
Koo, K.K.W.9
Rosinski, K.V.10
-
34
-
-
35549007239
-
Co-expression of cytokine and suicide genes to enhance the activity and safety of tumor-specific cytotoxic T lymphocytes
-
Quintarelli, C., Vera, J.F., Savoldo, B., Giordano Attianese, G.M.P., Pule, M., Foster, A.E., Heslop, H.E., Rooney, C.M., Brenner, M.K. and Dotti, G. (2007) Co-expression of cytokine and suicide genes to enhance the activity and safety of tumor-specific cytotoxic T lymphocytes. Blood, 110, 2793-2802.
-
(2007)
Blood
, vol.110
, pp. 2793-2802
-
-
Quintarelli, C.1
Vera, J.F.2
Savoldo, B.3
Giordano Attianese, G.M.P.4
Pule, M.5
Foster, A.E.6
Heslop, H.E.7
Rooney, C.M.8
Brenner, M.K.9
Dotti, G.10
-
35
-
-
67349252824
-
Genetic manipulation of tumor-specific cytotoxic T lymphocytes to restore responsiveness to IL-7
-
Vera, J.F., Hoyos, V., Savoldo, B., Quintarelli, C., Giordano Attianese, G.M.P., Leen, A.M., Liu, H., Foster, A.E., Heslop, H.E., Rooney, C.M., Brenner, M.K. and Dotti, G. (2009) Genetic manipulation of tumor-specific cytotoxic T lymphocytes to restore responsiveness to IL-7. Mol. Ther., 17, 880-888.
-
(2009)
Mol. Ther.
, vol.17
, pp. 880-888
-
-
Vera, J.F.1
Hoyos, V.2
Savoldo, B.3
Quintarelli, C.4
Giordano Attianese, G.M.P.5
Leen, A.M.6
Liu, H.7
Foster, A.E.8
Heslop, H.E.9
Rooney, C.M.10
Brenner, M.K.11
Dotti, G.12
-
36
-
-
77954590000
-
Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma/leukemia effects and safety
-
Hoyos, V., Savoldo, B., Quintarelli, C., Mahendravada, A., Zhang, M., Vera, J., Heslop, H.E., Rooney, C.M., Brenner, M.K. and Dotti, G. (2010) Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma/leukemia effects and safety. Leukemia, 24, 1160-1170.
-
(2010)
Leukemia
, vol.24
, pp. 1160-1170
-
-
Hoyos, V.1
Savoldo, B.2
Quintarelli, C.3
Mahendravada, A.4
Zhang, M.5
Vera, J.6
Heslop, H.E.7
Rooney, C.M.8
Brenner, M.K.9
Dotti, G.10
-
37
-
-
77951746241
-
IL-7 and IL-21 are superior to IL-2 and IL-15 in promoting human T cell-mediated rejection of systemic lymphoma in immunodeficient mice
-
Markley, J.C. and Sadelain, M. (2010) IL-7 and IL-21 are superior to IL-2 and IL-15 in promoting human T cell-mediated rejection of systemic lymphoma in immunodeficient mice. Blood, 115, 3508-3519.
-
(2010)
Blood
, vol.115
, pp. 3508-3519
-
-
Markley, J.C.1
Sadelain, M.2
-
38
-
-
44349117909
-
Adoptive cell therapy for patients with melanoma, using tumor-infiltrating lymphocytes genetically engineered to secrete interleukin-2
-
Heemskerk, B., Liu, K., Dudley, M.E., Johnson, L.A., Kaiser, A., Downey, S., Zheng, Z., Shelton, T.E., Matsuda, K., Robbins, P.F., Morgan, R.A. and Rosenberg, S.A. (2008) Adoptive cell therapy for patients with melanoma, using tumor-infiltrating lymphocytes genetically engineered to secrete interleukin-2. Hum. Gene Ther., 19, 496-510.
-
(2008)
Hum. Gene Ther.
, vol.19
, pp. 496-510
-
-
Heemskerk, B.1
Liu, K.2
Dudley, M.E.3
Johnson, L.A.4
Kaiser, A.5
Downey, S.6
Zheng, Z.7
Shelton, T.E.8
Matsuda, K.9
Robbins, P.F.10
Morgan, R.A.11
Rosenberg, S.A.12
-
39
-
-
77958063691
-
Enhanced tumor trafficking of GD2 chimeric antigen receptor T cells by expression of the chemokine receptor CCR2b
-
Craddock, J.A., Lu, A., Bear, A., Pule, M., Brenner, M.K., Rooney, C.M. and Foster, A.E. (2010) Enhanced tumor trafficking of GD2 chimeric antigen receptor T cells by expression of the chemokine receptor CCR2b. J. Immunother., 33, 780-788.
-
(2010)
J. Immunother.
, vol.33
, pp. 780-788
-
-
Craddock, J.A.1
Lu, A.2
Bear, A.3
Pule, M.4
Brenner, M.K.5
Rooney, C.M.6
Foster, A.E.7
-
40
-
-
55249117972
-
Antitumor activity of EBV-specific T lymphocytes transduced with a dominant negative TGF-beta receptor
-
Foster, A.E., Dotti, G., Lu, A., Khalil, M., Brenner, M.K., Heslop, H.E., Rooney, C.M. and Bollard, C.M. (2008) Antitumor activity of EBV-specific T lymphocytes transduced with a dominant negative TGF-beta receptor. J. Immunother., 31, 500-505.
-
(2008)
J. Immunother.
, vol.31
, pp. 500-505
-
-
Foster, A.E.1
Dotti, G.2
Lu, A.3
Khalil, M.4
Brenner, M.K.5
Heslop, H.E.6
Rooney, C.M.7
Bollard, C.M.8
-
41
-
-
67349098558
-
Human interleukin 10 receptor 1/IgG1-Fc fusion proteins: immunoadhesins for human IL-10 with therapeutic potential
-
Terai, M., Tamura, Y., Alexeev, V., Ohtsuka, E., Berd, D., Mastrangelo, M.J. and Sato, T. (2009) Human interleukin 10 receptor 1/IgG1-Fc fusion proteins: immunoadhesins for human IL-10 with therapeutic potential. Cancer Immunol. Immunother., 58, 1307-1317.
-
(2009)
Cancer Immunol. Immunother.
, vol.58
, pp. 1307-1317
-
-
Terai, M.1
Tamura, Y.2
Alexeev, V.3
Ohtsuka, E.4
Berd, D.5
Mastrangelo, M.J.6
Sato, T.7
-
42
-
-
20444425695
-
Human cytotoxic T lymphocytes with reduced sensitivity to Fas-induced apoptosis
-
Dotti, G., Savoldo, B., Pule, M., Straathof, K.C., Biagi, E., Yvon, E., Vigouroux, S., Brenner, M.K. and Rooney, C.M. (2005) Human cytotoxic T lymphocytes with reduced sensitivity to Fas-induced apoptosis. Blood, 105, 4677-4684.
-
(2005)
Blood
, vol.105
, pp. 4677-4684
-
-
Dotti, G.1
Savoldo, B.2
Pule, M.3
Straathof, K.C.4
Biagi, E.5
Yvon, E.6
Vigouroux, S.7
Brenner, M.K.8
Rooney, C.M.9
-
43
-
-
0029924619
-
Long-term restoration of immunity against Epstein-Barr virus infection by adoptive transfer of gene-modified virus-specific T lymphocytes
-
Heslop, H.E., Ng, C.Y., Li, C., Smith, C.A., Loftin, S.K., Krance, R.A., Brenner, M.K. and Rooney, C.M. (1996) Long-term restoration of immunity against Epstein-Barr virus infection by adoptive transfer of gene-modified virus-specific T lymphocytes. Nat. Med., 2, 551-555.
-
(1996)
Nat. Med.
, vol.2
, pp. 551-555
-
-
Heslop, H.E.1
Ng, C.Y.2
Li, C.3
Smith, C.A.4
Loftin, S.K.5
Krance, R.A.6
Brenner, M.K.7
Rooney, C.M.8
-
44
-
-
77649221824
-
Long-term outcome of EBV-specific T-cell infusions to prevent or treat EBV-related lymphoproliferative disease in transplant recipients
-
Heslop, H.E., Slobod, K.S., Pule, M.A., Hale, G.A., Rousseau, A., Smith, C.A., Bollard, C.M., Liu, H., Wu, M., Rochester, R.J. et al. (2010) Long-term outcome of EBV-specific T-cell infusions to prevent or treat EBV-related lymphoproliferative disease in transplant recipients. Blood, 115, 925-935.
-
(2010)
Blood
, vol.115
, pp. 925-935
-
-
Heslop, H.E.1
Slobod, K.S.2
Pule, M.A.3
Hale, G.A.4
Rousseau, A.5
Smith, C.A.6
Bollard, C.M.7
Liu, H.8
Wu, M.9
Rochester, R.J.10
-
45
-
-
0034123022
-
Tacrolimus: a further update of its pharmacology and therapeutic use in the management of organ transplantation
-
Plosker, G.L. and Foster, R.H. (2000) Tacrolimus: a further update of its pharmacology and therapeutic use in the management of organ transplantation. Drugs, 59, 323-389.
-
(2000)
Drugs
, vol.59
, pp. 323-389
-
-
Plosker, G.L.1
Foster, R.H.2
-
46
-
-
65349157330
-
Infusion of suicide-gene-engineered donor lymphocytes after family haploidentical haemopoietic stem-cell transplantation for leukaemia (the TK007 trial): a non-randomised phase I-II study
-
Ciceri, F., Bonini, C., Stanghellini, M.T.L., Bondanza, A., Traversari, C., Salomoni, M., Turchetto, L., Colombi, S., Bernardi, M., Peccatori, J. et al. (2009) Infusion of suicide-gene-engineered donor lymphocytes after family haploidentical haemopoietic stem-cell transplantation for leukaemia (the TK007 trial): a non-randomised phase I-II study. Lancet Oncol., 10, 489-500.
-
(2009)
Lancet Oncol
, vol.10
, pp. 489-500
-
-
Ciceri, F.1
Bonini, C.2
Stanghellini, M.T.L.3
Bondanza, A.4
Traversari, C.5
Salomoni, M.6
Turchetto, L.7
Colombi, S.8
Bernardi, M.9
Peccatori, J.10
-
47
-
-
34447310075
-
Inducible caspase 9 suicide gene to improve the safety of allodepleted T cells after haploidentical stem cell transplantation
-
Tey, S., Dotti, G., Rooney, C.M., Heslop, H.E. and Brenner, M.K. (2007) Inducible caspase 9 suicide gene to improve the safety of allodepleted T cells after haploidentical stem cell transplantation. Biol. Blood Marrow Transplant., 13, 913-924.
-
(2007)
Biol. Blood Marrow Transplant.
, vol.13
, pp. 913-924
-
-
Tey, S.1
Dotti, G.2
Rooney, C.M.3
Heslop, H.E.4
Brenner, M.K.5
-
48
-
-
10644253717
-
Activation of NK cell cytotoxicity
-
Smyth, M.J., Cretney, E., Kelly, J.M., Westwood, J.A., Street, S.E.A., Yagita, H., Takeda, K., van Dommelen, S.L.H., Degli-Esposti, M.A. and Hayakawa, Y. (2005) Activation of NK cell cytotoxicity. Mol. Immunol., 42, 501-510.
-
(2005)
Mol. Immunol.
, vol.42
, pp. 501-510
-
-
Smyth, M.J.1
Cretney, E.2
Kelly, J.M.3
Westwood, J.A.4
Street, S.E.A.5
Yagita, H.6
Takeda, K.7
van Dommelen, S.L.H.8
Degli-Esposti, M.A.9
Hayakawa, Y.10
-
49
-
-
0037103311
-
Retargeting of natural killer-cell cytolytic activity to ErbB2-expressing cancer cells results in efficient and selective tumor cell destruction
-
Uherek, C., Tonn, T., Uherek, B., Becker, S., Schnierle, B., Klingemann, H. and Wels, W. (2002) Retargeting of natural killer-cell cytolytic activity to ErbB2-expressing cancer cells results in efficient and selective tumor cell destruction. Blood, 100, 1265-1273.
-
(2002)
Blood
, vol.100
, pp. 1265-1273
-
-
Uherek, C.1
Tonn, T.2
Uherek, B.3
Becker, S.4
Schnierle, B.5
Klingemann, H.6
Wels, W.7
-
50
-
-
37349039692
-
Expression of a CD20-specific chimeric antigen receptor enhances cytotoxic activity of NK cells and overcomes NK-resistance of lymphoma and leukemia cells
-
Müller, T., Uherek, C., Maki, G., Chow, K.U., Schimpf, A., Klingemann, H., Tonn, T. and Wels, W.S. (2008) Expression of a CD20-specific chimeric antigen receptor enhances cytotoxic activity of NK cells and overcomes NK-resistance of lymphoma and leukemia cells. Cancer Immunol. Immunother., 57, 411-423.
-
(2008)
Cancer Immunol. Immunother.
, vol.57
, pp. 411-423
-
-
Müller, T.1
Uherek, C.2
Maki, G.3
Chow, K.U.4
Schimpf, A.5
Klingemann, H.6
Tonn, T.7
Wels, W.S.8
-
51
-
-
68049142423
-
2B4 (CD244) signaling by recombinant antigen-specific chimeric receptors costimulates natural killer cell activation to leukemia and neuroblastoma cells
-
Altvater, B., Landmeier, S., Pscherer, S., Temme, J., Schweer, K., Kailayangiri, S., Campana, D., Juergens, H., Pule, M. and Rossig, C. (2009) 2B4 (CD244) signaling by recombinant antigen-specific chimeric receptors costimulates natural killer cell activation to leukemia and neuroblastoma cells. Clin. Cancer Res., 15, 4857-4866.
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 4857-4866
-
-
Altvater, B.1
Landmeier, S.2
Pscherer, S.3
Temme, J.4
Schweer, K.5
Kailayangiri, S.6
Campana, D.7
Juergens, H.8
Pule, M.9
Rossig, C.10
-
52
-
-
2942755603
-
Characterization of interleukin-15 gene-modified human natural killer cells: implications for adoptive cellular immunotherapy
-
Zhang, J., Sun, R., Wei, H., Zhang, J. and Tian, Z. (2004) Characterization of interleukin-15 gene-modified human natural killer cells: implications for adoptive cellular immunotherapy. Haematologica, 89, 338-347.
-
(2004)
Haematologica
, vol.89
, pp. 338-347
-
-
Zhang, J.1
Sun, R.2
Wei, H.3
Zhang, J.4
Tian, Z.5
-
53
-
-
42449139629
-
Functional characterization of interleukin-15 gene transduction into the human natural killer cell line NKL
-
Jiang, W., Zhang, J. and Tian, Z. (2008) Functional characterization of interleukin-15 gene transduction into the human natural killer cell line NKL. Cytotherapy, 10, 265-274.
-
(2008)
Cytotherapy
, vol.10
, pp. 265-274
-
-
Jiang, W.1
Zhang, J.2
Tian, Z.3
-
54
-
-
34548477012
-
Cytokine gene therapy using adenovirally transduced, tumorseeking activated natural killer cells
-
Goding, S.R., Yang, Q., Knudsen, K.B., Potter, D.M. and Basse, P.H. (2007) Cytokine gene therapy using adenovirally transduced, tumorseeking activated natural killer cells. Hum. Gene Ther., 18, 701-711.
-
(2007)
Hum. Gene Ther.
, vol.18
, pp. 701-711
-
-
Goding, S.R.1
Yang, Q.2
Knudsen, K.B.3
Potter, D.M.4
Basse, P.H.5
-
55
-
-
76949100884
-
Accelerated production of antigen-specific T cells for preclinical and clinical applications using gas-permeable rapid expansion cultureware (G-Rex)
-
Vera, J.F., Brenner, L.J., Gerdemann, U., Ngo, M.C., Sili, U., Liu, H., Wilson, J., Dotti, G., Heslop, H.E., Leen, A.M. and Rooney, C.M. (2010) Accelerated production of antigen-specific T cells for preclinical and clinical applications using gas-permeable rapid expansion cultureware (G-Rex). J. Immunother., 33, 305-315.
-
(2010)
J. Immunother.
, vol.33
, pp. 305-315
-
-
Vera, J.F.1
Brenner, L.J.2
Gerdemann, U.3
Ngo, M.C.4
Sili, U.5
Liu, H.6
Wilson, J.7
Dotti, G.8
Heslop, H.E.9
Leen, A.M.10
Rooney, C.M.11
-
56
-
-
78149253287
-
Acquisition, preparation, and functional assessment of human NK cells for adoptive immunotherapy
-
Lee, D.A., Verneris, M.R. and Campana, D. (2010) Acquisition, preparation, and functional assessment of human NK cells for adoptive immunotherapy. Methods Mol. Biol., 651, 61-77.
-
(2010)
Methods Mol. Biol.
, vol.651
, pp. 61-77
-
-
Lee, D.A.1
Verneris, M.R.2
Campana, D.3
-
57
-
-
33750699642
-
A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer
-
Kershaw, M.H., Westwood, J.A., Parker, L.L., Wang, G., Eshhar, Z., Mavroukakis, S.A., White, D.E., Wunderlich, J.R., Canevari, S., Rogers-Freezer, L. et al. (2006) A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer. Clin. Cancer Res., 12, 6106-6115.
-
(2006)
Clin. Cancer Res.
, vol.12
, pp. 6106-6115
-
-
Kershaw, M.H.1
Westwood, J.A.2
Parker, L.L.3
Wang, G.4
Eshhar, Z.5
Mavroukakis, S.A.6
White, D.E.7
Wunderlich, J.R.8
Canevari, S.9
Rogers-Freezer, L.10
-
58
-
-
33947265424
-
Adoptive transfer of chimeric antigen receptor re-directed cytolytic T lymphocyte clones in patients with neuroblastoma
-
Park, J.R., Digiusto, D.L., Slovak, M., Wright, C., Naranjo, A., Wagner, J., Meechoovet, H.B., Bautista, C., Chang, W., Ostberg, J.R. and Jensen, M.C. (2007) Adoptive transfer of chimeric antigen receptor re-directed cytolytic T lymphocyte clones in patients with neuroblastoma. Mol. Ther., 15, 825-833.
-
(2007)
Mol. Ther.
, vol.15
, pp. 825-833
-
-
Park, J.R.1
Digiusto, D.L.2
Slovak, M.3
Wright, C.4
Naranjo, A.5
Wagner, J.6
Meechoovet, H.B.7
Bautista, C.8
Chang, W.9
Ostberg, J.R.10
Jensen, M.C.11
-
59
-
-
33646440024
-
Treatment of metastatic renal cell carcinoma with autologous T-lymphocytes genetically retargeted against carbonic anhydrase IX: first clinical experience
-
Lamers, C.H.J., Sleijfer, S., Vulto, A.G., Kruit, W.H.J., Kliffen, M., Debets, R., Gratama, J.W., Stoter, G. and Oosterwijk, E. (2006) Treatment of metastatic renal cell carcinoma with autologous T-lymphocytes genetically retargeted against carbonic anhydrase IX: first clinical experience. J. Clin. Oncol., 24, e20-e22.
-
(2006)
J. Clin. Oncol.
, vol.24
-
-
Lamers, C.H.J.1
Sleijfer, S.2
Vulto, A.G.3
Kruit, W.H.J.4
Kliffen, M.5
Debets, R.6
Gratama, J.W.7
Stoter, G.8
Oosterwijk, E.9
-
60
-
-
50549096284
-
Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells
-
Till, B.G., Jensen, M.C., Wang, J., Chen, E.Y., Wood, B.L., Greisman, H.A., Qian, X., James, S.E., Raubitschek, A., Forman, S.J. et al. (2008) Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells. Blood, 112, 2261-2271.
-
(2008)
Blood
, vol.112
, pp. 2261-2271
-
-
Till, B.G.1
Jensen, M.C.2
Wang, J.3
Chen, E.Y.4
Wood, B.L.5
Greisman, H.A.6
Qian, X.7
James, S.E.8
Raubitschek, A.9
Forman, S.J.10
-
61
-
-
77955510549
-
Antitransgene rejection responses contribute to attenuated persistence of adoptively transferred CD20/ CD19-specific chimeric antigen receptor redirected T cells in humans
-
Jensen, M.C., Popplewell, L., Cooper, L.J., DiGiusto, D., Kalos, M., Ostberg, J.R. and Forman, S.J. (2010) Antitransgene rejection responses contribute to attenuated persistence of adoptively transferred CD20/ CD19-specific chimeric antigen receptor redirected T cells in humans. Biol. Blood Marrow Transplant., 16, 1245-1256.
-
(2010)
Biol. Blood Marrow Transplant.
, vol.16
, pp. 1245-1256
-
-
Jensen, M.C.1
Popplewell, L.2
Cooper, L.J.3
DiGiusto, D.4
Kalos, M.5
Ostberg, J.R.6
Forman, S.J.7
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