Case studies to test: A framework for using structural, reactivity, metabolic and physicochemical similarity to evaluate the suitability of analogs for SAR-based toxicological assessments

Regulatory Toxicology and Pharmacology

Volumn 60, Issue 1, 2011, Pages 120-135

  Blackburn, Karen ^a   Bjerke, Donald ^a   Daston, George ^a   Felter, Susan ^a   Mahony, Catherine ^a   Naciff, Jorge ^a   Robison, Steven ^a   Wu, Shengde ^a  

^a PROCTER AND GAMBLE COMPANY   (United States)

Author keywords

Chemical analog identification; Chemical grouping; Read across; Risk assessment; Structural similarity; Toxicological assessments

Indexed keywords

1 METHYLETHENYL BENZENE; 1,2 DIMETHYL 4 NITROBENZENE; 1,3 PROPANEDIAMINE; 2 METHYLBENZYL ALCOHOL; 2 NITROTOLUENE; 3 NITROTOLUENE; 4 METHYLBENZYL ALCOHOL; 6 TERTBUTYL M CRESOL; ALCOHOL; AROMATIC AMIDE; BENZENE; CHLORIDE; CYCLOHEXANONE; DIETHYLENE GLYCOL; DODECYLAMINE; ETHYLENEDIAMIDE DIHYDROCHLORIDE; META CRESOL; N,N DIMETHYLDODECYLAMINE; NITROBENZENE; O TOLUENESULFONAMIDE; PHTHALIC ACID DIMETHYL ESTER; SULFONAMIDE; TEREPHTHALIC ACID; THIODIGLYCOL; UNCLASSIFIED DRUG;

ARTICLE; CARCINOGENICITY; CHEMICAL ANALYSIS; CHEMICAL REACTION; CONCEPTUAL FRAMEWORK; CONTROLLED STUDY; GENOTOXICITY; HUMAN; NONHUMAN; PHYSICAL CHEMISTRY; PREDICTION; PRIORITY JOURNAL; REPRODUCTIVE TOXICITY; RISK ASSESSMENT; STRUCTURE ACTIVITY RELATION; TOXICITY TESTING;

ANIMAL TESTING ALTERNATIVES; ANIMALS; BIOLOGICAL MARKERS; HUMANS; PREDICTIVE VALUE OF TESTS; REPRODUCIBILITY OF RESULTS; REPRODUCTION; RISK ASSESSMENT; SALMONELLA TYPHIMURIUM; STRUCTURE-ACTIVITY RELATIONSHIP; TOXICITY TESTS; TOXICOLOGY; XENOBIOTICS;

EID: 79956003626     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2011.03.002     Document Type: Article

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