A safety assessment of non-cyclic alcohols with unsaturated branched chain when used as fragrance ingredients. The RIFM expert panel

Food and Chemical Toxicology

Volumn 48, Issue SUPPL. 3, 2010, Pages

  Belsito, D ^a   Bickers, D ^b   Bruze, M ^c   Calow, P ^d   Greim, H ^e   Hanifin, J M ^f   Rogers, A E ^g   Saurat, J H ^h   Sipes, I G ⁱ   Tagami, H ^j  

^a UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

^b NewYork Presbyterian Hospital   (United States)

^c LUND UNIVERSITY HOSPITAL   (Sweden)

^d ROSKILDE UNIVERSITY   (Denmark)

^e TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^f OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^g BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h GENEVA UNIVERSITY HOSPITALS   (Switzerland)

ⁱ UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^j NONE   (Japan)

more..

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DIHYDROLINALOOL; 2 METHYL 2 HEPTEN 6 OL; 2 METHYL 6 METHYLENEOCT 7 EN 2 OL; 2 PENTEN 1 OL; 3 METHYL 2 BUTEN 1 OL; 3,5,6,6 TETRAMETHYL 4 METHYLENEHEPTAN 2 OL; 6 ETHYL 3 METHYLOCT 6 EN 1 OL; CITRONELLOL; DEHYDROLINALOOL; DIHYDROAPOFARNESOL; DIHYDROMYRCENOL; FARNESOL; FRAGRANCE; GERANIOL; HOMOCITRONELLOL; ISOPHYTOL; LINALOOL; METHYLHEPTENOL; MUGUOL; MYRCENOL; NEROL; NEROLIDOL; NONA 2,6 DIEN 1 OL; OCIMENOL; PHYTOL; RHODINOL; TETRAHYDROMUGUOL; UNCLASSIFIED DRUG; UNDECAVERTOL;

ALCOHOL OXIDATION; CARBON METABOLISM; CARCINOGENICITY; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CONJUGATION; GENOTOXICITY; HUMAN; HYDROGENATION; IN VITRO STUDY; IN VIVO STUDY; LIVER TOXICITY; MOLECULAR WEIGHT; NONHUMAN; PHOTOALLERGY; PHOTOTOXICITY; PHYSICAL CHEMISTRY; REPRODUCTIVE TOXICITY; REVIEW; RISK ASSESSMENT; SKIN IRRITATION; SKIN SENSITIZATION; SKIN TEST; TOXICITY TESTING;

ALCOHOLS; ANIMALS; HUMANS; ODORS;

EID: 77951944624     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2009.11.007     Document Type: Review

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115. Research Institute for Fragrance Materials, Inc. (RIFM), 1980h. Phototoxicity study of dimyrcetol. Unpublished report from International Flavors and Fragrance. Report number 50436. RIFM, Woodcliff Lake, NJ, USA.
116. Research Institute for Fragrance Materials, Inc. (RIFM), 1980i. In vitro phototoxicity assay. Unpublished Report from IFF. RIFM report number 47076, 6 August. RIFM, Woodcliff Lake, NJ, USA.
117. Research Institute for Fragrance Materials, Inc. (RIFM), 1981a. Report on human maximization studies. RIFM report number 1792. March to November. RIFM, Woodcliff Lake, NJ, USA.
118. Research Institute for Fragrance Materials, Inc. (RIFM), 1981b. Repeated insult patch test with 4-methyl-3-decen-5-ol. Unpublished report from Givaudan, Report number 49104, 28 April. RIFM, Woodcliff Lake, NJ, USA.
119. Research Institute for Fragrance Materials, Inc. (RIFM), 1981c. Phototoxicity testing of fragrance materials. Unpublished report from IFF Incorporated, RIFM report number 47075, 9 March. RIFM, Woodcliff Lake, NJ, USA.
120. Research Institute for Fragrance Materials, Inc. (RIFM), 1982a. Acute toxicity studies. Unpublished report from RIFM, RIFM report number 1689, February-September 1982. RIFM, Woodcliff Lake, NJ, USA.
121. Research Institute for Fragrance Materials, Inc. (RIFM), 1982b. Mutagenicity evaluation of linalool in the mouse lymphoma forward mutation assay. Report from Lorillard Tobacco Company, 31 August, cited in Heck et al. (1989). Report number 35826. RIFM, Woodcliff Lake, NJ, USA.
122. Research Institute for Fragrance Materials, Inc. (RIFM), 1982c. Acute toxicity studies. RIFM report number 1689, February 22. RIFM, Woodcliff Lake, NJ, USA.
123. Research Institute for Fragrance Materials, Inc. (RIFM), 1983a. Mutagenicity evaluation of linalool in the Ames Salmonella/microsome plate test. Unpublished report from Lorillard Tobacco Company, 20 July. Report number 35823. RIFM, Woodcliff Lake, NJ, USA.
124. Research Institute for Fragrance Materials, Inc. (RIFM), 1983b. Mutagenicity evaluation of linalool in an in vitro cytogenetic assay measuring chromosome aberration frequencies in Chinese hamster ovary (CHO) cells. Unpublished report from Lorillard Tobacco Company, Report number 35824, 7 October. RIFM, Woodcliff Lake, NJ, USA.
125. Research Institute for Fragrance Materials, Inc. (RIFM), 1984a. Primary irritation test in rabbits. RIFM report number 1795, June 01. RIFM, Woodcliff Lake, NJ, USA.
126. Research Institute for Fragrance Materials, Inc. (RIFM), 1984b. Acute eye irritation test of dimyrcetol in rabbits. Unpublished report from International Flavors and Fragrances, Report number 50435, April. RIFM, Woodcliff Lake, NJ, USA.
127. Research Institute for Fragrance Materials, Inc. (RIFM), 1985. Acute dermal irritation study in rabbits. RIFM report number 3099, June 01. RIFM, Woodcliff Lake, NJ, USA.
128. Research Institute for Fragrance Materials, Inc. (RIFM), 1986a. Unscheduled DNA synthesis in rat primary hepatocytes. Report from Lorillard Tobacco Company, 5 May, cited in Heck et al. (1989). Report number 35825. RIFM, Woodcliff Lake, NJ, USA.
129. Research Institute for Fragrance Materials, Inc. (RIFM), 1986b. Acute dermal irritation study in rabbits. RIFM report number 5664, June 01. RIFM, Woodcliff Lake, NJ, USA.
130. Research Institute for Fragrance Materials, Inc. (RIFM), 1989a. Report on the mutagenicity testing with farnesol. Unpublished report from Dragoco Gerberding and Co. GmbH. Report number 37820. RIFM, Woodcliff Lake, NJ, USA.
131. Research Institute for Fragrance Materials, Inc. (RIFM), 1989b. Report on the study of dehydrolinalool in the Ames test (Standard plate test and preincubation test with Salmonella typhimurium). Unpublished report from BASF. Report number 26074, 14 March. RIFM, Woodcliff Lake, NJ, USA.
132. Research Institute for Fragrance Materials, Inc. (RIFM), 1989c. Determination of photoallergenicity in albino guinea pigs with 4-methyl-3-decen-5-ol. Unpublished report from Givaudan, 27 November. Report number 49105. RIFM, Woodcliff Lake, NJ, USA.
133. Research Institute for Fragrance Materials, Inc. (RIFM), 1989d. Reproductive and developmental toxicity screening test of Coriander Oil administered orally via gavage to Crl: Cd(tm) (sd) br female rats. Unpublished report from Lorillard Tobacco Company, 12 April. Report number 36124. RIFM, Woodcliff Lake, NJ, USA.
134. Research Institute for Fragrance Materials, Inc. (RIFM), 1989e. Study on the acute inhalation toxicity of 2-methyl-3-buten-2-ol as a vapor in rats. Unpublished report from BASF. Report number 55325. RIFM, Woodcliff Lake, NJ, USA.
135. Research Institute for Fragrance Materials, Inc. (RIFM), 1989f. Report on the study of 2-methyl-3-buten-2-ol in the Ames test. Unpublished report from BASF. Report number 55328. RIFM, Woodcliff Lake, NJ, USA.
136. Research Institute for Fragrance Materials, Inc. (RIFM), 1989g. Report on the study of isophytol in the AMES test with Salmonella typhimurium. Unpublished report from BASF, 15 February. Report number 55368. RIFM, Woodcliff Lake, NJ, USA.
137. Research Institute for Fragrance Materials, Inc. (RIFM), 1989h. Report on the study of 3-methylbuten-2-o1-1 in the Ames test with Salmonella typhimurium. Unpublished report from BASF. Report number 55387, 24 February. RIFM, Woodcliff Lake, NJ, USA.
138. Research Institute for Fragrance Materials, Inc. (RIFM), 1990.A 28-day oral toxicity study of Coriander oil in rats. Unpublished report from Lorillard Tobacco Company, 25 January. Report number 36125. RIFM, Woodcliff Lake, NJ, USA.
139. Research Institute for Fragrance Materials, Inc. (RIFM), 1991. Report on the maximization test for the sensitizing potential of 2-methyl-3-buten-2-ol in guinea pigs. Unpublished report from BASF. Report number 55335. RIFM, Woodcliff Lake, NJ, USA.
140. Research Institute for Fragrance Materials, Inc. (RIFM), 1991b. Report on the study of isophytol in the liquid suspension assay modified Salmonella/Mammalian-Microsome mutagenicity test. Unpublished report from BASF, 15 October. Report number 55369. RIFM, Woodcliff Lake, NJ, USA.
141. Research Institute for Fragrance Materials, Inc. (RIFM), 1991c. Report on the study of 3-methylbuten-2-ol-1 in the liquid suspension assay modified Salmonella/mammalian-microsome mutagenicity test. Unpublished report from BASF. Report number 55388, 19 September. RIFM, Woodcliff Lake, NJ, USA.
142. Research Institute for Fragrance Materials, Inc. (RIFM), 1992. Cytogenetic study 2-methyl-3-buten-2-ol in mice. Unpublished report from BASF. Report number 55334. RIFM, Woodcliff Lake, NJ, USA.
143. Research Institute for Fragrance Materials, Inc. (RIFM), 1994a. Mutagenicity test on linalool in the L5178YTK mouse lymphoma forward mutation assay with a confirmatory assay. Unpublished report from Lorillard Tobacco Company, 3 March. Report number 35827. RIFM, Woodcliff Lake, NJ, USA.
144. Research Institute for Fragrance Materials, Inc. (RIFM), 1994b. Test for delayed contact hypersensitivity of dihydromyrcenol using the guinea pig maximization test. Unpublished report from Haarmann & Reimer GmbH. Report number 24241, 29 July. RIFM, Woodcliff Lake, NJ, USA.
145. Research Institute for Fragrance Materials, Inc. (RIFM), 1994c. The Buehler test on dihydromyrcenol. Unpublished report from Haarmann & Reimer GmbH. Report number 24242, 30 September. RIFM, Woodcliff Lake, NJ, USA.
146. Research Institute for Fragrance Materials, Inc. (RIFM), 1994d. Repeated dose oral toxicity study with 2-methyl-3-buten-2-ol in Wistar rats. Unpublished report from BASF. Report number 55324. RIFM, Woodcliff Lake, NJ, USA.
147. Research Institute for Fragrance Materials, Inc. (RIFM), 1995. Repeated insult patch test on dihydromyrcenol on human subjects. RIFM report number 25722, June 21. RIFM, Woodcliff Lake, NJ, USA.
148. Research Institute for Fragrance Materials, Inc. (RIFM), 1996. Local lymph node assay of dihydromyrcenol. Unpublished report from Haarmann & Reimer GmbH. Report number 35547. RIFM, Woodcliff Lake, NJ, USA.
149. Research Institute for Fragrance Materials, Inc. (RIFM), 1999. Toxicology studies of isophytol in the guinea pig. Unpublished report from Takasago International Corporation, Report number 35058. RIFM, Woodcliff Lake, NJ, USA.
150. Research Institute for Fragrance Materials, Inc. (RIFM), 2000. 4-Methyl-3-decen-5-ol: primary skin irritation study in rabbits (4h semi-occlusive application). Unpublished report from Givaudan Vernier SA. Report number 41335, 2 November. RIFM, Woodcliff Lake, NJ, USA.
151. Research Institute for Fragrance Materials, Inc. (RIFM), 2001a. Micronucleus test in bone marrow cells of the mouse with linalool. Unpublished report from Hoffmann-LaRoche. Report number 38577, 18 November. RIFM, Woodcliff Lake, NJ, USA.
152. Research Institute for Fragrance Materials, Inc. (RIFM), 2001b. Cytogenetic study in vivo with 3-methyl-2-buten-1-ol in the mouse micronucleus test after two intraperitoneal administrations. Unpublished report from BASF. Report number 55397, 14 May. RIFM, Woodcliff Lake, NJ, USA.
153. Research Institute for Fragrance Materials, Inc. (RIFM), 2002a. Evaluation of the mutagenic activity of 4-methyl-3-decen-5-ol in the Salmonella typhimurium reverse mutation assay. Unpublished report from Givaudan Vernier SA. RIFM report number 42179, 11 November. RIFM, Woodcliff Lake, NJ, USA.
154. Research Institute for Fragrance Materials, Inc. (RIFM), 2002b. Evaluation of the mutagenic activity of 3,7-dimethyl-1,6-nonadien-3-ol in the Salmonella typhimurium reverse mutation assay. Unpublished report from Givaudan. Report number 43045, 31 October. RIFM, Woodcliff Lake, NJ, USA.
155. Research Institute for Fragrance Materials, Inc. (RIFM), 2002c. 3-Methyl-2-buten-1-ol (Prenol): subchronic toxicity study in Wistar rats administered in drinking water for 3 months. Unpublished report from BASF. Report number 55401, 11 April RIFM, Woodcliff Lake, NJ, USA.
156. Research Institute for Fragrance Materials, Inc. (RIFM), 2002d. 3-Methyl-2-buten-1-ol (Prenol) - Prenatal developmental toxicity study in Wistar rats by oral administration (gavage). Unpublished report from BASF. Report number 55398, 27 March. RIFM, Woodcliff Lake, NJ, USA.
157. Research Institute for Fragrance Materials, Inc. (RIFM), 2003a. Translation: details on an acute oral toxicity study in the rat with 3-methyl-2-buten-1-ol. Unpublished report from BASF. Report number 55408, 8 January. RIFM, Woodcliff Lake, NJ, USA.
158. Research Institute for Fragrance Materials, Inc. (RIFM), 2003b. Translation: details on an acute intraperitoneal toxicity study in the mouse with 3-methyl-2-buten-1-ol. Unpublished report from BASF. Report number 55406, 8 January. RIFM, Woodcliff Lake, NJ, USA.
159. Research Institute for Fragrance Materials, Inc. (RIFM), 2003c. 3-Methyl-2-buten-1-ol (Prenol): Test study in Wistar rats administered in the drinking water and by gavage for 2 weeks. Unpublished report from BASF. Report number 55403, 24 January. RIFM, Woodcliff Lake, NJ, USA.
160. Research Institute for Fragrance Materials, Inc. (RIFM), 2003d. 3-Methyl-2-buten-1-ol (Prenol): palatability study in Wistar rats administered in drinking water for 2 weeks. Unpublished report from BASF. Report number 55404, 24 January. RIFM, Woodcliff Lake, NJ, USA.
161. Research Institute for Fragrance Materials, Inc. (RIFM), 2003e. Translation: details on an inhalation risk test in the rat with 3-methyl-2-buten-1-ol. Unpublished report from BASF. Report number 55407, 8 January. RIFM, Woodcliff Lake, NJ, USA.
162. Research Institute for Fragrance Materials, Inc. (RIFM), 2003f. Translation: details on an eye irritation / corrosion study in rabbits with 3-methyl-2-buten-1-ol. Unpublished report from BASF. Report number 55409, 8 January. RIFM, Woodcliff Lake, NJ, USA.
163. Research Institute for Fragrance Materials, Inc. (RIFM), 2003g. Details on a skin irritation/corrosion study in rabbits with 3-methyl-2-buten-1-ol. Unpublished report from BASF. Report number 55405, 8 January. RIFM, Woodcliff Lake, NJ, USA.
164. Research Institute for Fragrance Materials, Inc. (RIFM), 2003h. 3-Methyl-2-buten-1-ol (Prenol): maternal toxicity study in Wistar rats by oral administration (gavage). Unpublished report from BASF. Report number 55402, 23 January. RIFM, Woodcliff Lake, NJ, USA.
165. Research Institute for Fragrance Materials, Inc. (RIFM), 2004a. Toxicity studies with 7-nonen-2-ol, 4,8-dimethyl- in guinea pigs and rats. Unpublished report from Takasago International Corporation, 29 July. Report number 46339. RIFM, Woodcliff Lake, NJ, USA.
166. Research Institute for Fragrance Materials, Inc. (RIFM), 2006b. Repeated insult patch test (modified Draize procedure). RIFM report number 45702, February 01. RIFM, Woodcliff Lake, NJ, USA.
167. Research Institute for Fragrance Materials, Inc. (RIFM), 2006c. In vitro human skin penetration of fragrance material linalool under both in-use and occluded conditions from an ethanol/water vehicle. In: Draft. RIFM, Woodcliff Lake, NJ, USA.
168. Research Institute for Fragrance Materials, Inc. (RIFM), 2006d. In vitro human skin penetration of fragrance material linalool under both in-use and occluded conditions from a dipropylene glycol (DPG) vehicle. In: Draft. RIFM, Woodcliff Lake, NJ, USA.
169. Research Institute for Fragrance Materials, Inc. (RIFM), 2006e. In vitro human skin penetration of fragrance material linalool under both in-use and occluded conditions from a diethyl phthalate (DEP) vehicle. In: Draft. RIFM, Woodcliff Lake, NJ, USA.
170. Research Institute for Fragrance Materials, Inc. (RIFM), 2007a. Dimyrcetol: ninety day repeated dose oral (gavage) toxicity study in the rat. RIFM report number 52794, April 24. RIFM, Woodcliff Lake, NJ, USA.
171. Research Institute for Fragrance Materials, Inc. (RIFM), 2007b. Local Lymph Node Assay. RIFM report number 52911, May 21. RIFM, Woodcliff Lake, NJ, USA.
172. Research Institute for Fragrance Materials, Inc. (RIFM), 2007c. In vitro human skin penetration of fragrance material linalool under both in-use and occluded conditions from an ethanol/dipropylene glycol vehicle. In: Draft. RIFM, Woodcliff Lake, NJ, USA.
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