HIV gp41 six-helix bundle constructs induce rapid vesicle fusion at pH 3.5 and little fusion at pH 7.0: Understanding pH dependence of protein aggregation, membrane binding, and electrostatics, and implications for HIV-host cell fusion

European Biophysics Journal

Volumn 40, Issue 4, 2011, Pages 489-502

  Sackett, Kelly ^a   Terbush, Allan ^b   Weliky, David P ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b Michigan State University   (United States)

Author keywords

gp41; HIV; Membrane fusion; pH; Pre hairpin intermediate; Six helix bundle

Indexed keywords

GLYCOPROTEIN GP 41;

AMINO ACID SEQUENCE; ARTICLE; CELL FUSION; CELL MEMBRANE; CHEMISTRY; DRUG EFFECT; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MEMBRANE FUSION; METABOLISM; MOLECULAR GENETICS; PATHOLOGY; PH; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; SOLUBILITY; SOLUTION AND SOLUBILITY; STATIC ELECTRICITY;

AMINO ACID SEQUENCE; CELL FUSION; CELL MEMBRANE; HIV; HIV ENVELOPE PROTEIN GP41; HIV INFECTIONS; HUMANS; HYDROGEN-ION CONCENTRATION; MEMBRANE FUSION; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; SOLUBILITY; SOLUTIONS; STATIC ELECTRICITY;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 79955988323     PISSN: 01757571     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00249-010-0662-3     Document Type: Article

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