메뉴 건너뛰기




Volumn 43, Issue 2, 2011, Pages 116-127

Molecular assays in breast cancerpathology

Author keywords

Breast cancer; Chromosome 17; HER2; In situ hybridisation; MammaPrint; Molecular assays; Oncotype DX; Prognostic biomarkers; TOP2A

Indexed keywords

DNA BINDING PROTEIN; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE II ALPHA; TUMOR ANTIGEN;

EID: 79955973200     PISSN: 00313025     EISSN: 14653931     Source Type: Journal    
DOI: 10.1097/PAT.0b013e3283430926     Document Type: Review
Times cited : (19)

References (103)
  • 1
    • 0034690750 scopus 로고    scopus 로고
    • UK and USA breast cancer deaths down 25% in year 2000 at ages 20-69 years
    • Peto R, Boreham J, Clarke M, Davies C, Beral V. UK and USA breast cancer deaths down 25% in year 2000 at ages 20-69 years. Lancet 2000; 355: 1822. (Pubitemid 30265099)
    • (2000) Lancet , vol.355 , Issue.9217 , pp. 1822
    • Peto, R.1    Boreham, J.2    Clarke, M.3    Davies, C.4    Berai, C.5
  • 2
    • 19344364880 scopus 로고    scopus 로고
    • Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials
    • Early Breast Cancer Trialists' Collaborative Group (EBCTCG)
    • Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 2005; 365: 1687-717.
    • (2005) Lancet , vol.365 , pp. 1687-1717
  • 4
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987; 235: 177-82. (Pubitemid 17231334)
    • (1987) Science , vol.235 , Issue.4785 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3
  • 5
    • 0023640312 scopus 로고
    • Proto-oncogenes and human cancers
    • Slamon DJ.proto-oncogenes and human cancers. N Engl J Med 1987; 317: 955-7. (Pubitemid 17147940)
    • (1987) New England Journal of Medicine , vol.317 , Issue.15 , pp. 955-957
    • Slamon, D.J.1
  • 7
    • 77950481721 scopus 로고    scopus 로고
    • Understanding the HER family in breast cancer: Interaction with ligands, dimerization and treatments
    • Barros FF,powe DG, Ellis IO, Green AR. Understanding the HER family in breast cancer: interaction with ligands, dimerization and treatments. Histopathology 2010; 56: 560-72.
    • (2010) Histopathology , vol.56 , pp. 560-572
    • Barros, F.F.1    Powe, D.G.2    Ellis, I.O.3    Green, A.R.4
  • 10
    • 78650517326 scopus 로고    scopus 로고
    • Establishment of the Australian in situ hybridizationprogram for the assessment of HER2 amplification in breast cancer: A model for the introduction of new biomarkers into clinicalpractice
    • Farshid G, Armes JE, Bell R, et al. Establishment of the Australian in situ hybridizationprogram for the assessment of HER2 amplification in breast cancer: A model for the introduction of new biomarkers into clinicalpractice. Diagn Molpathol 2010; 19: 187-93.
    • (2010) Diagn Molpathol , vol.19 , pp. 187-193
    • Farshid, G.1    Armes, J.E.2    Bell, R.3
  • 11
    • 34347395733 scopus 로고    scopus 로고
    • Trastuzumab-mechanism of action and use in clinicalpractice
    • Hudis CA. Trastuzumab-mechanism of action and use in clinicalpractice. N Engl J Med 2007; 357: 39-51.
    • (2007) N Engl J Med , vol.357 , pp. 39-51
    • Hudis, C.A.1
  • 15
    • 34548444589 scopus 로고    scopus 로고
    • Adjuvant trastuzumab in the treatment of her-2-positive early breast cancer: A metaanalysis ofpublished randomized trials
    • Viani GA, Afonso SL, Stefano EJ, De Fendi LI, Soares FV. Adjuvant trastuzumab in the treatment of her-2-positive early breast cancer: a metaanalysis ofpublished randomized trials. BMC Cancer 2007; 7: 153.
    • (2007) BMC Cancer , vol.7 , pp. 153
    • Viani, G.A.1    Afonso, S.L.2    Stefano, E.J.3    De Fendi, L.I.4    Soares, F.V.5
  • 16
    • 73949090721 scopus 로고    scopus 로고
    • Giordano SH.prognosis of women with metastatic breast cancer by HER2 status and trastuzumab treatment: An institutional-based review
    • Dawood S, Broglio K, Buzdar AU, Hortobagyi GN, Giordano SH.prognosis of women with metastatic breast cancer by HER2 status and trastuzumab treatment: an institutional-based review. J Clin Oncol 2010; 28: 92-8.
    • (2010) J Clin Oncol , vol.28 , pp. 92-98
    • Dawood, S.1    Broglio, K.2    Buzdar, A.U.3    Hortobagyi, G.N.4
  • 22
    • 70349577111 scopus 로고    scopus 로고
    • Emerging technologies for assessing HER2 amplification
    • Penault-Llorca F, Bilous M, Dowsett M, et al. Emerging technologies for assessing HER2 amplification. Am J Clinpathol 2009; 132: 539-48.
    • (2009) Am J Clinpathol , vol.132 , pp. 539-548
    • Penault-Llorca, F.1    Bilous, M.2    Dowsett, M.3
  • 23
    • 40449131620 scopus 로고    scopus 로고
    • Chromogenic in situ hybridisation for the assessment of HER2 status in breast cancer: An international validation ring study
    • van de Vijver M, Bilous M, Hanna W, et al. Chromogenic in situ hybridisation for the assessment of HER2 status in breast cancer: an international validation ring study. Breast Cancer Res 2007; 9: R68.
    • (2007) Breast Cancer Res , vol.9
    • Van De Vijver, M.1    Bilous, M.2    Hanna, W.3
  • 24
    • 33645539711 scopus 로고    scopus 로고
    • Chromogenic in situ hybridisation testing for HER2 gene amplification in breast cancerproduces highly reproducible results concordant with fluorescence in situ hybridisation and immunohistochemistry
    • Bilous M, Morey A, Armes J, Cummings M, Francis G. Chromogenic in situ hybridisation testing for HER2 gene amplification in breast cancerproduces highly reproducible results concordant with fluorescence in situ hybridisation and immunohistochemistry.pathology 2006; 38: 120-4.
    • (2006) Pathology , vol.38 , pp. 120-124
    • Bilous, M.1    Morey, A.2    Armes, J.3    Cummings, M.4    Francis, G.5
  • 25
    • 77953044525 scopus 로고    scopus 로고
    • Silver in situ hybridization (SISH) for determination of HER2 gene status in breast carcinoma: Comparison with FISH and assessment of interobserver reproducibility
    • Papouchado BG, Myles J, Lloyd RV, et al. Silver in situ hybridization (SISH) for determination of HER2 gene status in breast carcinoma: comparison with FISH and assessment of interobserver reproducibility. Am J Surgpathol 2010; 34: 767-76.
    • (2010) Am J Surgpathol , vol.34 , pp. 767-776
    • Papouchado, B.G.1    Myles, J.2    Lloyd, R.V.3
  • 26
    • 62449090881 scopus 로고    scopus 로고
    • Guidelines for human epidermal growth factor receptor 2 testing: Biologic and methodologic considerations
    • Sauter G, Lee J, Bartlett JM, Slamon DJ,press MF. Guidelines for human epidermal growth factor receptor 2 testing: biologic and methodologic considerations. J Clin Oncol 2009; 27: 1323-33.
    • (2009) J Clin Oncol , vol.27 , pp. 1323-1333
    • Sauter, G.1    Lee, J.2    Bartlett, J.M.3    Slamon, D.J.4    Press, M.F.5
  • 28
    • 68849111431 scopus 로고    scopus 로고
    • Does chromosome 17 centromere copy numberpredictpolysomy in breast cancer? A fluorescence in situ hybridization and microarray-based CGH analysis
    • Marchio C, Lambros MB, Gugliotta P, et al. Does chromosome 17 centromere copy numberpredictpolysomy in breast cancer? A fluorescence in situ hybridization and microarray-based CGH analysis. J Pathol 2009; 219: 16-24.
    • (2009) J Pathol , vol.219 , pp. 16-24
    • Marchio, C.1    Lambros, M.B.2    Gugliotta, P.3
  • 30
    • 68849119063 scopus 로고    scopus 로고
    • The need to consider the mechanisms for CEP17 copy number changes in breast cancer
    • Viale G. Beprecise! The need to consider the mechanisms for CEP17 copy number changes in breast cancer. J Pathol 2009; 219: 1-2.
    • (2009) J Pathol , vol.219 , pp. 1-2
    • Beprecise, V.G.1
  • 31
    • 58049212010 scopus 로고    scopus 로고
    • Determination of HER2 amplification by in situ hybridization when should chromosome 17 also be determined?
    • Bartlett JM, Campbell FM, Mallon EA. Determination of HER2 amplification by in situ hybridization: when should chromosome 17 also be determined? Am J Clinpathol 2008; 130: 920-6.
    • (2008) Am J Clinpathol , vol.130 , pp. 920-926
    • Bartlett, J.M.1    Campbell, F.M.2    Mallon, E.A.3
  • 32
    • 0037272682 scopus 로고    scopus 로고
    • Chromosome 17 aneusomy is associated with poor prognostic factors in invasive breast carcinoma
    • DOI 10.1023/A:1021399923825
    • Watters AD, Going JJ, Cooke TG, Bartlett JM. Chromosome 17 aneusomy is associated withpoorprognostic factors in invasive breast carcinoma. Breast Cancer Res Treat 2003; 77: 109-14. (Pubitemid 36197611)
    • (2003) Breast Cancer Research and Treatment , vol.77 , Issue.2 , pp. 109-114
    • Watters, A.D.1    Going, J.J.2    Cooke, T.G.3    Bartlett, J.M.S.4
  • 33
    • 77449106709 scopus 로고    scopus 로고
    • A UK NEQAS ICC and ISH multicentre study using the Kreatechposeidon HER2 FISHprobe: Intersite variation can be rigorously controlled using FISH
    • Bartlett JM, Campbell FM, Ibrahim M, et al. A UK NEQAS ICC and ISH multicentre study using the Kreatechposeidon HER2 FISHprobe: intersite variation can be rigorously controlled using FISH. Histopathology 2010; 56: 297-304.
    • (2010) Histopathology , vol.56 , pp. 297-304
    • Bartlett, J.M.1    Campbell, F.M.2    Ibrahim, M.3
  • 34
    • 0036314362 scopus 로고    scopus 로고
    • Clinical laboratory assays for HER-2/neu amplification and overexpression: Quality assurance, standardisation, andproficiency testing
    • Pathologists CMaCCCoA. Clinical laboratory assays for HER-2/neu amplification and overexpression: Quality assurance, standardisation, andproficiency testing. Archpathol Lab Med 2002; 126: 803-8.
    • (2002) Archpathol Lab Med , vol.126 , pp. 803-808
    • Pathologists, C.1    Maccco, A.2
  • 36
    • 57349113761 scopus 로고    scopus 로고
    • Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen
    • Hurtado A, Holmes KA, Geistlinger TR, et al. Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen. Nature 2008; 456: 663-6.
    • (2008) Nature , vol.456 , pp. 663-666
    • Hurtado, A.1    Holmes, K.A.2    Geistlinger, T.R.3
  • 37
    • 0035879210 scopus 로고    scopus 로고
    • Value of epidermal growth factor receptor, HER2, p53, and steroid receptors in predicting the efficacy of tamoxifen in high-risk postmenopausal breast cancer patients
    • Knoop AS, Bentzen SM, Nielsen MM, Rasmussen BB, Rose C. Value of epidermal growth factor receptor, HER2,p53, and steroid receptors inpredicting the efficacy of tamoxifen in high-riskpostmenopausal breast cancerpatients. J Clin Oncol 2001; 19: 3376-84. (Pubitemid 32642190)
    • (2001) Journal of Clinical Oncology , vol.19 , Issue.14 , pp. 3376-3384
    • Knoop, A.S.1    Bentzen, S.M.2    Nielsen, M.M.3    Rasmussen, B.B.4    Rose, C.5
  • 38
    • 33646198056 scopus 로고    scopus 로고
    • Benefit from adjuvant tamoxifen therapy inprimary breast cancerpatients according oestrogen receptor,progesterone receptor EGF receptor and HER2 status
    • Dowsett M, Houghton J, Iden C, et al. Benefit from adjuvant tamoxifen therapy inprimary breast cancerpatients according oestrogen receptor, progesterone receptor, EGF receptor and HER2 status. Ann Oncol 2006; 17: 818-26.
    • (2006) Ann Oncol , vol.17 , pp. 818-826
    • Dowsett, M.1    Houghton, J.2    Iden, C.3
  • 39
    • 23044463773 scopus 로고    scopus 로고
    • Tumor-specific expression of vascular endothelial growth factor receptor 2 but not vascular endothelial growth factor or human epidermal growth factor receptor 2 is associated with impaired response to adjuvant tamoxifen in premenopausal breast cancer
    • DOI 10.1200/JCO.2005.08.126
    • Ryden L, Jirstrom K, BendahlpO, et al. Tumor-specific expression of vascular endothelial growth factor receptor 2 but not vascular endothelial growth factor or human epidermal growth factor receptor 2 is associated with impaired response to adjuvant tamoxifen inpremenopausal breast cancer. J Clin Oncol 2005; 23: 4695-704. (Pubitemid 46224072)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.21 , pp. 4695-4704
    • Ryden, L.1    Jirstrom, K.2    Bendahl, P.-O.3    Ferno, M.4    Nordenskjold, B.5    Stal, O.6    Thorstenson, S.7    Jonsson, P.-E.8    Landberg, G.9
  • 44
    • 2642566088 scopus 로고    scopus 로고
    • Anthracyclines: Molecular advances and pharmacologie developments in antitumor activity and cardiotoxicity
    • DOI 10.1124/pr.56.2.6
    • Minotti G, Menna P, Salvatorelli E, Cairo G, Gianni L. Anthracyclines: molecular advances andpharmacologic developments in antitumor activity and cardiotoxicity.pharmacol Rev 2004; 56: 185-229. (Pubitemid 38720829)
    • (2004) Pharmacological Reviews , vol.56 , Issue.2 , pp. 185-229
    • Minotti, G.1    Menna, P.2    Salvatorelli, E.3    Cairo, G.4    Gianni, L.5
  • 45
    • 24644476579 scopus 로고    scopus 로고
    • Randomized trial comparing cyclophosphamide, epirubicin, and fluorouracil with cyclophosphamide, methotrexate, and fluorouracil in premenopausal women with node-positive breast cancer: Update of National Cancer Institute of Canada Clinical Trials Group Trial MA5
    • DOI 10.1200/JCO.2005.09.423
    • Levine MN,pritchard KI, Bramwell VH, Shepherd LE, Tu D,paul N. Randomized trial comparing cyclophosphamide, epirubicin, and fluorouracil with cyclophosphamide, methotrexate, and fluorouracil inpremenopausal women with node-positive breast cancer: update of National Cancer Institute of Canada Clinical Trials Group Trial MA5. J Clin Oncol 2005; 23: 5166-70. (Pubitemid 46224025)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.22 , pp. 5166-5170
    • Levine, M.N.1    Pritchard, K.I.2    Bramwell, V.H.C.3    Shepherd, L.E.4    Tu, D.5    Paul, N.6
  • 47
    • 77957120408 scopus 로고    scopus 로고
    • Targeting anthracyclines in early breast cancer: New candidatepredictive biomarkers emerge
    • Munro AF, Cameron DA, Bartlett JM. Targeting anthracyclines in early breast cancer: new candidatepredictive biomarkers emerge. Oncogene 2010; 29: 5231-40.
    • (2010) Oncogene , vol.29 , pp. 5231-5240
    • Munro, A.F.1    Cameron, D.A.2    Bartlett, J.M.3
  • 48
    • 0030870295 scopus 로고    scopus 로고
    • The effect of HER-2/neu overexpression on chemotherapeutic drug sensitivity in human breast and ovarian cancer cells
    • Pegram MD, Finn RS, Arzoo K, Beryt M,pietras RJ, Slamon DJ. The effect of HER-2/neu overexpression on chemotherapeutic drug sensitivity in human breast and ovarian cancer cells. Oncogene 1997; 15: 537-47. (Pubitemid 27384731)
    • (1997) Oncogene , vol.15 , Issue.5 , pp. 537-547
    • Pegram, M.D.1    Finn, R.S.2    Arzoo, K.3    Beryt, M.4    Pietras, R.J.5    Slamon, D.J.6
  • 50
    • 77950691127 scopus 로고    scopus 로고
    • Association between HER2, TOP2A, and response to anthracycline- basedpreoperative chemotherapy in high-riskprimary breast cancer
    • Konecny GE,pauletti G, Untch M, et al. Association between HER2, TOP2A, and response to anthracycline-basedpreoperative chemotherapy in high-riskprimary breast cancer. Breast Cancer Res Treat 2010; 120: 481-9.
    • (2010) Breast Cancer Res Treat , vol.120 , pp. 481-489
    • Konecny, G.E.1    Pauletti, G.2    Untch, M.3
  • 51
    • 70149088984 scopus 로고    scopus 로고
    • Triple negative breast cancer-current status andprospective targeted treatment based on HER1 (EGFR), TOP2A and C-MYC gene assessment
    • Bouchalova K, Cizkova M, Cwiertka K, Trojanec R, Hajduch M. Triple negative breast cancer-current status andprospective targeted treatment based on HER1 (EGFR), TOP2A and C-MYC gene assessment. Biomedpap Med Fac Univpalacky Olomouc Czech Repub 2009; 153: 13-7.
    • (2009) Biomedpap Med Fac Univpalacky Olomouc Czech Repub , vol.153 , pp. 13-17
    • Bouchalova, K.1    Cizkova, M.2    Cwiertka, K.3    Trojanec, R.4    Hajduch, M.5
  • 52
    • 70449708986 scopus 로고    scopus 로고
    • The role of topoisomerase IIalpha and HER-2 inpredicting sensitivity to anthracyclines in breast cancerpatients
    • Oakman C, Moretti E, Galardi F, Santarpia L, Di Leo A. The role of topoisomerase IIalpha and HER-2 inpredicting sensitivity to anthracyclines in breast cancerpatients. Cancer Treat Rev 2009; 35: 662-7.
    • (2009) Cancer Treat Rev , vol.35 , pp. 662-667
    • Oakman, C.1    Moretti, E.2    Galardi, F.3    Santarpia, L.4    Di Leo, A.5
  • 53
    • 0043145754 scopus 로고    scopus 로고
    • Characterization of topoisomerase IIα gene amplification and deletion in breast cancer
    • DOI 10.1002/(SICI)1098-2264(199910)26:2<142::AID-GCC6>3.0.CO;2-B
    • Jarvinen TA, Tanner M, Barlund M, Borg A, Isola J. Characterization of topoisomerase II alpha gene amplification and deletion in breast cancer. Genes Chromosomes Cancer 1999; 26: 142-50. (Pubitemid 29416439)
    • (1999) Genes Chromosomes and Cancer , vol.26 , Issue.2 , pp. 142-150
    • Jarvinen, T.A.H.1    Tanner, M.2    Barlund, M.3    Borg, A.4    Isola, J.5
  • 54
    • 77952094228 scopus 로고    scopus 로고
    • Topoisomerase 2 alpha and the case for individualized breast cancer therapy
    • Glynn RW, Miller N, Whelan MC, Kerin MJ. Topoisomerase 2 alpha and the case for individualized breast cancer therapy. Ann Surg Oncol 2010; 17: 1392-7.
    • (2010) Ann Surg Oncol , vol.17 , pp. 1392-1397
    • Glynn, R.W.1    Miller, N.2    Whelan, M.C.3    Kerin, M.J.4
  • 55
    • 69849084891 scopus 로고    scopus 로고
    • Outcome ofpatients with earlystage breast cancer treated with doxorubicin-based adjuvant chemotherapy as a function of HER2 and TOP2A status
    • Tubbs R, Barlow WE, Budd GT, et al. Outcome ofpatients with earlystage breast cancer treated with doxorubicin-based adjuvant chemotherapy as a function of HER2 and TOP2A status. J Clin Oncol 2009; 27: 3881-6.
    • (2009) J Clin Oncol , vol.27 , pp. 3881-3886
    • Tubbs, R.1    Barlow, W.E.2    Budd, G.T.3
  • 56
    • 33744969590 scopus 로고    scopus 로고
    • Topoisomerase IIα gene amplification predicts favorable treatment response to tailored and dose-escalated anthracycline-based adjuvant chemotherapy in HER-2/neu-amplified breast cancer: Scandinavian Breast Group trial 9401
    • DOI 10.1200/JCO.2005.02.9264
    • Tanner M, Isola J, Wiklund T, et al. Topoisomerase IIalpha gene amplificationpredicts favorable treatment response to tailored and dose-escalated anthracycline-based adjuvant chemotherapy in HER-2/neuamplified breast cancer: Scandinavian Breast Group Trial 9401. J Clin Oncol 2006; 24: 2428-36. (Pubitemid 46630618)
    • (2006) Journal of Clinical Oncology , vol.24 , Issue.16 , pp. 2428-2436
    • Tanner, M.1    Isola, J.2    Wiklund, T.3    Erikstein, B.4    Kellokumpu-Lehtinen, P.5    Malmstrom, P.6    Wilking, N.7    Nilsson, J.8    Bergh, J.9
  • 59
    • 77349118709 scopus 로고    scopus 로고
    • Predictive markers of anthracycline benefit: Aprospectivelyplanned analysis of the UK National Epirubicin Adjuvant Trial (NEAT/BR9601)
    • Bartlett JM, Munro AF, Dunn JA, et al.predictive markers of anthracycline benefit: aprospectivelyplanned analysis of the UK National Epirubicin Adjuvant Trial (NEAT/BR9601). Lancet Oncol 2010; 11: 266-74.
    • (2010) Lancet Oncol , vol.11 , pp. 266-274
    • Bartlett, J.M.1    Munro, A.F.2    Dunn, J.A.3
  • 60
    • 77953231299 scopus 로고    scopus 로고
    • Topoisomerase IIalpha expression rather than gene amplificationpredicts responsiveness of adjuvant anthracycline-based chemotherapy in women withprimary breast cancer
    • Schindlbeck C, Mayr D, Olivier C, et al. Topoisomerase IIalpha expression rather than gene amplificationpredicts responsiveness of adjuvant anthracycline-based chemotherapy in women withprimary breast cancer. J Cancer Res Clin Oncol 2010; 136: 1029-37.
    • (2010) J Cancer Res Clin Oncol , vol.136 , pp. 1029-1037
    • Schindlbeck, C.1    Mayr, D.2    Olivier, C.3
  • 61
    • 65549158566 scopus 로고    scopus 로고
    • Topoisomerase II alpha and responsiveness of breast cancer to adjuvant chemotherapy
    • O'Malley FP, Chia S, Tu D, et al. Topoisomerase II alpha and responsiveness of breast cancer to adjuvant chemotherapy. J Natl Cancer Inst 2009; 101: 644-50.
    • (2009) J Natl Cancer Inst , vol.101 , pp. 644-650
    • O'malley, F.P.1    Chia, S.2    Tu, D.3
  • 63
    • 70249085601 scopus 로고    scopus 로고
    • Topoisomerase II{alpha} amplification does notpredict benefit from dose-intense cyclophosphamide, doxorubicin, and fluorouracil therapy in HER2-amplified early breast cancer: Results of CALGB 8541/150013
    • Harris LN, Broadwater G, Abu-Khalaf M, et al. Topoisomerase II{alpha} amplification does notpredict benefit from dose-intense cyclophosphamide, doxorubicin, and fluorouracil therapy in HER2-amplified early breast cancer: results of CALGB 8541/150013. J Clin Oncol 2009; 27: 3430-6.
    • (2009) J Clin Oncol , vol.27 , pp. 3430-3436
    • Harris, L.N.1    Broadwater, G.2    Abu-Khalaf, M.3
  • 64
    • 33847036026 scopus 로고    scopus 로고
    • Amplification of TOP2A and HER-2 genes in breast cancers occurring inpatients harbouring BRCA1 germline mutations
    • Hagen AI, Bofin AM, Ytterhus B, et al. Amplification of TOP2A and HER-2 genes in breast cancers occurring inpatients harbouring BRCA1 germline mutations. Acta Oncol 2007; 46: 199-203.
    • (2007) Acta Oncol , vol.46 , pp. 199-203
    • Hagen, A.I.1    Bofin, A.M.2    Ytterhus, B.3
  • 65
    • 32944475493 scopus 로고    scopus 로고
    • Retrospective analysis of topoisomerase IIa amplifications and deletions as predictive markers in primary breast cancer patients randomly assigned to cyclophosphamide, methotrexate, and fluorouracil or cyclophosphamide, epirubicin, and fluorouracil: Danish Breast Cancer Cooperative Group
    • DOI 10.1200/JCO.2005.11.007
    • Knoop AS, Knudsen H, Balslev E, et al. retrospective analysis of topoisomerase IIa amplifications and deletions aspredictive markers inprimary breast cancerpatients randomly assigned to cyclophosphamide, methotrexate, and fluorouracil or cyclophosphamide, epirubicin, and fluorouracil: Danish Breast Cancer Cooperative Group. J Clin Oncol 2005; 23: 7483-90. (Pubitemid 46291811)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.30 , pp. 7483-7490
    • Knoop, A.S.1    Knudsen, H.2    Balslev, E.3    Rasmussen, B.B.4    Overgaard, J.5    Nielsen, K.V.6    Schonau, A.7    Gunnarsdottir, K.8    Olsen, K.E.9    Mouridsen, H.10    Ejlertsen, B.11
  • 66
    • 47349086565 scopus 로고    scopus 로고
    • Phase III trial comparing AC-T with AC-TH and with TCH in the adjuvant treatment of HER2positive early breast cancerpatients: Second interim efficacy analysis
    • Dec 14-17, Abstract
    • Slamon D, Eiermann W, Robert N, et al.Phase III trial comparing AC-T with AC-TH and with TCH in the adjuvant treatment of HER2positive early breast cancerpatients: second interim efficacy analysis. San Antonio Breast Cancer Symposium, Dec 14-17, 2006, Abstract 52.
    • (2006) San Antonio Breast Cancer Symposium , pp. 52
    • Slamon, D.1    Eiermann, W.2    Et Al., R.N.3
  • 67
    • 1542343905 scopus 로고    scopus 로고
    • Amplification of the TOP2A gene does notpredict high levels of topoisomerase II alphaprotein in human breast tumor samples
    • DOI 10.1002/gcc.20008
    • Mueller RE,parkes RK, Andrulis I, O'Malley FP. Amplification of the TOP2A gene does notpredict high levels of topoisomerase II alphaprotein in human breast tumor samples. Genes Chromosomes Cancer 2004; 39: 288-97. (Pubitemid 38326310)
    • (2004) Genes Chromosomes and Cancer , vol.39 , Issue.4 , pp. 288-297
    • Mueller, R.E.1    Parkes, R.K.2    Andrulis, I.3    O'Malley, F.P.4
  • 68
    • 70149118628 scopus 로고    scopus 로고
    • Topoisomerase II alpha gene copy loss has adverseprognostic significance in ERBB2-amplified breast cancer: A retrospective study ofparaffinembedded tumor specimens and medical charts
    • Usha L, Tabesh B, Morrison LE, Rao RD, Jacobson K, Zhu A, et al. Topoisomerase II alpha gene copy loss has adverseprognostic significance in ERBB2-amplified breast cancer: a retrospective study ofparaffinembedded tumor specimens and medical charts. J Hematol Oncol 2008; 1: 12.
    • (2008) J Hematol Oncol , vol.1 , pp. 12
    • Usha, L.1    Tabesh, B.2    Morrison, L.E.3    Rao, R.D.4    Jacobson, K.5    Zhu, A.6
  • 69
    • 69849093714 scopus 로고    scopus 로고
    • Are HER2 and TOP2A useful asprognostic orpredictive biomarkers for anthracycline-based adjuvant chemotherapy for breast cancer?
    • Pritchard KI. Are HER2 and TOP2A useful asprognostic orpredictive biomarkers for anthracycline-based adjuvant chemotherapy for breast cancer? J Clin Oncol 2009; 27: 3875-6.
    • (2009) J Clin Oncol , vol.27 , pp. 3875-3876
    • Pritchard, K.I.1
  • 70
    • 67650687688 scopus 로고    scopus 로고
    • The clinical significance ofpolysomy 17 in the HER2+ N9831 intergroup adjuvant trastuzumab trial
    • Dec 13-16, Abstract
    • Reinholz MM, Jenkins RB, Hillman D, et al. The clinical significance ofpolysomy 17 in the HER2+ N9831 intergroup adjuvant trastuzumab trial. San Antonio Breast Cancer Symposium, Dec 13-16, 2007, Abstract 36.
    • (2007) San Antonio Breast Cancer Symposium , pp. 36
    • Reinholz, M.M.1    Jenkins, R.B.2    Hillman, D.3
  • 71
    • 35649011374 scopus 로고    scopus 로고
    • Benefit from adjuvant taxanes and endocrine responsiveness in breast cancer
    • Martin M, Mackey J, Vogel C. Benefit from adjuvant taxanes and endocrine responsiveness in breast cancer. Breast 2007; 16 (Suppl 2): S127-31.
    • (2007) Breast , vol.16 , Issue.SUPPL. 2
    • Martin, M.1    MacKey, J.2    Vogel, C.3
  • 72
    • 33645729721 scopus 로고    scopus 로고
    • NCCN Task Force Report: Adjuvant therapy for breast cancer
    • Carlson RW, Brown E, Burstein HJ, et al. NCCN Task Force Report: Adjuvant therapy for breast cancer. J Natl Compr Canc Netw 2006; 4 (Suppl 1): S1-26.
    • (2006) J Natl Compr Canc Netw , vol.4 , Issue.SUPPL. 1
    • Carlson, R.W.1    Brown, E.2    Burstein, H.J.3
  • 73
    • 4143089281 scopus 로고    scopus 로고
    • Conservation of breast cancer molecular subtypes and transcriptional patterns of tumor progression across distinct ethnic populations
    • DOI 10.1158/1078-0432.CCR-04-0085
    • Yu K, Lee CH, TanpH, Tanp. Conservation of breast cancer molecular subtypes and transcriptionalpatterns of tumorprogression across distinct ethnicpopulations. Clin Cancer Res 2004; 10: 5508-17. (Pubitemid 39100489)
    • (2004) Clinical Cancer Research , vol.10 , Issue.16 , pp. 5508-5517
    • Yu, K.1    Lee, C.H.2    Tan, P.H.3    Tan, P.4
  • 79
    • 62549091454 scopus 로고    scopus 로고
    • Breast cancer subtypes and response to docetaxel in node-positive breast cancer: Use of an immunohistochemical definition in the BCIRG 001 trial
    • Hugh J, Hanson J, Cheang MC, et al. Breast cancer subtypes and response to docetaxel in node-positive breast cancer: use of an immunohistochemical definition in the BCIRG 001 trial. J Clin Oncol 2009; 27: 1168-76.
    • (2009) J Clin Oncol , vol.27 , pp. 1168-1176
    • Hugh, J.1    Hanson, J.2    Cheang, M.C.3
  • 81
    • 65249104546 scopus 로고    scopus 로고
    • Triple-negative breast cancer: Distinguishing between basal and nonbasal subtypes
    • Rakha EA, Elsheikh SE, Aleskandarany MA, et al. Triple-negative breast cancer: distinguishing between basal and nonbasal subtypes. Clin Cancer Res 2009; 15: 2302-10.
    • (2009) Clin Cancer Res , vol.15 , pp. 2302-2310
    • Rakha, E.A.1    Elsheikh, S.E.2    Aleskandarany, M.A.3
  • 82
    • 70350441646 scopus 로고    scopus 로고
    • Prediction of local recurrence distant metastases and death after breast-conserving therapy in earlystage invasive breast cancer using a five-biomarkerpanel
    • Millar EK, GrahampH, O'Toole SA, et al.prediction of local recurrence, distant metastases, and death after breast-conserving therapy in earlystage invasive breast cancer using a five-biomarkerpanel. J Clin Oncol 2009; 27: 4701-8.
    • (2009) J Clin Oncol , vol.27 , pp. 4701-4708
    • Millar, E.K.1    Grahamp, H.2    O'toole, S.A.3
  • 83
    • 58149263068 scopus 로고    scopus 로고
    • BAG-1predictspatient outcome and tamoxifen responsiveness in ER-positive invasive ductal carcinoma of the breast
    • Millar EK, Anderson LR, McNeil CM, et al. BAG-1predictspatient outcome and tamoxifen responsiveness in ER-positive invasive ductal carcinoma of the breast. Br J Cancer 2009; 100: 123-33.
    • (2009) Br J Cancer , vol.100 , pp. 123-133
    • Millar, E.K.1    Anderson, L.R.2    McNeil, C.M.3
  • 84
    • 0035755679 scopus 로고    scopus 로고
    • Findings from recent national surgical adjuvant breast and bowelproject adjuvant studies in stage i breast cancer
    • Fisher B, Jeong J, Dignam J, et al. Findings from recent National Surgical Adjuvant Breast and Bowelproject adjuvant studies in stage I breast cancer. J Natl Cancer Inst Monogr 2001; 30: 62-6.
    • (2001) J Natl Cancer Inst Monogr , vol.30 , pp. 62-66
    • Fisher, B.1    Jeong, J.2    Dignam, J.3
  • 85
    • 45749157664 scopus 로고    scopus 로고
    • Commercialized multigene predictors of clinical outcome for breast cancer
    • DOI 10.1634/theoncologist.2007-0248
    • Ross JS, Hatzis C, Symmans WF,pusztai L, Hortobagyi GN. Commercialized multigenepredictors of clinical outcome for breast cancer. Oncologist 2008; 13: 477-93. (Pubitemid 351872866)
    • (2008) Oncologist , vol.13 , Issue.5 , pp. 477-493
    • Ross, J.S.1    Hatzis, C.2    Symmans, W.F.3    Pusztai, L.4    Hortobagyi, G.N.5
  • 88
    • 33744808550 scopus 로고    scopus 로고
    • Apopulation-based study of tumor gene expression and risk of breast cancer death among lymph nodenegativepatients
    • Habel LA, Shak S, Jacobs MK, et al. Apopulation-based study of tumor gene expression and risk of breast cancer death among lymph nodenegativepatients. Breast Cancer Res 2006; 8: R25.
    • (2006) Breast Cancer Res , vol.8
    • Habel, L.A.1    Shak, S.2    Jacobs, M.K.3
  • 91
    • 73249140371 scopus 로고    scopus 로고
    • Prognostic andpredictive value of the 21-gene recurrence score assay inpostmenopausal women with nodepositive oestrogen-receptor-positive breast cancer on chemotherapy: A retrospective analysis of a randomised trial
    • Albain KS, Barlow WE, Shak S, et al.prognostic andpredictive value of the 21-gene recurrence score assay inpostmenopausal women with nodepositive, oestrogen-receptor-positive breast cancer on chemotherapy: a retrospective analysis of a randomised trial. Lancet Oncol 2010; 11: 55-65.
    • (2010) Lancet Oncol , vol.11 , pp. 55-65
    • Albain, K.S.1    Barlow, W.E.2    Shak, S.3
  • 92
    • 52049089470 scopus 로고    scopus 로고
    • Does oncotype DX recurrence score affect the management ofpatients with early-stage breast cancer?
    • Asad J, Jacobson AF, Estabrook A, et al. Does oncotype DX recurrence score affect the management ofpatients with early-stage breast cancer? Am J Surg 2008; 196: 527-9.
    • (2008) Am J Surg , vol.196 , pp. 527-529
    • Asad, J.1    Jacobson, A.F.2    Estabrook, A.3
  • 93
    • 33947196825 scopus 로고    scopus 로고
    • Impact of a 21-gene RT-PCR assay on treatment decisions in early-stage breast cancer: An economic analysis based on prognostic and predictive validation studies
    • DOI 10.1002/cncr.22506
    • Lyman GH, Cosler LE, Kuderer NM, Hornberger J. Impact of a 21-gene RT-PCR assay on treatment decisions in early-stage breast cancer: an economic analysis based onprognostic andpredictive validation studies. Cancer 2007; 109: 1011-8. (Pubitemid 46435378)
    • (2007) Cancer , vol.109 , Issue.6 , pp. 1011-1018
    • Lyman, G.H.1    Cosler, L.E.2    Kuderer, N.M.3    Hornberger, J.4
  • 94
    • 78349308685 scopus 로고    scopus 로고
    • Prognostic value of a combined ERpgR Ki67 HER2 immunohistochemical (IHC4) score and comparison with the GHI recurrence score - Results from TransATAC
    • Dec 10-13, Abstract
    • Cuzick J, Dowsett M, Wale C, et al.prognostic value of a combined ER,pgR, Ki67, HER2 immunohistochemical (IHC4) score and comparison with the GHI recurrence score - results from TransATAC. San Antonio Breast Cancer Symposium, Dec 10-13, 2009, Abstract 74.
    • (2009) San Antonio Breast Cancer Symposium , pp. 74
    • Cuzick, J.1    Dowsett, M.2    Wale, C.3
  • 95
    • 36049042990 scopus 로고    scopus 로고
    • Frequency and reliability of oestrogen receptor, progesterone receptor and HER2 in breast carcinoma determined by immunohistochemistry in Australasia: Results of the RCPA Quality Assurance Program
    • DOI 10.1136/jcp.2006.044701
    • Francis GD, Dimech M, Giles L, Hopkins A. Frequency and reliability of oestrogen receptor,progesterone receptor and HER2 in breast carcinoma determined by immunohistochemistry in Australasia: results of the RCPA Quality Assuranceprogram. J Clinpathol 2007; 60: 1277-83. (Pubitemid 350084552)
    • (2007) Journal of Clinical Pathology , vol.60 , Issue.11 , pp. 1277-1283
    • Francis, G.D.1    Dimech, M.2    Giles, L.3    Hopkins, A.4
  • 96
    • 78449291165 scopus 로고    scopus 로고
    • Utility of oncotype DX risk estimates in clinically intermediate risk hormone receptor-positive, HER2-normal, grade II, lymph node-negative breast cancers
    • Kelly CM, Krishnamurthy S, Bianchini G, et al. Utility of oncotype DX risk estimates in clinically intermediate risk hormone receptor-positive, HER2-normal, grade II, lymph node-negative breast cancers. Cancer 2010; 116: 5161-7.
    • (2010) Cancer , vol.116 , pp. 5161-5167
    • Kelly, C.M.1    Krishnamurthy, S.2    Bianchini, G.3
  • 97
    • 78650860027 scopus 로고    scopus 로고
    • Recurrence risk of node-negative and ERpositive early-stage breast cancerpatients by combining recurrence score,Pathologic, and clinical information: A meta-analysis approach
    • abstr
    • Tang G, Cuzick J,Wale C, et al. Recurrence risk of node-negative and ERpositive early-stage breast cancerpatients by combining recurrence score,Pathologic, and clinical information: A meta-analysis approach. J Clin Oncol 2010; 28 (Suppl): abstr 509.
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL. , pp. 509
    • Tang, G.1    Cuzick Jwale, C.2
  • 101
    • 13444249852 scopus 로고    scopus 로고
    • Prediction of cancer outcome with microarrays: A multiple random validation strategy
    • DOI 10.1016/S0140-6736(05)17866-0
    • Michiels S, Koscielny S, Hill C.prediction of cancer outcome with microarrays: a multiple random validation strategy. Lancet 2005; 365: 488-92. (Pubitemid 40215731)
    • (2005) Lancet , vol.365 , Issue.9458 , pp. 488-492
    • Michiels, S.1    Koscielny, S.2    Hill, C.3
  • 102
    • 38149015568 scopus 로고    scopus 로고
    • Critical review of microarray-basedprognostic tests and trials in breast cancer
    • Koscielny S. Critical review of microarray-basedprognostic tests and trials in breast cancer. Curr Opin Obstet Gynecol 2008; 20: 47-50.
    • (2008) Curr Opin Obstet Gynecol , vol.20 , pp. 47-50
    • Koscielny, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.