메뉴 건너뛰기




Volumn 206, Issue 3, 2010, Pages 156-162

The topoisomerase II alpha gene status in primary breast cancer is a predictive marker of the response to anthracycline-based neoadjuvant chemotherapy

Author keywords

Anthracycline based neoadjuvant chemotherapy; Breast cancer; Fluorescent in situ hybridization (FISH); Immunohistochemistry; Topoisomerase II alpha (TOP2A)

Indexed keywords

ANASTROZOLE; ANTHRACYCLINE; CAPECITABINE; CYCLOPHOSPHAMIDE; DNA TOPOISOMERASE (ATP HYDROLYSING); DOXORUBICIN; EPIRUBICIN; NAVELBINE; PACLITAXEL;

EID: 76949087835     PISSN: 03440338     EISSN: 16180631     Source Type: Journal    
DOI: 10.1016/j.prp.2009.10.009     Document Type: Article
Times cited : (11)

References (32)
  • 1
    • 21044448678 scopus 로고    scopus 로고
    • Predictive value of apoptosis, proliferation, HER-2, and topoisomerase IIalpha for anthracycline chemotherapy in locally advanced breast cancer
    • Arpino G., Ciocca D.R., Weiss H., Allred D.C., Daguerre P., Vargas-Roig L., et al. Predictive value of apoptosis, proliferation, HER-2, and topoisomerase IIalpha for anthracycline chemotherapy in locally advanced breast cancer. Breast Cancer Res. Treat. 92 (2005) 69-75
    • (2005) Breast Cancer Res. Treat. , vol.92 , pp. 69-75
    • Arpino, G.1    Ciocca, D.R.2    Weiss, H.3    Allred, D.C.4    Daguerre, P.5    Vargas-Roig, L.6
  • 2
    • 0346125406 scopus 로고    scopus 로고
    • TOP2A and HER-2 gene amplification in fine needle aspirates from breast carcinomas
    • Bofin A.M., Ytterhus B., and Hagmar B.M. TOP2A and HER-2 gene amplification in fine needle aspirates from breast carcinomas. Cytopathology 14 (2003) 314-319
    • (2003) Cytopathology , vol.14 , pp. 314-319
    • Bofin, A.M.1    Ytterhus, B.2    Hagmar, B.M.3
  • 3
    • 33750611131 scopus 로고    scopus 로고
    • Analysis of ERBB2 and TOP2A gene status using fluorescence in situ hybridization versus immunohistochemistry in localized breast cancer
    • Bouchalova K., Trojanec R., Kolar Z., Cwiertka K., Cernakova I., Mihal V., et al. Analysis of ERBB2 and TOP2A gene status using fluorescence in situ hybridization versus immunohistochemistry in localized breast cancer. Neoplasma 53 (2006) 393-401
    • (2006) Neoplasma , vol.53 , pp. 393-401
    • Bouchalova, K.1    Trojanec, R.2    Kolar, Z.3    Cwiertka, K.4    Cernakova, I.5    Mihal, V.6
  • 4
    • 3843120055 scopus 로고    scopus 로고
    • Correlation between complete response to anthracycline-based chemotherapy and topoisomerase II-alpha gene amplification and protein overexpression in locally advanced/metastatic breast cancer
    • Cardoso F., Durbecq V., Larsimont D., Paesmans M., Leroy J.Y., Rouas G., et al. Correlation between complete response to anthracycline-based chemotherapy and topoisomerase II-alpha gene amplification and protein overexpression in locally advanced/metastatic breast cancer. Int. J. Oncol. 24 (2004) 201-209
    • (2004) Int. J. Oncol. , vol.24 , pp. 201-209
    • Cardoso, F.1    Durbecq, V.2    Larsimont, D.3    Paesmans, M.4    Leroy, J.Y.5    Rouas, G.6
  • 5
    • 0034923502 scopus 로고    scopus 로고
    • DNA topoisomerases: structure, function, and mechanism
    • Champoux J.J. DNA topoisomerases: structure, function, and mechanism. Annu. Rev. Biochem. 70 (2001) 369-413
    • (2001) Annu. Rev. Biochem. , vol.70 , pp. 369-413
    • Champoux, J.J.1
  • 6
    • 0036341143 scopus 로고    scopus 로고
    • A significant response to neoadjuvant chemotherapy in BRCA1/2 related breast cancer
    • Chappuis P.O., Goffin J., Wong N., Perret C., Ghadirian P., Tonin P.N., et al. A significant response to neoadjuvant chemotherapy in BRCA1/2 related breast cancer. J. Med. Genet. 39 (2002) 608-610
    • (2002) J. Med. Genet. , vol.39 , pp. 608-610
    • Chappuis, P.O.1    Goffin, J.2    Wong, N.3    Perret, C.4    Ghadirian, P.5    Tonin, P.N.6
  • 8
    • 0036554731 scopus 로고    scopus 로고
    • Amplification and overexpression of topoisomerase II alpha predict response to anthracycline-based therapy in locally advanced breast cancer
    • Coon J.S., Marcus E., Gupta-Burt S., Seelig S., Jacobson K., Chen S., et al. Amplification and overexpression of topoisomerase II alpha predict response to anthracycline-based therapy in locally advanced breast cancer. Clin. Cancer Res. 8 (2002) 1061-1067
    • (2002) Clin. Cancer Res. , vol.8 , pp. 1061-1067
    • Coon, J.S.1    Marcus, E.2    Gupta-Burt, S.3    Seelig, S.4    Jacobson, K.5    Chen, S.6
  • 9
    • 17944375163 scopus 로고    scopus 로고
    • HER-2 and topo-isomerase IIalpha as predictive markers in a population of node-positive breast cancer patients randomly treated with adjuvant CMF or epirubicin plus cyclophosphamide
    • Di Leo A., Larsimont D., Gancberg D., Jarvinen T., Beauduin M., Vindevoghel A., et al. HER-2 and topo-isomerase IIalpha as predictive markers in a population of node-positive breast cancer patients randomly treated with adjuvant CMF or epirubicin plus cyclophosphamide. Ann. Oncol. 12 (2001) 1081-1089
    • (2001) Ann. Oncol. , vol.12 , pp. 1081-1089
    • Di Leo, A.1    Larsimont, D.2    Gancberg, D.3    Jarvinen, T.4    Beauduin, M.5    Vindevoghel, A.6
  • 10
    • 0036091354 scopus 로고    scopus 로고
    • HER-2 amplification and topoisomerase IIalpha gene aberrations as predictive markers in node-positive breast cancer patients randomly treated either with an anthracycline-based therapy or with cyclophosphamide, methotrexate, and 5-fluorouracil
    • Di Leo A., Gancberg D., Larsimont D., Tanner M., Jarvinen T., Rouas G., et al. HER-2 amplification and topoisomerase IIalpha gene aberrations as predictive markers in node-positive breast cancer patients randomly treated either with an anthracycline-based therapy or with cyclophosphamide, methotrexate, and 5-fluorouracil. Clin. Cancer Res. 8 (2002) 1107-1116
    • (2002) Clin. Cancer Res. , vol.8 , pp. 1107-1116
    • Di Leo, A.1    Gancberg, D.2    Larsimont, D.3    Tanner, M.4    Jarvinen, T.5    Rouas, G.6
  • 11
    • 34447314153 scopus 로고    scopus 로고
    • p-53 gene mutations as a predictive marker in a population of advanced breast cancer patients randomly treated with doxorubicin or docetaxel in the context of a phase III clinical trial
    • Di Leo A., Tanner M., Desmedt C., Paesmans M., Cardoso F., Durbecq V., et al. p-53 gene mutations as a predictive marker in a population of advanced breast cancer patients randomly treated with doxorubicin or docetaxel in the context of a phase III clinical trial. Ann. Oncol. 18 (2007) 997-1003
    • (2007) Ann. Oncol. , vol.18 , pp. 997-1003
    • Di Leo, A.1    Tanner, M.2    Desmedt, C.3    Paesmans, M.4    Cardoso, F.5    Durbecq, V.6
  • 12
    • 7444252789 scopus 로고    scopus 로고
    • Topoisomerase-II alpha expression as a predictive marker in a population of advanced breast cancer patients randomly treated either with single-agent doxorubicin or single-agent docetaxel
    • Durbecq V., Paesmans M., Cardoso F., Desmedt C., Di Leo A., Chan S., et al. Topoisomerase-II alpha expression as a predictive marker in a population of advanced breast cancer patients randomly treated either with single-agent doxorubicin or single-agent docetaxel. Mol. Cancer Ther. 3 (2004) 1207-1214
    • (2004) Mol. Cancer Ther. , vol.3 , pp. 1207-1214
    • Durbecq, V.1    Paesmans, M.2    Cardoso, F.3    Desmedt, C.4    Di Leo, A.5    Chan, S.6
  • 13
    • 0026072872 scopus 로고
    • Pathological prognostic factors in breast cancer I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up
    • Elston C.W., and Ellis I.O. Pathological prognostic factors in breast cancer I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology 19 (1991) 403-410
    • (1991) Histopathology , vol.19 , pp. 403-410
    • Elston, C.W.1    Ellis, I.O.2
  • 14
    • 20944439542 scopus 로고    scopus 로고
    • The incidence of topoisomerase II-alpha genomic alterations in adenocarcinoma of the breast and their relationship to human epidermal growth factor receptor-2 gene amplification: a fluorescence in situ hybridization study
    • Hicks D.G., Yoder B.J., Pettay J., Swain E., Tarr S., Hartke M., et al. The incidence of topoisomerase II-alpha genomic alterations in adenocarcinoma of the breast and their relationship to human epidermal growth factor receptor-2 gene amplification: a fluorescence in situ hybridization study. Hum. Pathol. 36 (2005) 348-356
    • (2005) Hum. Pathol. , vol.36 , pp. 348-356
    • Hicks, D.G.1    Yoder, B.J.2    Pettay, J.3    Swain, E.4    Tarr, S.5    Hartke, M.6
  • 17
    • 0043145754 scopus 로고    scopus 로고
    • Characterization of topoisomerase II alpha gene amplification and deletion in breast cancer
    • Jarvinen T.A., Tanner M., Barlund M., Borg A., and Isola J. Characterization of topoisomerase II alpha gene amplification and deletion in breast cancer. Genes Chromosomes Cancer 26 (1999) 142-150
    • (1999) Genes Chromosomes Cancer , vol.26 , pp. 142-150
    • Jarvinen, T.A.1    Tanner, M.2    Barlund, M.3    Borg, A.4    Isola, J.5
  • 18
    • 0033870292 scopus 로고    scopus 로고
    • Amplification and deletion of topoisomerase IIalpha associate with ErbB-2 amplification and affect sensitivity to topoisomerase II inhibitor doxorubicin in breast cancer
    • Jarvinen T.A., Tanner M., Rantanen V., Barlund M., Borg A., Grenman S., et al. Amplification and deletion of topoisomerase IIalpha associate with ErbB-2 amplification and affect sensitivity to topoisomerase II inhibitor doxorubicin in breast cancer. Am. J. Pathol. 156 (2000) 839-847
    • (2000) Am. J. Pathol. , vol.156 , pp. 839-847
    • Jarvinen, T.A.1    Tanner, M.2    Rantanen, V.3    Barlund, M.4    Borg, A.5    Grenman, S.6
  • 20
    • 32944475493 scopus 로고    scopus 로고
    • Retrospective analysis of topoisomerase IIa amplifications and deletions as predictive markers in primary breast cancer patients randomly assigned to cyclophosphamide, methotrexate, and fluorouracil or cyclophosphamide, epirubicin, and fluorouracil: Danish Breast Cancer Cooperative Group
    • Knoop A.S., Knudsen H., Balslev E., Rasmussen B.B., Overgaard J., Nielsen K.V., et al. Retrospective analysis of topoisomerase IIa amplifications and deletions as predictive markers in primary breast cancer patients randomly assigned to cyclophosphamide, methotrexate, and fluorouracil or cyclophosphamide, epirubicin, and fluorouracil: Danish Breast Cancer Cooperative Group. J. Clin. Oncol. 23 (2005) 7483-7490
    • (2005) J. Clin. Oncol. , vol.23 , pp. 7483-7490
    • Knoop, A.S.1    Knudsen, H.2    Balslev, E.3    Rasmussen, B.B.4    Overgaard, J.5    Nielsen, K.V.6
  • 21
    • 0043236239 scopus 로고    scopus 로고
    • DNA topoisomerase IIalpha expression and the response to primary chemotherapy in breast cancer
    • MacGrogan G., Rudolph P., Mascarel I., Mauriac I., L., Durand M., Avril A., et al. DNA topoisomerase IIalpha expression and the response to primary chemotherapy in breast cancer. Br. J. Cancer 89 (2003) 666-671
    • (2003) Br. J. Cancer , vol.89 , pp. 666-671
    • MacGrogan, G.1    Rudolph, P.2    Mascarel, I.3    Mauriac I.,, L.4    Durand, M.5    Avril, A.6
  • 22
    • 4444249420 scopus 로고    scopus 로고
    • Serial topoisomerase II expression in primary breast cancer and response to neoadjuvant anthracycline-based chemotherapy
    • Martin-Richard M., Munoz M., Albanell J., Colomo L., Bellet M., Rey M.J., et al. Serial topoisomerase II expression in primary breast cancer and response to neoadjuvant anthracycline-based chemotherapy. Oncology 66 (2004) 388-394
    • (2004) Oncology , vol.66 , pp. 388-394
    • Martin-Richard, M.1    Munoz, M.2    Albanell, J.3    Colomo, L.4    Bellet, M.5    Rey, M.J.6
  • 23
    • 1542343905 scopus 로고    scopus 로고
    • Amplification of the TOP2A gene does not predict high levels of topoisomerase II alpha protein in human breast tumor samples
    • Mueller R.E., Parkes R.K., Andrulis I., and O'Malley F.P. Amplification of the TOP2A gene does not predict high levels of topoisomerase II alpha protein in human breast tumor samples. Genes Chromosomes Cancer 39 (2004) 288-297
    • (2004) Genes Chromosomes Cancer , vol.39 , pp. 288-297
    • Mueller, R.E.1    Parkes, R.K.2    Andrulis, I.3    O'Malley, F.P.4
  • 24
    • 33749622561 scopus 로고    scopus 로고
    • Topoisomerase II alpha protein overexpression has predictive utility in a randomized trial comparing CMF to CEF in premenopausal women with node positive breast cancer (NCIC CTG MA.5)
    • O'Malley F.P., Chia S., Tu D., Shepherd L.E., Levine M.N., Huntsman D., et al. Topoisomerase II alpha protein overexpression has predictive utility in a randomized trial comparing CMF to CEF in premenopausal women with node positive breast cancer (NCIC CTG MA.5). Breast Cancer Res. Treat. 24 (2006) 18S
    • (2006) Breast Cancer Res. Treat. , vol.24
    • O'Malley, F.P.1    Chia, S.2    Tu, D.3    Shepherd, L.E.4    Levine, M.N.5    Huntsman, D.6
  • 26
    • 33746875523 scopus 로고    scopus 로고
    • Topoisomerase II-alpha gene deletion is not frequent as its amplification in breast cancer
    • Park K., Han S., Gwak G.H., Kim H.J., Kim J., and Kim K.M. Topoisomerase II-alpha gene deletion is not frequent as its amplification in breast cancer. Breast Cancer Res. Treat. 98 (2006) 337-342
    • (2006) Breast Cancer Res. Treat. , vol.98 , pp. 337-342
    • Park, K.1    Han, S.2    Gwak, G.H.3    Kim, H.J.4    Kim, J.5    Kim, K.M.6
  • 27
    • 9144242764 scopus 로고    scopus 로고
    • Comparative value of tumour grade, hormonal receptors, Ki-67, HER-2 and topoisomerase II alpha status as predictive markers in breast cancer patients treated with neoadjuvant anthracycline-based chemotherapy
    • Petit T., Wilt M., Velten M., Millon R., Rodier J.F., Borel C., et al. Comparative value of tumour grade, hormonal receptors, Ki-67, HER-2 and topoisomerase II alpha status as predictive markers in breast cancer patients treated with neoadjuvant anthracycline-based chemotherapy. Eur. J. Cancer 40 (2004) 205-211
    • (2004) Eur. J. Cancer , vol.40 , pp. 205-211
    • Petit, T.1    Wilt, M.2    Velten, M.3    Millon, R.4    Rodier, J.F.5    Borel, C.6
  • 29
    • 33947317453 scopus 로고    scopus 로고
    • BCIRG 006:2nd interim analysis phase III randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel with doxorubicin and cyclophosphamide followed by doctaxel and trastuzumab with docetaxel, carboplatin and trastuzumab in HER2 neu positive early breast cancer patients
    • late-breaking abstract 52
    • D. Slamon, W. Eiermann, N. Robert, BCIRG 006:2nd interim analysis phase III randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel with doxorubicin and cyclophosphamide followed by doctaxel and trastuzumab with docetaxel, carboplatin and trastuzumab in HER2 neu positive early breast cancer patients. Breast Cancer Res. Treat. 100 (2006) late-breaking abstract 52.
    • (2006) Breast Cancer Res. Treat , vol.100
    • Slamon, D.1    Eiermann, W.2    Robert, N.3
  • 30
    • 0034594628 scopus 로고    scopus 로고
    • New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada
    • Therasse P., Arbuck S.G., Eisenhauer E.A., Wanders J., Kaplan R.S., Rubinstein L., et al. New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J. Natl. Cancer Inst. 92 (2000) 205-216
    • (2000) J. Natl. Cancer Inst. , vol.92 , pp. 205-216
    • Therasse, P.1    Arbuck, S.G.2    Eisenhauer, E.A.3    Wanders, J.4    Kaplan, R.S.5    Rubinstein, L.6
  • 31
    • 33645079372 scopus 로고    scopus 로고
    • Changes of topoisomerase IIalpha expression in breast tumors after neoadjuvant chemotherapy predicts relapse-free survival
    • Tinari N., Lattanzio R., Natoli C., Cianchetti E., Angelucci D., Ricevuto E., et al. Changes of topoisomerase IIalpha expression in breast tumors after neoadjuvant chemotherapy predicts relapse-free survival. Clin. Cancer Res. 12 (2006) 1501-1506
    • (2006) Clin. Cancer Res. , vol.12 , pp. 1501-1506
    • Tinari, N.1    Lattanzio, R.2    Natoli, C.3    Cianchetti, E.4    Angelucci, D.5    Ricevuto, E.6
  • 32
    • 0035751675 scopus 로고    scopus 로고
    • Preoperative chemotherapy in patients with operable breast cancer: nine-year results from National Surgical Adjuvant Breast and Bowel Project B-18
    • Wolmark N., Wang J., Mamounas E., Bryant J., and Fisher B. Preoperative chemotherapy in patients with operable breast cancer: nine-year results from National Surgical Adjuvant Breast and Bowel Project B-18. J. Natl. Cancer Inst. Monogr. (2001) 96-102
    • (2001) J. Natl. Cancer Inst. Monogr. , pp. 96-102
    • Wolmark, N.1    Wang, J.2    Mamounas, E.3    Bryant, J.4    Fisher, B.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.