Fetal Alcohol Spectrum Disorders: Gene-Environment Interactions, Predictive Biomarkers, and the Relationship Between Structural Alterations in the Brain and Functional Outcomes

Seminars in Pediatric Neurology

Volumn 18, Issue 1, 2011, Pages 49-55

  Reynolds, James N ^a   Weinberg, Joanne ^b   Clarren, Sterling ^c   Beaulieu, Christian ^d   Rasmussen, Carmen ^d   Kobor, Michael ^e   Dube, Marie Pierre ^f   Goldowitz, Daniel ^e  

^a QUEEN S UNIVERSITY   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c Canada Northwest FASD Research Network   (Canada)

^d UNIVERSITY OF ALBERTA   (Canada)

^e UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^f MONTREAL HEART INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BEHAVIOR DISORDER; COGNITIVE DEFECT; DIFFUSION WEIGHTED IMAGING; DISEASE SEVERITY; DNA MODIFICATION; ENVIRONMENTAL FACTOR; EPIGENETICS; EXPERIMENTAL MOUSE; EXPERIMENTAL RAT; FETAL ALCOHOL SYNDROME; GENE EXPRESSION; GENE INTERACTION; GENETIC ANALYSIS; HUMAN; MEDICAL RESEARCH; NEUROIMAGING; NONHUMAN; PHYSIOLOGICAL PROCESS; PRENATAL EXPOSURE; PROGNOSIS; SACCADIC EYE MOVEMENT;

ANIMALS; BIOLOGICAL MARKERS; BRAIN; BRAIN MAPPING; CANADA; CHILD; DISEASE MODELS, ANIMAL; EPIGENOMICS; FEMALE; FETAL ALCOHOL SYNDROME; GOVERNMENT PROGRAMS; HUMANS; INTERDISCIPLINARY STUDIES; PREGNANCY; PROGRAM DEVELOPMENT; TRANSLATIONAL RESEARCH;

EID: 79955963309     PISSN: 10719091     EISSN: 15580776     Source Type: Journal    
DOI: 10.1016/j.spen.2011.02.006     Document Type: Article

References (62)

1. May P.A., Gossage J.P., Kalberg W.O., et al. Prevalence and epidemiological characteristics of FASD from various research methods with an emphasis on recent in-school studies. Dev Disabil Res Rev 2009, 15:176-192.
2. Stade B., Ali A., Bennett D., et al. The burden of prenatal exposure to alcohol: Revised measurement of cost. Can J Clin Pharmacol 2009, 16:e91-e102.
3. Streisguth A.P., Dehaene P. Fetal alcohol syndrome in twins of alcoholic mothers: Concordance of diagnosis and IQ. Am J Med Genet 1993, 47:857-861.
4. Warren K.R., Li T.-K. Genetic polymorphisms: Impact on the risk of fetal alcohol spectrum disorders. Birth Defects Res A Clin Mol Teratol 2005, 73:195-203.
5. Jacobson S.W., Carr L.G., Croxford J., et al. Protective effects of the alcohol dehydrogenase-ADH1B allele in children exposed to alcohol during pregnancy. J Pediatr 2006, 148:30-37.
6. McCarver D.G., Thomasson H.R., Martier S.S., et al. Alcohol dehydrogenase-2*3 allele protects against alcohol-related birth defects among African Americans. J Pharmacol Exp Ther 1997, 283:1095-1101.
7. Stoler J.M., Ryan L.M., Holmes L.B. Alcohol dehydrogenase 2 genotypes, maternal alcohol use, and infant outcome. J Pediatr 2002, 141:780-785.
8. Viljoen D.L., Carr L.G., Foroud T.M., et al. Alcohol dehydrogenase-2*2 allele is associated with decreased prevalence of fetal alcohol syndrome in the mixed-ancestry population of the Western Cape Province, South Africa. Alcohol Clin Exp Res 2001, 25:1719-1722.
9. Henikoff S., Matzke M.A. Exploring and explaining epigentic effects. Trends Genet 1997, 13:293-295.
10. Haycock P.C. Fetal alcohol spectrum disorders: The epigenetic perspective. Biol Reprod 2009, 81:607-617.
11. Haycock P.C., Ramsay M. Exposure of mouse embryos to ethanol during preimplantation development: Effect on DNA methylation in the H19 imprinting control region. Biol Reprod 2009, 81:618-627.
12. Rasmussen C. Executive functioning and working memory in fetal alcohol spectrum disorder. Alcohol Clin Exp Res 2005, 29:1359-1367.
13. Rasmussen C., Bisanz J. Executive functioning in children with Fetal Alcohol Spectrum Disorders: Profiles and age-related differences. Child Neuropsychol 2009, 15:201-215.
14. Green C.R., Mihic A.M., Nikkel S.M., et al. Executive function deficits in children with fetal alcohol spectrum disorders (FASD) measured using the Cambridge Neuropsychological Tests Automated Battery (CANTAB). J Child Psychol Psychiatry 2009, 50:688-697.
15. Lebel C., Rasmussen C., Wyper K., et al. Brain Diffusion Abnormalities in children with fetal alcohol spectrum disorder. Alcohol Clin Exp Res 2008, 32:1732-1740.
16. Lebel C., Rasmussen C., Wyper K., et al. Brain microstructure is related to math ability in children with fetal alcohol spectrum disorder. Alcohol Clin Exp Res 2010, 34:354-363.
17. Green C.R., Mihic A.M., Brien D.C., et al. Oculomotor deficits in children with featl alcohol spectrum disorders assessed using a mobile laboratory. Eur J Neurosci 2009, 29:1302-1309.
18. Welberg L.A., Seckl J.R. Prenatal stress, glucocorticoids and the programming of the brain. J Neuroendocrinol 2001, 13:113-128.
19. Jacobson S.W., Bihun J.T., Chiodo L.M. Effects of prenatal alcohol and cocaine exposure on infant cortisol levels. Dev Psychopathol 1999, 11:195-208.
20. Haley D.W., Handmaker N.S., Lowe J. Infant stress reactivity and prenatal alcohol exposure. Alcohol Clin Exp Res 2006, 30:2055-2064.
21. Lupien S., Lecours A.R., Lussier I., et al. Basal cortisol levels and cognitive deficits in human aging. J Neurosci 1994, 14:2893-2903.
22. Smider N.A., Essex M.J., Kalin N.H., et al. Salivary cortisol as a predictor of socioemotional adjustment during kindergarten: A prospective study. Child Dev 2002, 73:75-92.
23. Scher A., Hall W.A., Zaidman-Zait A., et al. Sleep quality, cortisol levels, and behavioral regulation in toddlers. Dev Psychobiol 2010, 52:44-53.
24. Lombard Z., Tiffin N., Hofmann O., et al. Computational selection and prioritization of candidate genes for fetal alcohol syndrome. BMC Genomics 2007, 8:389-404.
25. Stead J.D., Neal C., Meng F., et al. Transcriptional profiling of the developing rat brain reveals that the most dramatic regional differentiation in gene expression occurs postpartum. J Neurosci 2006, 26:345-353.
26. Weaver I.C.G., Meaney M.J., Szyf M. Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood. Proc Natl Acad Sci U S A 2006, 103:3480-3485.
27. Chudley A.E., Conry J., Cook J.L., et al. Fetal alcohol spectrum disorder: Canadian guidelines for diagnosis. CMAJ 2005, 172:S1-S21.
28. Astley S.J., Aylward E.H., Olson H.C., et al. Magnetic resonance imaging outcomes from a comprehensive magnetic resonance study of children with fetal alcohol spectrum disorders. Alcohol Clin Exp Res 2009, 33:1671-1689.
29. Astley S.J., Richards T., Aylward E.H., et al. Magnetic resonance spectroscopy outcomes from a comprehensive magnetic resonance study of children with fetal alcohol spectrum disorders. Magn Reson Imaging 2009, 27:760-778.
30. Norman A.L., Crocker N., Mattson S.N., et al. Neuroimaging and fetal alcohol spectrum disorders. Dev Disabil Res Rev 2009, 15:209-217.
31. Archibald S.L., Fennema-Notestine C., Gamst A., et al. Brain dysmorphology in individuals with severe prenatal alcohol exposure. Dev Med Child Neurol 2001, 43:148-154.
32. Sowell E.R., Thompson P.M., Mattson S.N., et al. Voxel-based morphometric analyses of the brain in children and adolescents prenatally exposed to alcohol. Neuroreport 2001, 12:515-523.
33. Riley E.P., Mattson S.N., Sowell E.R., et al. Abnormalities of the corpus callosum in children prenatally exposed to alcohol. Alcohol Clin Exp Res 1995, 19:1198-1202.
34. McGee C.L., Riley E.P. Brain imaging and fetal alcohol spectrum disorders. Ann 1st Super Sanita 2006, 42:46-52.
35. Spadoni A.D., McGee C.L., Fryer S.L., et al. Neuroimaging and fetal alcohol spectrum disorders. Neurosci Biobehav Rev 2007, 31:239-245.
36. Riikonen R., Salonen I., Partanen K., et al. Brain perfusion SPECT and MRI in foetal alcohol syndrome. Dev Med Child Neurol 1999, 41:652-659.
37. Sowell E.R., Lu L.H., O'Hare E.D., et al. Functional magnetic resonance imaging of verbal learning in children with heavy prenatal alcohol exposure. Neuroreport 2007, 18:635-639.
38. Cortese B.M., Moore G.J., Bailey B.A., et al. Magnetic resonance and spectroscopic imaging in prenatal alcohol-exposed children: Preliminary findings in the caudate nucleus. Neurotoxicol Teratol 2006, 28:597-606.
39. Fagerlund A., Heikkinen S., Autti-Ramo I., et al. Brain metabolic alterations in adolescents and young adults with fetal alcohol spectrum disorders. Alcohol Clin Exp Res 2006, 30:2097-2104.
40. Sowell E.R., Mattson S.N., Kan E., et al. Abnormal cortical thickness and brain-behavior correlation patterns in individuals with heavy prenatal alcohol exposure. Cereb Cortex 2008, 18:136-144.
41. Bjorkquist O.A., Fryer S.L., Reiss A.L., et al. Cingulate gyrus morphology in children and adolescents with fetal alcohol spectrum disorders. Psychiatry Res 2010, 181:101-107.
42. Guerri C., Pascual M., Renau-Piqueras J. Glia and fetal alcohol syndrome. Neurotoxicology 2001, 22:593-599.
43. Basser P., Mattiello J., Le Bihan D. Estimation of the effective self-diffusion tensor from the NMR spin echo. J Magn Reson B 1994, 103:247-254.
44. Basser P.J., Pajevic S., Pierpaoli C., et al. In vivo fiber tractography using DT-MRI data. Magn Reson Med 2000, 44:625-632.
45. Conturo T.E., Lori N.F., Cull T.S., et al. Tracking neuronal fiber pathways in the living human brain. Proc Natl Acad Sci U S A 1999, 96:10422-10427.
46. Jones D.K., Simmons A., Williams S.C., et al. Non-invasive assessment of axonal fiber connectivity in the human brain via diffusion tensor MRI. Magn Reson Med 1999, 42:37-41.
47. Mori S., Crain B.J., Chacko V.P., et al. Three-dimensional tracking of axonal projections in the brain by magnetic resonance imaging. Ann Neurol 1999, 45:265-269.
48. Le Bihan D. Looking into the functional architecture of the brain with diffusion MRI. Nat Rev Neurosci 2003, 4:469-480.
49. Beaulieu C. The basis of anisotropic water diffusion in the nervous system-A technical review. NMR Biomed 2002, 15:435-455.
50. Ma X., Coles C.D., Lynch M.E., et al. Evaluation of corpus callosum anisotropy in young adults with fetal alcohol syndrome according to diffusion tensor imaging. Alcohol Clin Exp Res 2005, 29:1214-1222.
51. Wozniak J.R., Mueller B.A., Chang P.N., et al. Diffusion tensor imaging in children with fetal alcohol spectrum disorders. Alcohol Clin Exp Res 2006, 30:1799-1806.
52. Wozniak J.R., Muetzel R.L., Mueller B.A., et al. Microstructural corpus callosum anomalies in children with prenatal alcohol exposure: An extension of previous diffusion tensor imaging findings. Alcohol Clin Exp Res 2009, 33:1825-1835.
53. Li L., Coles C.D., Lynch M.E., et al. Voxel wise and skeleton-based region of interest analysis of fetal alcohol syndrome and fetal alcohol spectrum disorders in young adults. Hum Brain Map 2009, 30:3265-3274.
54. Sowell E.R., Johnson A., Kan E., et al. Mapping white matter integrity and neurobehavioral correlates in children with fetal alcohol spectrum disorders. J Neurosci 2008, 28:1313-1319.
55. Munoz D.P., Everling S. Look away: The antisaccade task and the voluntary control of eye movement. Nat Rev Neurosci 2004, 5:218-228.
56. Green C.R., Nikkel S., Munoz D.P., et al. Deficits in eye movement control in children with Fetal Alcohol Spectrum Disorders. Alcohol Clin Exp Res 2007, 31:500-511.
57. Mostofsky S.H., Lasker A.G., Singer H.S., et al. Oculomotor abnormalities in boys with Tourette syndrome with and without ADHD. J Am Acad Child Adolesc Psychiatry 2001, 40:1464-1472.
58. Munoz D.P., Armstrong I.T., Hampton K.A., et al. Altered control of visual fixation and saccadic eye movements in attention-deficit hyperactivity disorder. J Neurophysiol 2003, 90:503-514.
59. Itti L., Koch C. Computational modeling of visual attention. Nat Rev Neurosci 2001, 2:194-203.
60. Peirce J.L., Lu L., Gu J., et al. A new set of BXD recombinant inbred lines from advanced intercross populations in mice. BMC Genet 2004, 5:7.
61. Philip V.M., Duvurru S., Gomero B., et al. High-throughput behavioral phenotyping in the expanded panel of BXD recombinant inbred strains. Genes Brain Behav 2010, 9:129-159.
62. Hellemans K.G., Sliwowska J.H., Verma P., et al. Prenatal alcohol exposure: Fetal programming and later life vulnerability to stress, depression and anxiety disorders. Neurosci Biobehav Rev 2010, 34:791-807.