First report of multiple CEBPA mutations contributing to donor origin of leukemia relapse after allogeneic hematopoietic stem cell transplantation

Blood

Volumn 117, Issue 19, 2011, Pages 5257-5260

  Xiao, Haowen ^a,b   Shi, Jimin ^a   Luo, Yi ^a   Tan, Yamin ^a   He, Jingsong ^a   Xie, Wanzhuo ^a   Zhang, Lifei ^a   Wang, Yingjia ^a   Liu, Lizhen ^a   Wu, Kangni ^a   Yu, Xiaohong ^a   Cai, Zhen ^a   Lin, Maofang ^a   Ye, Xiujin ^a   Huang, He ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b Department of Haematology   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISOLONE; TACROLIMUS;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; CASE REPORT; CEBPA GENE; CLINICAL FEATURE; FEMALE; GENE; GENE DUPLICATION; GENE MUTATION; GRAFT VERSUS HOST REACTION; HUMAN; LEUKEMIA RELAPSE; MALE; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; SOMATIC MUTATION;

EID: 79955962327     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-12-326322     Document Type: Article

References (19)

1. Fialkow PJ, Thomas ED, Bryant JI, et al. Leukaemic transformation of engrafted human marrow cells in vivo. Lancet. 1971;1(7693):251-255.
2. Hertenstein B, Hambach L, Bacigalupo A, et al. Development of leukemia in donor cells after allogeneic stem cell transplantation: a survey of the European Group for Blood and Marrow Transplantation (EBMT). Haematologica. 2005;90(7): 969-975. (Pubitemid 41020299)
3. Sala-Torra O, Hanna C, Loken MR, et al. Evidence of donor-derived hematologic malignancies after hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2006;12(5):511-517. (Pubitemid 43956366)
4. Wiseman DH. Donor cell leukemia: a review [published online ahead of print October 14, 2010]. Biol Blood Marrow Transplant. doi: 10.1016/j.bbmt.2010. 10.010.
5. Knudson AG. Two genetic hits (more or less) to cancer. Nat Rev Cancer. 2001;1(2):157-162. (Pubitemid 33741891)
6. Stirewalt DL, Radich JP. The role of FLT3 in haematopoietic malignancies. Nat Rev Cancer. 2003;3(9):650-665. (Pubitemid 37328820)
7. Schubbert S, Bollag G, Shannon K. Deregulated Ras signaling in developmental disorders: new tricks for an old dog. Curr Opin Genet Dev. 2007; 17(1):15-22.
8. Ernst P, Wang J, Korsmeyer SJ. The role of MLL in hematopoiesis and leukemia. Curr Opin Hematol. 2002;9(4):282-287. (Pubitemid 34596871)
9. Nerlov C. C/EBPalpha mutations in acute myeloid leukaemias. Nat Rev Cancer. 2004;4(5):394-400. (Pubitemid 38579485)
10. Grisendi S, Mecucci C, Falini B, et al. Nucleophosmin and cancer. Nat Rev Cancer. 2006;6(7): 493-505. (Pubitemid 43980539)
11. Schlenk RF, Dohner K, Krauter J, et al. Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia. N Engl J Med. 2008; 358(18):1909-1918. (Pubitemid 351620111)
12. Marcucci G, Maharry K, Radmacher MD, et al. Prognostic significance of, and gene and microRNA expression signatures associated with, CEBPA mutations in cytogenetically normal acute myeloid leukemia with high-risk molecular features: a Cancer and Leukemia Group B Study. J Clin Oncol. 2008;26(31):5078-5087.
13. Ishikawa Y, Kiyoi H, Tsujimura A, et al. Comprehensive analysis of cooperative gene mutations between class I and class II in de novo acute myeloid leukemia. Eur J Haematol. 2009;83(2):90-98.
14. Döhner K, Schlenk RF, Habdank M, et al. Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations. Blood. 2005;106(12):3740-3746. (Pubitemid 41739007)
15. Wang H, Iakova P, Wilde M, et al. C/EBPalpha arrests cell proliferation through direct inhibition of Cdk2 and Cdk4. Mol Cell. 2001;8(4):817-828. (Pubitemid 33030215)
16. Kirstetter P, Schuster MB, Bereshchenko O, et al. Modeling of C/EBPalpha mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells. Cancer Cell. 2008;13(4):299-310. (Pubitemid 351446194)
17. Ruiz-Arguelles GJ, Ruiz-Arguelles A, Garces-Eisele J. Donor cell leukemia: a critical review. Leuk Lymphoma. 2007;48(1):25-38. (Pubitemid 46978621)
18. Klein RD, Marcucci G. Familial acute myeloid leukemia (AML) with mutated CEBPA. In: Pagon RA, Bird TC, Dolan CR, Stephens K, eds. Gene Reviews (http://www.ncbi.nlm.nih.gov/books/ NBK1116/). Accessed October 21, 2010.
19. Flynn CM, Kaufman DS. Donor cell leukemia: insight into cancer stem cells and the stem cell niche. Blood. 2007;109(7):2688-2692. (Pubitemid 46482059)