Acetylbritannilactone induces G1 arrest and apoptosis in vascular smooth muscle cells

International Journal of Cardiology

Volumn 149, Issue 1, 2011, Pages 30-38

  Liu, Bin ^a   Han, Mei ^a   Sun, Rong Hua ^a   Wang, Jun Jie ^a   Liu, Yue Ping ^a   Wen, Jin Kun ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Cell cycle; Proliferation; Restenosis; Vascular smooth muscle cell

Indexed keywords

ACETYLBRITANNILACTONE; CASPASE 3; CASPASE 9; CHEMOATTRACTANT; CYCLIN A; CYCLIN D1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN E; DNA POLYMERASE; INULA BRITANNICA EXTRACT; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PLANT EXTRACT; PLATELET DERIVED GROWTH FACTOR; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P21; UNCLASSIFIED DRUG; ACETYLBRITANNILATONE; CDKN1A PROTEIN, RAT; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLINE; LACTONE; MITOGEN ACTIVATED PROTEIN KINASE; PLANT MEDICINAL PRODUCT; PLATELET DERIVED GROWTH FACTOR RECEPTOR;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CAROTID ARTERY INJURY; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL PROLIFERATION; DNA SYNTHESIS; DRUG MECHANISM; IN VITRO STUDY; IN VIVO STUDY; INULA; INULA BRITANNICA; MALE; NONHUMAN; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; RESTENOSIS; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE; ANIMAL; CELL CULTURE; CELL DIVISION; CELL MOTION; CYTOLOGY; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; METABOLISM; PATHOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT; THORACIC AORTA;

ANGIOPLASTY, BALLOON; ANIMALS; AORTA, THORACIC; APOPTOSIS; CAROTID ARTERY INJURIES; CELL DIVISION; CELL MOVEMENT; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASES; CYCLINS; DISEASE MODELS, ANIMAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; G1 PHASE; INULA; LACTONES; MALE; MUSCLE, SMOOTH, VASCULAR; PLANT PREPARATIONS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR;

EID: 79955930905     PISSN: 01675273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijcard.2009.11.036     Document Type: Article

References (37)

1. Ip JH, Fuster V, Badimon L, Badimon J, Taubman MB, Chesebro JH. Syndromes of accelerated atherosclerosis: role of vascular injury and smooth muscle cell proliferation. J Am Coll Cardiol 1990;15:1667-87. (Pubitemid 20174335)
2. Tanner FC, Boehm M, Akyurek LM, et al. Differential effects of the cyclin-dependent kinase inhibitors p27(Kip1), p21(Cip1), and p16(Ink4) on vascular smooth muscle cell proliferation. Circulation 2000;101:2022-5.
3. Ihling C, Menzel G, Wellens E, Monting JS, Schaefer HE, Zeiher AM. Topographical association between the cyclin-dependent kinases inhibitor P21, p53 accumulation, and cellular proliferation in human atherosclerotic tissue. Arterioscler Thromb Vasc Biol 1997;17:2218-24. (Pubitemid 28057124)
4. Sherr CJ, Roberts JM. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev 1995;9:1149-63.
5. Lee B, Moon SK. Resveratrol inhibits TNF-alpha-induced proliferation and matrix metalloproteinase expression in human vascular smoothmuscle cells. J Nutr 2005;135:2767-73. (Pubitemid 43156539)
6. Isner JM, Kearney M, Bortman S, Passeri J. Apoptosis in human atherosclerosis and restenosis. Circulation 1995;91:2703-11.
7. Sata M, Perlman H, Muruve DA, et al. Fas ligand gene transfer to the vessel wall inhibits neointima formation and overrides the adenovirus-mediated T cell response. Proc Natl Acad Sci U S A 1998;95:1213-7. (Pubitemid 28124938)
8. Bai N, Lai CS, He K, et al. Sesquiterpene lactones from Inula britannica and their cytotoxic and apoptotic effects on human cancer cell lines. J Nat Prod 2006;69:531-5. (Pubitemid 43798096)
9. Park EJ, Kim J. Cytotoxic sesquiterpene lactones from Inula britannica. Planta Med 1998;64:752-4. (Pubitemid 29021577)
10. Rafi MM, Bai NS, Chi Tang H, et al. A sesquiterpenelactone from Inula britannica induces anti-tumor effects dependent on Bcl-2 phosphorylation. Anticancer Res 2005;25:313-8. (Pubitemid 40470125)
11. Liu B, Han M, Wen JK. Acetylbritannilactone inhibits neointimal hyperplasia after balloon injury of rat artery by suppressing nuclear factor-{kappa}B activation. J Pharmacol Exp Ther 2008;324:292-8. (Pubitemid 350294152)
12. Liu YP, Wen JK, Zheng B, Zhang DQ, Han M. Acetylbritannilactone suppresses lipopolysaccharide-induced vascular smooth muscle cell inflammatory response. Eur J Pharmacol 2007;577:28-34. (Pubitemid 47632521)
13. Han M, Wen JK, Zheng B, Cheng Y, Zhang C. Serum deprivation results in redifferentiation of human umbilical vascular smooth muscle cells. Am J Physiol Cell Physiol 2006;291:C50-8.
14. Iijima K, Yoshizumi M, Hashimoto M, et al. Red wine polyphenols inhibit vascular smooth muscle cell migration through two distinct signaling pathways. Circulation 2002;105:2404-10. (Pubitemid 34556393)
15. Clowes AW, Reidy MA, Clowes MM. Kinetics of cellular proliferation after arterial injury. I. Smooth muscle growth in the absence of endothelium. Lab Invest 1983;49:327-33.
16. Li JM, Brooks G. Cell cycle regulatory molecules (cyclins, cyclin-dependent kinases and cyclin-dependent kinase inhibitors) and the cardiovascular system; potential targets for therapy? Eur Heart J 1999;20:406-20.
17. Willis S, Day CL, HindsMG, Huang DC. The Bcl-2-regulated apoptotic pathway. J Cell Sci 2003;116:4053-6. (Pubitemid 37337079)
18. Cory S, Adams JM. The Bcl2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer 2002;2:647-56. (Pubitemid 37328916)
19. Lowe SW, Lin AW. Apoptosis in cancer. Carcinogenesis 2000;21:485-95. (Pubitemid 30137934)
20. Jiang C, Wang Z, Ganther H, Lu J. Caspases as key executors of methyl selenium-induced apoptosis (anoikis) of DU-145 prostate cancer cells. Cancer Res 2001;61:3062-70. (Pubitemid 32691955)
21. Kaufmann SH, Desnoyers S, Ottaviano Y, Davidson NE, Poirier GG. Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an earlymarker of chemotherapy-induced apoptosis. Cancer Res 1993;53:3976-85. (Pubitemid 23267698)
22. Fuster V, Badimon L, Badimon JJ, Chesebro JH. The pathogenesis of coronary artery disease and the acute coronary syndromes (1). N Engl J Med 1992;326:242-50.
23. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 1993;362:801-9. (Pubitemid 23132154)
24. Rosenkranz S, Knirel D, Dietrich H, Flesch M, Erdmann E, Bohm M. Inhibition of the PDGF receptor by red wine flavonoids provides a molecular explanation for the "French paradox". FASEB J 2002;16:1958-60.
25. Jones SM, Kazlauskas A. Growth-factor-dependentmitogenesis requires two distinct phases of signalling. Nat Cell Biol 2001;3:165-72. (Pubitemid 32118370)
26. Hu Y, Zou Y, Dietrich H, Wick G, Xu Q. Inhibition of neointima hyperplasia of mouse vein grafts by locally applied suramin. Circulation 1999;100:861-8. (Pubitemid 29398886)
27. Heldin CH, Westermark B. Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev 1999;79:1283-316. (Pubitemid 29473317)
28. Gallo R, Padurean A, Jayaraman T, et al. Inhibition of intimal thickening after balloon angioplasty in porcine coronary arteries by targeting regulators of the cell cycle. Circulation 1999;99:2164-70. (Pubitemid 29196802)
29. Ruef J, Meshel AS, Hu Z, et al. Flavopiridol inhibits smooth muscle cell proliferation in vitro and neointimal formation in vivo after carotid injury in the rat. Circulation 1999;100:659-65. (Pubitemid 29379757)
30. Yang HM, Kim HS, Park KW, et al. Celecoxib, a cyclooxygenase-2 inhibitor, reduces neointimal hyperplasia through inhibition of Akt signaling. Circulation 2004;110:301-8.
31. Chandrasekar B, Tanguay JF. Platelets and restenosis. J Am Coll Cardiol 2000;35:555-62. (Pubitemid 30167011)
32. Hoshi S, Goto M, Koyama N, Nomoto K, Tanaka H. Regulation of vascular smooth muscle cell proliferation by nuclear factor-kappaB and its inhibitor, I-kappaB. J Biol Chem 2000;275:883-9. (Pubitemid 30051130)
33. Nagata Y, Todokoro K. Requirement of activation of JNK and p38 for environmental stress-induced erythroid differentiation and apoptosis and of inhibition of ERK for apoptosis. Blood 1999;94:853-63. (Pubitemid 29361815)
34. Zelivianski S, Spellman M, Kellerman M, et al. ERK inhibitor PD98059 enhances docetaxel-induced apoptosis of androgen-independent human prostate cancer cells. Int J Cancer 2003;107:478-85. (Pubitemid 37266470)
35. Pullikuth AK, Catling AD. Scaffold mediated regulation of MAPK signaling and cytoskeletal dynamics: a perspective. Cell Signal 2007;19:1621-32. (Pubitemid 46935436)
36. Ray RM, Vaidya RJ, Johnson LR.MEK/ERK regulates adherens junctions andmigration through Rac1. Cell Motil Cytoskeleton 2007;64:143-56.
37. Coats AJ. Ethical authorship and publishing. Int J Cardiol 2009;131:149-50.