Acetylbritannilactone suppresses lipopolysaccharide-induced vascular smooth muscle cell inflammatory response

European Journal of Pharmacology

Volumn 577, Issue 1-3, 2007, Pages 28-34

  Liu, Yue Ping ^a   Wen, Jin Kun ^a   Zheng, Bin ^a   Zhang, Di Qun ^a   Han, Mei ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

1 O acetylbritannilactone; Cyclooxygenase 2; Nuclear factor B; Vascular smooth muscle cell

Indexed keywords

1 O ACETYLBRITANNILACTONE; CELECOXIB; CELEXIB; CYCLOOXYGENASE 2; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INULA BRITANNICA EXTRACT; LIPOPOLYSACCHARIDE; PLANT EXTRACT; PROSTAGLANDIN E2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DNA BINDING; DRUG MECHANISM; ENZYME IMMUNOASSAY; GEL MOBILITY SHIFT ASSAY; IMMUNOCYTOCHEMISTRY; INFLAMMATION; INULA; INULA BRITANNICA; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AORTA, THORACIC; BLOTTING, WESTERN; CELLS, CULTURED; CYCLOOXYGENASE 2; DINOPROSTONE; ELECTROPHORETIC MOBILITY SHIFT ASSAY; I-KAPPA B KINASE; IMMUNOENZYME TECHNIQUES; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INULA; LACTONES; LIPOPOLYSACCHARIDES; MALE; MUSCLE, SMOOTH, VASCULAR; NF-KAPPA B; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 35448965786     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2007.08.030     Document Type: Article

References (18)

1. Baeuerle P.A., and Baltimore D. IκB: a specific inhibitor of the NF-kB transcription factor. Science 242 (1988) 540-546
2. Baeuerle P.A., and Baichwal V.R. NF-κB as a frequent target for immuno-suppressive and anti-inflammatory molecules. Adv. Immunol. 65 (1997) 111-137
3. Baeuerle P.A., and Henkel T. Function and activation of NF-kappa B in the immune system. Annu. Rev. Immunol. 12 (1994) 141-179
4. Bian K., Harari Y., and Zhong M. Down-regulation of inducible nitric-oxide synthase (NOS-2) during parasite-induced gut inflammation: a path to identify a selective NOS-2 inhibitor. Mol. Pharmacol. 59 (2001) 939-947
5. Brand K., Page S., Rogler G., Bartsch A., Brandl R., and Ruth Knuechel R. Activated transcription factor nuclear factor-Kappa B is present in the atherosclerotic lesion. J. Clin. Invest. 97 (1996) 1715
6. Chang J.H., Ryang Y.S., Morio T., Lee S.K., and Chang E.J. Trichomonas vaginalis inhibits proinflammatory cytokine production in macrophages by suppressing NF-κB activation. Mol. Cells 18 (2004) 177-185
7. Collins T., and Cybulsky M.I. NF-κB: pivotal mediator or innocent bystander in atherogenesis?. J. Clin. Invest. 107 (2001) 255-264
8. Glinghammar B., Inoue H., and Rafter J.J. Deoxycholic acid causes DNA damage in colonic cells with subsequent induction of caspases, COX-2 promoter activity and the transcription factors NF-κB and AP-1. Carcinogenesis. 23 (2002) 839-845
9. Han W.J., Lee G.B., Kim K.Y., Yoon W.J., Jin K.H., Hong S., Lee Y.H., Lee R.K., and Lee W.H. Ergolide, sesquiterpene lactone from Inula britannica, inhibits inducible nitric oxide synthase and cyclo-oxygenase-2 expression in RAW264.7 macrophages through the inactivation of NF-κB. Br. J. Pharmacol. 133 (2001) 503-512
10. 2 synthesis in RAW 264.7 macrophages through the inhibition of iNOS and COX-2 gene expression. Life Sci. 75 (2004) 675-684
11. Han M., Wen J.K., Zheng B., Cheng Y., and Zhang C. Serum deprivation results in redifferentiation of human umbilical vascular smooth muscle cells. Am. J. Physiol., Cell Physiol. 291 (2006) 50-58
12. Hayden M.S., and Ghosh S. Signaling to NF-κB. Genes Dev. 18 (2004) 2195-2224
13. Kanters E., Pasparakis M., Glijbels M.J.J., Vergouwe M.N., Hendriks I.P., Fijneman R.J.A., Clausen B.E., Forster I., Kockx M.M., Rajewsky K., Kraal G., Hofker M.H., and de Winter M.P.J. Inhibition of NF-κB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice. J. Clin. Invest. 112 (2003) 1176-1185
14. Kreiss C., Birder L.A., Kiss S., Vanbibber M.M., and Bauer A.J. COX-2 dependent inflammation increases spinal Fos expression during rodent postoperative ileus. Gut 52 (2003) 527-534
15. Wang H.Q., and Smart R.C. Overexpression of protein kinase C-alpha in the epidermis of transgenic mice results in striking alterations in phorbol ester-induced inflammation and COX-2, MIP-2 and TNF-alpha expression but not tumor promotion. J. Cell Sci. 112 (1999) 3497-3506
16. Wang Y., Shi X.W., wei Fu Y., Cheng W., Zhang D.Q., and Zhang J.P. Preparation and determination of 1-O-acetylbritannilactone in Inula britannica L. Chin. J. Chromatography 6 (2005) 12-15
17. Wen J.K., Han M., and Liu D. Molecular cloning and characterization of promoter region of rat inducible nitric oxide synthase gene. Biochemistry (Mosc.). 65 (2000) 1327-1330
18. 2 synthesis and attenuates chlamydial growth. J. Med. Microbiol. 52 (2003) 409-415