Plasma cytokine levels in Tanzanian HIV-1-infected adults and the effect of antiretroviral treatment

Journal of Acquired Immune Deficiency Syndromes

Volumn 52, Issue 4, 2009, Pages 493-497

  Haissman, Judith M ^a   Vestergaard, Lasse S ^b,c   Sembuche, Samuel ^d   Erikstrup, Christian ^e   Mmbando, Bruno ^d   Mtullu, Samuel ^f   Lemnge, Martha M ^d   Gerstoft, Jan ^b   Ullum, Henrik ^a  

^a Copenhagen University Hospital ^*  (Denmark)

^b International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health   (Denmark)

^c STATENS SERUM INSTITUT   (Denmark)

^d NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (Tanzania)

^e AARHUS UNIVERSITY HOSPITAL   (Denmark)

^f Tanga Aids Working Group   (Tanzania)

Author keywords

Africa; Antiretroviral treatment; HIV; Immune activation; Plasma cytokines; Tanzania

Indexed keywords

ANTIRETROVIRUS AGENT; CD4 ANTIGEN; CYTOKINE; HEMOGLOBIN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 6; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA; VIRUS RNA;

ADULT; AFRICA; ARTICLE; BLOOD LEVEL; CD4 LYMPHOCYTE COUNT; CONTROLLED STUDY; FEMALE; HEMOGLOBIN DETERMINATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOSTIMULATION; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; TANZANIA; VIRUS REPLICATION;

ADULT; ANTI-HIV AGENTS; CD4 LYMPHOCYTE COUNT; CYTOKINES; FEMALE; HEMOGLOBINS; HIV INFECTIONS; HIV-1; HUMANS; MALE; RNA, VIRAL; TANZANIA; VIRUS REPLICATION;

EID: 74049155854     PISSN: 15254135     EISSN: None     Source Type: Journal    
DOI: 10.1097/QAI.0b013e3181b627dc     Document Type: Article

References (13)

1. Appay V, Sauce D. Immune activation and inflammation in HIV-1 infection: causes and consequences. J Pathol. 2008;214:231-241.
2. Bentwich Z, Kalinkovich A, Weisman Z. Immune activation is a dominant factor in the pathogenesis of African AIDS. Immunol Today. 1995;16: 187-191.
3. Rizzardini G, Trabattoni D, Saresella M, et al. Immune activation in HIV-infected African individuals. Italian-Ugandan AIDS cooperation program. AIDS. 1998;12:2387-2396.
4. Lawn SD. AIDS in Africa: the impact of coinfections on the pathogenesis of HIV-1 infection. J Infect. 2004;48:1-12.
5. Autran B, Carcelain G, Debre P. Immune reconstitution after highly active anti-retroviral treatment of HIV infection. Adv Exp Med Biol. 2001;495: 205-212.
6. Ayehunie S, Sonnerborg A, Yemane-Berhan T, et al. Raised levels of tumour necrosis factor-alpha and neopterin, but not interferon-alpha, in serum of HIV-1-infected patients from Ethiopia. Clin Exp Immunol. 1993; 91:37-42.
7. Chollet-Martin S, Simon F, Matheron S, et al. Comparison of plasma cytokine levels in African patients with HIV-1 and HIV-2 infection. AIDS. 1994;8:879-884.
8. Messele T, Brouwer M, Girma M, et al. Plasma levels of viro-immunological markers in HIV-infected and non-infected Ethiopians: correlation with cell surface activation markers. Clin Immunol. 2001;98: 212-219.
9. Thea DM, Porat R, Nagimbi K, et al. Plasma cytokines, cytokine antagonists, and disease progression in African women infected with HIV-1. Ann Intern Med. 1996;124:757-762.
10. Bisset LR, Rothen M, Joller-Jemelka HI, et al. Change in circulating levels of the chemokines macrophage inflammatory proteins 1 alpha and 11 beta, RANTES, monocyte chemotactic protein-1 and interleukin-16 following treatment of severely immunodeficient HIV-infected individuals with indinavir. AIDS. 1997;11:485-491.
11. Stylianou E, Aukrust P, Kvale D, et al. IL-10 in HIV infection: increasing serum IL-10 levels with disease progression\-down-regulatory effect of potent anti-retroviral therapy. Clin Exp Immunol. 1999;116:115-120.
12. Lawn SD, Shattock RJ, Acheampong JW, et al. Sustained plasma TNF-alpha and HIV-1 load despite resolution of other parameters of immune activation during treatment of tuberculosis in Africans. AIDS. 1999;13: 2231-2237.
13. Erikstrup C, Kallestrup P, Zinyama R, et al. Predictors of mortality in a cohort of HIV-1-infected adults in rural Africa. J Acquir Immune Defic Syndr. 2007;44:478-483.