Characterization of a synthetic human LINE-1 retrotransposon ORFeus-Hs

Mobile DNA

Volumn 2, Issue 1, 2011, Pages

  An, Wenfeng ^a,b   Dai, Lixin ^a   Niewiadomska, Anna Maria ^a   Yetil, Alper ^a,c   O'Donnell, Kathryn A ^a   Han, Jeffrey S ^a,d   Boeke, Jef D ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON STATE UNIVERSITY   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d GEOPHYSICAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; MESSENGER RNA; ORF1 PROTEIN; ORF2 PROTEIN; PROTEIN; RNA; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; AMINO ACID SEQUENCE; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DNA TRANSPOSITION; GENE AMPLIFICATION; GENE EXPRESSION; GENE FREQUENCY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LONG INTERSPERSED ELEMENT TYPE 1; LONG INTERSPERSED REPEAT; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETROPOSON;

MAMMALIA;

EID: 79955912784     PISSN: None     EISSN: 17598753     Source Type: Journal    
DOI: 10.1186/1759-8753-2-2     Document Type: Article

References (33)

1. High frequency retrotransposition in cultured mammalian cells. Moran JV, Holmes SE, Naas TP, DeBerardinis RJ, Boeke JD, Kazazian HH Jr, Cell 1996 87 917 927 10.1016/S0092-8674(00)81998-4 8945518 (Pubitemid 26404290)
2. LINE-mediated retrotransposition of marked Alu sequences. Dewannieux M, Esnault C, Heidmann T, Nat Genet 2003 35 41 48 10.1038/ng1223 12897783 (Pubitemid 37048594)
3. Isolation of an active human transposable element. Dombroski BA, Mathias SL, Nanthakumar E, Scott AF, Kazazian HH Jr, Science 1991 254 1805 1808 10.1126/science.1662412 1662412 (Pubitemid 21917533)
4. Size and structure of the highly repetitive BAM HI element in mice. Fanning TG, Nucleic Acids Res 1983 11 5073 5091 10.1093/nar/11.15.5073 6308571
5. LINE-1: a mammalian transposable element. Fanning TG, Singer MF, Biochim Biophys Acta 1987 910 203 212 2445384 (Pubitemid 17164808)
6. Defining the beginning and end of KpnI family segments. Grimaldi G, Skowronski J, Singer MF, EMBO J 1984 3 1753 1759 6090124
7. The sequence of a large L1Md element reveals a tandemly repeated 5' end and several features found in retrotransposons. Loeb DD, Padgett RW, Hardies SC, Shehee WR, Comer MB, Edgell MH, Hutchison CA, Mol Cell Biol 1986 6 168 182 3023821 (Pubitemid 16182096)
8. Origin of the human L1 elements: proposed progenitor genes deduced from a consensus DNA sequence. Scott AF, Schmeckpeper BJ, Abdelrazik M, Comey CT, O'Hara B, Rossiter JP, Cooley T, Heath P, Smith KD, Margolet L, Genomics 1987 1 113 125 10.1016/0888-7543(87)90003-6 3692483
9. Sequence-specific single-strand RNA binding protein encoded by the human LINE-1 retrotransposon. Hohjoh H, Singer MF, EMBO J 1997 16 6034 6043 10.1093/emboj/16.19.6034 9312060 (Pubitemid 27427298)
10. In vitro properties of the first ORF protein from mouse LINE-1 support its role in ribonucleoprotein particle formation during retrotransposition. Kolosha VO, Martin SL, Proc Natl Acad Sci USA 1997 94 10155 10160 10.1073/pnas.94.19.10155 9294179 (Pubitemid 27407010)
11. High-affinity, non-sequence-specific RNA binding by the open reading frame 1 (ORF1) protein from long interspersed nuclear element 1 (LINE-1). Kolosha VO, Martin SL, J Biol Chem 2003 278 8112 8117 10.1074/jbc.M210487200 12506113 (Pubitemid 36800552)
12. Nucleic acid chaperone activity of the ORF1 protein from the mouse LINE-1 retrotransposon. Martin SL, Bushman FD, Mol Cell Biol 2001 21 467 475 10.1128/MCB.21.2.467-475.2001 11134335 (Pubitemid 32037367)
13. Human L1 retrotransposon encodes a conserved endonuclease required for retrotransposition. Feng Q, Moran JV, Kazazian HH Jr, Boeke JD, Cell 1996 87 905 916 10.1016/S0092-8674(00)81997-2 8945517 (Pubitemid 26404289)
14. Reverse transcriptase encoded by a human transposable element. Mathias SL, Scott AF, Kazazian HH Jr, Boeke JD, Gabriel A, Science 1991 254 1808 10 10.1126/science.1722352 1722352 (Pubitemid 21917534)
15. Transcriptional disruption by the L1 retrotransposon and implications for mammalian transcriptomes. Han JS, Szak ST, Boeke JD, Nature 2004 429 268 274 10.1038/nature02536 15152245 (Pubitemid 38684807)
16. A highly active synthetic mammalian retrotransposon. Han JS, Boeke JD, Nature 2004 429 314 318 10.1038/nature02535 15152256 (Pubitemid 38684818)
17. Active retrotransposition by a synthetic L1 element in mice. An W, Han JS, Wheelan SJ, Davis ES, Coombes CE, Ye P, Triplett C, Boeke JD, Proc Natl Acad Sci USA 2006 103 18662 18667 10.1073/pnas.0605300103 17124176 (Pubitemid 44913467)
18. An actively retrotransposing, novel subfamily of mouse L1 elements. Naas TP, DeBerardinis RJ, Moran JV, Ostertag EM, Kingsmore SF, Seldin MF, Hayashizaki Y, Martin SL, Kazazian HH, EMBO J 1998 17 590 597 10.1093/emboj/17.2.590 9430649 (Pubitemid 28045498)
19. Determination of L1 retrotransposition kinetics in cultured cells. Ostertag EM, Prak ET, DeBerardinis RJ, Moran JV, Kazazian HH Jr, Nucleic Acids Res 2000 28 1418 1423 10.1093/nar/28.6.1418 10684937 (Pubitemid 30142685)
20. An element in the 3' untranslated region of human LINE-1 retrotransposon mRNA binds NXF1(TAP) and can function as a nuclear export element. Lindtner S, Felber BK, Kjems J, RNA 2002 8 345 356 10.1017/S1355838202027759 12003494 (Pubitemid 34311184)
21. Unconventional translation of mammalian LINE-1 retrotransposons. Alisch RS, Garcia-Perez JL, Muotri AR, Gage FH, Moran JV, Genes Dev 2006 20 210 224 10.1101/gad.1380406 16418485 (Pubitemid 43112939)
22. The dicistronic RNA from the mouse LINE-1 retrotransposon contains an internal ribosome entry site upstream of each ORF: implications for retrotransposition. Li PW, Li J, Timmerman SL, Krushel LA, Martin SL, Nucleic Acids Res 2006 34 853 864 10.1093/nar/gkj490 16464823 (Pubitemid 43380670)
23. Cis-preferential LINE-1 reverse transcriptase activity in ribonucleoprotein particles. Kulpa DA, Moran JV, Nat Struct Mol Biol 2006 13 655 660 10.1038/nsmb1107 16783376 (Pubitemid 44036477)
24. Requirements for polyadenylation at the 3' end of LINE-1 elements. Belancio VP, Whelton M, Deininger P, Gene 2007 390 98 107 10.1016/j.gene.2006. 07.029 17023124
25. LINE-1 RNA splicing and influences on mammalian gene expression. Belancio VP, Hedges DJ, Deininger P, Nucleic Acids Res 2006 34 1512 1521 10.1093/nar/gkl027 16554555
26. Ribonucleoprotein particle formation is necessary but not sufficient for LINE-1 retrotransposition. Kulpa DA, Moran JV, Hum Mol Genet 2005 14 3237 3248 10.1093/hmg/ddi354 16183655 (Pubitemid 41631298)
27. Human LINE-1 retrotransposon induces DNA damage and apoptosis in cancer cells. Belgnaoui SM, Gosden RG, Semmes OJ, Haoudi A, Cancer Cell Int 2006 6 13 10.1186/1475-2867-6-13 16670018
28. Retrotransposition-Competent Human LINE-1 Induces Apoptosis in Cancer Cells With Intact p53. Haoudi A, Semmes OJ, Mason JM, Cannon RE, J Biomed Biotechnol 2004 2004 185 194 10.1155/S1110724304403131 15467158 (Pubitemid 40128954)
29. The human LINE-1 retrotransposon creates DNA double-strand breaks. Gasior SL, Wakeman TP, Xu B, Deininger PL, J Mol Biol 2006 357 1383 1393 10.1016/j.jmb.2006.01.089 16490214
30. L1 mobile element expression causes multiple types of toxicity. Wallace NA, Belancio VP, Deininger PL, Gene 2008 419 75 81 10.1016/j.gene.2008.04.013 18555620
31. Optimizing scaleup yield for protein production: Computationally Optimized DNA Assembly (CODA) and Translation Engineering. Hatfield GW, Roth DA, Biotechnol Annu Rev 2007 13 27 42 full-text 17875472 (Pubitemid 47387122)
32. Single-step assembly of a gene and entire plasmid from large numbers of oligodeoxyribonucleotides. Stemmer WP, Crameri A, Ha KD, Brennan TM, Heyneker HL, Gene 1995 164 49 53 10.1016/0378-1119(95)00511-4 7590320
33. Huxley A, Brave New World London: HarperCollins 1932