Optimizing scaleup yield for protein production: Computationally Optimized DNA Assembly (CODA) and Translation Engineering™

Biotechnology Annual Review

Volumn 13, Issue , 2007, Pages 27-42

  Hatfield, G Wesley ^a,b   Roth, David A ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CODA Genomics Inc ^*  (United States)

Author keywords

codon context; codon pair utilization bias; fusion proteins; Hot Rod genes; monoclonal antibodies; Planned Pause genes; protein domains; protein expression; protein subunit vaccines.; protein therapeutics; SpeedPlots; synthetic biology; Translation Engineering; translational kinetics; translational step times

Indexed keywords

MESSENGER RNA; OLIGONUCLEOTIDE; RNA; RNA POLYMERASE;

AMINO ACID SEQUENCE; CODON; ESCHERICHIA COLI; GENE EXPRESSION; GENE EXPRESSION SYSTEM; GENE SEQUENCE; GENE SYNTHESIS; GENE TECHNOLOGY; GENETIC CODE; GENETIC TRANSCRIPTION; HETEROLOGOUS EXPRESSION; HOST; HUMAN; METHODOLOGY; NONHUMAN; PATENT; POLYSOME; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; RESTRICTION SITE; REVIEW; RIBOSOME; RNA STRUCTURE; RNA TRANSLATION; SCALE UP; SIGNAL TRANSDUCTION; THERMODYNAMICS;

ALGORITHMS; CODON; DNA, BACTERIAL; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; PILOT PROJECTS; PROTEIN BIOSYNTHESIS; PROTEIN ENGINEERING; RECOMBINANT PROTEINS;

ESCHERICHIA COLI;

EID: 34548585028     PISSN: 13872656     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1387-2656(07)13002-7     Document Type: Review

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