Local application of VEGF compensates callus deficiency after acute soft tissue trauma-results using a limb-shortening distraction procedure in rabbit tibia

Journal of Orthopaedic Research

Volumn 29, Issue 7, 2011, Pages 1093-1098

  Ochman, Sabine ^a   Frey, Sönke ^b   Raschke, Michael J ^a   Deventer, Jehan N ^a   Meffert, Rainer H ^b  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

angiogenesis; distraction osteogenesis; fracture healing; ossification; VEGF

Indexed keywords

VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; CALLUS; CONTROLLED STUDY; EXPERIMENTAL RABBIT; FOLLOW UP; FRACTURE EXTERNAL FIXATION; FRACTURE HEALING; NONHUMAN; PRIORITY JOURNAL; SOFT TISSUE INJURY; TIBIA;

ANIMALS; BIOMECHANICS; BONY CALLUS; FRACTURE HEALING; NEOVASCULARIZATION, PHYSIOLOGIC; OSTEOGENESIS, DISTRACTION; RABBITS; SOFT TISSUE INJURIES; TIBIA; TIBIAL FRACTURES; TORSION, MECHANICAL; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 79955912096     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.21340     Document Type: Article

References (27)

1. Betz AM, Hierner R, Baumgart R, et al. 1998. Primary shortening-secondary lengthening. A new treatment concept for reconstruction of extensive soft tissue and bone injuries after 3rd degree open fracture and amputation of the lower leg. Handchir Mikrochir Plast Chir 30: 30-39.
2. Meffert RH, Tis JE, Inoue N, et al. 2000. Primary resective shortening followed by distraction osteogenesis for limb reconstruction: a comparison with simple lengthening. J Orthop Res 18: 629-636.
3. Watson JT, Anders M, Moed BR., 1995. Management strategies for bone loss in tibial shaft fractures. Clin Orthop Relat Res 315: 138-152.
4. Mollenhoff G, Josten C, Muhr G., 1997. Callotaxis-osteogenesis by stretching-a conservative possibility for restoring leg length after post-traumatic primary tibial shortening ? Zentralbl Chir 122: 970-973.
5. Sales de Gauzy J, Vidal H, Cahuzac JP., 1993. Primary shortening followed by callus distraction for the treatment of a posttraumatic bone defect: case report. J Trauma 34: 461-463. (Pubitemid 23131350)
6. Meffert RH, Jansen H, Frey SP, et al. 2007. The influence of soft tissue trauma on bone regeneration after acute limb shortening. Clin Orthop Relat Res 460: 202-209. (Pubitemid 47056499)
7. Schmid J, Wallkamm B, Hammerle CH, et al. 1997. The significance of angiogenesis in guided bone regeneration. A case report of a rabbit experiment. Clin Oral Implants Res 8: 244-248. (Pubitemid 127688460)
8. Tsiridis E, Upadhyay N, Giannoudis P., 2007. Molecular aspects of fracture healing: which are the important molecules ? Injury 38 (Suppl 1): S11-S25. (Pubitemid 46440926)
9. Gerber HP, Vu TH, Ryan AM, et al. 1999. VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat Med 5: 623-628. (Pubitemid 29289424)
10. Ferrara N, Gerber HP, LeCouter J., 2003. The biology of VEGF and its receptors. Nat Med 9: 669-676. (Pubitemid 36749215)
11. Ferrara N., 2000. VEGF: an update on biological and therapeutic aspects. Curr Opin Biotechnol 11: 617-624.
12. Street J, Bao M, deGuzman L, et al. 2002. Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover. Proc Natl Acad Sci USA 99: 9656-9661. (Pubitemid 34831103)
13. Tarkka T, Sipola A, Jamsa T, et al. 2003. Adenoviral VEGF-A gene transfer induces angiogenesis and promotes bone formation in healing osseous tissues. J Gene Med 5: 560-566. (Pubitemid 40310399)
14. Geiger F, Bertram H, Berger I, et al. 2005. Vascular endothelial growth factor gene-activated matrix (VEGF165-GAM) enhances osteogenesis and angiogenesis in large segmental bone defects. J Bone Miner Res 20: 2028-2035. (Pubitemid 41532788)
15. Geiger F, Lorenz H, Xu W, et al. 2007. VEGF producing bone marrow stromal cells (BMSC) enhance vascularization and resorption of a natural coral bone substitute. Bone 41: 516-522. (Pubitemid 47385443)
16. Kleinheinz J, Stratmann U, Joos U, et al. 2005. VEGF-activated angiogenesis during bone regeneration. J Oral Maxillofac Surg 63: 1310-1316. (Pubitemid 41191257)
17. Li R, Stewart DJ, von Schroeder HP, et al. 2009. Effect of cell-based VEGF gene therapy on healing of a segmental bone defect. J Orthop Res 27: 8-14.
18. Peng H, Usas A, Olshanski A, et al. 2005. VEGF improves, whereas sFlt1 inhibits, BMP2-induced bone formation and bone healing through modulation of angiogenesis. J Bone Miner Res 20: 2017-2027. (Pubitemid 41532787)
19. Schipani E, Maes C, Carmeliet G, et al. 2009. Regulation of osteogenesis-angiogenesis coupling by HIFs and VEGF. J Bone Miner Res 24: 1347-1353.
20. Hu J, Zou S, Li J, et al. 2003. Temporospatial expression of vascular endothelial growth factor and basic fibroblast growth factor during mandibular distraction osteogenesis. J Craniomaxillofac Surg 31: 238-243. (Pubitemid 37081093)
21. Mori S, Akagi M, Kikuyama A, et al. 2006. Axial shortening during distraction osteogenesis leads to enhanced bone formation in a rabbit model through the HIF-1alpha/vascular endothelial growth factor system. J Orthop Res 24: 653-663. (Pubitemid 43804959)
22. Wan C, Gilbert SR, Wang Y, et al. 2008. Role of hypoxia inducible factor-1 alpha pathway in bone regeneration. J Musculoskelet Neuronal Interact 8: 323-324.
23. Jacobsen KA, Al-Aql ZS, Wan C, et al. 2008. Bone formation during distraction osteogenesis is dependent on both VEGFR1 and VEGFR2 signaling. J Bone Miner Res 23: 596-609. (Pubitemid 351575014)
24. Zheng LW, Ma L, Cheung LK., 2009. Angiogenesis is enhanced by continuous traction in rabbit mandibular distraction osteogenesis. J Craniomaxillofac Surg 37: 405-411.
25. Eckardt H, Ding M, Lind M, et al. 2005. Recombinant human vascular endothelial growth factor enhances bone healing in an experimental nonunion model. J Bone Joint Surg Br 87: 1434-1438. (Pubitemid 41511813)
26. Evans CH, Robbins PD., 1995. Possible orthopaedic applications of gene therapy. Bone Joint Surg Am 77: 1103-1114.
27. Kleinheinz J, Jung S, Wermker K, et al. 2010. Release kinetics of VEGF165 from a collagen matrix and structural matrix changes in a circulation model. Head Face Med 6: 17.