메뉴 건너뛰기




Volumn 13, Issue 3, 2011, Pages 211-218

Neurobiology of delusions in Alzheimer's disease

Author keywords

Alzheimer's; BPSD; Cognition; Confabulation; Delusions; Dementia; Genetics; Misidentifications; Neuropathology; Neuropsychiatric symptoms; Neuropsychiatry; NPS; Paranoia; Persecutory delusions; Psychosis; Suspiciousness

Indexed keywords

ALZHEIMER DISEASE; APOLIPOPROTEIN E4 GENE; ARTICLE; COGNITIVE DEFECT; DELUSION; DELUSIONAL MISIDENTIFICATION; DEMENTIA; DOPAMINE RECEPTOR 3 GENE; FRONTAL LOBE; FUNCTIONAL DISEASE; GENE; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; HALLUCINATION; HOMOZYGOSITY; HUMAN; INTERLEUKIN 1BETA GENE; MILD COGNITIVE IMPAIRMENT; NEUROBIOLOGY; NEUROFIBRILLARY TANGLE; NEUROPATHOLOGY; PERSECUTORY DELUSION; PSYCHOSIS; RISK FACTOR; SENILE PLAQUE; SEROTONIN 2A RECEPTOR GENE; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 79955910047     PISSN: 15233812     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11920-011-0195-1     Document Type: Article
Times cited : (55)

References (50)
  • 3
    • 0000293742 scopus 로고
    • Uber eine eigenartige rkrankung der hirnrinde
    • Alzheimer A. Uber eine eigenartige rkrankung der hirnrinde. Allg Z Psychiat Psych Gerichtl Med. 1907;64:146-8.
    • (1907) Allg Z Psychiat Psych Gerichtl Med , vol.64 , pp. 146-148
    • Alzheimer, A.1
  • 5
    • 33745904131 scopus 로고    scopus 로고
    • Cognitive neuroscience of delusions in aging
    • DOI 10.2147/nedt.2006.2.2.181
    • Holt AE, Albert ML. Cognitive neuroscience of delusions in aging. Neuropsychiatr Dis Treat. 2006;2:181-9. (Pubitemid 44043611)
    • (2006) Neuropsychiatric Disease and Treatment , vol.2 , Issue.2 , pp. 181-189
    • Holt, A.E.M.1    Albert, M.L.2
  • 6
    • 0033987420 scopus 로고    scopus 로고
    • Psychosis of Alzheimer's disease and related dementias: Diagnostic criteria for a distinct syndrome
    • Jeste DV, Finkel SI. Psychosis of Alzheimer's disease and related dementias. Diagnostic criteria for a distinct syndrome. Am J Geriatr Psychiatry. 2000;8:29-34. (Pubitemid 30036838)
    • (2000) American Journal of Geriatric Psychiatry , vol.8 , Issue.1 , pp. 29-34
    • Jeste, D.V.1    Finkel, S.I.2
  • 8
    • 0035191269 scopus 로고    scopus 로고
    • An evidence-based proposal for the classification of neuropsychiatric disturbance in Alzheimer's disease
    • DOI 10.1002/gps.440
    • Lyketsos CG, Breitner JC, Rabins PV. An evidence-based proposal for the classification of neuropsychiatric disturbance in Alzheimer's disease. Int J Geriatr Psychiatry. 2001;16:1037-42. (Pubitemid 33089267)
    • (2001) International Journal of Geriatric Psychiatry , vol.16 , Issue.11 , pp. 1037-1042
    • Lyketsos, C.G.1    Breitner, J.C.S.2    Rabins, P.V.3
  • 12
    • 0028138825 scopus 로고
    • Delusional misidentification in Alzheimer's disease: A summary of clinical and biological aspects
    • Forstl H, Besthorn C, Burns A, et al. Delusional misidentification in Alzheimer's disease: a summary of clinical and biological aspects. Psychopathology. 1994;27:194-9. (Pubitemid 24314117)
    • (1994) Psychopathology , vol.27 , Issue.3-5 , pp. 194-199
    • Forstl, H.1    Besthorn, C.2    Burns, A.3    Geiger-Kabisch, C.4    Levy, R.5    Sattel, A.6
  • 13
    • 27744593088 scopus 로고    scopus 로고
    • Epidemiology of and risk factors for psychosis of Alzheimer's disease: A review of 55 studies published from 1990 to 2003
    • Ropacki SA, Jeste DV. Epidemiology of and risk factors for psychosis of Alzheimer's disease: a review of 55 studies published from 1990 to 2003. Am J Psychiatry. 2005;162:2022-30.
    • (2005) Am J Psychiatry , vol.162 , pp. 2022-2030
    • Ropacki, S.A.1    Jeste, D.V.2
  • 14
    • 62649089309 scopus 로고    scopus 로고
    • The relationship of excess cognitive impairment in MCI and early Alzheimer's disease to the subsequent emergence of psychosis
    • Weamer EA, Emanuel JE, Varon D, et al. The relationship of excess cognitive impairment in MCI and early Alzheimer's disease to the subsequent emergence of psychosis. Int psychogeriatrics IPA. 2009;21:78-85.
    • (2009) Int Psychogeriatrics IPA , vol.21 , pp. 78-85
    • Weamer, E.A.1    Emanuel, J.E.2    Varon, D.3
  • 15
    • 79951888795 scopus 로고    scopus 로고
    • Psychotic Symptoms in a Population- Based Sample of 85-Year-Old Individuals with Dementia
    • Ostling S, Gustafson D, Blennow K, et al: Psychotic Symptoms in a Population- Based Sample of 85-Year-Old Individuals With Dementia. J Geriatr Psychiatry Neurol.
    • J Geriatr Psychiatry Neurol
    • Ostling, S.1    Gustafson, D.2    Blennow, K.3
  • 16
    • 77952430689 scopus 로고    scopus 로고
    • Management of behavioral problems in Alzheimer's disease
    • Gauthier S, Cummings J, Ballard C, et al. Management of behavioral problems in Alzheimer's disease. Int psychogeriatrics IPA. 2010;22:346-72.
    • (2010) Int Psychogeriatrics IPA , vol.22 , pp. 346-372
    • Gauthier, S.1    Cummings, J.2    Ballard, C.3
  • 17
    • 77950799868 scopus 로고    scopus 로고
    • Assessment and familial aggregation of psychosis in Alzheimer's disease from the National Institute on Aging Late Onset Alzheimer's Disease Family Study
    • Sweet RA, Bennett DA, Graff-Radford NR, et al. Assessment and familial aggregation of psychosis in Alzheimer's disease from the National Institute on Aging Late Onset Alzheimer's Disease Family Study. Brain. 2010;133:1155-62.
    • (2010) Brain , vol.133 , pp. 1155-1162
    • Sweet, R.A.1    Bennett, D.A.2    Graff-Radford, N.R.3
  • 18
    • 46249117591 scopus 로고    scopus 로고
    • The prevalence of misidentification syndromes in neurodegenerative diseases
    • Harciarek M, Kertesz A. The prevalence of misidentification syndromes in neurodegenerative diseases. Alzheimer disease and associated disorders 2008; 22:163-169
    • (2008) Alzheimer Disease and Associated Disorders , vol.22 , pp. 163-169
    • Harciarek, M.1    Kertesz, A.2
  • 19
    • 62149150921 scopus 로고    scopus 로고
    • Prevalence, correlates and course of behavioural and psychological symptoms of dementia in the population
    • This was a large longitudinal study that assessed the prevalence and incidence of NPS in dementia. Importantly, misidentifications were assessed separately from persecutory delusions and had differing incidence rates as well as differing associations in factor analysis
    • Savva GM, Zaccai J, Matthews FE, et al. Prevalence, correlates and course of behavioural and psychological symptoms of dementia in the population. Br J Psychiatry. 2009;194:212-9. This was a large longitudinal study that assessed the prevalence and incidence of NPS in dementia. Importantly, misidentifications were assessed separately from persecutory delusions and had differing incidence rates as well as differing associations in factor analysis.
    • (2009) Br J Psychiatry , vol.194 , pp. 212-219
    • Savva, G.M.1    Zaccai, J.2    Matthews, F.E.3
  • 20
    • 0026502161 scopus 로고
    • Cognitive deficits of patients with Alzheimer's disease with and without delusions
    • Jeste DV, Wragg RE, Salmon DP, et al. Cognitive deficits of patients with Alzheimer's disease with and without delusions. Am J Psychiatry. 1992;149:184-9.
    • (1992) Am J Psychiatry , vol.149 , pp. 184-189
    • Jeste, D.V.1    Wragg, R.E.2    Salmon, D.P.3
  • 21
    • 69449089727 scopus 로고    scopus 로고
    • Misplacing objects in mild to moderate Alzheimer's disease: A descriptive analysis fromthe VISTA clinical trial
    • Hamilton L, Fay S, Rockwood K. Misplacing objects in mild to moderate Alzheimer's disease: a descriptive analysis fromthe VISTA clinical trial. J Neurol Neurosurg Psychiatry. 2009;80:960-5.
    • (2009) J Neurol Neurosurg Psychiatry , vol.80 , pp. 960-965
    • Hamilton, L.1    Fay, S.2    Rockwood, K.3
  • 22
    • 70350075731 scopus 로고    scopus 로고
    • Risk factors for delusion of theft in patients with Alzheimer's disease showing mild dementia in Japan
    • Murayama N, Iseki E, Endo T, et al. Risk factors for delusion of theft in patients with Alzheimer's disease showing mild dementia in Japan. Aging Ment Health. 2009;13:563-8.
    • (2009) Aging Ment Health , vol.13 , pp. 563-568
    • Murayama, N.1    Iseki, E.2    Endo, T.3
  • 23
    • 68149096663 scopus 로고    scopus 로고
    • Correlation between a reduction in Frontal Assessment Battery scores and delusional thoughts in patients with Alzheimer's disease
    • This was a very important study of the role of cognition and delusions in AD. Methodologically, this study is important because it assessed persecutory delusions as separate from misidentifications and used the FAB rather than a crude global measure such as the MMSE
    • Nagata T, Ishii K, Ito T, et al. Correlation between a reduction in Frontal Assessment Battery scores and delusional thoughts in patients with Alzheimer's disease. Psychiatry Clin Neurosci. 2009;63:449-54. This was a very important study of the role of cognition and delusions in AD. Methodologically, this study is important because it assessed persecutory delusions as separate from misidentifications and used the FAB rather than a crude global measure such as the MMSE.
    • (2009) Psychiatry Clin Neurosci , vol.63 , pp. 449-454
    • Nagata, T.1    Ishii, K.2    Ito, T.3
  • 24
    • 9344266307 scopus 로고    scopus 로고
    • Confabulation, but not executive dysfunction discriminate AD from frontotemporal dementia
    • DOI 10.1111/j.1468-1331.2004.00981.x
    • Nedjam Z, Devouche E, Dalla Barba G. Confabulation, but not executive dysfunction discriminate AD from frontotemporal dementia. Eur J Neurol. 2004;11:728-33. (Pubitemid 39556752)
    • (2004) European Journal of Neurology , vol.11 , Issue.11 , pp. 728-733
    • Nedjam, Z.1    Devouche, E.2    Barba, G.D.3
  • 25
    • 58349119387 scopus 로고    scopus 로고
    • Functional outcome in delusional Alzheimer disease patients. A systematic review
    • Fischer CE, Verhoeff NP, Churchill K, et al. Functional outcome in delusional Alzheimer disease patients. A systematic review. Dement Geriatr Cogn Disord. 2009;27:105-10.
    • (2009) Dement Geriatr Cogn Disord , vol.27 , pp. 105-110
    • Fischer, C.E.1    Verhoeff, N.P.2    Churchill, K.3
  • 26
    • 0025782754 scopus 로고
    • Neuropathologic and neurochemical correlates of psychosis in primary dementia
    • Zubenko GS, Moossy J, Martinez AJ, et al. Neuropathologic and neurochemical correlates of psychosis in primary dementia. Arch Neurol. 1991;48:619-24.
    • (1991) Arch Neurol , vol.48 , pp. 619-624
    • Zubenko, G.S.1    Moossy, J.2    Martinez, A.J.3
  • 27
    • 0028469704 scopus 로고
    • Neuropathological correlates of psychotic phenomena in confirmed Alzheimer's disease
    • Forstl H, Burns A, Levy R, et al. Neuropathological correlates of psychotic phenomena in confirmed Alzheimer's disease. Br J Psychiatry. 1994;165:53-9. (Pubitemid 24224836)
    • (1994) British Journal of Psychiatry , vol.164 , Issue.JULY , pp. 53-59
    • Forstl, H.1    Burns, A.2    Levy, R.3    Cairns, N.4
  • 28
    • 0003029572 scopus 로고
    • Biochemical, neuropathological, and clinical correlations of neurofibrillary degeneration in Alzheimer's disease
    • Bergener M, Finkel SI, editors. New York: Springer
    • Mukaetova-Ladinska EB, Harrington CR, Roth M, et al. Biochemical, neuropathological, and clinical correlations of neurofibrillary degeneration in Alzheimer's disease. In: Bergener M, Finkel SI, editors. Treating Alzheimer's and other dementias. New York: Springer; 1995. p. 57-80.
    • (1995) Treating Alzheimer's and Other Dementias , pp. 57-80
    • Mukaetova-Ladinska, E.B.1    Harrington, C.R.2    Roth, M.3
  • 29
    • 0033669090 scopus 로고    scopus 로고
    • Increased neocortical neurofibrillary tangle density in subjects with Alzheimer disease and psychosis
    • Farber NB, Rubin EH, Newcomer JW, et al. Increased neocortical neurofibrillary tangle density in subjects with Alzheimer disease and psychosis. Arch Gen Psychiatry. 2000;57:1165-73.
    • (2000) Arch Gen Psychiatry , vol.57 , pp. 1165-1173
    • Farber, N.B.1    Rubin, E.H.2    Newcomer, J.W.3
  • 32
    • 34547670228 scopus 로고    scopus 로고
    • A decrease in N-acetylaspartate and an increase in myoinositol in the anterior cingulate gyrus are associated with behavioral and psychological symptoms in Alzheimer's disease
    • DOI 10.1016/j.jns.2007.04.017, PII S0022510X07002894
    • Shinno H, Inagaki T, Miyaoka T, et al. A decrease in N-acetylaspartate and an increase in myoinositol in the anterior cingulate gyrus are associated with behavioral and psychological symptoms in Alzheimer's disease. J Neurol Sci. 2007;260:132-8. (Pubitemid 47212216)
    • (2007) Journal of the Neurological Sciences , vol.260 , Issue.1-2 , pp. 132-138
    • Shinno, H.1    Inagaki, T.2    Miyaoka, T.3    Okazaki, S.4    Kawamukai, T.5    Utani, E.6    Inami, Y.7    Horiguchi, J.8
  • 35
    • 77149157824 scopus 로고    scopus 로고
    • Genetics of psychosis in Alzheimer's disease: A review
    • DeMichele-Sweet MA, Sweet RA. Genetics of psychosis in Alzheimer's disease: a review. J Alzheimers Dis. 2010;19:761-80.
    • (2010) J Alzheimers Dis , vol.19 , pp. 761-780
    • DeMichele-Sweet, M.A.1    Sweet, R.A.2
  • 39
    • 33645232895 scopus 로고    scopus 로고
    • Delusion symptoms are associated with ApoE epsilon4 allelic variant at the early stage of Alzheimer's disease with late onset
    • Spalletta G, Bernardini S, Bellincampi L, et al. Delusion symptoms are associated with ApoE epsilon4 allelic variant at the early stage of Alzheimer's disease with late onset. Eur J Neurol. 2006;13:176-82.
    • (2006) Eur J Neurol , vol.13 , pp. 176-182
    • Spalletta, G.1    Bernardini, S.2    Bellincampi, L.3
  • 42
    • 4043174258 scopus 로고    scopus 로고
    • Association of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in Alzheimer disease
    • DOI 10.1001/archneur.61.8.1249
    • Assal F, Alarcon M, Solomon EC, et al. Association of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in Alzheimer disease. Arch Neurol. 2004;61:1249-53. (Pubitemid 39062679)
    • (2004) Archives of Neurology , vol.61 , Issue.8 , pp. 1249-1253
    • Assal, F.1    Alarcon, M.2    Solomon, E.C.3    Masterman, D.4    Geschwind, D.H.5    Cummings, J.L.6
  • 43
    • 67650888591 scopus 로고    scopus 로고
    • Delusion symptoms and response to antipsychotic treatment are associated with the 5-HT2A receptor polymorphism (102 T/C) in Alzheimer's disease: A 3-year follow-up longitudinal study
    • Angelucci F, Bernardini S, Gravina P, et al. Delusion symptoms and response to antipsychotic treatment are associated with the 5-HT2A receptor polymorphism (102 T/C) in Alzheimer's disease: a 3-year follow-up longitudinal study. J Alzheimers Dis. 2009;17:203-11.
    • (2009) J Alzheimers Dis , vol.17 , pp. 203-211
    • Angelucci, F.1    Bernardini, S.2    Gravina, P.3
  • 45
    • 0031596301 scopus 로고    scopus 로고
    • 5-HT(2A) and 5-HT(2C) receptor polymorphisms and psychopathology in late onset Alzheimer's disease
    • DOI 10.1093/hmg/7.9.1507
    • Holmes C, Arranz MJ, Powell JF, et al. 5-HT2A and 5-HT2C receptor polymorphisms and psychopathology in late onset Alzheimer's disease. Hum Mol Genet. 1998;7:1507-9. (Pubitemid 28429933)
    • (1998) Human Molecular Genetics , vol.7 , Issue.9 , pp. 1507-1509
    • Holmes, C.1    Arranz, M.J.2    Powell, J.F.3    Collier, D.A.4    Lovestone, S.5
  • 48
    • 3042753372 scopus 로고    scopus 로고
    • The interleukin 1beta gene promoter polymorphism (-511) acts as a risk factor for psychosis in Alzheimer's dementia
    • DOI 10.1002/ana.20120
    • Craig D, Hart DJ, McCool K, et al. The interleukin 1beta gene promoter polymorphism (-511) acts as a risk factor for psychosis in Alzheimer's dementia. Ann Neurol. 2004;56:121-4. (Pubitemid 38857367)
    • (2004) Annals of Neurology , vol.56 , Issue.1 , pp. 121-124
    • Craig, D.1    Hart, D.J.2    McCool, K.3    McIlroy, S.P.4    Passmore, A.P.5
  • 49
    • 65249151342 scopus 로고    scopus 로고
    • Genetic variation in the alpha 7 nicotinic acetylcholine receptor is associated with delusional symptoms in Alzheimer's disease
    • This was a newer genetic study showing an association of a novel gene in the study of delusions in dementia, but one that has been studied in schizophrenia, demonstrating a potential association between the two
    • Carson R, Craig D, Hart D, et al. Genetic variation in the alpha 7 nicotinic acetylcholine receptor is associated with delusional symptoms in Alzheimer's disease. Neuromolecular Med. 2008;10:377-84. This was a newer genetic study showing an association of a novel gene in the study of delusions in dementia, but one that has been studied in schizophrenia, demonstrating a potential association between the two.
    • (2008) Neuromolecular Med , vol.10 , pp. 377-384
    • Carson, R.1    Craig, D.2    Hart, D.3
  • 50
    • 38449107464 scopus 로고    scopus 로고
    • A double-blind comparison of citalopram and risperidone for the treatment of behavioral and psychotic symptoms associated with dementia
    • Pollock BG, Mulsant BH, Rosen J, et al. A double-blind comparison of citalopram and risperidone for the treatment of behavioral and psychotic symptoms associated with dementia. Am J Geriatr Psychiatry. 2007;15:942-52.
    • (2007) Am J Geriatr Psychiatry , vol.15 , pp. 942-952
    • Pollock, B.G.1    Mulsant, B.H.2    Rosen, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.