Chemistry at the 2′ position of constituent nucleotides controls degradation pathways of highly modified oligonucleotide molecules

Oligonucleotides

Volumn 20, Issue 5, 2010, Pages 239-251

  Calvitt, C Jeffrey ^a   Levin, Daren S ^a   Shepperd, Benjamin T ^a   Gruenloh, Christopher J ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYGUANINE; NUCLEOTIDE; OLIGONUCLEOTIDE; SMALL INTERFERING RNA;

ARTICLE; CATALYSIS; MASS SPECTROMETRY; OXIDATION; PH; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; RNA DEGRADATION; RNA STRUCTURE; TEMPERATURE; CHEMISTRY; ISOMERISM; LIQUID CHROMATOGRAPHY; METABOLISM; RNA STABILITY;

CHROMATOGRAPHY, LIQUID; ISOMERISM; MASS SPECTROMETRY; OLIGONUCLEOTIDES; RNA STABILITY;

EID: 78049353260     PISSN: 15454576     EISSN: None     Source Type: Journal    
DOI: 10.1089/oli.2010.0250     Document Type: Article

References (11)

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