Microsatellite GT polymorphism in intron 2 of human Toll-like receptor (TLR) 2 gene and susceptibility to periodontitis

Clinical Oral Investigations

Volumn 15, Issue 3, 2011, Pages 435-441

  Folwaczny, Matthias ^a   Glas, Jürgen ^a   Tonenchi, Laurean ^a   Török, Helga Paula ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Lipopolysaccharide; Microsatellite; Pathogen associated molecular patterns (PAMPs); Pattern recognition receptor (PRR); Periodontitis; TLR2

Indexed keywords

GUANINE; THYMIDINE; TOLL LIKE RECEPTOR 2;

ADOLESCENT; ADULT; AGED; ARTICLE; CASE CONTROL STUDY; CHI SQUARE DISTRIBUTION; CHRONIC PERIODONTITIS; DINUCLEOTIDE REPEAT; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION; GENETICS; HUMAN; INTRON; MALE; MIDDLE AGED; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL MODEL;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; CHRONIC PERIODONTITIS; DINUCLEOTIDE REPEATS; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GUANINE; HUMANS; INTRONS; LOGISTIC MODELS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; THYMIDINE; TOLL-LIKE RECEPTOR 2; YOUNG ADULT;

EID: 79955871996     PISSN: 14326981     EISSN: 14363771     Source Type: Journal    
DOI: 10.1007/s00784-010-0396-8     Document Type: Article

References (36)

1. Medzhitov R (2001) Toll-like receptors and innate immunity. Nat Rev Immunol 1: 135-145.
2. Weber JR, Moreillon P, Tuomanen EI (2003) Innate sensors for Gram-positive bacteria. Curr Opin Immunol 15: 408-415.
3. Ren L, Leung WK, Darveau RP, Jin L (2005) The expression profile of lipopolysaccharide-binding protein, membrane-bound CD14, and toll-like receptors 2 and 4 in chronic periodontitis. J Periodontol 76: 1950-1959.
4. Beutler B, Rietschel ET (2003) Innate immune sensing and its roots: the story of endotoxin. Nat Rev Immunol 3: 169-176.
5. Schwadner R, Dziarski R, Wesche H, Rothe M, Kirschning CJ (1999) Peptidoglycan and lipoteichoic acid-induced cell activation is mediated by Toll-like receptor 2. J Biol Chem 274: 17406-17409.
6. Kirikae T, Nitta T, Kirikae F, Suda Y, Kusumoto S, Qureshi N, Nakano M (1999) Lipopolysaccharides (LPS) of oral black-pigmented bacteria induce tumor necrosis factor production by LPS-refractory C3H/HeJ macrophages in a way different from that of Salmonella LPS. Infect Immun 67: 1736-1742.
7. Kikkert R, Laine ML, Aarden LA, van Winkelhoff AJ (2007) Activation of Toll-like receptors 2 and 4 by Gram-negative periodontal bacteria. Oral Microbiol Immunol 22: 145-151.
8. Yim JJ, Ding L, Schäffer AA, Park GY, Shim YS, Holland SM (2004) A microsatellite polymorphims in intron 2 of human Toll-like receptor 2 gene: functional implications and racial differences. FEMS Immunol Med Microbiol 40: 163-169.
9. Lee EY, Yim JJ, Lee HS, Lee YJ, Lee EB, Song YW (2006) Dinucleotide repeat polymorphism in intron II of human Toll-like receptor 2 gene and susceptibility to rheumatoid arthritis. Int J Immunogenet 33: 211-215.
10. Yim JJ, Lee HW, Lee HS, Kim YW, Han SK, Shim YS, Holland SM (2006) The association between microsatellite polymorphisms in intron 2 of the human Toll-like receptor 2 gene and tuberculosis among Koreans. Genes Immun 7: 150-155.
11. Yim JJ, Kim HJ, Kwon OJ, Koh WJ (2008) Association between microsattelite polymorphisms in intron II of the human Toll-like receptor 2 gene and nontuberculous mycobacterial lung disease in a Korean population. Hum Immunol 69: 572-576.
12. Nunn ME (2003) Understanding the etiology of periodontitis: an overview of periodontal risk factors. Periodontol 2000(32): 11-23.
13. Kilian M, Frandsen EV, Haubek D (2000) Poulsen K (2006) The etiology of periodontal disease revisited by population genetic analysis. Periodontol 42: 158-179.
14. Michalowicz BS (1994) Genetic and heritable risk factors in periodontal disease. J Periodontol 65(5 Suppl): 479-488.
15. Michalowicz BS, Diehl SR, Gunsolley JC, Sparks BS, Brooks CH, Koertge TE, Califano JV, Burmeister JA, Schenkein HA (2000) Evidence of a substantial genetic basis for risk of adult periodontitis. J Periodontol 71: 1699-1707.
16. Kinane DF, Hart TC (2003) Genes and gene polymorphisms associated with periodontal disease. Crit Rev Oral Biol Med 14: 430-449.
17. Page RC, Offenbacher S, Schroeder HE, Seymour GJ, Kornman KS (2000) (1997) Advances in the pathogenesis of periodontitis: summary of developments, clinical implications and future directions. Periodontol 14: 216-248.
18. Honda T, Domon H, Okui T, Kajita K, Amanuma R, Yamazaki K (2006) Balance of inflammatory response in stable gingivitis and progressive periodontitis lesions. Clin Exp Immunol 144: 35-40.
19. Takashiba S, Naruishi K (2006) Gene polymorphisms in periodontal health and disease. Periodontol 2000 40: 94-106.
20. Nyman S, Lindhe J (1997) Examination of patients with periodontal disease. In: Lindhe J, Karring T, Lang NP (eds) Clinical periodontology and implant entistry. Munksgaard, Copenhagen, pp 383-395.
21. Miller SA, Dykes DD, Polesky HF (1998) A simple salting out procedure for extracting DNA from human nucleated cells. Nucl Acids Res 16: 1215.
22. Socransky S, Haffajee A, Cugini M, Smith C, Kent RJ (1998) Microbial complexes in subgingival plaque. J Clin Periodontol 25: 134-144.
23. Baker P, Dixon M, Evans R, Dufour L, Johnson E, Roopenian D (1999) CD4(+) T cells and the proinflammatory cytokines gamma interferon and interleukin-6 contribute to alveolar bone loss in mice. Infect Immunol 67: 2804-2809.
24. Graves D, Jiang Y, Genco C (2000) Periodontal disease: bacterial virulence factors, host response and impact on systemic health. Curr Opin Infect Dis 13: 227-232.
25. Taylor JT, Preshaw PM, Donaldson PT (2004) Cytokine gene polymorphisms and immunoregulation in periodontal disease. Periodontol 2000 35: 158-182.
26. Folwaczny M, Glas J, Török HP, Limbersky O, Folwaczny C (2004) Toll-like receptor (TLR) 2 and 4 mutations in periodontal disease. Clin Exp Immunol 135: 330-335.
27. Pravica V, Asderakis A, Perrey C, Hajeer A, Sinnott PJ, Hutchinson IV (1999) In vitro production of IFN-gamma correlates with CA repeat polymorphism in the human IFN-gamma gene. Eur J Immunogenet 26: 1-3.
28. Cavet J, Dickinson AM, Norden J, Taylor PR, Jackson GH, Middleton PG (2001) Interferon-gamma and interleukin-6 gene polymorphisms associate with graft-versus-host disease in HLA-matched sibling bone marrow transplantation. Blood 98: 1594-1600.
29. Rodriguez MR, Nunez-Roldan A, Aguilar F, Valenzuela A, Garcia A, Gonzalez-Escribano MF (2002) Association of the CTLA4 3′ untranslated region polymorphism with the susceptibility to rheumatoid arthritis. Hum Immunol 63: 76-81.
30. Veltkamp M, Wijnen PAHM, van Moorsel CHM, Rijkers GT, Ruven HJT, Heron M, Bekers O, Claessen AME, Drent M, van den Bosch JMM, Grutters JC (2007) Linkage between Toll-like (TLR) 2 promotor and intron polymorphisms: functional effects and relevance to sarcoidosis. Clin Exp Immunol 149: 453-462.
31. Pulendran B, Kumar P, Cutler CW, Mohamadzadeh M, van Dyke T, Banchereau J (2001) Lipopolysaccharides from distinct pathogens induce different classes of immune responses in vivo. J Immunol 167: 5067-5076.
32. Yoshimura A, Kaneko T, Kato Y, Golenbock DT, Hara Y (2002) Lipopolysaccharides from periodontopathic bacteria Porphyromonas gingivalis and Capnocytophaga ochracea are antagonists for human Toll-like receptor 4. Infect Immun 70: 218-225.
33. Darveau RP, Pham TT, Lemley K, Reife RA, Bainbridge BW, Coats SR, Howald WN, Way SS, Hajjar AM (2004) Porphyromonas gingivalis lipopolysaccharide contains multiple lipid A species that functionally interact with both toll-like receptors 2 and 4. Infect Immun 72: 5041-5051.
34. Coats SR, Reife RA, Bainbridge BW, Pham TT, Darveau RP (2003) Porphyromonas gingivalis lipopolysaccharide antagonizes Escherichia coli lipopolysaccharide at toll-like receptor 4 in human endothelial cells. Infect Immun 71: 6799-6807.
35. Tietze K, Dalpke A, Morath S, Mutters R, Heeg K, Nonnenmacher C (2006) Differences in innate immune responses upon stimulation with Gram-positive and Gram-negative bacteria. J Periodont Res 41: 447-454.
36. Palmer LJ, Cardon LR (2005) Shaking the tree: mapping complex disease genes with linkage disequilibrium. Lancet 366: 1223-1234.