Heterogeneous triangular structures of human islet amyloid polypeptide (Amylin) with internal hydrophobic cavity and external wrapping morphology reveal the polymorphic nature of amyloid fibrils

Biomacromolecules

Volumn 12, Issue 5, 2011, Pages 1781-1794

  Zhao, Jun ^a   Yu, Xiang ^a   Liang, Guizhao ^a,b   Zheng, Jie ^a  

^a The University of Akron   (United States)

^b CHONGQING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

3-FOLD SYMMETRY; AMYLOID FIBRIL; ATOMIC LEVELS; BIOPHYSICAL DATA; CONFORMATION SEARCH; CROSS SECTION; EXPERIMENTAL DATA; EXPLICIT SOLVENTS; FIBRIL GROWTH; HUMAN ISLETS; HYDROPHOBIC CAVITIES; HYDROPHOBIC CORE; LAYER ASSEMBLY; MISFOLDING; MOLECULAR DYNAMICS SIMULATIONS; MOLECULAR ORIGINS; PEPTIDE ELONGATION; POLYMORPHIC STRUCTURE; SANDWICH MODEL; SOLID STATE NMR; STRUCTURAL FEATURE; STRUCTURAL STABILITIES; TRIANGULAR STRUCTURES; TWO-DIMENSION; TYPE II;

COMPUTER SIMULATION; GROWTH (MATERIALS); HYDROPHOBICITY; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OLIGOMERS; POLYMORPHISM; POLYPEPTIDES; STABILITY;

GLYCOPROTEINS;

AMYLIN; AMYLIN[1-37]; AMYLOID; OLIGOMER; SOLVENT; UNCLASSIFIED DRUG;

ARTICLE; ELECTRON MICROSCOPY; HYDROPHOBICITY; MASS; MOLECULAR DYNAMICS; MORPHOLOGY; NUCLEAR MAGNETIC RESONANCE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN POLYMORPHISM; PROTEIN STABILITY; PROTEIN STRUCTURE; SIMULATION; STEREOSPECIFICITY;

AMYLOID; HUMANS; ISLET AMYLOID POLYPEPTIDE; MICROSCOPY, ELECTRON; MUTATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN CONFORMATION;

EID: 79955852760     PISSN: 15257797     EISSN: 15264602     Source Type: Journal    
DOI: 10.1021/bm2001507     Document Type: Article

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