Down-regulation of activating Fcγ receptors on monocytes of patients with rheumatoid arthritis upon methotrexate treatment

Rheumatology

Volumn 44, Issue 6, 2005, Pages 729-734

  Wijngaarden, S ^a   van Roon, J A G ^a   van de Winkel, J G J ^a,b   Bijlsma, J W J ^a   Lafeber, F P J G ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b GENMAB   (Netherlands)

Author keywords

Fc ; Methotrexate; Monocytes macrophages; Receptor; Rheumatoid arthritis

Indexed keywords

B7 ANTIGEN; CD40 ANTIGEN; CD86 ANTIGEN; DISEASE MODIFYING ANTIRHEUMATIC DRUG; FC RECEPTOR; IMMUNOGLOBULIN G; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; METHOTREXATE; RECEPTOR SUBTYPE; ANTIRHEUMATIC AGENT; FC GAMMA RECEPTOR IIA; FCGR1A PROTEIN, HUMAN; FCGR3A PROTEIN, HUMAN; LEUKOCYTE ANTIGEN;

ADULT; AGED; ANTIGEN ANTIBODY COMPLEX; ARTICLE; CELL ACTIVATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; DRUG MECHANISM; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; LOW DRUG DOSE; MALE; MONOCYTE; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; RHEUMATOID ARTHRITIS; CELL CULTURE; DOWN REGULATION; DRUG EFFECT; IMMUNOLOGY; MIDDLE AGED; ORAL DRUG ADMINISTRATION;

ADMINISTRATION, ORAL; ANTIGENS, CD; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; CELLS, CULTURED; DOWN-REGULATION; FEMALE; HUMANS; MALE; METHOTREXATE; MIDDLE AGED; MONOCYTES; RECEPTORS, IGG;

EID: 24944491814     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/keh583     Document Type: Article

References (29)

1. Burmester GR, Stuhlmuller B, Keyszer G, Kinne RW. Mononuclear phagocytes and rheumatoid synovitis. Mastermind or workhorse in arthritis? Arthritis Rheum 1997;40:5-18.
2. Kinne RW, Brauer R, Stuhlmuller B, Palombo-Kinne E, Burmester GR. Macropliages in rheumatoid arthritis. Arthritis Res 2000;2:189-202.
3. Smolen JS, Steiner G. Are autoantibodies active players or epiphenomena? Curr Opin Rheumatol 1998;10:201-6.
4. Dijstelbloem HM, Kallenberg CG, van de Winkel JG. Inflammation in autoimmunity: Receptors for IgG revisited. Trends Immunol 2001;22:510-6.
5. Salmon JE, Pricop L. Human receptors for immunoglobulin G: Key elements in the pathogenesis of rheumatic disease. Arthritis Rheum 2001;44:739-50.
6. Kimberly RP, Salmon JE, Edberg JC. Receptors for immunoglobulin G. Molecular diversity and implications for disease. Arthritis Rheum 1995;38:306-14.
7. Clarkson SB, Ory PA. CD16. Developmentally regulated IgG Fc receptors on cultured human monocytes. J Exp Med 1988;167:408-20.
8. Wijngaarden S, van Roon JA, Bijlsma JW, van de Winkel JG, Lafeber FP. Fcgamma receptor expression levels on monocytes are elevated in rheumatoid arthritis patients with high erythrocyte sedimentation rate who do not use anti-rheumatic drugs. Rheumatology 2003;42:681-8.
9. Verstappen SM, Jacobs JW, Bijlsma JW et al. Five-year followup of rheumatoid arthritis patients after early treatment with disease-modifying antirheumatic drugs versus treatment according to the pyramid approach in the first year. Arthritis Rheum 2003;48:1797-807.
10. Cronstein BN, Naime D, Ostad E. The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation. J Clin Invest 1993;92:2675-82.
11. Cronstein BN. Molecular therapeutics. Methotrexate and its mechanism of action. Arthritis Rheum 1996;39:1951-60.
12. Seitz M. Molecular and cellular effects of methotrexate. Curr Opin Rheumatol 1999;11:226-32.
13. Arnett FC, Edworthy SM, Bloch DA et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
14. van der Heijde DM, van't Hof M, Van Riel PL, Van De Putte LB. Development of a disease activity score based on judgment in clinical practice by rheumatologists. J Rheumatol 1993;20:579-81.
15. Qiu WQ, de Bruin D, Brownstein BH, Pearse R, Ravetch JV. Organization of the human and mouse low-affinity Fc gamma R genes: Duplication and recombination. Science 1990;248:732-5.
16. Van Den Herik-Oudijk I, Westerdaal NA et al. Binding heterogeneity within the CD32 panel of monoclonal antibodies. Leucocyte Typing V 1995;832-5.
17. Tishler M, Caspi D, Graff E, Segal R, Peretz H, Yaron M. Synovial and serum levels of methotrexate during methotrexate therapy of rheumatoid arthritis. Br J Rheumatol 1989;28:422-3.
18. Seitz M, Zwicker M, Loetscher P. Effects of methotrexate on differentiation of monocytes and production of cytokine inhibitors by monocytes. Arthritis Rheum 1998;41:2032-8.
19. Torsteinsdottir I, Arvidson NG, Hallgren R, Hakansson L. Monocyte activation in rheumatoid arthritis (RA): Increased integrin, Fc gamma and complement receptor expression and the effect of glucocorticoids. Clin Exp Immunol 1999;115:554-60.
20. Barrera P, Boerbooms AM, Janssen EM et al. Circulating soluble tumor necrosis factor receptors, interleukin-2 receptors, tumor necrosis factor alpha, and interleukin-6 levels in rheumatoid arthritis. Longitudinal evaluation during methotrexate and azathioprine therapy. Arthritis Rheum 1993;36:1070-9.
21. Barrera P, Boerbooms AM, Demacker PN, Van De Putte LB, Gallati H, Van der Meer JW. Circulating concentrations and production of cytokines and soluble receptors in rheumatoid arthritis patients: Effects of a single dose methotrexate. Br J Rheumatol 1994;33:1017-24.
22. Van Roon J, Wijngaarden S, Lafeber FP, Damen C, Van De Winkel JG, Bijlsma JW. Interleukin 10 treatment of patients with rheumatoid arthritis enhances fcg receptor expression on monocytes and responsiveness to immune complex stimulation. J Rheumatol 2003;30:648-51.
23. Wahl SM, Allen JB, Welch GR, Wong HL. Transforming growth factor-beta in synovial fluids modulates Fc gamma RII (CD16) expression on mononuclear phagocytes. J Immunol 1992;148: 485-90.
24. Ziegler-Heitbrock HW, Fingerle G, Strobel M et al. The novel subset of CD14+/CD16+ blood monocytes exhibits features of tissue macrophages. Eur J Immunol 1993;23:2053-8.
25. Abrahams VM, Cambridge G, Lydyard PM, Edwards JC. Induction of tumor necrosis factor alpha production by adhered human monocytes: A key role for Fcgamina receptor type IIIa in rheumatoid arthritis. Arthritis Rheum 2000;43:608-16.
26. Kawanaka N, Yamamura M, Aita T et al. CD14+,CD16+ blood monocytes and joint inflammation in rheumatoid arthritis. Arthritis Rheum 2002;46:2578-86.
27. Fingerle-Rowson G, Angstwurm M, Andreesen R, Ziegler-Heitbrock HW. Selective depletion of CD14+ CD16+ monocytes by glucocorticoid therapy. Clin Exp Immunol 1998;112:501-6.
28. Clynes R, Maizes JS, Guinamard R, Ono M, Takai T, Ravetch JV. Modulation of immune complex-induced inflammation in vivo by the coordinate expression of activation and inhibitory Fc receptors. J Exp Med 1999;189:179-85.
29. Yuasa T, Kubo S, Yoshino T et al. Deletion of fcgamma receptor IIB renders H-2(b) inice susceptible to collagen-induced arthritis. J Exp Med 1999;189:187-94.