Progress in protective effects of tetramethylpyrazine on diabetes complications in nervous system and possible mechanisms

Chinese Journal of Pharmacology and Toxicology

Volumn 25, Issue 1, 2011, Pages 114-118

  Tang, Ze Yao ^a   Wang, Shi Long ^a   Lin, Yuan ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

Diabetes complications; Nervous system diseases; Pharmacologic actions; Tetramethylpyrazine; diabetes mellitus

Indexed keywords

PURINERGIC P2 RECEPTOR; TETRAMETHYLPYRAZINE;

DIABETES MELLITUS; DRUG MECHANISM; ENDOTHELIUM CELL; NEUROLOGIC DISEASE; NEUROPROTECTION; NISSL SUBSTANCE; RETINA DEGENERATION; REVIEW;

EID: 79955822519     PISSN: 10003002     EISSN: None     Source Type: Journal    
DOI: 10.3867/j.issn.1000-3002.2011.01.023     Document Type: Review

References (33)

1. Tan Z. Erratum: Neural protection by naturopathic compounds - an example of tetramethylpyrazine from retina to brain [J]. J Ocul Biol Dis Infor, 2009, 2(3) : 137-144.
2. ZHAO JJ, LIU Y. Effect of tetramethylpyrazine on the spatial learning and memory function of rats after focal cerebral ischemia [J]. Neural Regen Res, 2006, 1(2) : 161-165.
3. Fan LH, Wang KZ, Cheng B, Wang CS, Dang XQ. Anti-apoptotic and neuroprotective effects of tetramethylpyrazine following spinal cord ischemia in rabbits[J]. BMC Neurosci, 2006, 7:48.
4. Chang Y, Hsiao G, Chen SH, Chen YC, Lin JH, Lin KH, et al. Tetramethylpyrazine suppresses HIF-1alpha, TNF-alpha, and activated caspase-3 expression in middle cerebral artery occlusion-induced brain ischemia in rats [J]. Acta Pharmacol Sin, 2007, 28(3) : 327-333.
5. Li M, Zhao MQ, Kumar Durairajan SS, Xie LX, Zhang HX, Kum WF, et al. Protective effect of tetramethylpyrazine and salvianolic acid B on apoptosis of rat cerebral microvascular endothelial cell under high shear stress[J]. Clin Hemorheol Microcirc, 2008, 38(3) : 177-187. (Pubitemid 351185405)
6. Kang Y, Hu M, Zhu Y, Gao X, Wang MW. Antioxidative effect of the herbal remedy Qin Huo Yi Hao and its active component tetramethylpyrazine on high glucose-treated endothelial cells[J]. Life Sci, 2009, 84(13-14) -.428-436.
7. Gao C, Liu X, Liu W, Shi H, Zhao Z, Chen H, et al. Antiapoptotic and neuroprotective effects of tetramethylpyrazine following subarachnoid hemorrhage in rats[J]. Auton Neurosci, 2008, 141(1-2) : 22-30.
8. Tian Y, Liu Y, Chen X, Zhang H, Shi Q, Zhang J, et al. Tetra methylpyrazine promotes proliferation and differentiation of neural stem cells from rat brain in hypoxic condition via mitogen - activated protein kinases pathway in vitro[J]. Neurosci Lett, 2010, 474 (1):26-31.
9. Kao TK, Ou YC, Kuo JS, Chen WY, Uao SL, Wu CW, et al. Neuroprotection by tetramethylpyrazine against ischemic brain injury in rats[J]. Neurochem Int, 2006, 48(3) : 166-176.
10. Zhu XL, Xiong LZ, Wang Q, Liu ZG, Ma X, Zhu ZH, et al. Therapeutic time window and mechanism of tetramethylpyrazine on transient focal cerebral ischemia/reperfusion injury in rats [J]. Neurosci Lett, 2009, 449(1) : 24-27.
11. Kao TK, Ou YC, Kuo JS, Chen WY, Liao SL, Wu CW, et al. Neuroprotection by tetramethylpyrazine against ischemic brain injury in rats[J]. Neurochem Int, 2006, 48(3) : 166-176.
12. Fan LH, Wang KZ, Cheng B, Wang CS, Dang XQ. Anti-apoptotic and neuroprotective effects of tetramethylpyrazine following spinal cord ischemia in rabbits[J]. BMC Neurosci, 2006, 7:48.
13. Wan H, Zhu H, Tian M, Hu X, Yang J, Zhao C, et al. Protective effect of chuanxiongzine-puerarin in a rat model of transient middle cerebral artery occlusion-induced focal cerebral ischemia [J]. Nucl Med Commun, 2008, 29(12) : 1113-1122.
14. U SY, Jia YH, Sun WG, Tang Y, An GS, Ni JH, et al. Stabilization of mitochondrial function by tetramethylpyrazine protects against kainate-induced oxidative lesions in the rat hippocampus [J]. free Radic Biol Med, 2010, 48(4) : 597-608.
15. Gao Y, Xu C, Liang S, Zhang A, Mu S, Wang Y, et al. Effect of tetramethylpyrazine on primary afferent transmission mediated by P2X3 receptor in neuropathic pain states[J]. Brain Res Bull, 2008, 77(1) : 27-32.
16. Liang SD, Gao Y, Xu CS, Xu BH, Mu SN. Effect of tetramethylpyrazine on acute nociception mediated by signaling of P2X receptor activation in rat [J]. Brain Res, 2004, 995 (2) : 247-252. (Pubitemid 37522025)
17. Gao Y, Xu C, Yu K, Uo G, Wan F, Liu S, et al. Effect of tetramethylpyrazine on DRG neuron P2X3 receptor involved in transmitting pain after bum[J]. Burns, 2010, 36(1) : 127-134.
18. Liang SD, Xu CS, Zhou T, Liu HQ, Gao Y, Li GL. Tetramethylpyrazine inhibits ATP-activated currents in rat dorsal root ganglion neurons[J]. Brain Res, 2005, 1040(1-2) : 92-97. (Pubitemid 40459624)
19. + channels of primary sensory neu ron and thermal nociception in the rat: a study on peripheral mechanism[J]. Neurosci Bull, 2006, 22(2) : 79-84.
20. Yang Z, Zhang Q, Ge J, Tan Z. Protective effects of tetramethylpyrazine on rat retinal cell cultures[J]. Neurochem Int, 2008, 52(6) : 1176-1187.
21. Zou Y, Jiang W, Chiou GC. Effect of tetramethylpyrazine on rat experimental choroidal neovascularization in vivo and endothelial cell cultures in vitro[J]. Curr Eye Res, 2007, 32(1): 71-75.
22. Yang JN, Chen JM, Luo L, Lin SC, Li D, Hu SX. Tetramethylpyrazine protected photoreceptor cells of rats by modulating nuclear translocation of NF-kappaB [J]. Acta Pharmacol Sin, 2005, 26(7); 887-392.