메뉴 건너뛰기




Volumn 31, Issue 17, 2011, Pages 6493-6503

The canonical nuclear factor-κB pathway regulates cell survival in a developmental model of spinal cord motoneurons

Author keywords

[No Author keywords available]

Indexed keywords

BIM PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; HOMODIMER; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NEUROTROPHIC FACTOR; PROTEIN BAX; PROTEIN BCL XL; SURVIVAL MOTOR NEURON PROTEIN; TRANSCRIPTION FACTOR RELA;

EID: 79955784663     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0206-11.2011     Document Type: Article
Times cited : (24)

References (42)
  • 1
    • 0036581222 scopus 로고    scopus 로고
    • The GDNF family: Signalling, biological functions and therapeutic value
    • Airaksinen MS, Saarma M (2002) The GDNF family: signalling, biological functions and therapeutic value. Nat Rev Neurosci 3:383-394.
    • (2002) Nat Rev Neurosci , vol.3 , pp. 383-394
    • Airaksinen, M.S.1    Saarma, M.2
  • 3
    • 0029059060 scopus 로고
    • Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B
    • Beg AA, Sha WC, Bronson RT, Ghosh S, Baltimore D (1995) Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B. Nature 376:167-170.
    • (1995) Nature , vol.376 , pp. 167-170
    • Beg, A.A.1    Sha, W.C.2    Bronson, R.T.3    Ghosh, S.4    Baltimore, D.5
  • 5
    • 0035911153 scopus 로고    scopus 로고
    • Activation of nuclear factor kappaB and Bcl-x survival gene expression by nerve growth factor requires tyrosine phosphorylation of IkappaBalpha
    • Bui NT, Livolsi A, Peyron JF, Prehn JH (2001) Activation of nuclear factor kappaB and Bcl-x survival gene expression by nerve growth factor requires tyrosine phosphorylation of IkappaBalpha. J Cell Biol 152:753-764.
    • (2001) J Cell Biol , vol.152 , pp. 753-764
    • Bui, N.T.1    Livolsi, A.2    Peyron, J.F.3    Prehn, J.H.4
  • 6
    • 0037762690 scopus 로고    scopus 로고
    • Neurotrophins and their receptors: A convergence point for many signalling pathways
    • Chao MV (2003) Neurotrophins and their receptors: a convergence point for many signalling pathways. Nat Rev Neurosci 4:299-309.
    • (2003) Nat Rev Neurosci , vol.4 , pp. 299-309
    • Chao, M.V.1
  • 7
    • 0028178798 scopus 로고
    • Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis
    • Cheng B, Christakos S, Mattson MP (1994) Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis. Neuron 12:139-153.
    • (1994) Neuron , vol.12 , pp. 139-153
    • Cheng, B.1    Christakos, S.2    Mattson, M.P.3
  • 8
    • 0033537719 scopus 로고    scopus 로고
    • Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation
    • Delhase M, Hayakawa M, Chen Y, Karin M (1999) Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation. Science 284:309-313.
    • (1999) Science , vol.284 , pp. 309-313
    • Delhase, M.1    Hayakawa, M.2    Chen, Y.3    Karin, M.4
  • 9
    • 0035683975 scopus 로고    scopus 로고
    • Cytokines promote motoneuron survival through the Janus kinase- dependent activation of the phosphatidylinositol 3-kinase pathway
    • Dolcet X, Soler RM, Gould TW, Egea J, Oppenheim RW, Comella JX (2001) Cytokines promote motoneuron survival through the Janus kinase- dependent activation of the phosphatidylinositol 3-kinase pathway. Mol Cell Neurosci 18:619-631.
    • (2001) Mol Cell Neurosci , vol.18 , pp. 619-631
    • Dolcet, X.1    Soler, R.M.2    Gould, T.W.3    Egea, J.4    Oppenheim, R.W.5    Comella, J.X.6
  • 11
    • 49949106621 scopus 로고    scopus 로고
    • Analysis of Ret knockin mice reveals a critical role for IKKs, but not PI 3-K, in neurotrophic factor-induced survival of sympathetic neurons
    • Encinas M, Rozen EJ, Dolcet X, Jain S, Comella JX, Milbrandt J, Johnson EM Jr (2008) Analysis of Ret knockin mice reveals a critical role for IKKs, but not PI 3-K, in neurotrophic factor-induced survival of sympathetic neurons. Cell Death Differ 15:1510-1521.
    • (2008) Cell Death Differ , vol.15 , pp. 1510-1521
    • Encinas, M.1    Rozen, E.J.2    Dolcet, X.3    Jain, S.4    Comella, J.X.5    Milbrandt, J.6    Johnson, E.M.7
  • 12
    • 34848921787 scopus 로고    scopus 로고
    • Nuclear factor-kB activation via tyrosine phosphorylation of inhibitor kB-q: Is crucial for ciliary neurotrophic factor-promoted neurite growth from developing neurons
    • Gallagher D, Gutierrez H, Gavalda N, O'Keeffe G, Hay R, Davies AM (2007) Nuclear factor-kB activation via tyrosine phosphorylation of inhibitor kB-q: is crucial for ciliary neurotrophic factor-promoted neurite growth from developing neurons. J Neurosci 27:9664-9669.
    • (2007) J Neurosci , vol.27 , pp. 9664-9669
    • Gallagher, D.1    Gutierrez, H.2    Gavalda, N.3    O'Keeffe, G.4    Hay, R.5    Davies, A.M.6
  • 15
    • 51149093503 scopus 로고    scopus 로고
    • Nuclear factor kB signaling either stimulates or inhibits neurite growth depending on the phosphorylation status of p65/RelA
    • Gutierrez H, O'Keeffe GW, Gavalda N, Gallagher D, Davies AM (2008) Nuclear factor kB signaling either stimulates or inhibits neurite growth depending on the phosphorylation status of p65/RelA. J Neurosci 28:8246- 8256.
    • (2008) J Neurosci , vol.28 , pp. 8246-8256
    • Gutierrez, H.1    O'Keeffe, G.W.2    Gavalda, N.3    Gallagher, D.4    Davies, A.M.5
  • 16
    • 4444376712 scopus 로고    scopus 로고
    • Signaling to NF-kappaB
    • Hayden MS, Ghosh S (2004) Signaling to NF-kappaB. Genes Dev 18: 2195-2224.
    • (2004) Genes Dev , vol.18 , pp. 2195-2224
    • Hayden, M.S.1    Ghosh, S.2
  • 17
    • 14044257944 scopus 로고    scopus 로고
    • Triple knock-out of CNTF, LIF, and CT-1 defines cooperative and distinct roles of these neurotrophic factors for motoneuron maintenance and function
    • Holtmann B, Wiese S, Samsam M, Grohmann K, Pennica D, Martini R, Sendtner M (2005) Triple knock-out of CNTF, LIF, and CT-1 defines cooperative and distinct roles of these neurotrophic factors for motoneuron maintenance and function. J Neurosci 25:1778-1787.
    • (2005) J Neurosci , vol.25 , pp. 1778-1787
    • Holtmann, B.1    Wiese, S.2    Samsam, M.3    Grohmann, K.4    Pennica, D.5    Martini, R.6    Sendtner, M.7
  • 19
    • 66849129318 scopus 로고    scopus 로고
    • IKKalpha and IKKbeta regulation of DNA damage-induced cleavage of huntingtin
    • Khoshnan A, Ko J, Tescu S, Brundin P, Patterson PH (2009) IKKalpha and IKKbeta regulation of DNA damage-induced cleavage of huntingtin. PLoS One 4:e5768.
    • (2009) PLoS One , vol.4
    • Khoshnan, A.1    Ko, J.2    Tescu, S.3    Brundin, P.4    Patterson, P.H.5
  • 20
    • 0035112978 scopus 로고    scopus 로고
    • NF-kappaB is involved in the survival of cerebellar granule neurons: Association of IkappaBbeta [correction of Ikappabeta] phosphorylation with cell survival
    • Koulich E, Nguyen T, Johnson K, Giardina C, D'Mello S (2001) NF-kappaB is involved in the survival of cerebellar granule neurons: association of IkappaBbeta [correction of Ikappabeta] phosphorylation with cell survival. J Neurochem 76:1188-1198.
    • (2001) J Neurochem , vol.76 , pp. 1188-1198
    • Koulich, E.1    Nguyen, T.2    Johnson, K.3    Giardina, C.4    D'mello, S.5
  • 22
    • 0034661272 scopus 로고    scopus 로고
    • Complete lack of NF-kappaB activity in IKK1 and IKK2 double-deficient mice: Additional defect in neurulation
    • Li Q, Estepa G, Memet S, Israel A, Verma IM (2000) Complete lack of NF-kappaB activity in IKK1 and IKK2 double-deficient mice: additional defect in neurulation. Genes Dev 14:1729-1733.
    • (2000) Genes Dev , vol.14 , pp. 1729-1733
    • Li, Q.1    Estepa, G.2    Memet, S.3    Israel, A.4    Verma, I.M.5
  • 23
    • 0033532386 scopus 로고    scopus 로고
    • The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis
    • Li ZW, Chu W, Hu Y, Delhase M, Deerinck T, Ellisman M, Johnson R, Karin M (1999) The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis. J Exp Med 189:1839-1845.
    • (1999) J Exp Med , vol.189 , pp. 1839-1845
    • Li, Z.W.1    Chu, W.2    Hu, Y.3    Delhase, M.4    Deerinck, T.5    Ellisman, M.6    Johnson, R.7    Karin, M.8
  • 24
    • 0029006149 scopus 로고
    • Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence
    • Lin YZ, Yao SY, Veach RA, Torgerson TR, Hawiger J (1995) Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence. J Biol Chem 270:14255-14258.
    • (1995) J Biol Chem , vol.270 , pp. 14255-14258
    • Lin, Y.Z.1    Yao, S.Y.2    Veach, R.A.3    Torgerson, T.R.4    Hawiger, J.5
  • 25
    • 0032535049 scopus 로고    scopus 로고
    • Nerve growth factor-dependent activation of NF-kB contributes to survival of sympathetic neurons
    • Maggirwar SB, Sarmiere PD, Dewhurst S, Freeman RS (1998) Nerve growth factor-dependent activation of NF-kB contributes to survival of sympathetic neurons. J Neurosci 18:10356-10365.
    • (1998) J Neurosci , vol.18 , pp. 10356-10365
    • Maggirwar, S.B.1    Sarmiere, P.D.2    Dewhurst, S.3    Freeman, R.S.4
  • 26
    • 2442629605 scopus 로고    scopus 로고
    • Identification of a novel cyclic AMP-response element (CRE-II) and the role of CREB-1 in the cAMP-induced expression of the survival motor neuron (SMN) gene
    • Majumder S, Varadharaj S, Ghoshal K, Monani U, Burghes AH, Jacob ST (2004) Identification of a novel cyclic AMP-response element (CRE-II) and the role of CREB-1 in the cAMP-induced expression of the survival motor neuron (SMN) gene. J Biol Chem 279:14803-14811.
    • (2004) J Biol Chem , vol.279 , pp. 14803-14811
    • Majumder, S.1    Varadharaj, S.2    Ghoshal, K.3    Monani, U.4    Burghes, A.H.5    Jacob, S.T.6
  • 27
    • 33646010041 scopus 로고    scopus 로고
    • Roles for NF-kappaB in nerve cell survival, plasticity, and disease
    • Mattson MP, Meffert MK (2006) Roles for NF-kappaB in nerve cell survival, plasticity, and disease. Cell Death Differ 13:852-860.
    • (2006) Cell Death Differ , vol.13 , pp. 852-860
    • Mattson, M.P.1    Meffert, M.K.2
  • 28
    • 0030611750 scopus 로고    scopus 로고
    • Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: Evidence for induction of manganese superoxide dis-mutase and suppression of peroxynitrite production and protein tyrosine nitration
    • Mattson MP, Goodman Y, Luo H, Fu W, Furukawa K (1997) Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dis-mutase and suppression of peroxynitrite production and protein tyrosine nitration. J Neurosci Res 49:681-697.
    • (1997) J Neurosci Res , vol.49 , pp. 681-697
    • Mattson, M.P.1    Goodman, Y.2    Luo, H.3    Fu, W.4    Furukawa, K.5
  • 29
    • 0033979815 scopus 로고    scopus 로고
    • Roles of nuclear factor kappaB in neuronal survival and plasticity
    • Mattson MP, Culmsee C, Yu Z, Camandola S (2000) Roles of nuclear factor kappaB in neuronal survival and plasticity. J Neurochem 74:443-456.
    • (2000) J Neurochem , vol.74 , pp. 443-456
    • Mattson, M.P.1    Culmsee, C.2    Yu, Z.3    Camandola, S.4
  • 31
    • 0030220893 scopus 로고    scopus 로고
    • Neurotrophic survival molecules for motoneurons: An embarrassment of riches
    • Oppenheim RW (1996) Neurotrophic survival molecules for motoneurons: an embarrassment of riches. Neuron 17:195-197.
    • (1996) Neuron , vol.17 , pp. 195-197
    • Oppenheim, R.W.1
  • 32
    • 1242339590 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor increases intracellular calcium concentration. Role of calcium/calmodulin in the activation of the phosphatidylinositol 3-kinase pathway
    • Pérez-García MJ, Ceña V, de Pablo Y, Llovera M, Comella JX, Soler RM (2004) Glial cell line-derived neurotrophic factor increases intracellular calcium concentration. Role of calcium/calmodulin in the activation of the phosphatidylinositol 3-kinase pathway. J Biol Chem 279:6132-6142.
    • (2004) J Biol Chem , vol.279 , pp. 6132-6142
    • Pérez-García, M.J.1    Ceña, V.2    de Pablo, Y.3    Llovera, M.4    Comella, J.X.5    Soler, R.M.6
  • 33
    • 33845768987 scopus 로고    scopus 로고
    • Integrating cell-signalling pathways with NF-kappaB and IKK function
    • Perkins ND (2007) Integrating cell-signalling pathways with NF-kappaB and IKK function. Nat Rev Mol Cell Biol 8:49-62.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 49-62
    • Perkins, N.D.1
  • 35
    • 0030931720 scopus 로고    scopus 로고
    • Inactivation of the survival motor neuron gene, a candidate gene for human spinal muscular atrophy, leads to massive cell death in early mouse embryos
    • Schrank B,Götz R,Gunnersen JM, Ure JM, Toyka KV, Smith AG, Sendtner M (1997) Inactivation of the survival motor neuron gene, a candidate gene for human spinal muscular atrophy, leads to massive cell death in early mouse embryos. Proc Natl Acad Sci U S A 94:9920-9925.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 9920-9925
    • Schrank, B.1    Götz, R.2    Gunnersen, J.M.3    Ure, J.M.4    Toyka, K.V.5    Smith, A.G.6    Sendtner, M.7
  • 36
    • 0032519650 scopus 로고    scopus 로고
    • Calmodulin is involved in membrane depolarization-mediated survival of motoneurons by phosphatidylinositol-3 kinase- and MAPK- independent pathways
    • Soler RM, Egea J, Mintenig GM, Sanz-Rodriguez C, Iglesias M, Comella JX (1998) Calmodulin is involved in membrane depolarization-mediated survival of motoneurons by phosphatidylinositol-3 kinase- and MAPK- independent pathways. J Neurosci 18:1230-1239.
    • (1998) J Neurosci , vol.18 , pp. 1230-1239
    • Soler, R.M.1    Egea, J.2    Mintenig, G.M.3    Sanz-Rodriguez, C.4    Iglesias, M.5    Comella, J.X.6
  • 37
    • 0033232936 scopus 로고    scopus 로고
    • Receptors of the glial cell line-derived neurotrophic factor family of neu-rotrophic factors signal cell survival through the phosphatidylinositol 3-kinase pathway in spinal cord motoneurons
    • Soler RM, Dolcet X, Encinas M, Egea J, Bayascas JR, Comella JX (1999) Receptors of the glial cell line-derived neurotrophic factor family of neu-rotrophic factors signal cell survival through the phosphatidylinositol 3-kinase pathway in spinal cord motoneurons. J Neurosci 19:9160-9169.
    • (1999) J Neurosci , vol.19 , pp. 9160-9169
    • Soler, R.M.1    Dolcet, X.2    Encinas, M.3    Egea, J.4    Bayascas, J.R.5    Comella, J.X.6
  • 38
    • 33646135323 scopus 로고    scopus 로고
    • Therapeutics development for spinal muscular atrophy
    • Sumner CJ (2006) Therapeutics development for spinal muscular atrophy. NeuroRx 3:235-245.
    • (2006) NeuroRx , vol.3 , pp. 235-245
    • Sumner, C.J.1
  • 39
    • 20444478655 scopus 로고    scopus 로고
    • Identification of direct genomic targets downstream of the nuclear factor-kappaB transcription factor mediating tumor necrosis factor signaling
    • Tian B, Nowak DE, Jamaluddin M, Wang S, Brasier AR (2005) Identification of direct genomic targets downstream of the nuclear factor-kappaB transcription factor mediating tumor necrosis factor signaling. J Biol Chem 280:17435-17448.
    • (2005) J Biol Chem , vol.280 , pp. 17435-17448
    • Tian, B.1    Nowak, D.E.2    Jamaluddin, M.3    Wang, S.4    Brasier, A.R.5
  • 41
    • 3142663912 scopus 로고    scopus 로고
    • Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKal-pha) to p100 and IKKalpha-mediated phosphorylation
    • Xiao G, Fong A, Sun SC (2004) Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKal-pha) to p100 and IKKalpha-mediated phosphorylation. J Biol Chem 279:30099-30105.
    • (2004) J Biol Chem , vol.279 , pp. 30099-30105
    • Xiao, G.1    Fong, A.2    Sun, S.C.3
  • 42
    • 46549088269 scopus 로고    scopus 로고
    • Bim(L) displacing Bcl-x(L) promotes Bax translocation during TNFalpha-induced apoptosis
    • Zhang L, Xing D, Chen M (2008) Bim(L) displacing Bcl-x(L) promotes Bax translocation during TNFalpha-induced apoptosis. Apoptosis 13:950-958.
    • (2008) Apoptosis , vol.13 , pp. 950-958
    • Zhang, L.1    Xing, D.2    Chen, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.