-
1
-
-
0036581222
-
The GDNF family: Signalling, biological functions and therapeutic value
-
Airaksinen MS, Saarma M (2002) The GDNF family: signalling, biological functions and therapeutic value. Nat Rev Neurosci 3:383-394.
-
(2002)
Nat Rev Neurosci
, vol.3
, pp. 383-394
-
-
Airaksinen, M.S.1
Saarma, M.2
-
2
-
-
0032948066
-
Cardiotrophin-1 requires LIFRbeta to promote survival of mouse motoneurons purified by a novel technique
-
Arce V, Garces A, de Bovis B, Filippi P, Henderson C, Pettmann B, deLapey-riere O (1999) Cardiotrophin-1 requires LIFRbeta to promote survival of mouse motoneurons purified by a novel technique. J Neurosci Res 55:119-126.
-
(1999)
J Neurosci Res
, vol.55
, pp. 119-126
-
-
Arce, V.1
Garces, A.2
de Bovis, B.3
Filippi, P.4
Henderson, C.5
Pettmann, B.6
Delapey-Riere, O.7
-
3
-
-
0029059060
-
Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B
-
Beg AA, Sha WC, Bronson RT, Ghosh S, Baltimore D (1995) Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B. Nature 376:167-170.
-
(1995)
Nature
, vol.376
, pp. 167-170
-
-
Beg, A.A.1
Sha, W.C.2
Bronson, R.T.3
Ghosh, S.4
Baltimore, D.5
-
4
-
-
0036813662
-
Constitutive nuclear factor-kB activity is required for central neuron survival
-
Bhakar AL, Tannis LL, Zeindler C, Russo MP, Jobin C, Park DS, MacPherson S, Barker PA (2002) Constitutive nuclear factor-kB activity is required for central neuron survival. J Neurosci 22:8466-8475.
-
(2002)
J Neurosci
, vol.22
, pp. 8466-8475
-
-
Bhakar, A.L.1
Tannis, L.L.2
Zeindler, C.3
Russo, M.P.4
Jobin, C.5
Park, D.S.6
Macpherson, S.7
Barker, P.A.8
-
5
-
-
0035911153
-
Activation of nuclear factor kappaB and Bcl-x survival gene expression by nerve growth factor requires tyrosine phosphorylation of IkappaBalpha
-
Bui NT, Livolsi A, Peyron JF, Prehn JH (2001) Activation of nuclear factor kappaB and Bcl-x survival gene expression by nerve growth factor requires tyrosine phosphorylation of IkappaBalpha. J Cell Biol 152:753-764.
-
(2001)
J Cell Biol
, vol.152
, pp. 753-764
-
-
Bui, N.T.1
Livolsi, A.2
Peyron, J.F.3
Prehn, J.H.4
-
6
-
-
0037762690
-
Neurotrophins and their receptors: A convergence point for many signalling pathways
-
Chao MV (2003) Neurotrophins and their receptors: a convergence point for many signalling pathways. Nat Rev Neurosci 4:299-309.
-
(2003)
Nat Rev Neurosci
, vol.4
, pp. 299-309
-
-
Chao, M.V.1
-
7
-
-
0028178798
-
Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis
-
Cheng B, Christakos S, Mattson MP (1994) Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis. Neuron 12:139-153.
-
(1994)
Neuron
, vol.12
, pp. 139-153
-
-
Cheng, B.1
Christakos, S.2
Mattson, M.P.3
-
8
-
-
0033537719
-
Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation
-
Delhase M, Hayakawa M, Chen Y, Karin M (1999) Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation. Science 284:309-313.
-
(1999)
Science
, vol.284
, pp. 309-313
-
-
Delhase, M.1
Hayakawa, M.2
Chen, Y.3
Karin, M.4
-
9
-
-
0035683975
-
Cytokines promote motoneuron survival through the Janus kinase- dependent activation of the phosphatidylinositol 3-kinase pathway
-
Dolcet X, Soler RM, Gould TW, Egea J, Oppenheim RW, Comella JX (2001) Cytokines promote motoneuron survival through the Janus kinase- dependent activation of the phosphatidylinositol 3-kinase pathway. Mol Cell Neurosci 18:619-631.
-
(2001)
Mol Cell Neurosci
, vol.18
, pp. 619-631
-
-
Dolcet, X.1
Soler, R.M.2
Gould, T.W.3
Egea, J.4
Oppenheim, R.W.5
Comella, J.X.6
-
10
-
-
33746840548
-
Proteasome inhibitors induce death but activate NF-kappaB on endometrial carcinoma cell lines and primary culture explants
-
Dolcet X, Llobet D, Encinas M, Pallares J, Cabero A, Schoenenberger JA, Comella JX, Matias-Guiu X (2006) Proteasome inhibitors induce death but activate NF-kappaB on endometrial carcinoma cell lines and primary culture explants. J Biol Chem 281:22118-22130.
-
(2006)
J Biol Chem
, vol.281
, pp. 22118-22130
-
-
Dolcet, X.1
Llobet, D.2
Encinas, M.3
Pallares, J.4
Cabero, A.5
Schoenenberger, J.A.6
Comella, J.X.7
Matias-Guiu, X.8
-
11
-
-
49949106621
-
Analysis of Ret knockin mice reveals a critical role for IKKs, but not PI 3-K, in neurotrophic factor-induced survival of sympathetic neurons
-
Encinas M, Rozen EJ, Dolcet X, Jain S, Comella JX, Milbrandt J, Johnson EM Jr (2008) Analysis of Ret knockin mice reveals a critical role for IKKs, but not PI 3-K, in neurotrophic factor-induced survival of sympathetic neurons. Cell Death Differ 15:1510-1521.
-
(2008)
Cell Death Differ
, vol.15
, pp. 1510-1521
-
-
Encinas, M.1
Rozen, E.J.2
Dolcet, X.3
Jain, S.4
Comella, J.X.5
Milbrandt, J.6
Johnson, E.M.7
-
12
-
-
34848921787
-
Nuclear factor-kB activation via tyrosine phosphorylation of inhibitor kB-q: Is crucial for ciliary neurotrophic factor-promoted neurite growth from developing neurons
-
Gallagher D, Gutierrez H, Gavalda N, O'Keeffe G, Hay R, Davies AM (2007) Nuclear factor-kB activation via tyrosine phosphorylation of inhibitor kB-q: is crucial for ciliary neurotrophic factor-promoted neurite growth from developing neurons. J Neurosci 27:9664-9669.
-
(2007)
J Neurosci
, vol.27
, pp. 9664-9669
-
-
Gallagher, D.1
Gutierrez, H.2
Gavalda, N.3
O'Keeffe, G.4
Hay, R.5
Davies, A.M.6
-
13
-
-
0029073131
-
Bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death
-
Gonzalez-García M, García I, Ding L, O'Shea S, Boise LH, Thompson CB, Nuñez G (1995) bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death. Proc Natl Acad Sci USA 92:4304-4308.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 4304-4308
-
-
Gonzalez-García, M.1
García, I.2
Ding, L.3
O'Shea, S.4
Boise, L.H.5
Thompson, C.B.6
Nuñez, G.7
-
14
-
-
69949164867
-
Specific vulnerability of mouse spinal cord motoneurons to membrane depolarization
-
Gou-Fabregas M, Garcera A, Mincheva S, Perez-Garcia MJ, Comella JX, Soler RM (2009) Specific vulnerability of mouse spinal cord motoneurons to membrane depolarization. JNeurochem 110:1842-1854.
-
(2009)
JNeurochem
, vol.110
, pp. 1842-1854
-
-
Gou-Fabregas, M.1
Garcera, A.2
Mincheva, S.3
Perez-Garcia, M.J.4
Comella, J.X.5
Soler, R.M.6
-
15
-
-
51149093503
-
Nuclear factor kB signaling either stimulates or inhibits neurite growth depending on the phosphorylation status of p65/RelA
-
Gutierrez H, O'Keeffe GW, Gavalda N, Gallagher D, Davies AM (2008) Nuclear factor kB signaling either stimulates or inhibits neurite growth depending on the phosphorylation status of p65/RelA. J Neurosci 28:8246- 8256.
-
(2008)
J Neurosci
, vol.28
, pp. 8246-8256
-
-
Gutierrez, H.1
O'Keeffe, G.W.2
Gavalda, N.3
Gallagher, D.4
Davies, A.M.5
-
16
-
-
4444376712
-
Signaling to NF-kappaB
-
Hayden MS, Ghosh S (2004) Signaling to NF-kappaB. Genes Dev 18: 2195-2224.
-
(2004)
Genes Dev
, vol.18
, pp. 2195-2224
-
-
Hayden, M.S.1
Ghosh, S.2
-
17
-
-
14044257944
-
Triple knock-out of CNTF, LIF, and CT-1 defines cooperative and distinct roles of these neurotrophic factors for motoneuron maintenance and function
-
Holtmann B, Wiese S, Samsam M, Grohmann K, Pennica D, Martini R, Sendtner M (2005) Triple knock-out of CNTF, LIF, and CT-1 defines cooperative and distinct roles of these neurotrophic factors for motoneuron maintenance and function. J Neurosci 25:1778-1787.
-
(2005)
J Neurosci
, vol.25
, pp. 1778-1787
-
-
Holtmann, B.1
Wiese, S.2
Samsam, M.3
Grohmann, K.4
Pennica, D.5
Martini, R.6
Sendtner, M.7
-
19
-
-
66849129318
-
IKKalpha and IKKbeta regulation of DNA damage-induced cleavage of huntingtin
-
Khoshnan A, Ko J, Tescu S, Brundin P, Patterson PH (2009) IKKalpha and IKKbeta regulation of DNA damage-induced cleavage of huntingtin. PLoS One 4:e5768.
-
(2009)
PLoS One
, vol.4
-
-
Khoshnan, A.1
Ko, J.2
Tescu, S.3
Brundin, P.4
Patterson, P.H.5
-
20
-
-
0035112978
-
NF-kappaB is involved in the survival of cerebellar granule neurons: Association of IkappaBbeta [correction of Ikappabeta] phosphorylation with cell survival
-
Koulich E, Nguyen T, Johnson K, Giardina C, D'Mello S (2001) NF-kappaB is involved in the survival of cerebellar granule neurons: association of IkappaBbeta [correction of Ikappabeta] phosphorylation with cell survival. J Neurochem 76:1188-1198.
-
(2001)
J Neurochem
, vol.76
, pp. 1188-1198
-
-
Koulich, E.1
Nguyen, T.2
Johnson, K.3
Giardina, C.4
D'mello, S.5
-
21
-
-
3242745060
-
Mechanism of NF-kappaB inactivation induced by survival signal withdrawal in cerebellar granule neurons
-
Kovacs AD, Chakraborty-Sett S, Ramirez SH, Sniderhan LF, Williamson AL, Maggirwar SB (2004) Mechanism of NF-kappaB inactivation induced by survival signal withdrawal in cerebellar granule neurons. Eur J Neurosci 20:345-352.
-
(2004)
Eur J Neurosci
, vol.20
, pp. 345-352
-
-
Kovacs, A.D.1
Chakraborty-Sett, S.2
Ramirez, S.H.3
Sniderhan, L.F.4
Williamson, A.L.5
Maggirwar, S.B.6
-
22
-
-
0034661272
-
Complete lack of NF-kappaB activity in IKK1 and IKK2 double-deficient mice: Additional defect in neurulation
-
Li Q, Estepa G, Memet S, Israel A, Verma IM (2000) Complete lack of NF-kappaB activity in IKK1 and IKK2 double-deficient mice: additional defect in neurulation. Genes Dev 14:1729-1733.
-
(2000)
Genes Dev
, vol.14
, pp. 1729-1733
-
-
Li, Q.1
Estepa, G.2
Memet, S.3
Israel, A.4
Verma, I.M.5
-
23
-
-
0033532386
-
The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis
-
Li ZW, Chu W, Hu Y, Delhase M, Deerinck T, Ellisman M, Johnson R, Karin M (1999) The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis. J Exp Med 189:1839-1845.
-
(1999)
J Exp Med
, vol.189
, pp. 1839-1845
-
-
Li, Z.W.1
Chu, W.2
Hu, Y.3
Delhase, M.4
Deerinck, T.5
Ellisman, M.6
Johnson, R.7
Karin, M.8
-
24
-
-
0029006149
-
Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence
-
Lin YZ, Yao SY, Veach RA, Torgerson TR, Hawiger J (1995) Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence. J Biol Chem 270:14255-14258.
-
(1995)
J Biol Chem
, vol.270
, pp. 14255-14258
-
-
Lin, Y.Z.1
Yao, S.Y.2
Veach, R.A.3
Torgerson, T.R.4
Hawiger, J.5
-
25
-
-
0032535049
-
Nerve growth factor-dependent activation of NF-kB contributes to survival of sympathetic neurons
-
Maggirwar SB, Sarmiere PD, Dewhurst S, Freeman RS (1998) Nerve growth factor-dependent activation of NF-kB contributes to survival of sympathetic neurons. J Neurosci 18:10356-10365.
-
(1998)
J Neurosci
, vol.18
, pp. 10356-10365
-
-
Maggirwar, S.B.1
Sarmiere, P.D.2
Dewhurst, S.3
Freeman, R.S.4
-
26
-
-
2442629605
-
Identification of a novel cyclic AMP-response element (CRE-II) and the role of CREB-1 in the cAMP-induced expression of the survival motor neuron (SMN) gene
-
Majumder S, Varadharaj S, Ghoshal K, Monani U, Burghes AH, Jacob ST (2004) Identification of a novel cyclic AMP-response element (CRE-II) and the role of CREB-1 in the cAMP-induced expression of the survival motor neuron (SMN) gene. J Biol Chem 279:14803-14811.
-
(2004)
J Biol Chem
, vol.279
, pp. 14803-14811
-
-
Majumder, S.1
Varadharaj, S.2
Ghoshal, K.3
Monani, U.4
Burghes, A.H.5
Jacob, S.T.6
-
27
-
-
33646010041
-
Roles for NF-kappaB in nerve cell survival, plasticity, and disease
-
Mattson MP, Meffert MK (2006) Roles for NF-kappaB in nerve cell survival, plasticity, and disease. Cell Death Differ 13:852-860.
-
(2006)
Cell Death Differ
, vol.13
, pp. 852-860
-
-
Mattson, M.P.1
Meffert, M.K.2
-
28
-
-
0030611750
-
Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: Evidence for induction of manganese superoxide dis-mutase and suppression of peroxynitrite production and protein tyrosine nitration
-
Mattson MP, Goodman Y, Luo H, Fu W, Furukawa K (1997) Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dis-mutase and suppression of peroxynitrite production and protein tyrosine nitration. J Neurosci Res 49:681-697.
-
(1997)
J Neurosci Res
, vol.49
, pp. 681-697
-
-
Mattson, M.P.1
Goodman, Y.2
Luo, H.3
Fu, W.4
Furukawa, K.5
-
29
-
-
0033979815
-
Roles of nuclear factor kappaB in neuronal survival and plasticity
-
Mattson MP, Culmsee C, Yu Z, Camandola S (2000) Roles of nuclear factor kappaB in neuronal survival and plasticity. J Neurochem 74:443-456.
-
(2000)
J Neurochem
, vol.74
, pp. 443-456
-
-
Mattson, M.P.1
Culmsee, C.2
Yu, Z.3
Camandola, S.4
-
30
-
-
34347222588
-
The nuclear factor kappaB-activator gene PLEKHG5 is mutated in a form of autosomal recessive lower motor neuron disease with childhood onset
-
Maystadt I, Rezsöhazy R, Barkats M, Duque S, Vannuffel P, Remacle S, Lambert B, Najimi M, Sokal E, Munnich A, Viollet L, Verellen-Dumoulin C (2007) The nuclear factor kappaB-activator gene PLEKHG5 is mutated in a form of autosomal recessive lower motor neuron disease with childhood onset. Am J Hum Genet 81:67-76.
-
(2007)
Am J Hum Genet
, vol.81
, pp. 67-76
-
-
Maystadt, I.1
Rezsöhazy, R.2
Barkats, M.3
Duque, S.4
Vannuffel, P.5
Remacle, S.6
Lambert, B.7
Najimi, M.8
Sokal, E.9
Munnich, A.10
Viollet, L.11
Verellen-Dumoulin, C.12
-
31
-
-
0030220893
-
Neurotrophic survival molecules for motoneurons: An embarrassment of riches
-
Oppenheim RW (1996) Neurotrophic survival molecules for motoneurons: an embarrassment of riches. Neuron 17:195-197.
-
(1996)
Neuron
, vol.17
, pp. 195-197
-
-
Oppenheim, R.W.1
-
32
-
-
1242339590
-
Glial cell line-derived neurotrophic factor increases intracellular calcium concentration. Role of calcium/calmodulin in the activation of the phosphatidylinositol 3-kinase pathway
-
Pérez-García MJ, Ceña V, de Pablo Y, Llovera M, Comella JX, Soler RM (2004) Glial cell line-derived neurotrophic factor increases intracellular calcium concentration. Role of calcium/calmodulin in the activation of the phosphatidylinositol 3-kinase pathway. J Biol Chem 279:6132-6142.
-
(2004)
J Biol Chem
, vol.279
, pp. 6132-6142
-
-
Pérez-García, M.J.1
Ceña, V.2
de Pablo, Y.3
Llovera, M.4
Comella, J.X.5
Soler, R.M.6
-
33
-
-
33845768987
-
Integrating cell-signalling pathways with NF-kappaB and IKK function
-
Perkins ND (2007) Integrating cell-signalling pathways with NF-kappaB and IKK function. Nat Rev Mol Cell Biol 8:49-62.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 49-62
-
-
Perkins, N.D.1
-
34
-
-
0035892721
-
Inhibition of nuclear factor-kappaB activation induces apoptosis in cerebellar granule cells
-
Piccioli P, Porcile C, Stanzione S, Bisaglia M, Bajetto A, Bonavia R, Florio T, Schettini G (2001) Inhibition of nuclear factor-kappaB activation induces apoptosis in cerebellar granule cells. J Neurosci Res 66:1064-1073.
-
(2001)
J Neurosci Res
, vol.66
, pp. 1064-1073
-
-
Piccioli, P.1
Porcile, C.2
Stanzione, S.3
Bisaglia, M.4
Bajetto, A.5
Bonavia, R.6
Florio, T.7
Schettini, G.8
-
35
-
-
0030931720
-
Inactivation of the survival motor neuron gene, a candidate gene for human spinal muscular atrophy, leads to massive cell death in early mouse embryos
-
Schrank B,Götz R,Gunnersen JM, Ure JM, Toyka KV, Smith AG, Sendtner M (1997) Inactivation of the survival motor neuron gene, a candidate gene for human spinal muscular atrophy, leads to massive cell death in early mouse embryos. Proc Natl Acad Sci U S A 94:9920-9925.
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 9920-9925
-
-
Schrank, B.1
Götz, R.2
Gunnersen, J.M.3
Ure, J.M.4
Toyka, K.V.5
Smith, A.G.6
Sendtner, M.7
-
36
-
-
0032519650
-
Calmodulin is involved in membrane depolarization-mediated survival of motoneurons by phosphatidylinositol-3 kinase- and MAPK- independent pathways
-
Soler RM, Egea J, Mintenig GM, Sanz-Rodriguez C, Iglesias M, Comella JX (1998) Calmodulin is involved in membrane depolarization-mediated survival of motoneurons by phosphatidylinositol-3 kinase- and MAPK- independent pathways. J Neurosci 18:1230-1239.
-
(1998)
J Neurosci
, vol.18
, pp. 1230-1239
-
-
Soler, R.M.1
Egea, J.2
Mintenig, G.M.3
Sanz-Rodriguez, C.4
Iglesias, M.5
Comella, J.X.6
-
37
-
-
0033232936
-
Receptors of the glial cell line-derived neurotrophic factor family of neu-rotrophic factors signal cell survival through the phosphatidylinositol 3-kinase pathway in spinal cord motoneurons
-
Soler RM, Dolcet X, Encinas M, Egea J, Bayascas JR, Comella JX (1999) Receptors of the glial cell line-derived neurotrophic factor family of neu-rotrophic factors signal cell survival through the phosphatidylinositol 3-kinase pathway in spinal cord motoneurons. J Neurosci 19:9160-9169.
-
(1999)
J Neurosci
, vol.19
, pp. 9160-9169
-
-
Soler, R.M.1
Dolcet, X.2
Encinas, M.3
Egea, J.4
Bayascas, J.R.5
Comella, J.X.6
-
38
-
-
33646135323
-
Therapeutics development for spinal muscular atrophy
-
Sumner CJ (2006) Therapeutics development for spinal muscular atrophy. NeuroRx 3:235-245.
-
(2006)
NeuroRx
, vol.3
, pp. 235-245
-
-
Sumner, C.J.1
-
39
-
-
20444478655
-
Identification of direct genomic targets downstream of the nuclear factor-kappaB transcription factor mediating tumor necrosis factor signaling
-
Tian B, Nowak DE, Jamaluddin M, Wang S, Brasier AR (2005) Identification of direct genomic targets downstream of the nuclear factor-kappaB transcription factor mediating tumor necrosis factor signaling. J Biol Chem 280:17435-17448.
-
(2005)
J Biol Chem
, vol.280
, pp. 17435-17448
-
-
Tian, B.1
Nowak, D.E.2
Jamaluddin, M.3
Wang, S.4
Brasier, A.R.5
-
40
-
-
0035957653
-
Proapo-ptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death
-
Wei MC, Zong WX, Cheng EH, Lindsten T, Panoutsakopoulou V, Ross AJ, Roth KA, MacGregor GR, Thompson CB, Korsmeyer SJ (2001) Proapo-ptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292:727-730.
-
(2001)
Science
, vol.292
, pp. 727-730
-
-
Wei, M.C.1
Zong, W.X.2
Cheng, E.H.3
Lindsten, T.4
Panoutsakopoulou, V.5
Ross, A.J.6
Roth, K.A.7
Macgregor, G.R.8
Thompson, C.B.9
Korsmeyer, S.J.10
-
41
-
-
3142663912
-
Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKal-pha) to p100 and IKKalpha-mediated phosphorylation
-
Xiao G, Fong A, Sun SC (2004) Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKal-pha) to p100 and IKKalpha-mediated phosphorylation. J Biol Chem 279:30099-30105.
-
(2004)
J Biol Chem
, vol.279
, pp. 30099-30105
-
-
Xiao, G.1
Fong, A.2
Sun, S.C.3
-
42
-
-
46549088269
-
Bim(L) displacing Bcl-x(L) promotes Bax translocation during TNFalpha-induced apoptosis
-
Zhang L, Xing D, Chen M (2008) Bim(L) displacing Bcl-x(L) promotes Bax translocation during TNFalpha-induced apoptosis. Apoptosis 13:950-958.
-
(2008)
Apoptosis
, vol.13
, pp. 950-958
-
-
Zhang, L.1
Xing, D.2
Chen, M.3
|