mToR inhibitors-induced proteinuria: mechanisms, significance, and management

Transplantation Reviews

Volumn 22, Issue 2, 2008, Pages 125-130

  Letavernier, Emmanuel ^a   Legendre, Christophe ^a  

^a HÔPITAL NECKER ENFANTS MALADES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN 2 RECEPTOR ANTAGONIST; AZATHIOPRINE; BASILIXIMAB; CALCINEURIN INHIBITOR; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; EVEROLIMUS; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; PROTEIN; RAPAMYCIN; STEROID;

ACUTE KIDNEY FAILURE; ARTICLE; CHRONIC ALLOGRAFT NEPHROPATHY; CHRONIC KIDNEY DISEASE; CLINICAL TRIAL; DOSE RESPONSE; DRUG INDUCED DISEASE; DRUG SUBSTITUTION; DRUG WITHDRAWAL; ENZYME INHIBITION; EVIDENCE BASED MEDICINE; FOCAL GLOMERULOSCLEROSIS; HEART TRANSPLANTATION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; NEPHROTIC SYNDROME; NONHUMAN; PANCREAS ISLET TRANSPLANTATION; PODOCYTE; PREDICTION; PROTEINURIA; THROMBOTIC THROMBOCYTOPENIC PURPURA; TREATMENT OUTCOME;

BIOPSY, NEEDLE; CALCINEURIN; GRAFT REJECTION; GRAFT SURVIVAL; HUMANS; IMMUNOHISTOCHEMISTRY; KIDNEY; KIDNEY TRANSPLANTATION; PROTEIN KINASES; PROTEINURIA; RENAL INSUFFICIENCY; SIROLIMUS; TOR SERINE-THREONINE KINASES;

EID: 40649124774     PISSN: 0955470X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trre.2007.12.001     Document Type: Article

References (45)

1. S. Hariharan M.A. McBride W.S. Cherikh Post-transplant renal function in the first year predicts long-term kidney transplant survival Kidney Int 62 2002 311 318
2. G. Opelz T. Wujciak E. Ritz Association of chronic kidney graft failure with recipient blood pressure. Collaborative Transplant Study Kidney Int 53 1998 217 222
3. B.J. Nankivell R.J. Borrows C.L. Fung The natural history of chronic allograft nephropathy N Engl J Med 349 2003 2326 2333
4. E. Morelon H. Kreis Sirolimus therapy without calcineurin inhibitors: Necker Hospital 8-year experience Transplant Proc 35 2003 52S 57S
5. F. Diekmann K. Budde F. Oppenheimer Predictors of success in conversion from calcineurin inhibitor to sirolimus in chronic allograft dysfunction Am J Transplant 4 2004 1869 1875
6. L. Butani Investigation of pediatric renal transplant recipients with heavy proteinuria after sirolimus rescue Transplantation 78 2004 1362 1366
7. E. Letavernier M.N. Peraldi A. Pariente Proteinuria following a switch from calcineurin inhibitors to sirolimus Transplantation 80 2005 1198 1203
8. V. Bumbea N. Kamar D. Ribes Long-term results in renal transplant patients with allograft dysfunction after switching from calcineurin inhibitors to sirolimus Nephrol Dial Transplant 20 2005 2517 2523
9. J.J. Sennesael J.L. Bosmans J.P. Bogers Conversion from cyclosporine to sirolimus in stable renal transplant recipients Transplantation 80 2005 1578 1585
10. M. Boratynska M. Banasik E. Watorek Conversion to sirolimus from cyclosporine may induce nephrotic proteinuria and progressive deterioration of renal function in chronic allograft nephropathy patients Transplant Proc 38 2006 101 104
11. H. Skhiri E. Morelon L.H. Noel Unusual post-transplantation recurrence of focal segmental glomerulosclerosis which resolved with cyclosporine but not with sirolimus Transpl Int 18 2005 458 460
12. E. Dittrich S. Schmaldienst A. Soleiman Rapamycin-associated post-transplantation glomerulonephritis and its remission after reintroduction of calcineurin-inhibitor therapy Transpl Int 17 2004 215 220
13. Y. Lebranchu I. Etienne O. Topance Preliminary results of a randomized trial comparing sirolimus (SRL) vs cyclosporine (CsA) in 150 transplant recipients receiving a cadavericrenal graft Transplantation 78 Suppl 1 2004 463
14. B.R. Stephany J.J. Augustine V. Krishnamurthi Differences in proteinuria and graft function in de novo sirolimus-based vs. calcineurin inhibitor-based immunosuppression in live donor kidney transplantation Transplantation 82 2006 368 374
15. J. Radermacher M. Mengel S. Ellis The renal arterial resistance index and renal allograft survival N Engl J Med 349 2003 115 124
16. A. Saurina J.M. Campistol C. Piera Conversion from calcineurin inhibitors to sirolimus in chronic allograft dysfunction: changes in glomerular haemodynamics and proteinuria Nephrol Dial Transplant 21 2006 488 493
17. B.D. Myers R. Sibley L. Newton The long-term course of cyclosporine-associated chronic nephropathy Kidney Int 33 1988 590 600
18. D. Ducloux G. Motte C. Billerey Cyclosporin withdrawal with concomitant conversion from azathioprine to mycophenolate mofetil in renal transplant recipients with chronic allograft nephropathy: a 2-year follow-up Transpl Int 15 2002 387 392
19. S.M. Flechner D. Goldfarb K. Solez Kidney transplantation with sirolimus and mycophenolate mofetil-based immunosuppression: 5-year results of a randomized prospective trial compared to calcineurin inhibitor drugs Transplantation 83 2007 883 892
20. F. Diekmann A. Gutierrez-Dalmau S. Lopez Influence of sirolimus on proteinuria in de novo kidney transplantation with expanded criteria donors: comparison of two CNI-free protocols Nephrol Dial Transplant 22 2007 2316 2321
21. E. Letavernier P. Bruneval C. Mandet High sirolimus levels may induce focal segmental glomerulosclerosis de novo Clin J Am Soc Nephrol 2 2007 326 333
22. J.M. van den Akker J.F. Wetzels A.J. Hoitsma Proteinuria following conversion from azathioprine to sirolimus in renal transplant recipients Kidney Int 70 2006 1355 1357
23. P.A. Senior B.W. Paty S.M. Cockfield Proteinuria developing after clinical islet transplantation resolves with sirolimus withdrawal and increased tacrolimus dosing Am J Transplant 5 2005 2318 2323
24. E. Raichlin Z. Khalpey W. Kremers Replacement of calcineurin-inhibitors with sirolimus as primary immunosuppression in stable cardiac transplant recipients Transplantation 84 2007 467 474
25. L. Straathof-Galema J.F. Wetzels H.B. Dijkman Sirolimus-associated heavy proteinuria in a renal transplant recipient: evidence for a tubular mechanism Am J Transplant 6 2006 429 433
26. E. Mreich J.D. Coombes G.K. Rangan Sirolimus does not reduce receptor-mediated endocytosis of albumin in proximal tubule cells Transplantation 83 2007 105 107
27. A. Takeda K. Uchida T. Haba Chronic cyclosporin nephropathy: long-term effects of cyclosporin on renal allografts Clin Transplant 15 Suppl 5 2001 22 29
28. S.M. Meehan M. Pascual W.W. Williams De novo collapsing glomerulopathy in renal allografts Transplantation 65 1998 1192 1197
29. H. Sartelet O. Toupance M. Lorenzato Sirolimus-induced thrombotic microangiopathy is associated with decreased expression of vascular endothelial growth factor in kidneys Am J Transplant 5 2005 2441 2447
30. D. Sarbassov dos S.M. Ali S. Sengupta Prolonged rapamycin treatment inhibits mToRC2 assembly and Akt/PKB Mol Cell 22 2006 159 168
31. C. Daniel R. Ziswiler B. Frey Proinflammatory effects in experimental mesangial proliferative glomerulonephritis of the immunosuppressive agent SDZ RAD, a rapamycin derivative Exp Nephrol 8 2000 52 62
32. J.D. Coombes E. Mreich C. Liddle Rapamycin worsens renal function and intratubular cast formation in protein overload nephropathy Kidney Int 68 2005 2599 25607
33. F. Diekmann J. Rovira J. Carreras Mammalian target of rapamycin inhibition halts the progression of proteinuria in a rat model of reduced renal mass J Am Soc Nephrol 18 2007 2653 2660
34. R.G. Bonegio R. Fuhro Z. Wang Rapamycin ameliorates proteinuria-associated tubulointerstitial inflammation and fibrosis in experimental membranous nephropathy J Am Soc Nephrol 16 2005 2063 2072
35. G. Alperovich I. Rama N. Lloberas New immunosuppresor strategies in the treatment of murine lupus nephritis Lupus 16 2007 18 24
36. G.K. Rangan J.D. Coombes Renoprotective effects of sirolimus in non-immune initiated focal segmental glomerulosclerosis Nephrol Dial Transplant 22 2007 2175 2182
37. C. Legendre Y. Brault J.M. Morales Factors influencing glomerular filtration rate in renal transplantation after cyclosporine withdrawal using sirolimus-based therapy: a multivariate analysis of results at five years Clin Transplant 21 2007 330 336
38. F.C. Fervenza P.M. Fitzpatrick J. Mertz Acute rapamycin nephrotoxicity in native kidneys of patients with chronic glomerulopathies Nephrol Dial Transplant 19 2004 1288 1292
39. R.A. McTaggart D. Gottlieb J. Brooks Sirolimus prolongs recovery from delayed graft function after cadaveric renal transplantation Am J Transplant 3 2003 416 423
40. W. Lieberthal R. Fuhro C.C. Andry Rapamycin impairs recovery from acute renal failure: role of cell-cycle arrest and apoptosis of tubular cells Am J Renal Physiol 281 2001 F693 F706
41. M.E. Cho J.K. Hurley J.B. Kopp Sirolimus therapy of focal segmental glomerulosclerosis is associated with nephrotoxicity Am J Kidney Dis 49 2007 310 317
42. J.A. Tumlin D. Miller M. Near A prospective, open-label trial of sirolimus in the treatment of focal segmental glomerulosclerosis Clin J Am Soc Nephrol 1 2006 109 116
43. J. Morales A. Fierro D. Benavente Conversion from a calcineurin inhibitor-based immunosuppressive regimen to everolimus in renal transplant recipients: effect on renal function and proteinuria Transplant Proc 39 2007 591 593
44. M.I. Lorber S. Mulgaonkar K.M. Butt Everolimus versus mycophenolate mofetil in the prevention of rejection in de novo renal transplant recipients: a 3-year randomized, multicenter, phase III study Transplantation 80 2005 244 252
45. S. Hiremath D. Fergusson S. Doucette Renin angiotensin system blockade in kidney transplantation: a systematic review of the evidence Am J Transplant 7 2007 2350 2360