The juxtaposition of a promoter with a locus control region transcriptional domain activates gene expression

EMBO Reports

Volumn 9, Issue 9, 2008, Pages 891-898

  Ho, Yugong ^a   Tadevosyan, Aleksey ^a   Liebhaber, Stephen A ^a   Cooke, Nancy E ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN GROWTH HORMONE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE ACTIVATION; GENE CONTROL; GENE DELETION; GENE LOCUS; GENE REPRESSION; GENE STRUCTURE; GENETIC TRANSCRIPTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; STRUCTURAL GENE;

ANIMALS; CHROMATIN; CHROMATIN IMMUNOPRECIPITATION; GENE EXPRESSION REGULATION; HUMAN GROWTH HORMONE; HUMANS; LOCUS CONTROL REGION; MICE; MICE, TRANSGENIC; POLYMERASE CHAIN REACTION; PROMOTER REGIONS, GENETIC; TRANSCRIPTION, GENETIC;

EID: 51049102986     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/embor.2008.126     Document Type: Article

References (25)

1. Bennani-Baiti IM, Cooke NE, Liebhaber SA (1998) Physical linkage of the human growth hormone gene cluster and the CD79b (lg beta/B29) gene. Genomics 48: 258-264
2. Berger SL (2007) The complex language of chromatin regulation during transcription. Nature 447: 407-412
3. Chen EY, Liao YC, Smith DH, Barrera-Saldana HA, Gelinas RE, Seeburg PH (1989) The human growth hormone focus: Nucleotide sequence, biology, and evolution. Genomics 4: 479-497
4. Cullen KE, Kladde MP, Seyfred MA (1993) Interaction between transcription regulatory regions of prolactin chromatin. Science 261: 203-206
5. Dean A (2006) On a chromosome far, far away: LCRs and gene expression. Trends Genet 22: 38-45
6. Dekker J, Rippe K, Dekker M, Kleckner N (2002) Capturing chromosome conformation. Science 295: 1306-1311
7. Elefant F, Cooke NE, Liebhaber SA (2000) Targeted recruitment of histone acetyltransferase activity to a locus control region. J Biol Chem 275: 13827-13834
8. Forsberg EC, Bresnick EH (2001) Histone acetylation beyond promoters: long-range acetylation patterns in the chromatin world. Bioessays 23: 820-830
9. Gerber M, Shilatifard A (2003) Transcriptional elongation by RNA polymerase II and histone methylation. J Biol Chem-278: 26303-26306
10. Grande MA, van der Kraan I, de Jong L, van Driel R (1997) Nuclear distribution of transcription factors in relation to sites of transcription and RNA polymerase II. J Cell Sci 110: 1781-1791
11. Ho Y, Elefant F, Cooke N, Liebhaber S (2002) A defined locus control region determinant links chromatin domain acetylation with long-range gene activation. Mol Cell 9: 291-302
12. Ho Y, Liebhaber SA, Cooke NE (2004) Activation of the human GH gene cluster: Roles for targeted chromatin modification. Trends Endocrinol Metab 15: 40-45
13. Ho Y, Elefant F, Liebhaber SA, Cooke NE (2006) Locus control region transcription plays an active role in long-range gene activation. Mol Cell 23: 365-375
14. Iborra FJ, Pombo A, Jackson DA, Cook PR (1996) Active RNA polymerases are localized within discrete transcription 'factories' in human nuclei. J Cell Sci 109: 1427-1436
15. Jones BK, Monks BR, Liebbaber SA, Cooke NE (1995) The human growth hormone gene is regulated by a multicomponent locus control region. Mol Cell Biol 15: 7010-7021
16. Liu Z, Garrard WT (2005) Long-range interactions between three transcriptional enhancers, active Vkappa gene promoters, and a 3′ boundary sequence spanning 46 kilobases. Mol Cell Biol 25: 3220-3231
17. Mayo KE, Hammer RE, Swanson LW, Brinster RL, Rosenfeld MG, Evans RM (1988) Dramatic pituitary hyperplasia in transgenic mice expressing a human growth hormone-releasing factor gene. Mol Endocrinol 2 606-612
18. Osborne CS et al (2004) Active genes dynamically colocalize to shared sites of ongoing transcription. Nat Genet 36: 1065-1071
19. Palstra RJ, Tolhuis B, Splinter E, Nijmeijer R, Grosveld F, de Laat W (2003) The beta-globin nuclear compartment in development and erythroid differentiation. Nat Genet 35: 190-194
20. Ragoczy T, Bender MA, Telling A, Byron R, Groudine M (2006) The locus control region is required for association of the murine beta-globin locus with engaged transcription factories during erythroid maturation. Genes Dev 20: 1447-1457
21. Sawado T, Halow J, Bender MA, Groudine M (2003) The beta-globin locus control region (LCR) functions primarily by enhancing the transition from transcription initiation to elongation. Genes Dev 17: 1009-1018
22. Shewchuk BM, Asa SL, Cooke NE, Liebhaber SA (1999) Pit-1 binding sites at the somatotrope-specific DNase I hypersensitive sites I, II of the human growth hormone locus control region are essential for in vivo hGH-N gene activation. J Biol Chem 274: 35725-35733
23. Su Y, Liebhaber SA, Cooke NE (2000) The human growth hormone gene cluster locus control region supports position-independent pituitary- and placenta-specific expression in the transgenic mouse. J Biol Chem 275: 7902-7909
24. Tolhuis B, Palstra RJ, Splinter E, Grosveld F, De Laat W (2002) Looping and interaction between hypersensitive sites in the active beta-globin locus. Mol Cell 10: 1453-1465
25. Weintraub H et al (1991) The myoD gene family: Nodal point during specification of the muscle cell lineage. Science 251: 761-766