Advancing the treatment of conjunctival scarring: A novel ex vivo model

Archives of Ophthalmology

Volumn 129, Issue 5, 2011, Pages 619-627

  Tovell, Victoria E ^a   Dahlmann Noor, Annegret H ^a   Khaw, Peng T ^a   Bailly, Maryse ^a  

^a MOORFIELDS EYE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYFLUORESCEIN DIACETATE SUCCINIMIDYL ESTER; COLLAGEN; ILOMASTAT; TRANSFORMING GROWTH FACTOR BETA2;

ANIMAL TISSUE; ARTICLE; CELL VIABILITY; COLLAGEN DEGRADATION; CONFOCAL MICROSCOPY; CONJUNCTIVA; CONJUNCTIVA DISEASE; CONJUNCTIVAL SCARRING; CONTROLLED STUDY; EX VIVO STUDY; HUMAN; HUMAN CELL; KINETICS; MULTIPHOTON MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; TISSUE CULTURE;

ANIMALS; CATTLE; CELL SURVIVAL; CELLS, CULTURED; CICATRIX; COLLAGEN; CONJUNCTIVAL DISEASES; CONTRACTURE; DIPEPTIDES; FIBROBLASTS; HUMANS; MATRIX METALLOPROTEINASE 3; MICROSCOPY, FLUORESCENCE, MULTIPHOTON; MODELS, BIOLOGICAL; PROTEASE INHIBITORS; RABBITS; SERUM; SWINE; TENON CAPSULE; TISSUE SCAFFOLDS; TRANSFORMING GROWTH FACTOR BETA2;

EID: 79955770827     PISSN: 00039950     EISSN: 15383601     Source Type: Journal    
DOI: 10.1001/archophthalmol.2011.91     Document Type: Article

References (29)

1. Addicks EM, Quigley HA, Green WR, Robin AL. Histologic characteristics of filtering blebs in glaucomatous eyes. Arch Ophthalmol. 1983;101(5):795-798. (Pubitemid 13133119)
2. Hitchings RA, Grierson I. Clinico pathological correlation in eyes with failed fistulizing surgery. Trans Ophthalmol Soc U K. 1983;103(pt 1):84-88. (Pubitemid 14233800)
3. Dahlmann AH, Mireskandari K, Cambrey AD, Bailly M, Khaw PT. Current and future prospects for the prevention of ocular fibrosis. Ophthalmol Clin North Am. 2005;18(4):539-559. (Pubitemid 41728022)
4. Khaw PT, Doyle JW, Sherwood MB, Grierson I, Schultz G, McGorray S. Prolonged localized tissue effects from 5-minute exposures to fluorouracil and mitomycin C. Arch Ophthalmol. 1993;111(2):263-267. (Pubitemid 23053580)
5. Crowston JG, Akbar AN, Constable PH, Occleston NL, Daniels JT, Khaw PT. Antimetabolite-induced apoptosis in Tenon's capsule fibroblasts. Invest Ophthalmol Vis Sci. 1998;39(2):449-454. (Pubitemid 28093886)
6. Mietz H, Addicks K, Bloch W, Krieglstein GK. Long-term intraocular toxic effects of topical mitomycin C in rabbits. J Glaucoma. 1996;5(5):325-333. (Pubitemid 26364643)
7. Grinnell F. Fibroblasts, myofibroblasts, and wound contraction. J Cell Biol. 1994;124(4):401-404. (Pubitemid 24064453)
8. Bell E, Ivarsson B, Merrill C. Production of a tissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferative potential in vitro. Proc Natl Acad Sci U S A. 1979;76(3):1274-1278.
9. Occleston NL, Alexander RA, Mazure A, Larkin G, Khaw PT. Effects of single exposures to antiproliferative agents on ocular fibroblast-mediated collagen contraction. Invest Ophthalmol Vis Sci. 1994;35(10):3681-3690. (Pubitemid 24337981)
10. Even-Ram S, Yamada KM. Cell migration in 3D matrix. Curr Opin Cell Biol. 2005;17(5):524-532. (Pubitemid 41267167)
11. Sawhney RK, Howard J. Slow local movements of collagen fibers by fibroblasts drive the rapid global self-organization of collagen gels. J Cell Biol. 2002;157(6):1083-1091. (Pubitemid 34839782)
12. Chandran PL, Barocas VH. Microstructural mechanics of collagen gels in confined compression: poroelasticity, viscoelasticity, and collapse. J Biomech Eng. 2004;126(2):152-166. (Pubitemid 38621128)
13. Dallon JC, Ehrlich HP. A review of fibroblast-populated collagen lattices. Wound Repair Regen. 2008;16(4):472-479. (Pubitemid 352000311)
14. Dahlmann-Noor AH, Martin-Martin B, Eastwood M, Khaw PT, Bailly M. Dynamic protrusive cell behaviour generates force and drives early matrix contraction by fibroblasts. Exp Cell Res. 2007;313(20):4158-4169. (Pubitemid 350087046)
15. Cordeiro MF, Bhattacharya SS, Schultz GS, Khaw PT. TGF-β1, -β2, and -β3 in vitro: biphasic effects on Tenon's fibroblast contraction, proliferation, and migration. Invest Ophthalmol Vis Sci. 2000;41(3):756-763. (Pubitemid 30158886)
16. Daniels JT, Cambrey AD, Occleston NL, et al. Matrix metalloproteinase inhibition modulates fibroblast-mediated matrix contraction and collagen production in vitro. Invest Ophthalmol Vis Sci. 2003;44(3):1104-1110. (Pubitemid 36297828)
17. Mead AL, Wong TT, Cordeiro MF, Anderson IK, Khaw PT. Evaluation of anti-TGF-β2 antibody as a new postoperative anti-scarring agent in glaucoma surgery. Invest Ophthalmol Vis Sci. 2003;44(8):3394-3401. (Pubitemid 36909776)
18. Cordeiro MF, Gay JA, Khaw PT. Human anti-transforming growth factor-β2 antibody: a new glaucoma anti-scarring agent. Invest Ophthalmol Vis Sci. 1999;40(10):2225-2234. (Pubitemid 29418376)
19. 2) monoclonal antibody (CAT-152) to prevent scarring after first-time trabeculectomy. Ophthalmology. 2007;114(10):1822-1830.
20. Vanni S, Lagerholm BC, Otey C, Taylor DL, Lanni F. Internet-based image analysis quantifies contractile behavior of individual fibroblasts inside model tissue. Biophys J. 2003;84(4):2715-2727. (Pubitemid 36373592)
21. Theodossiou TA, Thrasivoulou C, Ekwobi C, Becker DL. Second harmonic generation confocal microscopy of collagen type I from rat tendon cryosections. Biophys J. 2006;91(12):4665-4677. (Pubitemid 44904251)
22. Wong TT, Mead AL, Khaw PT. Matrix metalloproteinase inhibition modulates postoperative scarring after experimental glaucoma filtration surgery. Invest Ophthalmol Vis Sci. 2003;44(3):1097-1103. (Pubitemid 36297827)
23. Meshel AS, Wei Q, Adelstein RS, Sheetz MP. Basic mechanism of three-dimensional collagen fibre transport by fibroblasts. Nat Cell Biol. 2005;7(2):157-164. (Pubitemid 40268130)
24. Sawhney RK, Howard J. Molecular dissection of the fibroblast-traction machinery. Cell Motil Cytoskeleton. 2004;58(3):175-185. (Pubitemid 38849955)
25. Ravanti L, Kähäri VM. Matrix metalloproteinases in wound repair [review]. Int J Mol Med. 2000;6(4):391-407.
26. Wong TT, Sethi C, Daniels JT, Limb GA, Murphy G, Khaw PT. Matrix metalloproteinases in disease and repair processes in the anterior segment. Surv Ophthalmol. 2002;47(3):239-256. (Pubitemid 34575357)
27. Wong TT, Mead AL, Khaw PT. Prolonged antiscarring effects of ilomastat and MMC after experimental glaucoma filtration surgery. Invest Ophthalmol Vis Sci. 2005;46(6):2018-2022.
28. Nicoli S, Ferrari G, Quarta M, et al. Porcine sclera as a model of human sclera for in vitro transport experiments: histology, SEM, and comparative permeability. Mol Vis. 2009;15:259-266.
29. Turner HC, Alvarez LJ, Candia OA, Bernstein AM. Characterization of serotonergic receptors in rabbit, porcine and human conjunctivae. Curr Eye Res. 2003;27(4):205-215. (Pubitemid 37315479)