Characterization of serotonergic receptors in rabbit, porcine and human conjunctivae

Current Eye Research

Volumn 27, Issue 4, 2003, Pages 205-215

  Turner, Helen C ^a   Alvarez, Lawrence J ^a   Candia, Oscar A ^a   Bernstein, Audrey M ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Conjunctival epithelium; Immunofluorescence; RT PCR; Serotonin receptors; Short circuit current

Indexed keywords

ADENYLATE CYCLASE; MESSENGER RNA; RECEPTOR SUBTYPE; SEROTONIN 1B RECEPTOR; SEROTONIN 1D RECEPTOR; SEROTONIN 1F RECEPTOR; SEROTONIN 4 RECEPTOR; SEROTONIN 7 RECEPTOR; SEROTONIN RECEPTOR;

ANIMAL TISSUE; ARTICLE; CONJUNCTIVA; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RABBIT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SHORT CIRCUIT CURRENT; SPECIES COMPARISON; SPECIES DIFFERENCE; SWINE; TISSUE DISTRIBUTION;

ADENYLATE CYCLASE; ANIMALS; CONJUNCTIVA; ELECTROPHYSIOLOGY; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; IMMUNOHISTOCHEMISTRY; PROTEIN ISOFORMS; RABBITS; RECEPTORS, SEROTONIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SWINE;

EID: 0142231546     PISSN: 02713683     EISSN: None     Source Type: Journal    
DOI: 10.1076/ceyr.27.4.205.16600     Document Type: Article

References (30)

1. Wei ZG, Sun TT, Lavker RM. Rabbit conjunctival and corneal epithelial cells belong to two separate lineages. Invest Ophthalmol Vis Sci. 1996;37:523-533.
2. Turner HC, Alvarez LJ, Bildin VN, Candia OA. Immunolocalization of Na-K-ATPase, Na-K-Cl and Na-glucose cotransporters in the conjunctival epithelium. Curr Eye Res. 2000;21:843-850.
3. Turner HC, Alvarez LJ, Candia OA. Identification and localization of acid-base transporters in the conjunctival epithelium. Exp Eye Res. 2001;72:519-531.
4. Turner HC, Bernstein A, Candia OA. Presence of CFTR in the conjunctival epithelium. Curr Eye Res. 2002;24:182-187.
5. Kompella UB, Kim KJ, Lee VH. Active chloride transport in the pigmented rabbit conjunctiva. Curr Eye Res. 1993; 12:1041-1048.
6. Shi XP, Candia OA. Active sodium and chloride transport across the isolated rabbit conjunctiva. Curr Eye Res. 1995;14:927-935.
7. Alvarez LJ, Turner HC, Zamudio AC, Candia OA. Serotonin-elicited inhibition of Cl-secretion in the rabbit conjunctival epithelium. Am J Physiol Cell Physiol. 2001;280:C581-C592.
8. Hoyer D, Clarke DE, Fozard JR, Hartig PR, Martin GR, Mylecharane EJ, Saxena PR, Humphrey PP. International union of pharmacology classification of receptors for 5-Hydroxytrypamine (serotonin). Pharm Rev. 1994;46:157-203.
9. Gerhardt CC, van Heerikhuizen H. Functional characteristics of heterologously expressed 5-HT receptors. Eur J Pharmacol. 1997;334:1-23.
10. Hoyer D, Hannon JP, Martin GR. Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacol Biochem Behav. 2002;71:533-554.
11. Kilpatrick GJ, Dautzenberg FM, Martin GR, Eglen RM. 7TM receptors: The splicing on the cake. Trends Pharmacol Sci. 1999;20:294-301.
12. Krobert KA, Bach T, Syversveen T, Kvingedal AM, Levy FO. The cloned human 5-HT7 receptor splice variants: A comparative characterization of their pharmacology, function and distribution. Naunyn Schmiedebergs Arch Pharmacol. 2001;363:620-632.
13. Bach T, Syversveen T, Kvingedal AM, Krobert KA, Brattelid T, Kaumann AJ, Levy FO. 5HT4(a) and 5-HT4(b) receptors have nearly identical pharmacology and are both expressed in human atrium and ventricle. Naunyn Schmiedebergs Arch Pharmacol. 2001;363:146-160.
14. Pootanakit K, Brunken WJ. 5-HT(1A) and 5-HT(7) receptor expression in the mammalian retina. Brain Res. 2000;875:152-156.
15. Chidlow G, Le Corre S, Osborne NN. Localization of 5-hydroxytryptamine1 A and 5-hydroxytryptamine7 receptors in rabbit ocular and brain tissues. Neuroscience. 1998;87: 675-689.
16. Hinton JM, Adams D, Garland CJ. 5-Hdroxytryptamine stimulation of phospholipase D activity in the rabbit isolated mesenteric artery. Brit J Pharmacol. 1999;126:1601-1608.
17. Miyata K, Simokawa H, Higo T, Yamawaki T, Katsumata N, Kandabashi T, Tanaka E, Takamura Y, Yogo K, Egashira K, Takeshita A. Sarpogrelate, a selective 5-HT2A serotonergic receptor antagonist, inhibits serotonin-induced coronary artery spasm in a porcine model. J Cardiovasc Pharm. 2000;35:294-301.
18. Nilsson T, Longmore J, Shaw D, Olesen IJ, Edvinsson L. Contractile 5-HT1B receptors in human cerebral arteries: Pharmacological characterization and localization with immunocytochemistry. Br J Pharmacol. 1999;128:1133-1140.
19. Ullmer C, Schmuck K, Kalkman HO, Lubbert H. Expression of serotonin receptor mRNAs in blood vessels. FEBS Lett. 1995;370:215-221.
20. Turner HC, Alvarez LJ, Candia OA. Cyclic AMP-dependent stimulation of basolateral K+ conductance in the rabbit conjunctival epithelium. Exp Eye Res. 2000;70:295-305.
21. 2-adrenergic receptors in Cl- transport across frog corneal epithelium. Am J Physiol Cell Physiol. 1988;255:C724-C730.
22. Li Y, Kuang K, Yerxa B, Wen Q, Rosskothen H, Fischbarg J. Rabbit conjunctival epithelium transports fluid, and P2Y2(2) receptor agonists stimulate Cl- and fluid secretion. Am J Physiol Cell Physiol. 2001;281:C595-C602.
23. Shiue MH, Kulkarni AA, Gukasyan HJ, Swisher JB, Kim KJ, Lee VH. Pharmacological modulation of fluid secretion in the pigmented rabbit conjunctiva. Life Sci. 2000;66:105-111.
24. Zamudio AC, Candia OA. Epinephrine stimulates fluid secretion across the isolated conjunctiva. Invest Ophthalmol Vis Sci. 2001;42:S501 (Abstract).
25. Duncan G, Collison DJ. Calcium signalling in ocular tissues: Functional activity of G-protein and tyrosine-kinase coupled receptors. Exp Eye Res. 2002;75:377-389.
26. Verdugo P. Goblet cells secretion and mucogenesis. Annu Rev Physiol. 1990;52:157-176.
27. Dartt DA. Regulation of mucin and fluid secretion by conjunctival epithelial cells. Prog Ret Eye Res. 2002;21: 555-576.
28. Kessler TL, Dartt DA. Neural stimulation of conjunctival goblet cell mucous secretion in rats. Adv Exp Med Biol. 1994;350:393-398.
29. Stefulj J, Jernej B, Cicin-Sain L, Rinner I, Schauenstein K. mRNA expression of serotonin receptors in cells of the immune tissues of the rat. Brain Behav Immun. 2000;14: 219-224.
30. Barnett NL, Osborne NN. The presence of serotonin (5-HT1) receptors negatively coupled to adenylate cyclase in rabbit and human iris-ciliary processes. Exp Eye Res. 1993;57(2):209-216.