Real time ammonia detection in exhaled human breath using a distributed feedback quantum cascade laser based sensor

Proceedings of SPIE - The International Society for Optical Engineering

Volumn 7945, Issue , 2011, Pages

  Lewicki, Rafał ^a   Kosterev, Anatoliy A ^a   Thomazy, David M ^a   Risby, Terence H ^b   Solga, Steven ^c   Schwartz, Timothy B ^c   Tittel, Frank K ^a  

^a Rice University   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^c ST LUKE S HOSPITAL   (United States)

Author keywords

distributed feedback quantum cascade laser; Quartz enhanced photoacoustic spectroscopy; trace gas ammonia detection; wavelength modulation

Indexed keywords

ABSORPTION LINES; AMMONIA DETECTION; BREATH ANALYSIS; CONCENTRATION MEASUREMENT; CONTINUOUS WAVE; DISTRIBUTED FEEDBACK; DISTRIBUTED FEEDBACK QUANTUM CASCADE LASER; GAS CELL; GAS EXCHANGE; HUMAN BREATH; KIDNEY DISORDERS; MINIMUM DETECTABLE CONCENTRATIONS; NON-INVASIVE; OPTICAL POWER; QUANTITATIVE DETECTION; QUANTUM CASCADES; QUARTZ ENHANCED PHOTOACOUSTIC SPECTROSCOPY; QUARTZ-ENHANCED PHOTOACOUSTIC SPECTROSCOPIES; REAL TIME; RESEARCH CENTER; SENSOR PLATFORM; THERMOELECTRICALLY-COOLED; TIME RESOLUTION; TRACE GAS; WAVELENGTH MODULATION;

NANOPHOTONICS; PHOTOACOUSTIC EFFECT; PHOTOACOUSTIC SPECTROSCOPY; QUANTUM CASCADE LASERS; QUARTZ; SENSORS;

AMMONIA;

EID: 79955757488     PISSN: 0277786X     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1117/12.874887     Document Type: Conference Paper

References (17)

1. Dweik, R. A., Amann, A., "Exhaled breath analysis: the new frontier in medical testing", Journal of Breath Research 2 (2008)
2. Risby, T. H., Solga, S. F., "Current status of clinical breath analysis", Applied Physics B: Lasers and Optics 85, 421-26 (2006) (Pubitemid 44451363)
3. Risby, T., Tittel, F. K., "Current Status of Mid-Infrared Quantum and Interband Cascade Lasers for Clinical Breath Analysis", Optical Engineering 49, 000000-1 (2010)
4. Phillips, M., "Breath tests in medicine", Scientific American 267, 74-79 (1992) (Pubitemid 23236501)
5. Duveen, D. I., Klickstein, H. S., "Antoine Laurent Lavoisier's contributions to medicine and public health", Bulletin of the History of Medicine 29, 164-79 (1955)
6. Frank Kneepkens, C. M., Lepage, G., Roy, C. C., "The potential of the hydrocarbon breath test as a measure of lipid peroxidation", Free Radical Biology and Medicine 17, 127-60 (1994) (Pubitemid 24217183)
7. Phillips, M., Greenberg, J., "Method for the collection and analysis of volatile compounds in the breath", Journal of Chromatography B: Biomedical Sciences and Applications 564, 242-49 (1991)
8. Cheng, W.-H., Lee, W.-J., "Technology development in breath microanalysis for clinical diagnosis", Journal of Laboratory and Clinical Medicine 133, 218-28 (1999) (Pubitemid 29112083)
9. Westhoff, M., Litterst, P., Freitag, L., Urfer, W., Bader, S., Baumbach, J.-I., "Ion mobility spectrometry for the detection of volatile organic compounds in exhaled breath of patients with lung cancer: results of a pilot study", Thorax 64, 744-48 (2009)
10. Smith, D., Španěl, P., "Selected ion flow tube mass spectrometry (SIFT-MS) for on-line trace gas analysis", Mass Spectrometry Reviews 24, 661-700 (2005) (Pubitemid 41615714)
11. McCurdy, M. R., Bakhirkin, Y., Wysocki, G., Tittel, F. K., "Performance of an exhaled nitric oxide and carbon dioxide sensor using quantum cascade laser-based integrated cavity output spectroscopy", Journal of Biomedical Optics, 12 (2007)
12. Roller, C. B., Holland, B. P., McMillen, G., Step, D. L., Krehbiel, C. R., Namjou, K., McCann, P. J., "Measurement of exhaled nitric oxide in beef cattle using tunable diode laser absorption spectroscopy", Appl. Opt. 46, 1333-42 (2007) (Pubitemid 46515990)
13. Mürtz, M., Hering, P., "Online Monitoring of Exhaled Breath Using Mid-Infrared Laser Spectroscopy", Mid-Infrared Coherent Sources and Applications, Springer Netherlands, 535-55 (2008)
14. Wang, C., Sahay, P., "Breath Analysis Using Laser Spectroscopic Techniques: Breath Biomarkers, Spectral Fingerprints, and Detection Limits", Sensors 9, 8230-62 (2009)
15. Kosterev, A. A., Bakhirkin, Y. A., Curl, R. F., Tittel, F. K., "Quartz-enhanced photoacoustic spectroscopy", Opt. Lett. 27, 1902-04 (2002)
16. Kosterev, A. A., Tittel, F. K., "Ammonia Detection by Use of Quartz-Enhanced Photoacoustic Spectroscopy with a Near-IR Telecommunication Diode Laser", Appl. Opt. 43, 6213-17 (2004)
17. Dong, L., Kosterev, A., Thomazy, D., Tittel, F., "QEPAS spectrophones: design, optimization, and performance", Applied Physics B: Lasers and Optics 100, 627-35 (2010)