Role of the Hypocretin (Orexin) Receptor 2 (Hcrt-r2) in the Regulation of Hypocretin Level and Cataplexy

Journal of Neuroscience

Volumn 31, Issue 17, 2011, Pages 6305-6310

  Wu, Ming Fung ^a   Nienhuis, Robert ^a   Maidment, Nigel ^b   Lam, Hoa A ^b   Siegel, Jerome M ^a,b  

^a Neurobiology Research (151A3)   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; LABETALOL; METHAMPHETAMINE; NORADRENALIN; OREXIN; OREXIN 2 RECEPTOR; PHENYLEPHRINE; PHYSOSTIGMINE; PRAZOSIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE; CATAPLEXY; CONTROLLED STUDY; DOG; FEEDBACK SYSTEM; FEMALE; HEART RATE; MALE; MUTANT; NARCOLEPSY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CEREBROSPINAL FLUID LEVEL; PROTEIN FUNCTION;

ANIMALS; BLOOD PRESSURE; CATAPLEXY; CHOLINESTERASE INHIBITORS; DISEASE MODELS, ANIMAL; DOGS; FEMALE; GENE EXPRESSION REGULATION; HEART RATE; HYPNOTICS AND SEDATIVES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MUTATION; NEUROPEPTIDES; PHENYLEPHRINE; PHYSOSTIGMINE; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROPEPTIDE; RESPIRATION; SYMPATHOMIMETICS; THIOPENTAL;

EID: 79955748389     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0365-11.2011     Document Type: Article

References (43)

1. Aldrich MS, Hollingsworth Z, Penney JB (1993) Autoradiographic studies of post-mortem human narcoleptic brain. Neurophysiol Clin 23:35-45.
2. Brisbare-Roch C, Dingemanse J, Koberstein R, Hoever P, Aissaoui H, Flores S, Mueller C, Nayler O, van Gerven J, de Haas SL, Hess P, Qiu C, Buch-mann S, Scherz M, Weller T, Fischli W, Clozel M, Jenck F (2007) Promotion of sleep by targeting the orexin system in rats, dogs and humans. Nat Med 13:150-155.
3. Burlet S, Tyler CJ, Leonard CS (2002) Direct and indirect excitation of lat-erodorsalteg mental neurons by hypocretin/orexin peptides: implications for wakefulness and narcolepsy. J Neurosci 22:2862-2872.
4. Carter ME, Yizhar O, Chikahisa S, Nguyen H, Adamantidis A, Nishino S, Deisseroth K, de Lecea L (2010) Tuning arousal with optogenetic modulation of locus ceruleusneurons. Nat Neurosci 13:1526-1533.
5. Chemelli RM, Willie JT, Sinton CM, Elmquist JK, Scammell T, Lee C, Richardson JA, Williams SC, Xiong Y, Kisanuki Y, Fitch TE, Nakazato M, Hammer RE, Saper CB, Yanagisawa M (1999) Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 98:437-451.
6. Deadwyler SA, Porrino L, Siegel JM, Hampson RE (2007) Systemic and nasal delivery of orexin-A (hypocretin-1) reduces the effects of sleep deprivation on cognitive performance in nonhuman primates. J Neurosci 27:14239-14247.
7. Fruhstorfer B, Mignot E, Bowersox S, Nishino S, Dement WC, Guil-leminault C (1989) Canine narcolepsy is associated with an elevated number of alpha-2 receptors in the locus coeruleus. Brain Res 500:209-214.
8. Gerashchenko D, Murillo-Rodriguez E, Lin L, Xu M, Hallett L, Nishino S, Mignot E, Shiromani PJ (2003) Relationship between CSF hypocre-tin levels and hypocretin neuronal loss. Exp Neurol 184:1010-1016.
9. John J, Wu MF, Siegel JM (2000) Systemic administration of hypocretin-1 reduces cataplexy and normalizes sleep and waking durations in narco-leptic dogs. Sleep Res Online 3:23-28.
10. John J, Wu MF, Boehmer LN, Siegel JM (2004a) Cataplexy-active neurons in the posterior hypothalamus: implications for the role of histamine in sleep and waking behavior. Neuron 42:619-634.
11. John J, Wu MF, Maidment NT, Lam HA, Boehmer LN, Patton M, Siegel JM (2004b) Developmental changes in CSF hypocretin-1 (orexin-A) level in normal and genetically narcoleptic doberman pinschers. J Physiol 560:587-592.
12. Kalogiannis M, Grupke SL, Potter PE, Edwards JG, Chemelli RM, Kisanuki YY, Yanagisawa M, Leonard CS (2010) Narcoleptic orexin receptor knockout mice express enhanced cholinergic properties in laterodorsal tegmental neurons. Eur J Neurosci 32:130-142.
13. Kilduff TS, Bowersox SS, Kaitin KI, Baker TL, Ciaranello RD, Dement WC (1986) Muscarinic cholinergic receptors and the canine model of narcolepsy. Sleep 9:102-106.
14. Kuwaki T, Zhang W, Nakamura A, Deng BS (2008) Emotional and state-dependent modification of cardiorespiratory function: role of orexinergic neurons. Auton Neurosci 142:11-16.
15. Lai YY, Siegel JM, Wilson WJ (1987) Effect of blood pressure on changes inmuscle tone produced by stimulation of the medial medulla. Am J Physiol 252:H1249-H1257.
16. Li Y, Gao XB, Sakurai T, van den Pol AN (2002) Hypocretin/orexin excites hypocretin neurons via a local glutamate neuron; a potential mechanism for orchestrating the hypothalamic arousal system. Neuron 36:1169-1181.
17. Lin L, Faraco J, Li R, Kadotani H, Rogers W, Lin X, Qiu X, de Jong PJ, Nishino S, Mignot E (1999) The REM sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor gene. Cell 98:365-376.
18. Luppi PH, Aston-Jones G, Akaoka H, Chouvet G, Jouvet M (1995) Afferent projections to the rat locus coeruleus demonstrated by retrograde and anterograde tracing with cholera-toxin B subunit and Phaseolus vulgaris leucoagglutinin. Neuroscience 65:119-160.
19. Maidment NT, Evans CJ (1991) Measurement of extra cellular neuropeptides in the brain: microdialysis linked to solid phase radio immunoassays with sub femtomole limits of detection. In: Microdialysis in the neurosciences (Robinson TE, Justice JB Jr, eds), pp 275-303. Amsterdam: Elsevier.
20. McGregor R, Siegel JM (2010) Illuminating the locus coeruleus: control of posture and arousal. Nat Neurosci 13:1448-1449.
21. Mefford IN, Baker TL, Boehme R, Foutz AS, Ciaranello RD, Barchas JD, Dement WC (1983) Narcolepsy: biogenic amine deficits in an animal model. Science 220:629-632.
22. Mieda M, Willie JT, Hara J, Sinton CM, Sakurai T, Yanagisawa M (2004) Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice. Proc Natl Acad Sci USA 101:4649-4654.
23. Mignot E, Nishino S, Sharp LH, Arrigoni J, Siegel JM, Reid MS, Edgar DM, Ciaranello RD, DementWC (1993) Heterozygosityatthe canarc-1 locus can confer susceptibility for narcolepsy: Induction of cataplexy in heterozygous asymptomatic dogs after administration of a combination of drugs acting on monoaminergic and cholinergic systems. J Neurosci 13:1057-1064.
24. Mileykovskiy BY, Kiyashchenko LI, Kodama T, Lai YY, Siegel JM (2000) Activation of pontine and medullary motor inhibitory regions reduces discharge in neurons located in the locus coeruleus and the anatomical equivalent of the midbrain locomotor region. J Neurosci 20:8551-8558.
25. Mileykovskiy BY, Kiyashchenko LI, Siegel JM (2005) Behavioral correlates of activity in identified hypocretin/orexin neurons. Neuron 46:787-798.
26. Mishima K, Fujiki N, Yoshida Y, Sakurai T, Honda M, Mignot E, Nishino S (2008) Hypocretin receptor expression in canine and murine narcolepsy models and in hypocretin-ligand deficient human narcolepsy. Sleep 31:1119-1126.
27. Mori T, Ito S, Kuwaki T, Yanagisawa M, Sakurai T, Sawaguchi T (2010) Monoaminergic neuronal changes in orexin deficient mice. Neurophar-macology 58:826-832.
28. Nishino S, Mignot E (1997) Pharmacological aspects of human and canine narcolepsy. Prog Neurobiol 52:27-78.
29. Nishino S, Sagawa Y (2010) The neurochemistry of awakening: Findings from sleep disorder narcolepsy. In: International review of neurobiology science of awakening (Angela Clow and Lisa Thorn, eds), pp 229-255. New York: Academic.
30. Nishino S, Reid MS, Dement W, Mignot E (1994) Neuropharmacology and neurochemistry of canine narcolepsy. Sleep 17 [8 Suppl]:S84-S92.
31. Nishino S, Ripley B, Overeem S, Lammers GJ, Mignot E (2000) Hypocretin (orexin) deficiency in human narcolepsy. Lancet 355:39-40.
32. Nitz D, Andersen A, Fahringer H, Nienhuis R, Mignot E, Siegel J (1995) Altered distribution of cholinergic cells in the narcoleptic dog. Neurore-port 6:1521-1524.
33. Peyron C, Faraco J, Rogers W, Ripley B, Overeem S, Charnay Y, Nevsimalova S, Aldrich M, Reynolds D, Albin R, Li R, Hungs M, Pedrazzoli M, Padi-garu M, Kucherlapati M, Fan J, Maki R, Lammers GJ, Bouras C, Kucher-lapati R, et al (2000) A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat Med 6:991-997.
34. Siegel JM, Fahringer H, Tomaszewski KS, Kaitin K, Kilduff T, Dement WC (1986) Heart rate and blood pressure changes associated with cataplexy in canine narcolepsy. Sleep 9:216-221.
35. Siegel JM, Tomaszewski KS, Fahringer H, Cave G, Kilduff T, Dement WC (1989) Heart rate and blood pressure changes during sleep-waking cycles and cataplexy in narcoleptic dogs. Am J Physiol 256:H111-H119.
36. Siegel JM, Nienhuis R, Fahringer HM, Paul R, Shiromani P, Dement WC, Mignot E, Chiu C (1991) Neuronal activity in narcolepsy: identification of cataplexy related cells in the medial medulla. Science 252:1315-1318.
37. Siegel JM, Nienhuis R, Gulyani S, Ouyang S, Wu MF, Mignot E, Switzer RC, McMurry G, Cornford M (1999) Neuronal degeneration in canine narcolepsy. J Neurosci 19:248-257.
38. Tafti M, Nishino S, Liao W, Dement WC, Mignot E (1997) Mesopontine organization of cholinergic and catecholaminergic cell groups in the normal and narcoleptic dog. J Comp Neurol 379:185-197.
39. Thannickal TC, Nienhuis R, Ramanathan L, Gulyani S, Turner K, Chestnut B, Siegel JM. (2000a) Preservation of hypocretin neurons in genetically narcoleptic dogs. Sleep 23:A296.
40. Thannickal TC, Moore RY, Nienhuis R, Ramanathan L, Gulyani S, Aldrich M, Cornford M, Siegel JM (2000b) Reduced number of hypocretin neurons in human narcolepsy. Neuron 27:469-474.
41. Wu MF, Gulyani SA, Yau E, Mignot E, Phan B, Siegel JM (1999) Locus coeruleus neurons: cessation of activity during cataplexy. Neuroscience 91:1389-1399.
42. Yamanaka A, Muraki Y, Tsujino N, Goto K, Sakurai T (2003) Regulation of orexin neurons by the mono aminergic and cholinergic systems. Biochem Biophys Res Commun 303:120-129.
43. Yamanaka A, Tabuchi S, Tsunematsu T, Fukazawa Y, Tominaga M (2010) Orexin directly excites orexin neurons through orexin 2 receptor. J Neu-rosci 30:12642-12652.