Increased CD36 expression in middle-aged mice contributes to obesity-related cardiac hypertrophy in the absence of cardiac dysfunction

Journal of Molecular Medicine

Volumn 89, Issue 5, 2011, Pages 459-469

  Sung, Miranda M Y ^a   Koonen, Debby P Y ^b   Soltys, Carrie Lynn M ^a   Jacobs, René L ^a   Febbraio, Maria ^c   Dyck, Jason R B ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^c LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Aging; Cardiac hypertrophy; Molecular biology; Signal transduction

Indexed keywords

CD36 ANTIGEN; CERAMIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HEART DISEASE; HEART VENTRICLE HYPERTROPHY; LIPID DIET; LOW FAT DIET; MALE; MOUSE; NONHUMAN; OBESITY; PROTEIN EXPRESSION; PROTEIN SYNTHESIS;

AGING; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANTIGENS, CD36; CARDIOMEGALY; CARDIOMYOPATHIES; DIETARY FATS; IMMUNOBLOTTING; MALE; MICE; OBESITY;

EID: 79955721448     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-010-0720-4     Document Type: Article

References (37)

1. NM Borradaile JE Schaffer 2005 Lipotoxicity in the heart Curr Hypertens Rep 7 412 417 16386196 10.1007/s11906-005-0035-y 1:CAS:528:DC%2BD28XhtFaiurY%3D (Pubitemid 43136936)
2. T Park Y Hu H Noh K Drosatos K Okajima J Buchanan J Tuinei S Homma X Jiang E Dale I Goldberg 2008 Ceramide is a cardiotoxin in lipotoxic cardiomyopathy J Lipid Res 49 2101 2112 18515784 10.1194/jlr.M800147-JLR200 1:CAS:528:DC%2BD1cXhtF2jt7bO
3. YT Zhou P Grayburn A Karim M Shimabukuro M Higa D Baetens L Orci RH Unger 2000 Lipotoxic heart disease in obese rats: implications for human obesity Proc Natl Acad Sci USA 97 1784 1789 10677535 10.1073/pnas.97.4.1784 1:CAS:528:DC%2BD3cXhsFCrt7Y%3D (Pubitemid 30118520)
4. HC Chiu A Kovacs DA Ford FF Hsu R Garcia P Herrero JE Saffitz JE Schaffer 2001 A novel mouse model of lipotoxic cardiomyopathy J Clin Invest 107 813 822 11285300 10.1172/JCI10947 1:CAS:528:DC%2BD3MXisFWhsbc%3D (Pubitemid 32274034)
5. J Yang N Sambandam X Han RW Gross M Courtois A Kovacs M Febbraio BN Finck DP Kelly 2007 CD36 deficiency rescues lipotoxic cardiomyopathy Circ Res 100 1208 1217 17363697 10.1161/01.RES.0000264104.25265.b6 1:CAS:528: DC%2BD2sXktlOhs7s%3D (Pubitemid 46684134)
6. L Cheng G Ding Q Qin Y Huang W Lewis N He RM Evans MD Schneider FA Brako Y Xiao YE Chen Q Yang 2004 Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy Nat Med 10 1245 1250 15475963 10.1038/nm1116 1:CAS:528:DC%2BD2cXptVOgsbo%3D (Pubitemid 39540443)
7. JF Glatz JJ Luiken A Bonen 2010 Membrane fatty acid transporters as regulators of lipid metabolism: implications for metabolic disease Physiol Rev 90 367 417 20086080 10.1152/physrev.00003.2009 1:CAS:528:DC%2BC3cXitFGgsLY%3D
8. SL Menard E Croteau O Sarrhini R Gelinas P Brassard R Ouellet M Bentourkia JE van Lier C Des Rosiers R Lecomte AC Carpentier 2010 Abnormal in vivo myocardial energy substrate uptake in diet-induced type 2 diabetic cardiomyopathy in rats Am J Physiol Endocrinol Metab 298 E1049 1057 20159856 10.1152/ajpendo.00560.2009 1:CAS:528:DC%2BC3cXmtlWjt70%3D
9. DE Greenwalt SH Scheck T Rhinehart-Jones 1995 Heart CD36 expression is increased in murine models of diabetes and in mice fed a high fat diet J Clin Invest 96 1382 1388 7544802 10.1172/JCI118173 1:CAS:528:DyaK2MXnvVGqtL0%3D
10. DM Ouwens M Diamant M Fodor DD Habets MM Pelsers M El Hasnaoui ZC Dang CE van den Brom R Vlasblom A Rietdijk C Boer SL Coort JF Glatz JJ Luiken 2007 Cardiac contractile dysfunction in insulin-resistant rats fed a high-fat diet is associated with elevated CD36-mediated fatty acid uptake and esterification Diabetologia 50 1938 1948 17639306 10.1007/s00125-007-0735-8 1:CAS:528:DC%2BD2sXos1Cjt7w%3D (Pubitemid 47222854)
11. DP Koonen M Febbraio S Bonnet J Nagendran ME Young ED Michelakis JR Dyck 2007 CD36 expression contributes to age-induced cardiomyopathy in mice Circulation 116 2139 2147 17967771 10.1161/CIRCULATIONAHA.107.712901 1:CAS:528:DC%2BD2sXht1elsrnM (Pubitemid 350060351)
12. CC Preston AS Oberlin EL Holmuhamedov A Gupta S Sagar RH Syed SA Siddiqui S Raghavakaimal A Terzic A Jahangir 2008 Aging-induced alterations in gene transcripts and functional activity of mitochondrial oxidative phosphorylation complexes in the heart Mech Ageing Dev 129 304 312 18400259 10.1016/j.mad.2008. 02.010 1:CAS:528:DC%2BD1cXmtVSgtLw%3D
13. M Febbraio NA Abumrad DP Hajjar K Sharma W Cheng SF Pearce RL Silverstein 1999 A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism J Biol Chem 274 19055 19062 10383407 10.1074/jbc.274.27.19055 1:CAS:528:DyaK1MXksVWlsbY%3D (Pubitemid 29314101)
14. JR Dyck TA Hopkins S Bonnet ED Michelakis ME Young M Watanabe Y Kawase K Jishage GD Lopaschuk 2006 Absence of malonyl coenzyme A decarboxylase in mice increases cardiac glucose oxidation and protects the heart from ischemic injury Circulation 114 1721 1728 17030679 10.1161/CIRCULATIONAHA.106.642009 1:CAS:528:DC%2BD28XhtVKrt7vI (Pubitemid 44607120)
15. V Bodart M Febbraio A Demers N McNicoll P Pohankova A Perreault T Sejlitz E Escher RL Silverstein D Lamontagne H Ong 2002 CD36 mediates the cardiovascular action of growth hormone-releasing peptides in the heart Circ Res 90 844 849 11988484 10.1161/01.RES.0000016164.02525.B4 1:CAS:528: DC%2BD38XjslWntbs%3D (Pubitemid 34633875)
16. RL Jacobs C Devlin I Tabas DE Vance 2004 Targeted deletion of hepatic CTP:phosphocholine cytidylyltransferase alpha in mice decreases plasma high density and very low density lipoproteins J Biol Chem 279 47402 47410 15331603 10.1074/jbc.M404027200 1:CAS:528:DC%2BD2cXptFejtLg%3D (Pubitemid 39518397)
17. MJ Riedel I Baczko GJ Searle N Webster M Fercho L Jones J Lang J Lytton JR Dyck PE Light 2006 Metabolic regulation of sodium-calcium exchange by intracellular acyl CoAs EMBO J 25 4605 4614 16977318 10.1038/sj.emboj.7601321 1:CAS:528:DC%2BD28XhtVans73F (Pubitemid 44498133)
18. AC Nicholson M Febbraio J Han RL Silverstein DP Hajjar 2000 CD36 in atherosclerosis. The role of a class B macrophage scavenger receptor Ann N Y Acad Sci 902 128 131 10865832 10.1111/j.1749-6632.2000.tb06307.x 1:CAS:528:DC%2BD3cXksFSlu7Y%3D discussion 131-123
19. JR Goudriaan VE Dahlmans B Teusink DM Ouwens M Febbraio JA Maassen JA Romijn LM Havekes PJ Voshol 2003 CD36 deficiency increases insulin sensitivity in muscle, but induces insulin resistance in the liver in mice J Lipid Res 44 2270 2277 12923231 10.1194/jlr.M300143-JLR200 1:CAS:528:DC%2BD2cXmsVymtg%3D%3D (Pubitemid 38082485)
20. AY Chan CL Soltys ME Young CG Proud JR Dyck 2004 Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte J Biol Chem 279 32771 32779 15159410 10.1074/jbc.M403528200 1:CAS:528:DC%2BD2cXmtVChtb0%3D (Pubitemid 39014736)
21. AA Noga CL Soltys AJ Barr S Kovacic GD Lopaschuk JR Dyck 2007 Expression of an active LKB1 complex in cardiac myocytes results in decreased protein synthesis associated with phenylephrine-induced hypertrophy Am J Physiol Heart Circ Physiol 292 H1460 1469 17098823 10.1152/ajpheart.01133.2006 1:CAS:528:DC%2BD2sXjsVylsbo%3D (Pubitemid 46377134)
22. AY Chan VW Dolinsky CL Soltys B Viollet S Baksh PE Light JR Dyck 2008 Resveratrol inhibits cardiac hypertrophy via AMP-activated protein kinase and Akt J Biol Chem 283 24194 24201 18562309 10.1074/jbc.M802869200 1:CAS:528:DC%2BD1cXhtVWktrjI
23. VW Dolinsky AY Chan I Robillard Frayne PE Light C Des Rosiers JR Dyck 2009 Resveratrol prevents the prohypertrophic effects of oxidative stress on LKB1 Circulation 119 1643 1652 19289642 10.1161/CIRCULATIONAHA.108.787440 1:CAS:528:DC%2BD1MXjsVKrtLs%3D
24. Y Wu P Song J Xu M Zhang MH Zou 2007 Activation of protein phosphatase 2A by palmitate inhibits AMP-activated protein kinase J Biol Chem 282 9777 9788 17255104 10.1074/jbc.M608310200 1:CAS:528:DC%2BD2sXjtlCiurs%3D (Pubitemid 47104626)
25. NA Bourbon L Sandirasegarane M Kester 2002 Ceramide-induced inhibition of Akt is mediated through protein kinase Czeta: implications for growth arrest J Biol Chem 277 3286 3292 11723139 10.1074/jbc.M110541200 1:CAS:528: DC%2BD38XhtVaksLY%3D (Pubitemid 34953194)
26. KM Schubert MP Scheid V Duronio 2000 Ceramide inhibits protein kinase B/Akt by promoting dephosphorylation of serine 473 J Biol Chem 275 13330 13335 10788440 10.1074/jbc.275.18.13330 1:CAS:528:DC%2BD3cXjtFyksb4%3D (Pubitemid 30257390)
27. SA Summers LA Garza H Zhou MJ Birnbaum 1998 Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide Mol Cell Biol 18 5457 5464 9710629 1:CAS:528: DyaK1cXls1Sgurg%3D (Pubitemid 28388128)
28. B DeBosch I Treskov TS Lupu C Weinheimer A Kovacs M Courtois AJ Muslin 2006 Akt1 is required for physiological cardiac growth Circulation 113 2097 2104 16636172 10.1161/CIRCULATIONAHA.105.595231 1:CAS:528:DC%2BD28XjslKiur0%3D
29. I Shiojima K Walsh 2006 Regulation of cardiac growth and coronary angiogenesis by the Akt/PKB signaling pathway Genes Dev 20 3347 3365 17182864 10.1101/gad.1492806 1:CAS:528:DC%2BD2sXhs1aqtA%3D%3D (Pubitemid 44969154)
30. I Shiojima M Yefremashvili Z Luo Y Kureishi A Takahashi J Tao A Rosenzweig CR Kahn ED Abel K Walsh 2002 Akt signaling mediates postnatal heart growth in response to insulin and nutritional status J Biol Chem 277 37670 37677 12163490 10.1074/jbc.M204572200 1:CAS:528:DC%2BD38XnsVejsbY%3D
31. DP Koonen MM Sung CK Kao VW Dolinsky TR Koves O Ilkayeva RL Jacobs DE Vance PE Light DM Muoio M Febbraio JR Dyck 2010 Alterations in skeletal muscle fatty acid handling predisposes middle-aged mice to diet-induced insulin resistance Diabetes 59 1366 1375 20299464 10.2337/db09-1142 1:CAS:528: DC%2BC3cXotFGktbk%3D
32. CP Liang S Han H Okamoto R Carnemolla I Tabas D Accili AR Tall 2004 Increased CD36 protein as a response to defective insulin signaling in macrophages J Clin Invest 113 764 773 14991075 1:CAS:528:DC%2BD2cXhvFOksLo%3D (Pubitemid 38544170)
33. E Griffin A Re N Hamel C Fu H Bush T McCaffrey AS Asch 2001 A link between diabetes and atherosclerosis: glucose regulates expression of CD36 at the level of translation Nat Med 7 840 846 11433350 10.1038/89969 1:CAS:528:DC%2BD3MXltVagt7g%3D (Pubitemid 32691640)
34. L Zhang JR Ussher T Oka VJ Cadete C Wagg GD Lopaschuk 2010 Cardiac diacylglycerol accumulation in high fat-fed mice is associated with impaired insulin-stimulated glucose oxidation Cardiovasc Res 89 148 156 20729341 10.1093/cvr/cvq266
35. GD Lopaschuk CD Folmes WC Stanley 2007 Cardiac energy metabolism in obesity Circ Res 101 335 347 17702980 10.1161/CIRCRESAHA.107.150417 1:CAS:528:DC%2BD2sXhtVGrurrL (Pubitemid 47267702)
36. E Aasum AM Khalid OA Gudbrandsen OJ How RK Berge TS Larsen 2008 Fenofibrate modulates cardiac and hepatic metabolism and increases ischemic tolerance in diet-induced obese mice J Mol Cell Cardiol 44 201 209 17931655 10.1016/j.yjmcc.2007.08.020 1:CAS:528:DC%2BD1cXht1yjtw%3D%3D
37. D Levy RJ Garrison DD Savage WB Kannel WP Castelli 1990 Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study N Engl J Med 322 1561 1566 2139921 10.1056/ NEJM199005313222203 1:STN:280:DyaK3c3ksFSmug%3D%3D (Pubitemid 20176696)