Time course of the angiogenic response during normotrophic and hypertrophic scar formation in humans

Wound Repair and Regeneration

Volumn 19, Issue 3, 2011, Pages 292-301

  Van Der Veer, Willem M ^a   Niessen, Frank B ^a   Ferreira, José A ^a   Zwiers, Peter J ^b   De Jong, Etty H ^c   Middelkoop, Esther ^a   Molema, Grietje ^b  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN 1; ANGIOPOIETIN 2; ANGIOPOIETIN RECEPTOR; UROKINASE; VASCULOTROPIN;

ADULT; AGED; ANGIOGENESIS; ARTICLE; CAPILLARY DENSITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; HYPERTROPHIC SCAR; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; MALE; MICROVASCULATURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCAR FORMATION; SKIN BIOPSY; STERNOTOMY; THORAX SURGERY; TIME; WOUND HEALING;

ADULT; AGED; ANGIOPOIETIN-1; ANGIOPOIETIN-2; CICATRIX, HYPERTROPHIC; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICROVESSELS; MIDDLE AGED; NEOVASCULARIZATION, PATHOLOGIC; RECEPTOR, TIE-2; TIME FACTORS; UROKINASE-TYPE PLASMINOGEN ACTIVATOR; VASCULAR ENDOTHELIAL GROWTH FACTOR A; WOUND HEALING;

EID: 79955711890     PISSN: 10671927     EISSN: 1524475X     Source Type: Journal    
DOI: 10.1111/j.1524-475X.2011.00692.x     Document Type: Article

References (38)

1. van der Veer WM, Bloemen MC, Ulrich MM, Molema G, van Zuijlen PP, Middelkoop E, Niessen FB. Potential cellular and molecular causes of hypertrophic scar formation. Burns 2009; 35: 15-29.
2. Tonnesen MG, Feng X, Clark RA. Angiogenesis in wound healing. J Investig Dermatol Symp Proc 2000; 5: 40-6. (Pubitemid 32044088)
3. Amadeu T, Braune A, Mandarim-de-Lacerda C, Porto L, Desmouliere A, Costa A. Vascularization pattern in hypertrophic scars and keloids: a stereological analysis. Pathol Res Pract 2003; 199: 469-73. (Pubitemid 37107305)
4. Niessen FB, Spauwen PH, Robinson PH, Fidler V, Kon M. The use of silicone occlusive sheeting (Sil-K) and silicone occlusive gel (Epiderm) in the prevention of hypertrophic scar formation. Plast Reconstr Surg 1998; 102: 1962-72.
5. van Meurs M, Kumpers P, Ligtenberg JJ, Meertens JH, Molema G, Zijlstra JG. Bench-to-bedside review: angiopoietin signalling in critical illness-a future target? Crit Care 2009; 13: 207.
6. Yu Q. The dynamic roles of angiopoietins in tumor angiogenesis. Future Oncol 2005; 1: 475-84.
7. Olsson A-K, Dimberg A, Kreuger J, Claesson-Welsh L. VEGF receptor signalling-in control of vascular function. Nat Rev Mol Cell Biol 2006; 7: 359-71.
8. Cesarman-Maus G, Hajjar KA. Molecular mechanisms of fibrinolysis. Br J Haematol 2005; 129: 307-21. (Pubitemid 40646889)
9. van der Veer WM, Ferreira JA, de Jong EH, Molema G, Niessen FB. Perioperative conditions affect long-term hypertrophic scar formation. Ann Plast Surg 2010; 65: 321-5.
10. Peacock EE, Madden JW, Trier WC. Biologic basis for the treatment of keloids and hypertrophic scars. South Med J 1970; 63: 755-60.
11. Zeng W, Gouw AS, van den Heuvel MC, Zwiers PJ, Zondervan PE, Poppema S, Zhang N, Platteel I, de Jong KP, Molema G. The angiogenic makeup of human hepatocellular carcinoma does not favor vascular endothelial growth factor/angiopoietin-driven sprouting neovascularization. Hepatology 2008; 48: 1517-27.
12. Fox SB, Leek RD, Weekes MP, Whitehouse RM, Gatter KC, Harris AL. Quantitation and prognostic value of breast cancer angiogenesis: comparison of microvessel density, Chalkley count, and computer image analysis. J Pathol 1995; 177: 275-83.
13. Vermeulen PB, Gasparini G, Fox SB, Colpaert C, Marson LP, Gion M, Beliën JA, de Waal RM, Van Marck E, Magnani E, Weidner N, Harris AL, Dirix LY. Second international consensus on the methodology and criteria of evaluation of angiogenesis quantification in solid human tumours. Eur J Cancer 2002; 38: 1564-79. (Pubitemid 34876495)
14. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Roy Stat Soc B Met 1995; 57: 289-300.
15. Livak K, Schmittgen T. Analysis of relative gene expression data using real-time quantitative PCR and the 2(T)(-Delta Delta C) method. Methods 2001; 25: 402-8. (Pubitemid 34164012)
16. Brown N, Smyth E, Cross S, Reed M. Angiogenesis induction and regression in human surgical wounds. Wound Repair Regen 2002; 10: 245-51. (Pubitemid 35006786)
17. Kumar I, Staton CA, Cross SS, Reed MWR, Brown NJ. Angiogenesis, vascular endothelial growth factor and its receptors in human surgical wounds. Br J Surg 2009; 96: 1484-91.
18. Nagy JA, Chang SH, Dvorak AM, Dvorak HF. Why are tumour blood vessels abnormal and why is it important to know? Br J Cancer 2009; 100: 865-9.
19. Benest AV, Augustin HG. Tension in the vasculature. Nat Med 2009; 15: 608-10.
20. Staton CA, Valluru M, Hoh L, Reed MW, Brown NJ. Angiopoietin-1, angiopoietin-2 and Tie-2 receptor expression in human dermal wound repair and scarring. Br J Dermatol 2010; 163: 920-7.
21. Fiedler U, Reiss Y, Scharpfenecker M, Grunow V, Koidl S, Thurston G, Gale NW, Witzenrath M, Rosseau S, Suttorp N, Sobke A, Herrmann M, Preissner KT, Vajkoczy P, Augustin HG. Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation. Nat Med 2006; 12: 235-9. (Pubitemid 43214752)
22. Bitto A, Minutoli L, Galeano MR, Altavilla D, Polito F, Fiumara T, Calò M, Lo Cascio P, Zentilin L, Giacca M, Squadrito F. Angiopoietin-1 gene transfer improves impaired wound healing in genetically diabetic mice without increasing VEGF expression. Clin Sci 2008; 114: 707-18. (Pubitemid 351799330)
23. Cho C-H, Sung H-K, Kim K-T, Cheon HG, Oh GT, Hong HJ, Yoo OJ, Koh GY. COMP-angiopoietin-1 promotes wound healing through enhanced angiogenesis, lymphangiogenesis, and blood flow in a diabetic mouse model. Proc Natl Acad Sci USA 2006; 103: 4946-51.
24. Galeano M, Deodato B, Altavilla D, Squadrito G, Seminara P, Marini H, Stagno d'Alcontres F, Colonna M, Calò M, Lo Cascio P, Torre V, Giacca M, Venuti FS, Squadrito F. Effect of recombinant adeno-associated virus vector-mediated vascular endothelial growth factor gene transfer on wound healing after burn injury. Crit Care Med 2003; 31: 1017-25.
25. Bao P, Kodra A, Tomic-Canic M, Golinko MS, Ehrlich HP, Brem H. The role of vascular endothelial growth factor in wound healing. J Surg Res 2009; 153: 347-58.
26. Rakic JM, Maillard C, Jost M, Bajou K, Masson V, Devy L, Lambert V, Foidart JM, Noël A. Role of plasminogen activator-plasmin system in tumor angiogenesis. Cell Mol Life Sci 2003; 60: 463-73. (Pubitemid 36459526)
27. Heymans S, Luttun A, Nuyens D, Theilmeier G, Creemers E, Moons L, Dyspersin GD, Cleutjens JP, Shipley M, Angellilo A, Levi M, Nübe O, Baker A, Keshet E, Lupu F, Herbert JM, Smits JF, Shapiro SD, Baes M, Borgers M, Collen D, Daemen MJ, Carmeliet P. Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure. Nat Med 1999; 5: 1135-42. (Pubitemid 29474417)
28. Traktuev DO, Tsokolaeva ZI, Shevelev AA, Talitskiy KA, Stepanova VV, Johnstone BH, Rahmat-Zade TM, Kapustin AN, Tkachuk VA, March KL, Parfyonova YV. Urokinase gene transfer augments angiogenesis in ischemic skeletal and myocardial muscle. Mol Ther 2007; 15: 1939-46. (Pubitemid 350011733)
29. Leake D, Doerr TD, Scott G. Expression of urokinase-type plasminogen activator and its receptor in keloids. Arch Otolaryngol Head Neck Surg 2003; 129: 1334-8. (Pubitemid 37523110)
30. Plouët J, Moro F, Bertagnolli S, Coldeboeuf N, Mazarguil H, Clamens S, Bayard F. Extracellular cleavage of the vascular endothelial growth factor 189-amino acid form by urokinase is required for its mitogenic effect. J Biol Chem 1997; 272: 13390-6. (Pubitemid 27216772)
31. Bloch W, Huggel K, Sasaki T, Grose R, Bugnon P, Addicks K, Timpl R, Werner S. The angiogenesis inhibitor endostatin impairs blood vessel maturation during wound healing. FASEB J 2000; 14: 2373-6.
32. Duan WR, Patyna S, Kuhlmann MA, Li S, Blomme EAG. A multitargeted receptor tyrosine kinase inhibitor, SU6668, does not affect the healing of cutaneous full-thickness incisional wounds in SKH-1 mice. J Invest Surg 2006; 19: 245-54. (Pubitemid 44103000)
33. Niethammer AG, Xiang R, Becker JC, Wodrich H, Pertl U, Karsten G, Eliceiri BP, Reisfeld RA. A DNA vaccine against VEGF receptor 2 prevents effective angiogenesis and inhibits tumor growth. Nat Med 2002; 8: 1369-75. (Pubitemid 36019421)
34. Roman CD, Choy H, Nanney L, Riordan C, Parman K, Johnson D, Beauchamp RD. Vascular endothelial growth factor-mediated angiogenesis inhibition and postoperative wound healing in rats. J Surg Res 2002; 105: 43-7. (Pubitemid 34713210)
35. Lange-Asschenfeldt B, Velasco P, Streit M, Hawighorst T, Pike SE, Tosato G, Delmar M. The angiogenesis inhibitor vasostatin does not impair wound healing at tumor-inhibiting doses. J Invest Dermatol 2001; 117: 1036-41. (Pubitemid 34205895)
36. Kilarski WW, Samolov B, Petersson L, Kvanta A, Gerwins P. Biomechanical regulation of blood vessel growth during tissue vascularization. Nat Med 2009; 15: 657-64.
37. Minami T, Aird WC. Endothelial cell gene regulation. Trends Cardiovasc Med 2005; 15: 174-84.
38. Molema G. Heterogeneity in endothelial responsiveness to cytokines, molecular causes, and pharmacological consequences. Semin Thromb Hemost 2010; 36: 246-64.