Prenatal and perinatal acrylamide disrupts the development of cerebellum in rat: Biochemical and morphological studies

Toxicology and Industrial Health

Volumn 27, Issue 4, 2011, Pages 291-306

  Allam, A ^a   El Ghareeb, Aa ^b   Abdul Hamid, M ^a   Baikry, A ^a   Sabri, Mi ^c  

^a Beni Suef University   (Egypt)

^b CAIRO UNIVERSITY   (Egypt)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Acrylamide; cerebellum; oxidative stress; postnatal development; Purkinje cells

Indexed keywords

ACRYLAMIDE; GLUTATHIONE; PEROXIDASE; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; THIOL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; BODY WEIGHT; BRAIN CELL; BRAIN DEVELOPMENT; CELL DIFFERENTIATION; CELL LOSS; CELL MIGRATION; CELL PROLIFERATION; CELL ULTRASTRUCTURE; CEREBELLUM; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HISTOLOGY; LACTATION; MALE; MORPHOLOGY; NEUROTOXICITY; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PERINATAL DEVELOPMENT; PRENATAL DEVELOPMENT; PURKINJE CELL; RAT; TERATOGENICITY;

ACRYLAMIDE; ADMINISTRATION, ORAL; ANIMALS; ANIMALS, NEWBORN; BEHAVIOR, ANIMAL; CELL DEATH; CELL DIFFERENTIATION; CELL MOVEMENT; CEREBELLUM; EMBRYONIC DEVELOPMENT; FEMALE; FETAL DEVELOPMENT; GLUTATHIONE; GROWTH AND DEVELOPMENT; LIPID PEROXIDATION; MALE; MATERNAL EXPOSURE; OXIDATIVE STRESS; OXIDOREDUCTASES; PREGNANCY; PURKINJE CELLS; RATS; WEIGHT GAIN;

ANIMALIA; RATTUS;

EID: 79955698389     PISSN: 07482337     EISSN: None     Source Type: Journal    
DOI: 10.1177/0748233710386412     Document Type: Article

References (85)

1. Abdul-Hamid M., Allam AA, and Hussein MB (2007) Effect of ethanol administration during gestation on the cerebral cortex and spinal cord of albino rat newborns and on the development of their sensorimotor reflexes. Egyptian Journal of Zoology, 48: 137-162.
2. Allam AA, El-Ghareeb AW, Abdul-Hamid M., Bakery AE, Gad M., and Sabri M. (2010) Effect of prenatal and perinatal acrylamide on the biochemical and morphological changes in liver of developing albino rat. Archives of Toxicology, 84(2): 129-141.
3. Altman J. (1969) Autoradiographic and histological studies of postnatal neurogenesis. III-Dating the time of production and onset of differentiation of cerebellar macro-neurons in rats. Journal of Comparative Neurology, 136: 269-294.
4. Altman J., Anderson WJ, and Wright KA (1967) Selective destruction of precursors of microneurons of the cerebellar cortex with fractional low-dose X-rays. Experimental Neurology, 17: 481-497.
5. Altman J., Winfree AT (1977) Postnatal development of the cerebellar cortex in the rat. V-spatial organization of the Purkinje cells perikarya. Journal of Comparative Neurology, 171: 1-16.
6. Awad ME, Abdel-Rahman MS, and Hassan SA (1998) Acrylamide toxicity in isolated rat hepatocytes. Toxicology, 12: 699-704.
7. Bahgat M., Abdul-Hamid M., and Allam AA (2006) Effect of ethanol ingestion on the development of cerebellar cortex neurons in albino rat. Journal of Egyptian German Society of Zoology, 50C: 137-159.
8. Bandhopadhay U., Das D., and Banerjee KR (1999) Reactive oxygen species: oxidative damage and pathogenesis. Current Science, 77: 658-665.
9. Beutler E., Duron O., and Kelly BM (1963) Improved method for determination of blood glutathione. Journal of. Laboratory and Clinical Medicine, 61: 882-888.
10. Bhadauria M., Jadon A., Sharma A., and Shukla S. (2002) Effect of propriety herbal formulation against chronic carbon tetrachloride induced hepatotoxicity. Indian Journal of Experimental Biology, 40(11): 1254-1259.
11. Bolles RC, Woods PJ (1964) The ontogeny of behavior in the albino rat. Animal Behavior, 12: 427-441.
12. Bondok AA, EL-Mohandes EA, and Uthman MA (1991) Postnatal development of the rat cerebellar cortex. Experimental delay in the normal postnatal maturation. Egyptian Journal of Histology, 14(1): 221-233.
13. Calleman CJ, Bergmark E., and Costa L. (1990) Acrylamide is metabolized to glycidamide in the rat: evidence from hemoglobin adducts formation. Chemical Research in Toxicology, 3(5): 406-412.
14. Cavanagh JB, Gysbers MF (1983) Ultrastructural features of the Purkinje cell damage caused by acrylamide in the rat: a new phenomenon in cellular neuropathology. Neurocytology, 12: 413-437.
15. Chatterjea MN, and Shinde R. (2002) Text Book of Medical Biochemistry. 5th ed. New Delhi: Jaypee Brothers Medical Publishers Ltd, 317.
16. Conklin KA (2000) Dietary antioxidants during cancer chemotherapy: impact on chemotherapeutic effectiveness and development of side effects. Nutrition and Cancer, 37: 1-18.
17. Dalia MS (2002) Comparative studies on the ontogeny of sensorimotor reflexes and locomotive activity in small mammals and their applications on infants. Ph D thesis, Faculty of Science, Mansoura University, Egypt.
18. Das M., Mukhtar H., and Seth P. (1982) Effect of acrylamide on brain and hepatic mixed function oxidases. Toxicology and Applied Pharmacology, 66: 420-426.
19. Dixit R., Das M., and Seth PK (1984) Interaction of acrylamide with glutathione in rat erythrocytes. Toxicology Letters, 23(3): 291-298.
20. Dixit R., Mukhtar H., and Seth PK (1980) Binding of acrylamide with glutathione-S-transferases. Chemical and Biological Interactions, 32(3): 353-359.
21. Dixit R., Mukhtar H., and Seth PK (1981) Conjugation of acrylamide with glutathione catalyzed by glutathioneS-transferases of rat liver and brain. Biochemical Pharmacology, 30(13): 1739-1744.
22. Dixit R., Seth PK, and Mukjtar H. (1982) Metabolism of acrylamide into urinary mercapturic acid and cysteine conjugates in rats. Drug Metabolism and Disposition, 10(2): 196-197.
23. Doerge DR, Young JF, Chen JJ, Dinovi MJ, and Henry SH (2008) Using dietary exposure and physiologically based pharmacokinetic/ pharmacodynamic modeling in human risk extrapolations for acrylamide toxicity. Journal of Agricultural and Food Chemistry, 56(15): 6031-6038.
24. Dybing E., Sanner T. (2003) Risk assessment of acrylamide in foods. Toxicological Sciences, 75: 7-15.
25. EL-Bakary NA, Mousa AM (2006) Light and electron microscopic study on the effect of acrylamide on the cerebellar cortex of adult albino rat and the possible protective role of vitamin B6. Egyptian Journal of Histology, 29(2): 179-192.
26. Feulgen R., Rossenbeck H. (1924) Mikroskopisch Chemischer Nach weis einen Nucleinsaure von Typus der Thymonucleinsaure und de darauf berhende elective Farbung von Zelkernen in microskopischen preparaten. Zeitschrift fur Physiologische Chemie, 135: 203.
27. Frieda SG, William PR (1999) Effects of lactational administration of acrylamide on rat dams and offspring. Reproductive Toxicology, 13: 511-520.
28. Friedman M. (2003) Chemistry, biochemistry, and safety of acrylamide. A review. Journal of Agricultural and Food Chemistry, 51: 4504-4526.
29. Friedman M., Rochelle W., Tyl R., Marr M., Myers C., Gerling F., et al. (1999) Effects of lactational administration of acrylamide on rat dams and offspring. Reproductive Toxicology, 13: 511-520.
30. Garey J., Sherry AF, and Merle GP (2005) Developmental and behavioral effects of acrylamide in Fischer 344 rats. Neurotoxicology and Teratology, 27(4): 553-563.
31. Gerson RJ, Shaikh ZA (1984) Differences in the uptake of cadmium and mercury by the rat hepatocytes primary cultures. Role of sulfhydryl carrier. Biochemistry and Pharmacology, 33: 199-203.
32. Ghosh R., Mukherjee B., and Chatterjee M. (1994) A novel effect of selenium on streptozotocin-induced diabetic mice. Diabetes Research, 25: 165-171.
33. Gohil K., Viguie C., Stanley WC, Brooks GA, and Packer L. (1988) Blood glutathione oxidation during human exercise. Journal of Applied Physiology, 64(1): 115-119.
34. Gold BG, Schaumberg HH, Spencer PS, Schaumberg HH, and Ludolph A. (2000) Experimental and Clinical Neurotoxicology. 2nd ed. New York: Oxford University Press, 124-132.
35. Griffin W., Sue T., Donold JW, and Rita C. (1977) Malnutrition-induce alterations of developing Purkinje cells. Experimental Neurology, 56: 298-311.
36. Haddera M., Negm I., Abd-Elkader G., and Matta W. (1975) Effect of hypothyroidism on the postnatal development of the cerebellum of the mouse. Al-Azhar Medical Journal, 4(2): 161-168.
37. Hammersen FMD (1985) Colour Atlas of Microscopic Anatomy. 3rd ed. Munchen: Urban & Schwarzenberg.
38. Jacobson M. (1970) Development specification and diversification of neuronal connection. In: Schmitt FO (ed) The Neuroscience: Second Study Program. New York : The Rockefeller University Press.
39. Kar M., Mishra D. (1976) Catalase, peroxidase and polyphenoloxidase activities during rice leaf senescence. Plant Physiology, 57: 315-319.
40. Ko MH, Chen WP, Linshiau SY, and Hsieh ST (1999) Age-dependent acrylamide neurotoxicity in mice: morphology, physiology and function. Experimental Neurology, 158(1): 37-46.
41. Koster JP, Biermond P., and Sawaak AJ (1986) Intracellular and extracellular sulph-hydryl levels in rheumatoid arthritis. Annals of Rheumatic Diseases, 45: 44-46.
42. Krause WJ, and Cutts JH (1994) Essentials of Histology. London : Little, Brown and Company.
43. Leedle RA, Aust SD (1990) The effect of glutathione on the vitamin E requirement for inhibition of liver microsomal lipid peroxidation. Lipids, 25: 241-245.
44. LoPachin RM (2004) The changing view of acrylamide neurotoxicity. Neurotoxicology, 25: 617-630.
45. Louis WC, and Williams SJ (1995) Neurotoxicology Approaches and Methods. San Diego, New York and Toronto : Academic Press Inc.
46. Mallory FB (1988) Pathological Technique. Philadelphia : WB Saunders.
47. Marcelo RSV, Fahad S. (2002) The cerebellum at birth in therian mammals, with special reference to rodents. Brain Behavior, 59: 101-113.
48. Marklund S., Marklund G. (1974) Involvement of superoxide anion radical in the auto-oxidation of pyrogallol and convenient assay for superoxide dismutase. European Journal of Biochemistry, 47: 469-474.
49. Marlowe C., Clark MJ, and Mast RW (1986) The distribution of (14C) acrylamide in male and pregnant Swiss Webster mice by whole body autoradiography. Toxicology and Applied Pharmacology, 86: 457-465.
50. Miale IL, Sidman RL (1961) An autoradiographic analysis of histogenesis in the mouse cerebellum. Journal of Experimental Neurology, 4: 277-296.
51. Miller MJ, Carter DE, and Sipes IG (1982) Pharmacokinetics of acrylamide in Fisher-334 Rats. Toxicology and Applied Pharmacology, 63: 36-44.
52. Mukhtar H., Dixit R., and Seth P. (1981) Reduction in cutaneous and hepatic glutathione contents, glutathioneS-transferases and aryl hydrocarbon hydroxylase activities following topical application of acrylamide to mouse. Toxicology Letters, 9: 153-156.
53. Noor El-Din MA (1966) Qualitative and quantitative studies of the postnatal development of the cerebellum of mouse. MSc thesis, Assiut University, Egypt.
54. Ohta Y., Sasaki E., Nishida K., Kobayashi T., Nagata M., and Ishiguro I. (1995) Preventive effect of dai-saiko-to (da-chai-hu-tang) extract on disrupted hepatic active oxygen metabolism in rats with carbon tetrachloride-induced liver injury. American Journal of Chinese Medicine, 23(1): 53-64.
55. Preuss HG, Jarrel ST, Scheckenbach R., Lieberman S., and Anderson RA (1998) Comparative effects of chromium, vanadium and Gymnema sylvestre on sugar-induced blood pressure elevations in SHR. Journal of American College of Nutrition, 17(2): 116-123.
56. Rajesh MG, Latha MS (2004) Protective activity of Glycyrrhiza glabra Linn. on carbon tetrachloride-induced peroxidative damage. Indian Journal of Pharmacology, 36(5): 284-287.
57. Rao M., and Blane K. (1995) PC-STAT. One Way Analysis of Variance Procedure. Version 1A. Pilot ed. Georgia University.
58. Rao GMM, Rao CV, Pushpangadan P., and Shirwaikar A. (2006) Hepatoprotective effects of rubiadin, a major constituent of Rubia cordifolia Linn. Journal of Ethnopharmacology, 103(3): 484-490.
59. Recknagel RO, Glende JEA, and Britton RS (1991) Free radical damage and lipid peroxidation. In: Meeks RG, Harrison SD, and Bull RJ (eds) Hepatotoxicology. Florida: CRC Press, 401-436.
60. Rister M., Bachner RL (1976) The alteration of superoxide dismutase, catalase, glutathione peroxidase and NADPH cytochrome-C-reductase in guinea pig polymorphonuclear leukocytes and alveolar macrophages during hypoxia. Journal of Clinical Investigation, 58: 1174-1184.
61. Saleh MN, Saleh MM, Desouky MA, Sayed SR, and Saber EA (1993) Effect of alcohol on the postnatal development of cerebellar cortex in rat. I. Histological and morphometric studies. Assiut Veterinary Medical Journal, 30(59): 11-31.
62. Saleh MN, Saleh MM, Desouky MA, Sayed SR, and Saber EA (1995) Effect of alcohol on postnatal development of white matter of the cerebellum of the rat. Assiut Veterinary Medical Journal, 32(64): 1-15.
63. Shaheed IB, Kawkab AA, and Makhlouf MM (2006) Toxicological and pathological studies on acrylamide neurotoxicity in albino rats. Egyptian Journal of Comparative Pathology and Clinical Pathology, 19: 63-82.
64. Shigeoka S., Takeda T., and Hanaoka T. (1991) Characterization and immunological properties of selenium-containing glutathione peroxidase induced by selenite in Clamydomonas reinhardtii. Biochemistry Journal, 275: 623-627.
65. Smart JL, Dobbing J. (1971) Vulnerability of developing brain. II. Effects of early nutritional deprivation on reflex ontogeny and development of behaviour in the rat. Brain Research, 28: 85-95.
66. Sorgel F., Weissenbacher R., Kinzig-Schippers M., Hofmann A., Illauer M., Skott A., et al. (2002) Acrylamide: increased concentrations in home made food and first evidence of its variable absorption from food, variable metabolism and placental and breast milk transfer in humans. Chemotherapy, 48: 267-274.
67. Spencer PS, Schaumburg HH (1977a) Ultrastructural studies of the dying-back process. III. The evolution of experimental peripheral giant axonal degeneration. Journal of Neuropathology and Experimental Neurology, 36: 276-299.
68. Spencer PS, Schaumburg HH (1977b) Ultrastructural studies of the dying-back process. IV. Differential vulnerability of PNS and CNS fibers in experimental central-peripheral distal axonopathy. Journal of Neuropathology and Experimental Neurology, 36: 300-320.
69. Spencer PS, Schaumburg HH (1979) Clinical and experimental studies of distal axonopathy. A frequent form of brain and nerve damage produced by environmental chemical hazards. New York Academy of Sciences, 329: 14-29.
70. Sridevi B., Reddy KV, and Reddy SLN (1998) Effect of trivalent and hexavalent chromium on antioxidant enzyme activities and lipid peroxidation in a freshwater field crab, Barytelphusa guerini. Bulletin of Environmental Contamination and Toxicology, 61: 384-390.
71. Srivastava SP, Das M., and Seth PR (1983) Enhancement of lipid peroxidation in rat liver on acute exposure to styrene and acrylamide. A consequence of glutathione depletion. Chemical and Biological Interactions, 45: 373-380.
72. Sumner SCJ, Bahman A., and Williams CC (2001) Acrylamide, Metabolism, Distribution, and Hemoglobin Adducts in Male F344 Rats and B6C3F1 Mice Following Inhalation Exposure and Distribution and Hemoglobin Adducts Following Dermal Application to F344 Rats. Research Triangle Park, NC: CIIT.
73. Sumner SCJ, MacNeela JP, and Fennell TR (1992) Characterization and quantitation of urinary metabolites of {1,2,3-13C}acrylamide in rats and mice using 13C nuclear magnetic resonance spectroscopy. Chemical Research in Toxicology, 5: 81-89.
74. Sumner SCJ, Selvaraj L., and Nauhaus SK (1997) Urinary metabolites from F344 rats and B6C3F1 mice coadministered acrylamide and acrylonitrile for 1 or 5 Days. Chemical Research in Toxicology, 10(10): 1152-1160.
75. Tabatabaie T., Floyd RA (1994) Susceptibility of glutathione peroxidase and glutathione reductase to oxidative damage and the protective effect of spin trapping agents. Archives of Biochemistry and Biophysics, 314: 112-119.
76. Takahashi M., Shibutani M., Inoue K., Fujimoto H., Hirose M., and Nishikawa A. (2008) Pathological assessment of the nervous and male reproductive systems of rat offspring exposed maternally to acrylamide during the gestation and lactation periods-a preliminary study. Journal of Toxicological Sciences, 33(1): 11-24.
77. Tong GC, Cornwell WK, and Means GE (2004) Reactions of acrylamide with glutathione and serum albumin. Toxicology Letters, 147: 127-131.
78. Tyl RW, Friedman MA, Losco PE, and Ross WP (2000a) Rat two-generation reproduction and dominant lethal study of acrylamide in drinking water. Reproductive Toxicology, 14: 385-401.
79. Tyl RW, Marr MC, Myers CB, Ross WP, and Friedman MA (2000b) Relationship between acrylamide reproductive and neurotoxicity in male rats. Reproductive Toxicology, 14: 147-157.
80. Uličná O., Greksak M., Vancova O., Zlatos L., Galbavy S., Bozek P., et al. (2003) Hepatoprotective effect of Rooibos tea (Aspalathus linearis) on CCl4-induced liver damage in rats. Physiology Research, 52: 461-466.
81. Uphouse LL, Nemeroff CB, Mason G., Prange AJ, and Bondy SC (1982) Interactions between “handling” and acrylamide on endocrine responses in rats. Neurotoxicology, 3(1): 121-125.
82. Van de Casteele M., Van Pelt JF, Nevens F., Fevery J., and Reichen J. (2003) Low NO bioavailability in CCl4 cirrhotic rat livers might result from low NO synthesis combined with decreased superoxide dismutase activity allowing superoxide-mediated NO breakdown: a comparison of two portal hypertensive rat models with healthy controls. Comparative Hepatology, 2(1): 2.
83. Wise LD, Gordon LR, Soper KA, Duchai DM, and Morrissey RE (1995) Developmental neurotoxicity evaluation of acrylamide in Sprague-Dawley rats. Neurotoxicology and Teratology, 17: 189-198.
84. Yousef MI, El-Demerdash FM (2006) Acrylamide-induced oxidative stress and biochemical perturbations in rats. Toxicology, 219: 133-141.
85. Zhu YJ, Zeng T., Zhu YB, Yu SF, Wang QS, Zhang LP, et al. (2008) Effects of acrylamide on the nervous tissue antioxidant system and sciatic nerve electrophysiology in the rat. Neurochemical Research, 33(11): 2310-2317.