Characterisation of the epitope for a herpes simplex virus glycoprotein B-specific monoclonal antibody with high protective capacity

Medical Microbiology and Immunology

Volumn 200, Issue 2, 2011, Pages 85-97

  Däumer, Martin P ^a,c   Schneider, Beate ^a   Giesen, Doris M ^a   Aziz, Sheriff ^a   Kaiser, Rolf ^a,d   Kupfer, Bernd ^a   Schneweis, Karl E ^a   Schneider Mergener, Jens ^b   Reineke, Ulrich ^b,e   Matz, Bertfried ^a   Eis Hübinger, Anna M ^a  

^a UNIVERSITY OF BONN   (Germany)

^b Jerini AG   (Germany)

^c Rheinland Pfälzische Technische Universität Kaiserslautern Landau   (Germany)

^d UNIVERSITY OF COLOGNE   (Germany)

^e Pharmaceuticals GmbH 3B   (Germany)

Author keywords

Discontinuous epitope; Epitope mapping; Glycoprotein B; Herpes simplex virus; Monoclonal antibody

Indexed keywords

AMINO ACID; ASPARTIC ACID; EPITOPE; GLUTAMIC ACID; GLYCINE; GLYCOPROTEIN B; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 2C; PEPTIDE; PHENYLALANINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL STRAIN COS1; CONTROLLED STUDY; DRUG BINDING SITE; FEMALE; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; INOCULATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN VARIANT; VIRUS MUTANT; VIRUS NEUTRALIZATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, VIRAL; ANTIBODY SPECIFICITY; BINDING SITES; CERCOPITHECUS AETHIOPS; COS CELLS; EPITOPE MAPPING; EPITOPES; FEMALE; HERPES SIMPLEX; HERPESVIRUS 1, HUMAN; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; MUTATION; VERO CELLS; VIRAL ENVELOPE PROTEINS;

EID: 79955680697     PISSN: 03008584     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00430-010-0174-x     Document Type: Article

References (58)

1. Eis-Hübinger AM, Mohr K, Schneweis KE (1991) Different mechanisms of protection by monoclonal and polyclonal antibodies during the course of herpes simplex virus infection. Intervirology 32:351-360
2. Eis-Hübinger AM, Schmidt DS, Schneweis KE (1993) Antiglycoprotein B monoclonal antibody protects T cell-depleted mice against herpes simplex virus infection by inhibition of virus replication at the inoculated mucous membranes. J Gen Virol 74:379-385 (Pubitemid 23092890)
3. Whitley RJ, Roizman B (2001) Herpes simplex virus infections. Lancet 357:1513-1518 (Pubitemid 32488876)
4. Roizman B, Knipe DM, Whitley RJ (2007) Herpes simplex viruses. In: Knipe DM, Howley (eds) Fields virology, 5th edn. Lippincott, Philadelphia, pp 2501-2601
5. Gupta R, Warren T, Wald A (2007) Genital herpes. Lancet 370:2127-2137 (Pubitemid 350296304)
6. Corey L, Wald A (2009) Maternal and neonatal herpes simplex virus infections. N Engl J Med 361:1376-1385
7. Pass RF, Whitley RJ, Whelchel JD, Diethelm AG, Reynolds DW, Alford CA (1979) Identification of patients with increased risk of infection with herpes simplex virus after renal transplantation. J Infect Dis 140:487-492 (Pubitemid 10172719)
8. Siegal FP, Lopez C, Hammer GS, Brown AE, Kornfeld SJ, Gold J, Hassett J, Hirschman SZ, Cunningham-Rundles C, Adelsberg BR, Parham DM, Siegal M, Cunningham-Rundles S, Armstrong D (1981) Severe acquired immunodeficiency in male homosexuals, manifested by chronic perianal ulcerative herpes simplex lesions. N Engl J Med 305:1439-1444 (Pubitemid 12240078)
9. Bartlett JG (2004) Recent developments in the management of herpes simplex virus infection in HIV-infected persons. Clin Infect Dis 39:S237-S239
10. Cunningham AL, Diefenbach RJ, Miranda-Saksena M, Bosnjak L, Kim M, Jones C, Douglas MW (2006) The cycle of human herpes simplex virus infection: virus transport and immune control. J Infect Dis 194:S11-S18 (Pubitemid 44420867)
11. Cernik C, Gallina K, Brodell RT (2008) The treatment of herpes simplex infections: an evidence-based review. Arch Intern Med 168:1137-1144 (Pubitemid 351831395)
12. Wilson SS, Fakioglu E, Herold BC (2009) Novel approaches in fighting herpes simplex virus infections. Expert Rev Anti Infect Ther 7:559-568
13. Dasgupta G, Chentoufi AA, Nesburn AB, Wechsler SL, BenMohamed L (2009) New concepts in herpes simplex virus vaccine development: notes from the battlefield. Expert Rev Vaccines 8:1023-1035
14. Pellett PE, Kousoulas KG, Pereira L, Roizman B (1985) Anatomy of the herpes simplex virus 1 strain F glycoprotein B gene: primary sequence and predicted protein structure of the wild type and of monoclonal antibody-resistant mutants. J Virol 53:243-253 (Pubitemid 15194961)
15. Pereira L (1994) Function of glycoprotein B homologues of the family herpesviridae. Infect Agents Dis 3:9-28
16. Reske A, Pollara G, Krummenacher C, Chain BM, Katz DR (2007) Understanding HSV-1 entry glycoproteins. Rev Med Virol 17:205-215
17. Bzik DJ, Fox BA, DeLuca NA, Person S (1984) Nucleotide sequence of a region of the herpes simplex virus type 1 gB glycoprotein gene: mutations affecting rate of virus entry and cell fusion. Virology 137:185-190 (Pubitemid 14068867)
18. Cai W, Gu B, Person S (1988) Role of glycoprotein B of herpes simplex virus type 1 in viral entry and cell fusion. J Virol 62:2596-2604
19. Butcher M, Raviprakash K, Ghosh HP (1990) Acid pH-induced fusion of cells by herpes simplex virus glycoproteins gB an gD. J Biol Chem 265:5862-5868
20. Bender FC, Whitbeck JC, Ponce de Leon M, Lou H, Eisenberg RJ, Cohen GH (2003) Specific association of glycoprotein B with lipid rafts during herpes simplex virus entry. J Virol 77:9542-9552 (Pubitemid 37011049)
21. Heldwein EE, Lou H, Bender FC, Cohen GH, Eisenberg RJ, Harrison SC (2006) Crystal structure of glycoprotein B from herpes simplex virus 1. Science 313:217-220 (Pubitemid 44066251)
22. Hannah BP, Cairns TM, Bender FC, Whitbeck JC, Lou H, Eisenberg RJ, Cohen GH (2009) Herpes simplex virus glycoprotein B associates with target membranes via its fusion loops. J Virol 83:6825-6836
23. Wright CC, Wisner TW, Hannah BP, Eisenberg RJ, Cohen GH, Johnson DC (2009) Fusion between perinuclear virions and the outer nuclear membrane requires the fusogenic activity of herpes simplex virus gB. J Virol 83:11847-11856
24. Atanasiu D, Whitbeck JC, Ponce de Leon M, Lou H, Hannah BP, Cohen GH, Eisenberg RJ (2010) Bimolecular complementation defines functional regions of herpes simplex virus gB that are involved with gH/gL as a necessary step leading to cell fusion. J Virol 84:3825-3834
25. Ejercito PM, Kieff ED, Roizman B (1968) Characterization of herpes simplex virus strains differing in their effects on social behaviour of infected cells. J Gen Virol 2:357-364
26. Holland TC, Marlin SD, Levine M, Glorioso J (1983) Antigenic variants of herpes simplex virus selected with glycoprotein-specific monoclonal antibodies. J Virol 45:672-682 (Pubitemid 13225433)
27. Kousoulas KG, Pellett PE, Pereira L, Roizman B (1984) Mutations affecting conformation or sequence of neutralizing epitopes identified by reactivity of viable plaques segregate from syn and ts domains of HSV-1(F) gB gene. Virology 135:379-394 (Pubitemid 14088922)
28. Kousoulas KG, Huo B, Pereira L (1988) Antibody-resistant mutations in cross-reactive and type-specific epitopes of herpes simplex virus 1 glycoprotein B map in separate domains. Virology 166:423-431
29. Highlander SL, Dorney DJ, Gage PJ, Holland TC, Cai W, Person S, Levine M, Glorioso JC (1989) Identification of mar mutations in herpes simplex virus type 1 glycoprotein B which alter antigenic structure and function in virus penetration. J Virol 63:730-738 (Pubitemid 19057239)
30. Pereira L, Ali M, Kousoulas K, Huo B, Banks T (1989) Domain structure of herpes simplex virus 1 glycoprotein B: neutralizing epitopes map in regions of continuous and discontinuous residues. Virology 172:11-24 (Pubitemid 19221432)
31. Qadri I, Gimeno C, Navarro D, Pereira L (1991) Mutations in conformation-dependent domains of herpes simplex virus 1 glycoprotein B affect the antigenic properties, dimerization, and transport of the molecule. Virology 180:135-152
32. Navarro D, Paz P, Pereira L (1992) Domains of herpes simplex virus I glycoprotein B that function in virus penetration, cell-to-cell spread, and cell fusion. Virology 186:99-112
33. McGeoch DJ, Dalrymple MA, Davison AJ, Dolan A, Frame MC, McNab D, Perry LJ, Scott JE, Taylor P (1988) The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1. J Gen Virol 69:1531-1574
34. Sambrook J, Fritsch EF, Maniatis T (eds) (1989) Molecular cloning: a laboratory manual, 2nd edn. Cold Spring Harbor Laboratory Press, NY
35. Graham FL, van der Eb AJ (1973) A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52:456-467
36. Stow ND, Wilkie NM (1976) An improved technique for obtaining enhanced infectivity with herpes simplex virus type 1 DNA. J Gen Virol 33:447-458
37. Frank R (1992) Spot synthesis: an easy technique for the positionally addressable, parallel chemical synthesis on a membrane support. Tetrahedron 48:9217-9232
38. Kramer A, Schneider-Mergener J (1998) Synthesis and screening of peptide libraries on continuous cellulose membrane supports. Methods Mol Biol 87:25-39
39. Geysen HM, Rodda SJ, Mason TJ, Tribbick G, Schoofs PG (1987) Strategies for epitope analysis using peptide synthesis. J Immunol Methods 102:259-274 (Pubitemid 17139413)
40. Reineke U (2009) Antibody epitope mapping using de novo generated synthetic peptide libraries. Methods Mol Biol 524:203-211
41. Pinilla C, Appel JR, Houghten RA (1993) Functional importance of amino acid residues making up peptide antigenic determinants. Mol Immunol 30:577-585
42. Reineke U, Ivascu C, Schlief M, Landgraf C, Gericke S, Zahn G, Herzel H, Volkmer-Engert R, Schneider-Mergener J (2002) Identification of distinct antibody epitopes and mimotopes from a peptide array of 5520 randomly generated sequences. J Immunol Methods 267:37-51 (Pubitemid 34804811)
43. Kahlon J, Whitley RJ (1988) Antibody response of the newborn after herpes simplex virus infection. J Infect Dis 158:925-933 (Pubitemid 18266040)
44. Reed LJ, Muench H (1938) A simple method of estimating fifty percent endpoints. Am J Hyg 27:493-497
45. Andersen PH, Nielsen M, Lund O (2006) Prediction of residues in discontinuous B-cell epitopes using protein 3D structures. Protein Sci 15:2558-2567 (Pubitemid 44771693)
46. Van Regenmortel MHV (2009) What is a B-cell epitope? Methods Mol Biol 524:3-20
47. Gao B, Esnouf MP (1996) Elucidation of the core residues of an epitope using membrane-based combinatorial peptide libraries. J Biol Chem 271:24634-24638 (Pubitemid 26333205)
48. Korth C, Stierli B, Streit P, Moser M, Schaller O, Fischer R, Schulz-Schaeffer W, Kretzschmar H, Raeber A, Braun U, Ehrensperger F, Hornemann S, Glockshuber R, Riek R, Billeter M, Wüthrich K, Oesch B (1997) Prion (PrPSc)-specific epitope defined by a monoclonal antibody. Nature 390:74-77 (Pubitemid 27494758)
49. Prodinger WM, Schwendinger MG, Schoch J, Köchle M, Larcher C, Dierich MP (1998) Characterization of C3dg binding to a recess formed between short consensus repeats 1 and 2 of complement receptor type 2 (CR2; CD21). J Immunol 161:4604-4610 (Pubitemid 28492033)
50. Reineke U, Sabat R, Misselwitz R, Welfle H, Volk HD, Schneider-Mergener J (1999) A synthetic mimic of a discontinuous binding site on interleukin-10. Nat Biotechnol 17:271-275 (Pubitemid 29123036)
51. Bian C, Zhang X, Cai X, Zhang L, Chen Z, Zha Y, Xu Y, Xu K, Lu W, Yan L, Yuan J, Feng J, Hao P, Wang Q, Zhao G, Liu G, Zhu X, Shen H, Zheng B, Shen B, Sun B (2009) Conserved amino acids W423 and N424 in receptor-binding domain of SARS-CoV are potential targets for therapeutic monoclonal antibody. Virology 383:39-46
52. Villard S, Piquer D, Raut S, Léonetti JP, Saint-Remy JM, Granier C (2002) Low molecular weight peptides restore the procoagulant activity of factor VIII in the presence of the potent inhibitor antibody ESH8. J Biol Chem 277:27232-27239 (Pubitemid 34951740)
53. Liljeqvist JA, Trybala E, Hoebeke J, Svennerholm B, Bergström T (2002) Monoclonal antibodies and human sera directed to the secreted glycoprotein G of herpes simplex virus type 2 recognize type-specific antigenic determinants. J Gen Virol 83:157-165 (Pubitemid 34036486)
54. Reineke U, Schneider-Mergener J, Schutkowski M (2006) Peptide arrays in proteomics and drug discovery. In: Ozkan M, Heller MJ (eds) BioMEMS and biomedical nanotechnology, volume II, micro and nano-technologies for genomics and proteomics. Springer, Berlin, pp 161-282
55. Roche S, Bressanelli S, Rey FA, Gaudin Y (2006) Crystal structure of the low-pH form of the vesicular stomatitis virus glycoprotein G. Science 313:187-191 (Pubitemid 44066243)
56. Roche S, Rey FA, Gaudin Y, Bressanelli S (2007) Structure of the prefusion form of the vesicular stomatitis virus glycoprotein G. Science 315:843-848
57. Lin E, Spear PG (2007) Random linker-insertion mutagenesis to identify functional domains of herpes simplex virus type 1 glycoprotein B. Proc Natl Acad Sci USA 104:13140-13145 (Pubitemid 351737606)
58. Bender FC, Samanta M, Heldwein EE, Ponce de Leon M, Bilman E, Lou H, Whitbeck JC, Eisenberg RJ, Cohen GH (2007) Antigenic and mutational analyses of herpes simplex virus glycoprotein B reveal four functional regions. J Virol 81:3827-3841 (Pubitemid 46586880)