Conserved amino acids W423 and N424 in receptor-binding domain of SARS-CoV are potential targets for therapeutic monoclonal antibody

Virology

Volumn 383, Issue 1, 2009, Pages 39-46

  Bian, Chao ^a   Zhang, Xiuqin ^a   Cai, Xingfeng ^a   Zhang, Linqi ^c   Chen, Zhiwei ^c   Zha, Ye ^a   Xu, Ying ^a   Xu, Ke ^a   Lu, Wei ^a   Yan, Linchen ^a   Yuan, Jianwei ^a   Feng, Jiannan ^d   Hao, Pei ^e   Wang, Qidi ^f   Zhao, Guoping ^e   Liu, Gang ^f   Zhu, Xueliang ^a   Shen, Hao ^g,h   Zheng, Bojian ⁱ   Shen, Beifen ^d   Sun, Bing ^a,b,j   more..

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^b INSTITUTE PASTEUR OF SHANGHAI   (China)

^c ROCKEFELLER UNIVERSITY   (United States)

^d INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^e CHINESE NATIONAL HUMAN GENOME CENTER AT SHANGHAI   (China)

^f INSTITUTE OF MATERIA MEDICA   (China)

^g UNIVERSITY OF PENNSYLVANIA   (United States)

^h SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

ⁱ UNIVERSITY OF HONG KONG   (Hong Kong)

^j E Institute of Immunology   (China)

more..

Author keywords

Chimeric; Epitope; Monoclonal antibody; Neutralization; Receptor binding domain; SARS CoV

Indexed keywords

AMINO ACID; EPITOPE; MONOCLONAL ANTIBODY; N424 AMINO ACID; PEPTIDE; PROTEIN ACE2; UNCLASSIFIED DRUG; VIRUS PROTEIN; W423 AMINO ACID;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; ARTICLE; DRUG ACTIVITY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PEPTIDE SYNTHESIS; PLASMID; PRIORITY JOURNAL; RECEPTOR BINDING; SARS CORONAVIRUS; SEVERE ACUTE RESPIRATORY SYNDROME; SITE DIRECTED MUTAGENESIS; VACCINIA VIRUS; VIRUS STRAIN;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, VIRAL; CONSERVED SEQUENCE; EPITOPES; FEMALE; HUMANS; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEUTRALIZATION TESTS; PROTEIN STRUCTURE, TERTIARY; SARS VIRUS; VIRAL ENVELOPE PROTEINS; VIRUS ATTACHMENT;

CORONAVIRUS; MURINAE; SARS CORONAVIRUS;

EID: 57049087447     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2008.09.029     Document Type: Article

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