Structure of the prefusion form of the vesicular stomatitis virus glycoprotein G

Science

Volumn 315, Issue 5813, 2007, Pages 843-848

  Roche, Stéphane ^a   Rey, Félix A ^a,b   Gaudin, Yves ^a   Bressanelli, Stéphane ^a  

^a CNRS   (France)

^b INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

THROMBOSPONDIN;

ANTIGEN; MEMBRANE; PROTEIN; SIGNAL; ULTRASTRUCTURE; VIRUS;

ARTICLE; CONFORMATIONAL TRANSITION; MEMBRANE FUSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN STRUCTURE; STRUCTURE ANALYSIS; VESICULAR STOMATITIS VIRUS;

AMINO ACID SEQUENCE; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; HYDROGEN-ION CONCENTRATION; HYDROPHOBICITY; MEMBRANE FUSION; MEMBRANE GLYCOPROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; VESICULAR STOMATITIS-INDIANA VIRUS; VIRAL ENVELOPE PROTEINS; VIRAL FUSION PROTEINS;

VESICULAR STOMATITIS VIRUS;

EID: 33846959065     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1135710     Document Type: Article

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39. We thank A. Flamand for constant support on this project; J. Lepault, R. Ruigrok, M. Knossow, A. Benmansour, C. Tuffereau, and D. Blondel for helpful discussions at different stages of this work; and C. Maheu for virus purification. Data collections were performed at the Swiss Light Source (SLS), Paul Scherrer Institut, Villigen, Switzerland, and at the European Synchrotron Radiation Facility (ESRF), Grenoble, France. We acknowledge the help of T. Tomizaki (beamline X06SA, SLS), G. Leonard and D. Bourgeois (beamlines ID29 and ID23-2, ESRF), and S. Duquerroy and G. Squires in data collection. We acknowledge support from the CNRS and INRA, the CNRS program "Physique et Chimie du Vivant," the INRA Animal health department program "Les virus des animaux et leurs interactions avec la cellule," the Ministère de l'éducation nationale, de la recherche et de la technologie program "Action Concertée Incitative blanche," and the Agence Nationale de la Recherche program. S.R. was the recipient of an Agence Nationale de Recherche sur le Sida fellowship during part of this project. Coordinates and structure factors have been deposited with the Protein Data Bank under accession code 2j6j.