A re-evaluation of the mitogenic effect of serotonin on vascular endothelial cells

Journal of Biological Regulators and Homeostatic Agents

Volumn 25, Issue 1, 2011, Pages 13-20

  Ruiz Perez M V ^a   Sanchez Jimenez F ^a,b   Quesada, A R ^a,b   Medina, Miguel Ángel ^a,b  

^a UNIVERSITY OF MÁLAGA   (Spain)

^b CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES RARAS CIBERER   (Spain)

Author keywords

Serotonin, mitogenic effect, endothelial cell, angiogenesis

Indexed keywords

SEROTONIN; MITOGENIC AGENT; SEROTONIN AGONIST;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; MITOGENESIS; NONHUMAN; VASCULAR ENDOTHELIUM; ANGIOGENESIS; ANIMAL; CATTLE; CELL CULTURE; CYTOLOGY; DRUG EFFECT; METABOLISM; PHYSIOLOGY;

ANIMALS; CATTLE; CELL PROLIFERATION; CELLS, CULTURED; ENDOTHELIAL CELLS; MITOGENS; NEOVASCULARIZATION, PHYSIOLOGIC; SEROTONIN; SEROTONIN RECEPTOR AGONISTS;

EID: 79955653439     PISSN: 0393974X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Berger M, Gray JA, Roth BL. The expanded biology of serotonin. Annu Rev Med 2009; 60:355-66.
2. Jonnakuty C, Gragnoli C. What do we know about serotonin? J Cell Physiol 2008; 217:301-6.
3. Nocito A, Dahm F, Jochum W, Jang JH, Georgiev P, Bader M, Graf R, Clavien PA. Serotonin regulates macrophage-mediated angiogenesis in a mouse model of colon cancer allografts. Cancer Res 2008; 68:5152-8.
4. Ruddell RG, Mann DA, Ramm GA. The function of serotonin within the liver. J Hepatol 2008; 48:666-75.
5. Ramage AG, Villalon CM. 5-hydroxytryptamine and cardiovascular regulation. Trends Pharmacol Sci 2008; 29:472-81.
6. Nishikawa T, Tsuno NH, Shuno Y, et al. Antiangiogenic Effect of a Selective 5-HT4 Receptor Agonist. J Surg Res 2010; 159:696-704.
7. Small R, Macarak E, Fisher AB. Production of 5-hydroxyindoleacetic acid from serotonin by cultured endothelial cells. J Cell Physiol 1977; 90:225-31.
8. Tutton PJ, Barkla DH. Serotonin receptors influencing cell proliferation in the jejunal crypt epithelium and in colonic adenocarcinomas. Anticancer Res 1986; 6:1123-6. (Pubitemid 17229564)
9. Nemecek GM, Coughlin SR, Handley DA, Moskowitz MA. Stimulation of aortic smooth muscle cell mitogenesis by serotonin. Proc Natl Acad Sci USA 1986; 83:674-8. (Pubitemid 16035536)
10. Seuwen K, Magnaldo I, Pouyssegur J. Serotonin stimulates DNA synthesis in fibroblasts acting through 5-HT1B receptors coupled to a Gi-protein. Nature 1988; 335:254-6.
11. Takuwa N, Ganz M, Takuwa Y, Sterzel RB, Rasmussen H. Studies of the mitogenic effect of serotonin in rat renal mesangial cells. Am J Physiol 1989; 257:431-9.
12. Ishizuka J, Beauchamp RD, Townsend CM Jr, Greeley GH Jr, Thompson JC. Receptor-mediated autocrine growth-stimulatory effect of 5-hydroxytryptamine on cultured human pancreatic carcinoid cells. J Cell Physiol 1992; 150:1-7.
13. Nocito A, Georgiev P, Dahm F, Jochum W, Bader M, Graf R, Clavien PA. Platelets and platelet-derived serotonin promote tissue repair after normothermic hepatic ischemia in mice. Hepatology 2007; 45:369-76. (Pubitemid 46374593)
14. Yang M, Li K, Ng PC, et al. Promoting effects of serotonin on hematopoiesis: ex vivo expansion of cord blood CD34+ stem/progenitor cells, proliferation of bone marrow stromal cells, and antiapoptosis. Stem Cells 2007; 25:1800-06. (Pubitemid 47121859)
15. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100:57-70. (Pubitemid 30046295)
16. Asada M, Ebihara S, Yamanda S, Niu K, Okazaki T, Sora I, Arai H. Depletion of serotonin and selective inhibition of 2B receptor suppressed tumor angiogenesis by inhibiting endothelial nitric oxide synthase and extracellular signal-regulated kinase 1/2 phosphorylation. Neoplasia 2009; 11:408-17.
17. Pakala R, Willerson JT, Benedict CR. Mitogenic effect of serotonin on vascular endothelial cells. Circulation 1994; 90:1919-26. (Pubitemid 24320943)
18. Pakala R, Benedict CR. Effect of serotonin and thromboxane A2 on endothelial cell proliferation: effect of specific receptor antagonists. J Lab Clin Med 1998; 131:527-37. (Pubitemid 28278571)
19. Lee SL, Wang WW, Lanzillo JJ, Fanburg BL. Serotonin produces both hyperplasia and hypertrophy of bovine pulmonary artery smooth muscle cells in culture. Am J Physiol 1994; 266:46-52.
20. Marcondes S, Lafay M, Brohard-Bohn B, De Nucci G, Rendu F. Platelets induce human umbilical vein endothelial cell proliferation through P-selectin. Life Sci 2000; 66:1817-26. (Pubitemid 30198587)
21. Rodríguez-Nieto S, González-Iriarte M, Carmona R, Muñoz-Chápuli R, Medina MA, Quesada AR. Antiangiogenic activity of aeroplysinin-1, a brominated compound isolated from a marine sponge. Faseb J 2002; 16:261-3.
22. Martinez-Poveda B, Munoz-Chapuli R, Rodriguez-Nieto S, Quintela JM, Fernandez A, Medina MA, Quesada AR. IB05204, a dichloropyridodithienotria zine, inhibits angiogenesis in vitro and in vivo. Mol Cancer Ther 2007; 6:2675-85. (Pubitemid 350058148)
23. Medina MA, Urdiales JL, Rodriguez-Caso C, Ramirez FJ, Sanchez-Jimenez F. Biogenic amines and polyamines: similar biochemistry for different physiological missions and biomedical applications. Crit Rev Biochem Mol Biol 2003; 38:23-59. (Pubitemid 36308350)
24. Quesada AR, Munoz-Chapuli R, Medina MA. Antiangiogenic drugs: from bench to clinical trials. Med Res Rev 2006; 26:483-530. (Pubitemid 43939203)
25. Medina MA, Munoz-Chapuli R, Quesada AR. Challenges of antiangiogenic cancer therapy: trials and errors, and renewed hope. J Cell Mol Med 2007; 11:374-82. (Pubitemid 47153451)
26. Schoeffter P, Ullmer C, Gutierrez M, Weitz-Schmidt G, Lubbert H. Functional serotonin 5-HT1D receptors and 5-HT1D beta receptor mRNA expression in human umbilical vein endothelial cells. Naunyn Schmiedebergs Arch Pharmacol 1995; 352:580-2.
27. Kvachnina E, Liu G, Dityatev A, et al. 5-HT7 receptor is coupled to G alpha subunits of heterotrimeric G12-protein to regulate gene transcription and neuronal morphology. J Neurosci 2005; 25:7821-30. (Pubitemid 41208654)
28. Parrish JC, Nichols DE. Serotonin 5-HT(2A) receptor activation induces 2-arachidonoylglycerol release through a phospholipase c-dependent mechanism. J Neurochem 2006; 99:1164-75. (Pubitemid 44655282)
29. Linder AE, Ni W, Diaz JL, Szasz T, Burnett R, Watts SW. Serotonin (5-HT) in veins: not all in vain. J Pharmacol Exp Ther 2007; 323:415-21. (Pubitemid 350005109)
30. Bianchi P, Kunduzova O, Masini E, et al. Oxidative stress by monoamine oxidase mediates receptor-independent cardiomyocyte apoptosis by serotonin and postischemic myocardial injury. Circulation 2005; 112:3297-305. (Pubitemid 43739375)