The function of serotonin within the liver

Journal of Hepatology

Volumn 48, Issue 4, 2008, Pages 666-675

  Ruddell, Richard G ^a   Mann, Derek A ^b   Ramm, Grant A ^a  

^a ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

5 Hydroxytryptamine serotonin; Haemodynamics; Innervation; Liver; Wound healing

Indexed keywords

SEROTONIN; SEROTONIN 2A RECEPTOR; SEROTONIN 2B RECEPTOR; SEROTONIN RECEPTOR;

CELL PROLIFERATION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LIVER BLOOD FLOW; LIVER CELL; LIVER REGENERATION; NONHUMAN; PRIORITY JOURNAL; REVIEW; WOUND HEALING;

ANIMALS; HUMANS; LIVER; LIVER CIRCULATION; SEROTONIN;

EID: 39849091033     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2008.01.006     Document Type: Review

References (55)

1. Hoyer D., Clarke D.E., Fozard J.R., Hartig P.R., Martin G.R., Mylecharane E.J., et al. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin). Pharmacol Rev 46 (1994) 157-203
2. de Herder W.W. Biochemistry of neuroendocrine tumours. Best Pract Res Clin Endocrinol Metab 21 (2007) 33-41
3. Raymond J.R., Mukhin Y.V., Gelasco A., Turner J., Collinsworth G., Gettys T.W., et al. Multiplicity of mechanisms of serotonin receptor signal transduction. Pharmacol Ther 92 (2001) 179-212
4. Goadsby P.J. Serotonin receptor ligands: treatments of acute migraine and cluster headache. Handb Exp Pharmacol (2007) 129-143
5. Firk C., and Markus C.R. Review: Serotonin by stress interaction: a susceptibility factor for the development of depression?. J Psychopharmacol 21 (2007) 538-544
6. Alex K.D., and Pehek E.A. Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission. Pharmacol Ther 113 (2007) 296-320
7. Zarros A., Kalopita K.S., and Tsakiris S.T. Serotoninergic impairment and aggressive behavior in Alzheimer's disease. Acta Neurobiol Exp (Wars) 65 (2005) 277-286
8. Kaumann A.J., and Levy F.O. 5-Hydroxytryptamine receptors in the human cardiovascular system. Pharmacol Ther 111 (2006) 674-706
9. Crowell M.D., and Wessinger S.B. 5-HT and the brain-gut axis: opportunities for pharmacologic intervention. Expert Opin Investig Drugs 16 (2007) 761-765
10. Cruise J.L., Knechtle S.J., Bollinger R.R., Kuhn C., and Michalopoulos G. Alpha 1-adrenergic effects and liver regeneration. Hepatology 7 (1987) 1189-1194
11. Kato H., and Shimazu T. Effect of autonomic denervation on DNA synthesis during liver regeneration after partial hepatectomy. Eur J Biochem 134 (1983) 473-478
12. Hsu C.T. The role of the autonomic nervous system in chemically-induced liver damage and repair-using the essential hypertensive animal model (SHR). J Auton Nerv Syst 51 (1995) 135-142
13. el-Salhy M., Stenling R., and Grimelius L. Peptidergic innervation and endocrine cells in the human liver. Scand J Gastroenterol 28 (1993) 809-815
14. Stoyanova I.I. Relevance of mast cells and hepatic lobule innervation to liver injury. Rom J Gastroenterol 13 (2004) 203-209
15. Pyroja S., Joseph B., and Paulose C.S. Increased 5-HT(2C) receptor binding in the brain stem and cerebral cortex during liver regeneration and hepatic neoplasia in rats. J Neurol Sci 254 (2007) 3-8
16. Rapport M.M. The discovery of serotonin. Perspect Biol Med 40 (1997) 260-273
17. Richardson P.D., and Withrington P.G. A comparison of the effects of bradykinin, 5-hydroxytryptamine and histamine on the hepatic arterial and portal venous vascular beds of the dog: histamine H1 and H2-receptor populations. Br J Pharmacol 60 (1977) 123-133
18. Cummings S.A., Groszmann R.J., and Kaumann A.J. Hypersensitivity of mesenteric veins to 5-hydroxytryptamine- and ketanserin-induced reduction of portal pressure in portal hypertensive rats. Br J Pharmacol 89 (1986) 501-513
19. Koshy A., Sekiyama T., Hadengue A., Cerini R., Braillon A., and Lebrec D. Effects of alpha 1 and beta-adrenergic antagonists and 5-hydroxytryptamine receptor antagonist on portal-systemic collateral vascular resistance in conscious rats with portal hypertension. J Gastroenterol Hepatol 7 (1992) 449-454
20. Cummings S.A., Kaumann A.J., and Groszmann R.J. Comparison of the hemodynamic responses to ketanserin and prazosin in portal hypertensive rats. Hepatology 8 (1988) 1112-1115
21. Mastai R., Giroux L., Semret M., and Huet P.M. Ritanserin decreases portal pressure in conscious and unrestrained cirrhotic rats. Gastroenterology 98 (1990) 141-145
22. Nevens F., Pizcueta M.P., Fernandez M., Bosch J., and Rodes J. Effects of ritanserin, a selective and specific S2-serotonergic antagonist, on portal pressure and splanchnic hemodynamics in portal hypertensive rats. Hepatology 14 (1991) 1174-1178
23. Mastai R., Rocheleau B., and Huet P.M. Serotonin blockade in conscious, unrestrained cirrhotic dogs with portal hypertension. Hepatology 9 (1989) 265-268
24. Cummings J.L., Cilento E.V., and Reilly F.D. Hepatic microvascular regulatory mechanisms. XII. Effects of 5-HT2-receptor blockade on serotonin-induced intralobular hypoperfusion. Int J Microcirc Clin Exp 13 (1993) 99-112
25. Ruddell R.G., Oakley F., Hussain Z., Yeung I., Bryan-Lluka L.J., Ramm G.A., et al. A role for serotonin (5-HT) in hepatic stellate cell function and liver fibrosis. Am J Pathol 169 (2006) 861-876
26. Rockey D.C., Housset C.N., and Friedman S.L. Activation-dependent contractility of rat hepatic lipocytes in culture and in vivo. J Clin Invest 92 (1993) 1795-1804
27. Brauneis U., Gatmaitan Z., and Arias I.M. Serotonin stimulates a Ca2+ permeant nonspecific cation channel in hepatic endothelial cells. Biochem Biophys Res Commun 186 (1992) 1560-1566
28. Gatmaitan Z., Varticovski L., Ling L., Mikkelsen R., Steffan A.M., and Arias I.M. Studies on fenestral contraction in rat liver endothelial cells in culture. Am J Pathol 148 (1996) 2027-2041
29. Hadengue A., Lee S.S., Moreau R., Braillon A., and Lebrec D. Beneficial hemodynamic effects of ketanserin in patients with cirrhosis: possible role of serotonergic mechanisms in portal hypertension. Hepatology 7 (1987) 644-647
30. Hadengue A., Moreau R., Cerini R., Koshy A., Lee S.S., and Lebrec D. Combination of ketanserin and verapamil or propranolol in patients with alcoholic cirrhosis: search for an additive effect. Hepatology 9 (1989) 83-87
31. Islam M.Z., Williams B.C., Madhavan K.K., Hayes P.C., and Hadoke P.W. Selective alteration of agonist-mediated contraction in hepatic arteries isolated from patients with cirrhosis. Gastroenterology 118 (2000) 765-771
32. Vorobioff J., Garcia-Tsao G., Groszmann R., Aceves G., Picabea E., Villavicencio R., et al. Long-term hemodynamic effects of ketanserin, a 5-hydroxytryptamine blocker, in portal hypertensive patients. Hepatology 9 (1989) 88-91
33. Laffi G., Marra F., Gresele P., Romagnoli P., Palermo A., Bartolini O., et al. Evidence for a storage pool defect in platelets from cirrhotic patients with defective aggregation. Gastroenterology 103 (1992) 641-646
34. Beaudry P., Hadengue A., Callebert J., Gaudin C., Soliman H., Moreau R., et al. Blood and plasma 5-hydroxytryptamine levels in patients with cirrhosis. Hepatology 20 (1994) 800-803
35. Tripodi A., Primignani M., Chantarangkul V., Clerici M., Dell'Era A., Fabris F., et al. Thrombin generation in patients with cirrhosis: the role of platelets. Hepatology 44 (2006) 440-445
36. Mabuchi A., Mullaney I., Sheard P.W., Hessian P.A., Mallard B.L., Tawadrous M.N., et al. Role of hepatic stellate cell/hepatocyte interaction and activation of hepatic stellate cells in the early phase of liver regeneration in the rat. J Hepatol 40 (2004) 910-916
37. Kulinskii A.S., Saratikov A.S., Vstavskaia Iu A., and Udovitsina T.I. Effect of substances altering the metabolism of endogenous serotonin on mitotic activity in the regenerating liver of mice. Farmakol Toksikol 46 (1983) 92-95
38. Kulinskii V.I., Saratikov A.S., Vstavskaia Iu A., and Udovitsina T.I. Receptors mediating serotonin-stimulating liver regeneration in mice. Biull Eksp Biol Med 95 (1983) 89-91
39. Kulinskii V.I., Udovitsina T.I., Vstavskaia Iu A., and Rykov S.A. Comparison of the changes in mitotic activity and in serotonin concentration in regenerating liver. Vopr Med Khim 29 (1983) 104-107
40. Aslamova L.I., Blium Ia B., Tsudzevich B.A., and Kucherenko N.E. Cyclic nucleotide levels in the regenerating liver of rats following irradiation and protection by serotonin. Radiobiologiia 25 (1985) 324-327
41. Roy A.K., Bhadra R., and Datta A.G. The effect of epinephrine and serotonin on hepatic poly(A)+ RNA synthesis. Life Sci 36 (1985) 2301-2307
42. Lesurtel M., Graf R., Aleil B., Walther D.J., Tian Y., Jochum W., et al. Platelet-derived serotonin mediates liver regeneration. Science 312 (2006) 104-107
43. Papadimas G.K., Tzirogiannis K.N., Panoutsopoulos G.I., Demonakou M.D., Skaltsas S.D., Hereti R.I., et al. Effect of serotonin receptor 2 blockage on liver regeneration after partial hepatectomy in the rat liver. Liver Int 26 (2006) 352-361
44. Tzirogiannis K.N., Panoutsopoulos G.I., Papadimas G.K., Demonakou M.D., Hereti R.I., Manta G.A., et al. The effect of hepatic stimulator substance (HSS) on liver regeneration arrest induced by 5-HT2 receptor blockade. In Vivo 19 (2005) 841-847
45. Balasubramanian S., and Paulose C.S. Induction of DNA synthesis in primary cultures of rat hepatocytes by serotonin: possible involvement of serotonin S2 receptor. Hepatology 27 (1998) 62-66
46. Endo Y., and Nakamura M. The effect of lipopolysaccharide, interleukin-1 and tumour necrosis factor on the hepatic accumulation of 5-hydroxytryptamine and platelets in the mouse. Br J Pharmacol 105 (1992) 613-619
47. Marzioni M., Glaser S., Francis H., Marucci L., Benedetti A., Alvaro D., et al. Autocrine/paracrine regulation of the growth of the biliary tree by the neuroendocrine hormone serotonin. Gastroenterology 128 (2005) 121-137
48. Benbow S.J., and Gill G. Paroxetine and hepatotoxicity. BMJ 314 (1997) 1387
49. Cosme A., Barrio J., Lobo C., Gil I., Castiella A., and Arenas J.I. Acute cholestasis by fluoxetine. Am J Gastroenterol 91 (1996) 2449-2450
50. Milkiewicz P., Chilton A.P., Hubscher S.G., and Elias E. Antidepressant induced cholestasis: hepatocellular redistribution of multidrug resistant protein (MRP2). Gut 52 (2003) 300-303
51. Nakamura N., Hamada N., Murata R., Kobayashi A., Ishizaki N., Taira A., et al. Contribution of serotonin to liver injury following canine small-intestinal ischemia and reperfusion. J Surg Res 99 (2001) 17-24
52. Murata R., Hamada N., Nakamura N., Kobayashi A., Fukueda M., Taira A., et al. Serotonin activity and liver dysfunction following hepatic ischemia and reperfusion. In Vivo 17 (2003) 567-572
53. Nocito A., Georgiev P., Dahm F., Jochum W., Bader M., Graf R., et al. Platelets and platelet-derived serotonin promote tissue repair after normothermic hepatic ischemia in mice. Hepatology 45 (2007) 369-376
54. Bianchi P., Kunduzova O., Masini E., Cambon C., Bani D., Raimondi L., et al. Oxidative stress by monoamine oxidase mediates receptor-independent cardiomyocyte apoptosis by serotonin and postischemic myocardial injury. Circulation 112 (2005) 3297-3305
55. Nocito A., Dahm F., Jochum W., Jang J.H., Georgiev P., Bader M., et al. Serotonin mediates oxidative stress and mitochondrial toxicity in a murine model of nonalcoholic steatohepatitis. Gastroenterology 133 (2007) 608-618