Age-related changes in renal expression of oxidant and antioxidant enzymes and oxidative stress markers in male SHR and WKY rats

Experimental Gerontology

Volumn 46, Issue 6, 2011, Pages 468-474

  Simão, Sónia ^a   Gomes, Pedro ^a   Pinto, Vanda ^a   Silva, Elisabete ^a   Amaral, João S ^a   Igreja, Bruno ^a,b   Afonso, Joana ^a   Serrão, Maria Paula ^a   Pinho, Maria João ^a   Soares da Silva, Patrício ^a  

^a University of Porto   (Portugal)

^b DEPARTMENT OF RESEARCH AND DEVELOPMENT   (Portugal)

Author keywords

Aging; Hypertension; Kidney; Obesity; Oxidative stress

Indexed keywords

CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; EXTRACELLULAR SUPEROXIDE DISMUTASE; GLUTATHIONE PEROXIDASE; HYDROGEN PEROXIDE; MANGANESE SUPEROXIDE DISMUTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE SUBUNIT P22 PHOX; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG;

AGING; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; HEART RATE; KIDNEY CORTEX; MALE; NONHUMAN; OBESITY; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; STRAIN DIFFERENCE; SYSTOLIC BLOOD PRESSURE; URINALYSIS; WEIGHT GAIN; WISTAR KYOTO RAT;

AGING; ANIMALS; ANTIOXIDANTS; BLOOD PRESSURE; BODY WEIGHT; DISEASE MODELS, ANIMAL; HYDROGEN PEROXIDE; HYPERTENSION; KIDNEY; MALE; OXIDANTS; OXIDATIVE STRESS; RATS; RATS, INBRED SHR; RATS, INBRED WKY; SUPEROXIDE DISMUTASE;

RATTUS;

EID: 79955647610     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2011.02.003     Document Type: Article

References (35)

1. Adler S., Huang H. Oxidant stress in kidneys of spontaneously hypertensive rats involves both oxidase overexpression and loss of extracellular superoxide dismutase. Am J Physiol Renal Physiol 2004, 287:F907-913.
2. Alvarez M.C., Caldiz C., Fantinelli J.C., Garciarena C.D., Console G.M., Chiappe de Cingolani G.E., Mosca S.M. Is cardiac hypertrophy in spontaneously hypertensive rats the cause or the consequence of oxidative stress?. Hypertens Res 2008, 31:1465-1476.
3. Bedard K., Krause K.H. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev 2007, 87:245-313.
4. Biswas S.K., Peixoto E.B., Souza D.S., de Faria J.B. Hypertension increases pro-oxidant generation and decreases antioxidant defense in the kidney in early diabetes. Am J Nephrol 2008, 28:133-142.
5. Chabrashvili T., Tojo A., Onozato M.L., Kitiyakara C., Quinn M.T., Fujita T., Welch W.J., Wilcox C.S. Expression and cellular localization of classic NADPH oxidase subunits in the spontaneously hypertensive rat kidney. Hypertension 2002, 39:269-274.
6. Davi G., Guagnano M.T., Ciabattoni G., Basili S., Falco A., Marinopiccoli M., Nutini M., Sensi S., Patrono C. Platelet activation in obese women: role of inflammation and oxidant stress. JAMA 2002, 288:2008-2014.
7. de Cavanagh E.M., Toblli J.E., Ferder L., Piotrkowski B., Stella I., Inserra F. Renal mitochondrial dysfunction in spontaneously hypertensive rats is attenuated by losartan but not by amlodipine. Am J Physiol Regul Integr Comp Physiol 2006, 290:R1616-1625.
8. Finkel T., Holbrook N.J. Oxidants, oxidative stress and the biology of ageing. Nature 2000, 408:239-247.
9. Fortepiani L.A., Reckelhoff J.F. Increasing oxidative stress with molsidomine increases blood pressure in genetically hypertensive rats but not normotensive controls. Am J Physiol Regul Integr Comp Physiol 2005, 289:R763-770.
10. Furukawa S., Fujita T., Shimabukuro M., Iwaki M., Yamada Y., Nakajima Y., Nakayama O., Makishima M., Matsuda M., Shimomura I. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 2004, 114:1752-1761.
11. Griendling K.K., Sorescu D., Ushio-Fukai M. NAD(P)H oxidase: role in cardiovascular biology and disease. Circ Res 2000, 86:494-501.
12. Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol 1956, 11:298-300.
13. Judge S., Jang Y.M., Smith A., Hagen T., Leeuwenburgh C. Age-associated increases in oxidative stress and antioxidant enzyme activities in cardiac interfibrillar mitochondria: implications for the mitochondrial theory of aging. FASEB J 2005, 19:419-421.
14. Jung K.J., Lee E.K., Kim J.Y., Zou Y., Sung B., Heo H.S., Kim M.K., Lee J., Kim N.D., Yu B.P., Chung H.Y. Effect of short term calorie restriction on pro-inflammatory NF-kB and AP-1 in aged rat kidney. Inflamm Res 2009, 58:143-150.
15. Kerr S., Brosnan M.J., McIntyre M., Reid J.L., Dominiczak A.F., Hamilton C.A. Superoxide anion production is increased in a model of genetic hypertension: role of the endothelium. Hypertension 1999, 33:1353-1358.
16. Kregel K.C., Zhang H.J. An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations. Am J Physiol Regul Integr Comp Physiol 2007, 292:R18-36.
17. Lambertucci R.H., Levada-Pires A.C., Rossoni L.V., Curi R., Pithon-Curi T.C. Effects of aerobic exercise training on antioxidant enzyme activities and mRNA levels in soleus muscle from young and aged rats. Mech Ageing Dev 2007, 128:267-275.
18. Li H., Matheny M., Tumer N., Scarpace P.J. Aging and fasting regulation of leptin and hypothalamic neuropeptide Y gene expression. Am J Physiol 1998, 275:E405-411.
19. Li W.G., Miller F.J., Zhang H.J., Spitz D.R., Oberley L.W., Weintraub N.L. H(2)O(2)-induced O(2) production by a non-phagocytic NAD(P)H oxidase causes oxidant injury. J Biol Chem 2001, 276:29251-29256.
20. Ohkawa H., Ohishi N., Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979, 95:351-358.
21. Opalach K., Rangaraju S., Madorsky I., Leeuwenburgh C., Notterpek L. Lifelong calorie restriction alleviates age-related oxidative damage in peripheral nerves. Rejuvenation Res 2010, 13:65-74.
22. Paravicini T.M., Touyz R.M. NADPH oxidases, reactive oxygen species, and hypertension: clinical implications and therapeutic possibilities. Diabetes Care 2008, 31(Suppl 2):S170-180.
23. Percy C.J., Brown L., Power D.A., Johnson D.W., Gobe G.C. Obesity and hypertension have differing oxidant handling molecular pathways in age-related chronic kidney disease. Mech Ageing Dev 2009, 130:129-138.
24. Pratico, D., 2002. Lipid peroxidation and the aging process. Sci Aging Knowledge Environ 2002, re5.
25. Ricci E., Smallwood S., Chouabe C., Mertani H.C., Raccurt M., Morel G., Bonvallet R. Electrophysiological characterization of left ventricular myocytes from obese Sprague-Dawley rat. Obesity (Silver Spring) 2006, 14:778-786.
26. Schnackenberg C.G., Wilcox C.S. Two-week administration of tempol attenuates both hypertension and renal excretion of 8-Iso prostaglandin F2alpha. Hypertension 1999, 33:424-428.
27. Suzuki A., Fujii A., Jokura H., Tokimitsu I., Hase T., Saito I. Hydroxyhydroquinone interferes with the chlorogenic acid-induced restoration of endothelial function in spontaneously hypertensive rats. Am J Hypertens 2008, 21:23-27.
28. Touyz R.M. Reactive oxygen species, vascular oxidative stress, and redox signaling in hypertension: what is the clinical significance?. Hypertension 2004, 44:248-252.
29. Trippodo N.C., Frohlich E.D. Similarities of genetic (spontaneous) hypertension. Man and rat. Circ Res 1981, 48:309-319.
30. Ulker S., McMaster D., McKeown P.P., Bayraktutan U. Impaired activities of antioxidant enzymes elicit endothelial dysfunction in spontaneous hypertensive rats despite enhanced vascular nitric oxide generation. Cardiovasc Res 2003, 59:488-500.
31. Urakawa H., Katsuki A., Sumida Y., Gabazza E.C., Murashima S., Morioka K., Maruyama N., Kitagawa N., Tanaka T., Hori Y., Nakatani K., Yano Y., Adachi Y. Oxidative stress is associated with adiposity and insulin resistance in men. J Clin Endocrinol Metab 2003, 88:4673-4676.
32. Ward W.F., Qi W., Van Remmen H., Zackert W.E., Roberts L.J., Richardson A. Effects of age and caloric restriction on lipid peroxidation: measurement of oxidative stress by F2-isoprostane levels. J Gerontol A Biol Sci Med Sci 2005, 60:847-851.
33. Wilcox C.S. Reactive oxygen species: roles in blood pressure and kidney function. Curr Hypertens Rep 2002, 4:160-166.
34. Zhan C.D., Sindhu R.K., Vaziri N.D. Up-regulation of kidney NAD(P)H oxidase and calcineurin in SHR: reversal by lifelong antioxidant supplementation. Kidney Int 2004, 65:219-227.
35. Zhan C.D., Sindhu R.K., Pang J., Ehdaie A., Vaziri N.D. Superoxide dismutase, catalase and glutathione peroxidase in the spontaneously hypertensive rat kidney: effect of antioxidant-rich diet. J Hypertens 2004, 22:2025-2033.