-
2
-
-
0028007092
-
DNA oxidative damage and life expectancy in houseflies
-
Agarwal S, Sohal RS. DNA oxidative damage and life expectancy in houseflies. Proc Natl Acad Sci USA 1994;91: 12332-12335.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 12332-12335
-
-
Agarwal, S.1
Sohal, R.S.2
-
3
-
-
0028116159
-
Effect of age and caloric restriction on DNA oxidative damage in different tissues of C57BL=6 mice
-
Sohal RS, Agarwal S, Candas M, Forster MJ, Lal H. Effect of age and caloric restriction on DNA oxidative damage in different tissues of C57BL=6 mice. Mech Ageing Dev 1994; 76:215-224.
-
(1994)
Mech Ageing Dev
, vol.76
, pp. 215-224
-
-
Sohal, R.S.1
Agarwal, S.2
Candas, M.3
Forster, M.J.4
Lal, H.5
-
5
-
-
0034890357
-
Lipid hydroperoxide-mediated DNA damage
-
Blair I. A. Lipid hydroperoxide-mediated DNA damage. Exp Gerontol 2001;36:1473-1481.
-
(2001)
Exp Gerontol
, vol.36
, pp. 1473-1481
-
-
Blair, I.A.1
-
6
-
-
0032950964
-
Demyelination: The role of reactive oxygen and nitrogen species
-
Smith KJ, Kapoor R, Felts PA. Demyelination: The role of reactive oxygen and nitrogen species. Brain Pathol 1999;9:69-92.
-
(1999)
Brain Pathol
, vol.9
, pp. 69-92
-
-
Smith, K.J.1
Kapoor, R.2
Felts, P.A.3
-
7
-
-
0034891783
-
Oxidative modification of proteins during aging
-
Levine RL, Stadtman ER. Oxidative modification of proteins during aging. Exp Gerontol 2001;36:1495-1502.
-
(2001)
Exp Gerontol
, vol.36
, pp. 1495-1502
-
-
Levine, R.L.1
Stadtman, E.R.2
-
8
-
-
0041669528
-
The proteasomal system and HNE-modified proteins
-
Grune T, Davies KJ. The proteasomal system and HNE-modified proteins. Mol Aspects Med 2003;24:195-204.
-
(2003)
Mol Aspects Med
, vol.24
, pp. 195-204
-
-
Grune, T.1
Davies, K.J.2
-
9
-
-
57949087452
-
Molecular inflammation: Underpinnings of aging and age-related diseases
-
Chung H. Y. Cesari M, Anton S, Marzetti E, Giovannini S, Seo AY, Carter C, Yu BP, Leeuwenburgh C. Molecular inflammation: underpinnings of aging and age-related diseases. Ageing Res Rev 2009;8:18-30.
-
(2009)
Ageing Res Rev
, vol.8
, pp. 18-30
-
-
Chung, H.1
Cesari Y, M.2
Anton, S.3
Marzetti, E.4
Giovannini, S.5
Seo, A.Y.6
Carter, C.7
Yu, B.P.8
Leeuwenburgh, C.9
-
10
-
-
0030929766
-
Calorie restriction inhibits the age-related dysregulation of the cytokines TNF-alpha and IL-6 in C3B10RF1 mice
-
Spaulding CC, Walford RL, Effros RB. Calorie restriction inhibits the age-related dysregulation of the cytokines TNF-alpha and IL-6 in C3B10RF1 mice. Mech Ageing Dev 1997; 93:87-94.
-
(1997)
Mech Ageing Dev
, vol.93
, pp. 87-94
-
-
Spaulding, C.C.1
Walford, R.L.2
Effros, R.B.3
-
11
-
-
33646697132
-
Hepatic oxidative stress during aging: Effects of 8% long-term calorie restriction and lifelong exercise
-
Seo AY, Hofer T, Sung B, Judge S, Chung HY, Leeu-wenburgh C. Hepatic oxidative stress during aging: Effects of 8% long-term calorie restriction and lifelong exercise. Antioxid Redox Signal 2006;8:529-538.
-
(2006)
Antioxid Redox Signal
, vol.8
, pp. 529-538
-
-
Seo, A.Y.1
Hofer, T.2
Sung, B.3
Judge, S.4
Chung, H.Y.5
Leeu-Wenburgh, C.6
-
12
-
-
42449142360
-
Interaction of aging-associated signaling cascades: Inhibition of NF-kappaB signaling by longevity factors FoxOs and SIRT1
-
Salminen A, Ojala J, Huuskonen U, Kauppinen A, Suuronen T, Kaarniranta K. Interaction of aging-associated signaling cascades: inhibition of NF-kappaB signaling by longevity factors FoxOs and SIRT1. Cell Mol Life Sci 2008;65:1049-1058.
-
(2008)
Cell Mol Life Sci
, vol.65
, pp. 1049-1058
-
-
Salminen, A.1
Ojala, J.2
Huuskonen, U.3
Kauppinen, A.4
Suuronen, T.5
Kaarniranta, K.6
-
13
-
-
39049162829
-
Decreased peripheral nerve damage after ischemia-reperfusion injury in mice lacking TNF-alpha
-
Wang Y, Kawamura N, Schmelzer JD, Schmeichel AM, Low PA. Decreased peripheral nerve damage after ischemia-reperfusion injury in mice lacking TNF-alpha. J Neurol Sci 2008;267:107-111.
-
(2008)
J Neurol Sci
, vol.267
, pp. 107-111
-
-
Wang, Y.1
Kawamura, N.2
Schmelzer, J.D.3
Schmeichel, A.M.4
Low, P.A.5
-
14
-
-
33748540014
-
Caloric restriction and intermittent fasting: Two potential diets for successful brain aging
-
Martin B, Mattson MP, Maudsley S. Caloric restriction and intermittent fasting: two potential diets for successful brain aging. Ageing Res Rev 2006;5:332-353.
-
(2006)
Ageing Res Rev
, vol.5
, pp. 332-353
-
-
Martin, B.1
Mattson, M.P.2
Maudsley, S.3
-
15
-
-
0030038103
-
Oxidative stress, caloric restriction, and aging
-
Sohal RS, Weindruch R. Oxidative stress, caloric restriction, and aging. Science 1996;273:59-63.
-
(1996)
Science
, vol.273
, pp. 59-63
-
-
Sohal, R.S.1
Weindruch, R.2
-
16
-
-
4344690373
-
Effect of ageing and caloric restriction on specific markers of protein oxidative damage and membrane peroxidizability in rat liver mitochondria
-
Lambert AJ, Portero-Otin M, Pamplona R, Merry BJ. Effect of ageing and caloric restriction on specific markers of protein oxidative damage and membrane peroxidizability in rat liver mitochondria. Mech Ageing Dev 2004;125:529-538.
-
(2004)
Mech Ageing Dev
, vol.125
, pp. 529-538
-
-
Lambert, A.J.1
Portero-Otin, M.2
Pamplona, R.3
Merry, B.J.4
-
17
-
-
34548512483
-
Autophagy in the heart and liver during normal aging and calorie restriction
-
Wohlgemuth SE, Julian D, Akin DE, Fried J, Toscano K, Leeuwenburgh C, Dunn WA Jr. Autophagy in the heart and liver during normal aging and calorie restriction. Rejuvenation Res 2007;10:281-292.
-
(2007)
Rejuvenation Res
, vol.10
, pp. 281-292
-
-
Wohlgemuth, S.E.1
Julian, D.2
Akin, D.E.3
Fried, J.4
Toscano, K.5
Leeuwenburgh, C.6
Dunn WA, Jr.7
-
18
-
-
63549138319
-
Molecular architecture of myelinated peripheral nerves is supported by calorie restriction with aging
-
Rangaraju S, Hankins D, Madorsky I, Madorsky E, Lee WH, Carter CS, Leeuwenburgh C, Notterpek L. Molecular architecture of myelinated peripheral nerves is supported by calorie restriction with aging. Aging Cell 2009;8:178-191.
-
(2009)
Aging Cell
, vol.8
, pp. 178-191
-
-
Rangaraju, S.1
Hankins, D.2
Madorsky, I.3
Madorsky, E.4
Lee, W.H.5
Carter, C.S.6
Leeuwenburgh, C.7
Notterpek, L.8
-
19
-
-
51449110339
-
Iron accumulation with age, oxidative stress and functional decline
-
Xu J, Knutson MD, Carter CS, Leeuwenburgh C. Iron accumulation with age, oxidative stress and functional decline. PLoS One 2008;3:e2865.
-
(2008)
PLoS One
, vol.3
-
-
Xu, J.1
Knutson, M.D.2
Carter, C.S.3
Leeuwenburgh, C.4
-
20
-
-
0033398548
-
Growth curves and survival characteristics of the animals used in the Biomarkers of Aging Program
-
Turturro A, Witt WW, Lewis S, Hass BS, Lipman BD, Hart RW. Growth curves and survival characteristics of the animals used in the Biomarkers of Aging Program. J Gerontol A Biol Sci Med Sci 1999;54:B492-B501.
-
(1999)
J Gerontol A Biol Sci Med Sci
, vol.54
-
-
Turturro, A.1
Witt, W.W.2
Lewis, S.3
Hass, B.S.4
Lipman, B.D.5
Hart, R.W.6
-
21
-
-
63549138319
-
The molecular architecture of myelinated peripheral nerves is supported by calorie restriction with aging
-
Rangaraju S, Hankins D, Madorsky I, Madorsky E, Lee WH, Carter CS, Leeuwenburgh C, Nottepek L. The molecular architecture of myelinated peripheral nerves is supported by calorie restriction with aging. Aging Cell 2009);8:178-191.
-
(2009)
Aging Cell
, vol.8
, pp. 178-191
-
-
Rangaraju, S.1
Hankins, D.2
Madorsky, I.3
Madorsky, E.4
Lee, W.H.5
Carter, C.S.6
Leeuwenburgh, C.7
Nottepek, L.8
-
22
-
-
4344677922
-
Decreased prote-olysis caused by protein aggregates, inclusion bodies, plaques, lipofuscin, ceroid, and 'aggresomes' during oxidative stress, aging, and disease
-
Grune T, Jung T, Merker K, Davies KJ. Decreased prote-olysis caused by protein aggregates, inclusion bodies, plaques, lipofuscin, ceroid, and 'aggresomes' during oxidative stress, aging, and disease. Int J Biochem Cell Biol 2004;36: 2519-2530.
-
(2004)
Int J Biochem Cell Biol
, vol.36
, pp. 2519-2530
-
-
Grune, T.1
Jung, T.2
Merker, K.3
Davies, K.J.4
-
23
-
-
36549035313
-
Lipofuscin: Formation, distribution, and metabolic consequences
-
Jung T, Bader N, Grune T. Lipofuscin: formation, distribution, and metabolic consequences. Ann NY Acad Sci 2007; 1119:97-111.
-
(2007)
Ann NY Acad Sci
, vol.1119
, pp. 97-111
-
-
Jung, T.1
Bader, N.2
Grune, T.3
-
24
-
-
0035072229
-
Degradation of oxidized proteins by the 20S proteasome
-
Davies KJ. Degradation of oxidized proteins by the 20S proteasome. Biochimie 2001;83:301-310.
-
(2001)
Biochimie
, vol.83
, pp. 301-310
-
-
Davies, K.J.1
-
25
-
-
0035434379
-
Reactive carbonyl formation by oxida-tive and non-oxidative pathways
-
Adams S, Green P, Claxton R, Simcox S, Williams MV, Walsh K, Leeuwenburgh C. Reactive carbonyl formation by oxida-tive and non-oxidative pathways. Front Biosci 2001;6:A17-A24.
-
(2001)
Front Biosci
, vol.6
-
-
Adams, S.1
Green, P.2
Claxton, R.3
Simcox, S.4
Williams, M.V.5
Walsh, K.6
Leeuwenburgh, C.7
-
26
-
-
0035869418
-
4-Hydro-xynonenal, a lipid peroxidation byproduct of spinal cord injury, is cytotoxic for oligodendrocyte progenitors and inhibits their responsiveness to PDGF
-
Gard AL, Solodushko VG, Waeg G, Majic, T. 4-Hydro-xynonenal, a lipid peroxidation byproduct of spinal cord injury, is cytotoxic for oligodendrocyte progenitors and inhibits their responsiveness to PDGF. Microsc Res Tech 2001; 52:709-718.
-
(2001)
Microsc Res Tech
, vol.52
, pp. 709-718
-
-
Gard, A.L.1
Solodushko, V.G.2
Waeg, G.3
Majic, T.4
-
27
-
-
0031916984
-
The free radical theory of aging matures
-
Beckman KB, Ames BN. The free radical theory of aging matures. Physiol Rev 1998;78:547-581.
-
(1998)
Physiol Rev
, vol.78
, pp. 547-581
-
-
Beckman, K.B.1
Ames, B.N.2
-
28
-
-
0026746211
-
Inflammatory mediators in demyelinating disorders of the CNS and PNS
-
Hartung HP, Jung S, Stoll G, Zielasek J, Schmidt B, Archelos JJ, Toyka KV. Inflammatory mediators in demyelinating disorders of the CNS and PNS. J Neuroimmunol 1992;40: 197-210.
-
(1992)
J Neuroimmunol
, vol.40
, pp. 197-210
-
-
Hartung, H.P.1
Jung, S.2
Stoll, G.3
Zielasek, J.4
Schmidt, B.5
Archelos, J.J.6
Toyka, K.V.7
-
29
-
-
0036847146
-
Matrix metalloproteinase mediated degradation of basement membrane proteins in Trembler J neuropathy nerves
-
Misko A, Ferguson T, Notterpek L. Matrix metalloproteinase mediated degradation of basement membrane proteins in Trembler J neuropathy nerves. J Neurochem 2002;83:885-894.
-
(2002)
J Neurochem
, vol.83
, pp. 885-894
-
-
Misko, A.1
Ferguson, T.2
Notterpek, L.3
-
31
-
-
34247158551
-
Calorie restriction in nonhuman primates: Assessing effects on brain and behavioral aging
-
Ingram DK, Young J, Mattison JA. Calorie restriction in nonhuman primates: assessing effects on brain and behavioral aging. Neuroscience 2007;145:1359-1364.
-
(2007)
Neuroscience
, vol.145
, pp. 1359-1364
-
-
Ingram, D.K.1
Young, J.2
Mattison, J.A.3
-
32
-
-
45049086767
-
Comparative proteomic analysis of brains of naturally aging mice
-
Yang S, Liu T, Li S, Zhang X, Ding W, Que H, Yan X, Wei K, Liu S. Comparative proteomic analysis of brains of naturally aging mice. Neuroscience 2008;154:1107-1120.
-
(2008)
Neuroscience
, vol.154
, pp. 1107-1120
-
-
Yang, S.1
Liu, T.2
Li, S.3
Zhang, X.4
Ding, W.5
Que, H.6
Yan, X.7
Wei, K.8
Liu, S.9
-
33
-
-
0036236006
-
The mitochondrial-lysosomal axis theory of aging: Accumulation of damaged mitochondria as a result of imperfect autophagocytosis
-
Brunk UT, Terman A. The mitochondrial-lysosomal axis theory of aging: Accumulation of damaged mitochondria as a result of imperfect autophagocytosis. Eur J Biochem 2002; 269:1996-2002.
-
(2002)
Eur J Biochem
, vol.269
, pp. 1996-2002
-
-
Brunk, U.T.1
Terman, A.2
-
34
-
-
62149126997
-
Intermittent fasting alleviates the neuropathic phenotype in a mouse model of Charcot-Marie-Tooth disease
-
Madorsky I, Opalach K, Waber A, Verrier JD, Solmo C, Foster T, Dunn WA Jr, Nottepek L. Intermittent fasting alleviates the neuropathic phenotype in a mouse model of Charcot-Marie-Tooth disease. Neurobiol Dis 2009;34: 146-154.
-
(2009)
Neurobiol Dis
, vol.34
, pp. 146-154
-
-
Madorsky, I.1
Opalach, K.2
Waber, A.3
Verrier, J.D.4
Solmo, C.5
Foster, T.6
Nottepek, L.7
-
35
-
-
33748413303
-
Intracellular quality control by au-tophagy: How does autophagy prevent neurodegeneration?
-
Mizushima N, Hara T. Intracellular quality control by au-tophagy: how does autophagy prevent neurodegeneration? Autophagy 2006;2:302-304.
-
(2006)
Autophagy
, vol.2
, pp. 302-304
-
-
Mizushima, N.1
Hara, T.2
-
36
-
-
21044455137
-
Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice
-
Komatsu M, Waguri S, Ueno T, Iwata J, Murata S, Tanida I, Ezaki J, Mizushima N, Ohsumi Y, Uchiyama Y, Kominami E, Tanaka K, Chiba T. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 2005;169:425-434.
-
(2005)
J Cell Biol
, vol.169
, pp. 425-434
-
-
Komatsu, M.1
Waguri, S.2
Ueno, T.3
Iwata, J.4
Murata, S.5
Tanida, I.6
Ezaki, J.7
Mizushima, N.8
Ohsumi, Y.9
Uchiyama, Y.10
Kominami, E.11
Tanaka, K.12
Chiba, T.13
-
37
-
-
0036570159
-
Oxidatively modified proteins in aging and disease
-
Beal MF. Oxidatively modified proteins in aging and disease. Free Radic Biol Med 2002;32:797-803.
-
(2002)
Free Radic Biol Med
, vol.32
, pp. 797-803
-
-
Beal, M.F.1
-
38
-
-
0034043908
-
Low fatty acid unsaturation: A mechanism for lowered lipoperoxidative modification of tissue proteins in mammalian species with long life spans
-
Pamplona R, Portero-Otin M, Riba D, Requena JR, Thorpe SR, Lopez-Torres M, Barja G. Low fatty acid unsaturation: a mechanism for lowered lipoperoxidative modification of tissue proteins in mammalian species with long life spans. J Gerontol A Biol Sci Med Sci 2000;55:B286-B291.
-
(2000)
J Gerontol A Biol Sci Med Sci
, vol.55
-
-
Pamplona, R.1
Portero-Otin, M.2
Riba, D.3
Requena, J.R.4
Thorpe, S.R.5
Lopez-Torres, M.6
Barja, G.7
-
39
-
-
0038239701
-
Selective degradation of oxidatively modified protein substrates by the pro-teasome
-
Grune T, Merker K, Sandig G, Davies KJ. Selective degradation of oxidatively modified protein substrates by the pro-teasome. Biochem Biophys Res Commun 2003;305:709-718.
-
(2003)
Biochem Biophys Res Commun
, vol.305
, pp. 709-718
-
-
Grune, T.1
Merker, K.2
Sandig, G.3
Davies, K.J.4
-
41
-
-
33644662970
-
Proteasome function in aging and oxi-dative stress: Implications in protein maintenance failure
-
Farout L, Friguet B. Proteasome function in aging and oxi-dative stress: Implications in protein maintenance failure. Antioxid Redox Signal 2006;8:205-216.
-
(2006)
Antioxid Redox Signal
, vol.8
, pp. 205-216
-
-
Farout, L.1
Friguet, B.2
-
42
-
-
33747699723
-
The clinical impact of systemic low-level inflammation in elderly populations. with special reference to cardiovascular disease, dementia and mortality
-
Bruunsgaard H. The clinical impact of systemic low-level inflammation in elderly populations. With special reference to cardiovascular disease, dementia and mortality. Dan Med Bull 2006;53:285-309.
-
(2006)
Dan Med Bull
, vol.53
, pp. 285-309
-
-
Bruunsgaard, H.1
-
43
-
-
16344385647
-
Muscle fiber specific apoptosis and TNF-alpha signaling in sarcopenia are attenuated by lifelong calorie restriction
-
Phillips T, Leeuwenburgh C. Muscle fiber specific apoptosis and TNF-alpha signaling in sarcopenia are attenuated by lifelong calorie restriction. FASEB J 2005;19:668-670.
-
(2005)
FASEB J
, vol.19
, pp. 668-670
-
-
Phillips, T.1
Leeuwenburgh, C.2
-
44
-
-
0030613551
-
The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation
-
Zandi E, Rothwarf DM, Delhase M, Hayakawa M, Karin M. The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation. Cell 1997;91: 243-252.
-
(1997)
Cell
, vol.91
, pp. 243-252
-
-
Zandi, E.1
Rothwarf, D.M.2
Delhase, M.3
Hayakawa, M.4
Karin, M.5
-
45
-
-
33750591642
-
Role for IKK2 in muscle: Waste not, want not
-
Karin M. Role for IKK2 in muscle: Waste not, want not. J Clin Invest 2006;116:2866-2868.
-
(2006)
J Clin Invest
, vol.116
, pp. 2866-2868
-
-
Karin, M.1
-
46
-
-
0031014865
-
Induction of nuclear factor kappaB and activation protein 1 in postischemic myocardium
-
Chandrasekar B, Freeman G. L. Induction of nuclear factor kappaB and activation protein 1 in postischemic myocardium. FEBS Lett 1997;401:30-34).
-
(1997)
FEBS Lett
, vol.401
, pp. 30-34
-
-
Chandrasekar, B.1
Freeman, G.L.2
-
47
-
-
0037093677
-
Molecular exploration of age-related NF-kappaB=IKK downregulation by calorie restriction in rat kidney
-
Kim HJ, Yu BP, Chung HY. Molecular exploration of age-related NF-kappaB=IKK downregulation by calorie restriction in rat kidney. Free Radic Biol Med 2002;32:991-1005.
-
(2002)
Free Radic Biol Med
, vol.32
, pp. 991-1005
-
-
Kim, H.J.1
Yu, B.P.2
Chung, H.Y.3
-
48
-
-
0035364524
-
Expression and distribution of transcription factor NF-kappaB and inhibitor IkappaB in the inflamed peripheral nervous system
-
Andorfer B, Kieseier BC, Mathey E, Armati P, Pollard J, Oka N, Hartung HP. Expression and distribution of transcription factor NF-kappaB and inhibitor IkappaB in the inflamed peripheral nervous system. J Neuroimmunol 2001;116:226-232.
-
(2001)
J Neuroimmunol
, vol.116
, pp. 226-232
-
-
Andorfer, B.1
Kieseier, B.C.2
Mathey, E.3
Armati, P.4
Pollard, J.5
Oka, N.6
Hartung, H.P.7
-
49
-
-
0033452148
-
Morphometric and ultrastructural changes with ageing in mouse peripheral nerve
-
Ceballos D, Cuadras J, Verdu E, Navarro X. Morphometric and ultrastructural changes with ageing in mouse peripheral nerve. J Anat 1999;195(Pt 4):563-576.
-
(1999)
J Anat
, vol.195
, Issue.PART 4
, pp. 563-576
-
-
Ceballos, D.1
Cuadras, J.2
Verdu, E.3
Navarro, X.4
-
50
-
-
0037010302
-
Ultrastructural analysis of the paranodal junction of myelinated fibers in 31-month-old-rats
-
Sugiyama I, Tanaka K, Akita M, Yoshida K, Kawase T, Asou H. Ultrastructural analysis of the paranodal junction of myelinated fibers in 31-month-old-rats. J Neurosci Res 2002; 70:309-317.
-
(2002)
J Neurosci Res
, vol.70
, pp. 309-317
-
-
Sugiyama, I.1
Tanaka, K.2
Akita, M.3
Yoshida, K.4
Kawase, T.5
Asou, H.6
|