Systematic evaluation of the descriptive and predictive performance of Paediatric morphine population models

Pharmaceutical Research

Volumn 28, Issue 4, 2011, Pages 797-811

  Krekels, Elke H J ^a,b   Van Hasselt, Johan G C ^a   Tibboel, Dick ^b   Danhof, Meindert ^a   Knibbe, Catherijne A J ^a,b,c  

^a LEIDEN UNIVERSITY   (Netherlands)

^b SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^c ST ANTONIUS HOSPITAL   (Netherlands)

Author keywords

model evaluation; morphine; paediatric pharmacokinetic population modeling

Indexed keywords

MORPHINE; MORPHINE 3 GLUCURONIDE; MORPHINE 6 GLUCURONIDE;

ACCURACY; ALLOMETRY; ARTICLE; CHILD; CONCEPTUAL FRAMEWORK; CONTINUOUS INFUSION; CONTROLLED STUDY; COVARIANCE; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG INTERMITTENT THERAPY; HUMAN; INFANT; NEWBORN; PARAMETRIC TEST; PEDIATRIC POPULATION MODEL; POPULATION MODEL; PREDICTIVE VALUE; PRESCHOOL CHILD; PRIORITY JOURNAL; STATISTICAL ANALYSIS;

CHILD, PRESCHOOL; COMPUTER SIMULATION; FORECASTING; HUMANS; INFANT; INFANT, NEWBORN; METABOLIC CLEARANCE RATE; MODELS, BIOLOGICAL; MORPHINE DERIVATIVES;

EID: 79955640306     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-010-0333-1     Document Type: Article

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