Endogenously expressed matrix protein M1 and nucleoprotein of influenza a are efficiently presented by class I and class II major histocompatibility complexes

Journal of General Virology

Volumn 92, Issue 5, 2011, Pages 1162-1171

  Doucet, Jean Daniel ^a   Forget, Marie Andree ^a   Grange, Cecile ^a   Rouxel, Ronan Nicolas ^b   Arbour, Nathalie ^a   von Messling, Veronika ^b   Lapointe, Rejean ^a  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^b INRS INSTITUT ARMAND FRAPPIER   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MATRIX PROTEIN; MATRIX PROTEIN M1; NUCLEOPROTEIN; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL EXPANSION; CELLULAR IMMUNITY; CONTROLLED STUDY; CROSS PRESENTATION; CYTOKINE PRODUCTION; CYTOKINE RELEASE; EFFECTOR CELL; ELECTROPORATION; HUMAN; HUMAN CELL; INFLUENZA VIRUS A; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTIGEN PRESENTATION; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CELLS, CULTURED; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INTERFERON-GAMMA; RNA-BINDING PROTEINS; TUMOR NECROSIS FACTOR-ALPHA; VIRAL CORE PROTEINS; VIRAL MATRIX PROTEINS;

EID: 79955639524     PISSN: 00221317     EISSN: 14652099     Source Type: Journal    
DOI: 10.1099/vir.0.029777-0     Document Type: Article

References (52)

1. + T cell response. J Immunol 183, 7919-7930.
2. + T cell subsets identified by expression of IL-7 receptor a and CD62L. J Immunol 175, 4686-4696.
3. Baumgarth, N. & Kelso, A. (1996). In vivo blockade of gamma interferon affects the influenza virus-induced humoral and the local cellular immune response in lung tissue. J Virol 70, 4411-4418.
4. Bednarek, M. A., Sauma, S. Y., Gammon, M. C., Porter, G., Tamhankar, S., Williamson, A. R. & Zweerink, H. J. (1991). The minimum peptide epitope from the influenza virus matrix protein. Extra and intracellular loading of HLA-A2. J Immunol 147, 4047-4053.
5. Berkhoff, E. G. M., de Wit, E., Geelhoed-Mieras, M. M., Boon, A. C. M., Symons, J., Fouchier, R. A. M., Osterhaus, A. D. M. E. & Rimmelzwaan, G. F. (2006). Fitness costs limit escape from cytotoxic T lymphocytes by influenza A viruses. Vaccine 24, 6594-6596.
6. + T cells identifies functionally and phenotypically defined memory T cells during acute resolving hepatitis B virus infection. J Virol 80, 3532-3540.
7. Boon, A. C. M., de Mutsert, G., Graus, Y. M. F., Fouchier, R. A. M., Sintnicolaas, K., Osterhaus, A. D. M. E. & Rimmelzwaan, G. F. (2002). The magnitude and specificity of influenza A virus-specific cytotoxic T-lymphocyte responses in humans is related to HLA-A and -B phenotype. J Virol 76, 582-590.
8. Bui, H.-H., Peters, B., Assarsson, E., Mbawuike, I. & Sette, A. (2007). Ab and T cell epitopes of influenza A virus, knowledge and opportunities. Proc Natl Acad Sci USA 104, 246-251.
9. Deng, Y., Jing, Y., Campbell, A. E. & Gravenstein, S. (2004). Age-related impaired type 1 T cell responses to influenza: reduced activation ex vivo, decreased expansion in CTL culture in vitro, and blunted response to influenza vaccination in vivo in the elderly. J Immunol 172, 3437-3446.
10. De Rosa, S. C., Lu, F. X., Yu, J., Perfetto, S. P., Falloon, J., Moser, S., Evans, T. G., Koup, R., Miller, C. J. & Roederer, M. (2004). Vaccination in humans generates broad T cell cytokine responses. J Immunol 173, 5372-5380.
11. Doucet, J.-D., Gauchat, D. & Lapointe, R. (2010). Identification of influenza T cell epitopes by a novel mRNA PCR-based epitope chasing technique. In Canadian Pandemic Preparedness Meeting: Outcomes, Impacts and Lessons Learned, abstract on p. 45. Montreal, Quebec, Canada: Public Health Agency of Canada. http://www.ppsri-irscip.ca/print/handbook-010.pdf, accessed 21 February 2011.
12. Epstein, S. L., Tumpey, T. M., Misplon, J. A., Lo, C. Y., Cooper, L. A., Subbarao, K., Renshaw, M., Sambhara, S. & Katz, J. M. (2002). DNA vaccine expressing conserved influenza virus proteins protective against H5N1 challenge infection in mice. Emerg Infect Dis 8, 796-801.
13. Furuya, Y., Chan, J., Regner, M., Lobigs, M., Koskinen, A., Kok, T., Manavis, J., Li, P., Mullbacher, A. & Alsharifi, M. (2010). Cytotoxic T cells are the predominant players providing cross-protective immunity induced by gamma-irradiated influenza A viruses. J Virol 84, 4212-4221.
14. + mediated cellular immune response to recombin-ant influenza nucleoprotein. Vaccine 20, 3731-3738.
15. Gueguen, M. & Long, E. O. (1996). Presentation of a cytosolic antigen by major histocompatibility complex class II molecules requires a long-lived form of the antigen. Proc Natl Acad Sci USA 93, 14692-14697.
16. Heiny, A. T., Miotto, O., Srinivasan, K. N., Khan, A. M., Zhang, G. L., Brusic, V., Tan, T. W. & August, J. T. (2007). Evolutionarily conserved protein sequences of influenza A viruses, avian and human, as vaccine targets. PLoS ONE 2, e1190.
17. Hikono, H., Kohlmeier, J. E., Ely, K. H., Scott, I., Roberts, A. D., Blackman, M. A. & Woodland, D. L. (2006). T-cell memory and recall responses to respiratory virus infections. Immunol Rev 211, 119-132.
18. + T lymphocyte memory to influenza A viruses of swine and avian species. J Immunol 162, 7578-7583.
19. + T lymphocytes. Nature 421, 852-856.
20. Jaraquemada, D., Marti, M. & Long, E. O. (1990). An endogenous processing pathway in vaccinia virus-infected cells for presentation of cytoplasmic antigens to class II-restricted T cells. J Exp Med 172, 947-954.
21. Kim, J. H. & Jacob, J. (2009). DNA vaccines against influenza viruses. Curr Top Microbiol Immunol 333, 197-210.
22. + T cell response to respiratory virus infections. Immunity 29, 101-113.
23. Kreijtz, J. H., de Mutsert, G., van Baalen, C. A., Fouchier, R. A., Osterhaus, A. D. & Rimmelzwaan, G. F. (2008). Cross-recognition of avian H5N1 influenza virus by human cytotoxic T-lymphocyte populations directed to human influenza A virus. J Virol 82, 5161-5166.
24. Lapointe, R., Bellemare-Pelletier, A., Housseau, F., Thibodeau, J. & Hwu, P. (2003). CD40-stimulated B lymphocytes pulsed with tumor antigens are effective antigen-presenting cells that can generate specific T cells. Cancer Res 63, 2836-2843.
25. Lee, L. Y., Ha, L. A., Simmons, C., de Jong, M. D., Chau, N. V., Schumacher, R., Peng, Y. C., McMichael, A. J., Farrar, J. J. & other authors (2008). Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals. J Clin Invest 118, 3478-3490.
26. Lepage, S. & Lapointe, R. (2006). Melanosomal targeting sequences from gp100 are essential for MHC class II-restricted endogenous epitope presentation and mobilization to endosomal compartments. Cancer Res 66, 2423-2432.
27. Maecker, H. T., Umetsu, D. T., DeKruyff, R. H. & Levy, S. (1998). Cytotoxic T cell responses to DNA vaccination: dependence on antigen presentation via class II MHC. J Immunol 161, 6532-6536.
28. McMichael, A. J., Gotch, F. M., Noble, G. R. & Beare, P. A. (1983). Cytotoxic T-cell immunity to influenza. N Engl J Med 309, 13-17.
29. + T cell responses to smallpox and yellow fever vaccines. Immunity 28, 710-722.
30. Moss, R. B. (2009). Prospects for control of emerging infectious diseases with plasmid DNA vaccines. J Immune Based Ther Vaccines 7, 3. http://www.jibtherapies.com/content/7/1/3
31. + T-cell responses. J Virol 84, 1847-1855.
32. + T-cell help. Nature 462, 510-513.
33. Nuchtern, J. G., Biddison, W. E. & Klausner, R. D. (1990). Class II MHC molecules can use the endogenous pathway of antigen presentation. Nature 343, 74-76.
34. Pelletier, S., Tanguay, S., Lee, S., Gunaratnam, L., Arbour, N. & Lapointe, R. (2009). TGF-alpha as a candidate tumor antigen for renal cell carcinomas. Cancer Immunol Immunother 58, 1207-1218.
35. Price, G. E., Soboleski, M. R., Lo, C.-Y., Misplon, J. A., Pappas, C., Houser, K. V., Tumpey, T. M. & Epstein, S. L. (2009). Vaccination focusing immunity on conserved antigens protects mice and ferrets against virulent H1N1 and H5N1 influenza A viruses. Vaccine 27, 6512-6521.
36. + T cells by DNA vaccination depends on appropriate targeting of sufficient levels of immunologically relevant antigen to appropriate processing pathways. J Immunol 169, 4951-4960.
37. Schmid, D., Pypaert, M. & Münz, C. (2007). Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes. Immunity 26, 79-92.
38. Schultze, J. L., Michalak, S., Seamon, M. J., Dranoff, G., Jung, K., Daley, J., Delgado, J. C., Gribben, J. G. & Nadler, L. M. (1997). CD40-activated human B cells: an alternative source of highly efficient antigen presenting cells to generate autologous antigen-specific T cells for adoptive immunotherapy. J Clin Invest 100, 2757-2765.
39. Schweiger, B., Zadow, I. & Heckler, R. (2002). Antigenic drift and variability of influenza viruses. Med Microbiol Immunol (Berl) 191, 133-138.
40. Seder, R. A., Darrah, P. A. & Roederer, M. (2008). T-cell quality in memory and protection: implications for vaccine design. Nat Rev Immunol 8, 247-258.
41. Skountzou, I., Koutsonanos, D. G., Kim, J. H., Powers, R., Satyabhama, L., Masseoud, F., Weldon, W. C., Martin, M. P., Mittler, R. S. & other authors (2010). Immunity to pre-1950 H1N1 influenza viruses confers cross-protection against the pandemic swine-origin 2009 A (H1N1) influenza virus. J Immunol 185, 1642-1649.
42. + T cells in protective immunity to influenza. Immunol Rev 211, 8-22.
43. Taylor, P. M. & Askonas, B. A. (1986). Influenza nucleoprotein-specific cytotoxic T-cell clones are protective in vivo. Immunology 58, 417-420.
44. Teijaro, J. R., Verhoeven, D., Page, C. A., Turner, D. & Farber, D. L. (2010). Memory CD4 T cells direct protective responses to influenza virus in the lungs through helper-independent mechanisms. J Virol 84, 9217-9226.
45. Thomas, P. G., Keating, R., Hulse-Post, D. J. & Doherty, P. C. (2006). Cell-mediated protection in influenza infection. Emerg Infect Dis 12, 48-54.
46. Touvrey, C., Derré, L., Devevre, E., Corthesy, P., Romero, P., Rufer, N. & Speiser, D. E. (2009). Dominant human CD8 T cell clonotypes persist simultaneously as memory and effector cells in memory phase. J Immunol 182, 6718-6726.
47. Turcotte, S., Forget, M.-A., Beauseigle, D., Nassif, E. & Lapointe, R. (2007). Prostate-derived Ets transcription factor overexpression is associated with nodal metastasis and hormone receptor positivity in invasive breast cancer. Neoplasia 9, 788-796.
48. + T-cells using mRNA-electroporated CD40-activated autologous B-cells. J Immunother 29, 512-523.
49. + T cells. Cancer Res 62, 7195-7199.
50. WHO (2009). Pandemic (H1N1) 2009. http://www.who.int/csr/disease/swineflu/en/index.html, accessed 10 March 2010.
51. Zhirnov, O. P., Isaeva, E. I., Konakova, T. E., Thoidis, G., Piskareva, L. M., Akopova, I. I., Kartashov, A., Altstein, A. D., Ilyinskii, P. O. & Shneider, A. M. (2007). Protection against mouse and avian influenza A strains via vaccination with a combination of conserved proteins NP, M1 and NS1. Influenza Other Respir Viruses 1, 71-79.
52. Zhou, Z., Jiang, X., Liu, D., Fan, Z., Hu, X., Yan, J., Wang, M. & Gao, G. F. (2009). Autophagy is involved in influenza A virus replication. Autophagy 5, 321-328.