A novel product from the reaction of 6-aminopyrimidines and 3-formylchromone

Tetrahedron Letters

Volumn 43, Issue 50, 2002, Pages 9061-9063

  Quiroga, Jairo ^a   Rengifo, Armando ^a   Insuasty, Braulio ^a   Abonía, Rodrigo ^a   Nogueras, Manuel ^b   Sánchez, Adolfo ^b  

^a UNIVERSIDAD DEL VALLE   (Colombia)

^b UNIVERSITY OF JAÉN   (Spain)

Author keywords

3 Formylchromone; 6 aminopyrimidine; Microwave irradiation; Pyrido 2,3 d pyrimidine

Indexed keywords

3 FORMYLCHROMONE; 6 AMINOPYRIMIDINE; ALCOHOL; CHROMONE DERIVATIVE; PYRIMIDINE DERIVATIVE; PYRIMIDINONE DERIVATIVE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; CHEMICAL REACTION; DRUG SYNTHESIS; HEATING; MICROWAVE IRRADIATION; STRUCTURE ANALYSIS;

EID: 0037049172     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(02)02316-X     Document Type: Article

References (23)

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17. General procedure for synthesis of compounds 6a-e. Method A: A solution of 1.40 mmoles of aminopyrimidine 4 and 1.40 mmoles of 3-formylchromone 2 in 25 ml of absolute ethanol, was refluxed during 2-3 h (TLC control). The reaction mixture was cooled. The cyclized products 6 were collected by filtration, washed with ethanol and recrystallized from DMF-water. Method B: Equimolar amounts of amine 4 and 3-formylchromone 2 were placed into pyrex-glass open vessels and irradiated in a domestic microwave oven for 2-3 min (at 600 W). Products 6 were treated with ethanol as described in method A.
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