Effects of clopidogrel on platelet activation and coagulation of non- anticoagulated rat blood under high shear stress

Haemostasis

Volumn 29, Issue 4, 1999, Pages 189-196

  Taka, Tomomi ^a   Okano, Emi ^a   Seki, Junji ^b   Yamamoto, Junichiro ^a  

^a KOBE GAKUIN UNIVERSITY   (Japan)

^b NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

Author keywords

Antithrombotic agent; Clopidogrel; Non anticoagulated blood; Platelet aggregation; Shear stress

Indexed keywords

ACETYLSALICYLIC ACID; CLOPIDOGREL; TICLOPIDINE;

ANTICOAGULATION; ARTICLE; BLOOD CLOTTING; DRUG EFFECT; DRUG POTENCY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SHEAR STRESS; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION INHIBITION;

EID: 0343920824     PISSN: 03010147     EISSN: None     Source Type: Journal    
DOI: 10.1159/000022501     Document Type: Article

References (42)

1. Sixma JJ: Interaction of blood platelets with the vessel wall; in Bloom AL, Forbes CD, Thomas DP, Tuddenham EGD (eds): Haemostasis and Thrombosis. London, Churchill Livingstone, 1994, pp 259-285.
2. Larsson PT, Hjemdahl P, Olsson G, Egberg N, Hornstra G: Altered platelet function during mental stress and adrenaline infusion in humans: Evidence for an increased aggregability in vivo as measured by filtragometry. Clin Sci 1989;76: 369-376.
3. Peters NS, Abrams LS, Dymond DS, Kovacs IB: Platelet hyperreactivity and inefficient spontaneous thrombolysis in patients at high risk from an acute coronary event. Cardiovasc Res 1989;23:567-572.
4. Ratnatunga CP, Edmondson SF, Rees GM, Kovacs IB: High-dose aspirin inhibits shear-induced platelet reaction involving thrombin generation. Circulation 1992;85:1077-1082.
5. Cattaneo M, Pareti FI, Zighetti ML, Lecchi A, Lombardi R, Mannucci PM: Platelet aggregation at high shear is impaired in patients with congenital defects of platelet secretion and is corrected by DDAVP: Correlation with the bleeding time. J Lab Clin Med 1995;125:540-547.
6. Moake JL: Thrombotic thrombocytopenic purpura. Thromb Haemost 1995;74:240-245.
7. Tokuue J, Hayashi J, Hata Y, Nakahara K, Ikeda Y: Enhanced platelet aggregability under high shear stress after treadmill exercise in patients with effort angina. Thromb Haemost 1996;75:833-837.
8. Muffrand JP, Bernat A, Delebassee D, Defreyn G, Cazenave JP, Gordon JL: ADP plays a key role in thrombogenesis in rats. Thromb Haemost 1988;59:225-230.
9. Gachet C, Stierle A, Cazenave JP, Ohlmann P, Lanza F, Bouloux C, Maffrand JP: The thienopyridine PCR 4099 selectively inhibits ADP-induced platelet aggregation and fibrinogen binding without modifying the membrane glycoprotein IIb-IIIa complex in rat and in man. Biochem Pharmacol 1990;40:229-238.
10. Cattaneo M, Akkawat B, Lecchi A, Cimminiello C, Capitanio AM, Mannucci PM: Ticlopidine selectively inhibits human platelet responses to adenosine diphosphate. Thromb Haemost 1991;66:694-699.
11. Herbert JM, Frehel D, Vallee E, Kieffer G, Gouy D, Berger Y, Necciari J, Defreyn G, Maffrand JP: Clopidogrel, a novel antiplatelet and antithrombotic agent. Cardiovasc Drug Rev 1993;11:180-198.
12. Gorog P, Ahmed A: Haemostatometer: A new in vitro technique for assessing haemostatic activity of blood. Thromb Res 1984;34:341-357.
13. Kovacs IB, Hutton RA, Kernoff PB: Hemostatic evaluation in bleeding disorders from native blood. Clinical experience with the hemostatometer. Am J Clin Pathol 1989; 91:271-279.
14. Yamamoto J, Taka T, Nakajima S, Ueda M, Sugimoto E, Sasaki Y, Muraki T, Seki J, Watanabe S: A shear-induced in vitro platelet function test can assess clinically relevant anti-thrombotic effects. Platelets 1999;10:178-184.
15. Chow TW, Hellums JD, Moake JL, Kroll MH: Shear stress-induced von Willebrand factor binding to platelet glycoprotein 1b initiates calcium influx associated with aggregation. Blood 1992;80:113-120.
16. Sakariassen KS, Ottenhof-Rovers M, Sixma JJ: Factor VIII-von Willebrand factor requires calcium for facilitation of platelet adherence. Blood 1984;63:996-1003.
17. Ikeda Y, Handa M, Kamata T, Kawano K, Kawai Y, Watanabe K, Kawakami K, Sakai K, Fukuyama M, Itagaki I, Yoshioka A, Ruggeri ZM: Transmembrane calcium influx associated with von Willebrand factor binding to GP Ib in the initiation of shear-induced platelet aggregation. Thromb Haemost 1993;69:496-502.
18. Gorog P, Kovacs IB: Modelling coronary thrombosis from nonanticoagulated human blood in vitro. Hematol Pathol 1990;4:43-52.
19. Heras M, Chesebro JH, Webster MW, Mruk JS, Grill DE, Penny WJ, Bowie EJ, Badimon L, Fuster V: Hirudin, heparin, and placebo during deep arterial injury in the pig. The in vivo role of thrombin in platelet-mediated thrombosis. Circulation 1990;82:1476-1484.
20. Jang IK, Gold HK, Ziskind AA, Leinbach RC, Fallon JT, Collen D: Prevention of platelet-rich arterial thrombosis by selective thrombin inhibition. Circulation 1990;81: 219-225.
21. Yamashita T, Yamamoto J, Sasaki Y, Matsuoka A: The antithrombotic effect of low molecular weight synthetic thrombin inhibitors, argatroban and PPACK, on He-Ne laser-induced thrombosis in rat mesenteric microvessels. Thromb Res 1993; 69:93-100.
22. Valles J, Santos MT, Aznar J, Marcus AJ, Martinez-Sales V, Portoles M, Broekman MJ, Safier LB: Erythrocytes metabolically enhance collagen-induced platelet responsiveness via increased thromboxane production, adenosine diphosphate release, and recruitment. Blood 1991;78: 154-162.
23. Lopez-Farre A, Riesco A, Digiuni E, Mosquera JR, Caramelo C, Miguel LS, Millas I, Frutos T, Cernadas MR, Monton M, Alonso J, Casado S: Aspirin-stimulated nitric oxide production by neutrophils after acute myocardial ischemia in rabbits. Circulation 1996;94:83-87.
24. Valles J, Santos MT, Marcus AJ, Safier LB, Brockman MJ, Islam N, Ullman HL, Aznar J: Downregulation of human platelet reactivity by neutrophils. Participation of lipoxygenase derivatives and adhesive proteins. J Clin Invest 1993;92: 1357-1365.
25. Ikeda Y, Handa M, Kawano K, Kamata T, Murata M, Araki Y, Anbo H, Kawai Y, Watanabe K, Itagaki I, Sakai K, Ruggeri ZM: The role of von Willebrand factor and fibrinogen in platelet aggregation under varying shear stress. J Clin Invest 1991;87:1234-1240.
26. Barstad RM, Roald HE, Cui Y, Turitto VT, Sakariassen KS: A perfusion chamber developed to investigate thrombus formation and shear profiles in flowing native human blood at the apex of well-defined stenoses. Arterioscler Thromb 1994; 14:1984-1991.
27. Turitlo VT: Blood viscosity, mass transport, and thrombogenesis. Prog Hemost Thromb 1982;6:139-177.
28. Strony J, Beaudoin A, Brands D, Adelman B: Analysis of shear stress and hemodynamic factors in a model of coronary artery stenosis and thrombosis. Am J Physiol 1993;265: H1787-H1796.
29. Yao SK, Ober JC, McNatt J, Benedict CR, Rosolowsky M, Anderson HV, Cut K, Maffrand JP, Campbell WB, Buja LM, Willerson JT: ADP plays an important role in mediating platelet aggregation and cyclic flow variations in vivo in stenosed and endothelium-injured canine coronary arteries. Circ Res 1992;70:39-48.
30. Umemura K, Kawai H, Ishihara H, Nakashima M: Inhibitory effect of clopidogrel, vapiprost and argatroban on the middle cerebral artery thrombosis in the rat. Jpn J Pharmacol 1995;67:253-258.
31. Moritz MW, Reimers RC, Baker RK, Sutera SP, Joist JH: Role of cytoplasmic and releasable ADP in platelet aggregation induced by laminar shear stress. J Lab Clin Med 1983;101:537-544.
32. Moake JL, Turner NA, Stathopoulos NA, Nolasco L, Hellums JD: Shear-induced platelet aggregation can be mediated by vWF released from platelets, as well as by exogenous large or unusually large vWF multimers, requires adenosine diphosphate, and is resistant to aspirin. Blood 1988;71:1366-1374.
33. Cattaneo M, Zighetti ML, Lombardi R, Mannucci PM: Role of ADP in platelet aggregation at high shear: Studies in a patient with congenital defect of platelet responses to ADP. Br J Haematol 1994;88:826-829.
34. Roald HE, Barstad RM, Kierulf P, Skjorten F, Dickinson JP, Kieffer G, Sakariassen KS: Clopidogrel - A platelet inhibitor which inhibits thrombogenesis in non-anticoagulated human blood independently of the blood flow conditions. Thromb Haemost 1994;71:655-662.
35. Roald HE, Sakariassen KS: Axial dependence of collagen-induced thrombus formation in flowing nonanticoagulated human blood. Antiplatelet drugs impair thrombus growth and increase platelet-colla-gen adhesion. Thromb Haemost 1995;73:126-131.
36. Schror K: The basic pharmacology of ticlopidine and clopidogrel. Platelets 1993;4:252-261.
37. Savi P, Nurden P, Nurden AT, Levy-Toledano S, Herbert JM: Clopidogrel: A review of its mechanism of action. Platelets 1998;9:251-255.
38. Yamamoto J, Ishii I, Sasaki Y, Matsuda T, Ando E: Antithrombotic effect of ticlopidine on He-Ne laser-induced thrombus formation in rat mesenteric microvessels. Haemostasis 1992;22:147-152.
39. Umemura K, Ishihara H, Nakashima M: Anti-platelet effects of clopidogrel in rat middle cerebral artery thrombosis model. Thromb Res 1995;80:209-216.
40. Sowemimo-Coker SO, Kovacs IB, Pickles H, Hedges A, Turner P: Dipyridamole increases red cell deformability. Br J Clin Pharmacol 1983; 16:423-425.
41. Kovacs IB, O'Grady J: Impaired red blood cell deformability after oral administration of aspirin in man. Biomed Biochim Acta 1984;43: S395-S398.
42. CAPRIE Steering Comittee: A randomised, blinded trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet 1996;348:1329-1339.