Sex-dependent effects of long-term oral methylphenidate treatment on spontaneous and learned fear behaviors

Neuroscience Letters

Volumn 496, Issue 1, 2011, Pages 30-34

  Bethancourt, José A ^a   Vásquez, Carol E ^a   Britton, Gabrielle B ^a  

^a INSTITUTO DE INVESTIGACIONES CIENTÍFICAS Y SERVICIOS DE ALTA TECNOLOGÍA   (Panama)

Author keywords

Anxiety; Fear; Methylphenidate; Sex differences; Stimulants

Indexed keywords

METHYLPHENIDATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIOR; CONTROLLED STUDY; FEAR; FEMALE; LOCOMOTION; MALE; NONHUMAN; OPEN FIELD BEHAVIOR; OPEN FIELD TEST; PRIORITY JOURNAL; RAT; SEX DIFFERENCE;

EID: 79955621445     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2011.03.080     Document Type: Article

References (43)

1. Andersen S.L., Rutstein M., Benzo J.M., Hostetter J.C., Teicher M.H. Sex differences in dopamine receptor overproduction and elimination. Neuroreport 1997, 8:1495-1498.
2. Beatty W.W. Gonadal hormones and sex differences in nonreproductive behaviors in rodents: organizational and activational influences. Horm. Behav. 1979, 12:112-163.
3. Bethancourt J.A., Camarena Z.Z., Britton G.B. Exposure to oral methylphenidate from adolescence through adult periods produces transient effects on hippocampal-sensitive memory. Behav. Brain Res. 2009, 202:50-57.
4. Biederman J., Faraone S. Attention deficit hyperactivity disorder. Lancet 2005, 366:237-248.
5. Bolaños C.A., Barrot M., Berton O., Wallace-Black D., Nestler E.J. Methylphenidate treatment during pre- and periadolescence alters behavioral responses to emotional stimuli at adulthood. Biol. Psychiatry 2003, 54:1317-1329.
6. Bouton M.E., Bolles R.C. Conditioned fear assessed by freezing and by the suppression of three different baselines. Anim. Learn. Behav. 1980, 8:429-434.
7. Brandon C.L., Marinelli M., White F.J. Adolescent exposure to methylphenidate alters activity of rat midbrain dopamine neurons. Biol. Psychiatry 2003, 54:1338-1344.
8. Brenhouse H.C., Napierata L., Kussmaul L., Leussis M., Andersen S.L. Juvenile methylphenidate exposure and factors that influence incentive processing. Dev. Neurosci. 2009, 31:95-106.
9. Britton G.B., Bethancourt J.A. Characterization of anxiety-related responses in male rats following prolonged exposure to therapeutic doses of oral methylphenidate. Pharm. Biochem. Behav. 2009, 93:451-459.
10. Britton G.B., Segan A.T., Sejour J., Mancebo S. Early exposure to methylphenidate increases fear responses in an aversive context in adult rats. Dev. Psychobiol. 2007, 49:265-275.
11. Cahill L. Why sex matters for neuroscience. Nat. Rev. Neurosci. 2006, 7:477-484.
12. Carlezon W.A., Mague S.D., Andersen S.L. Enduring behavioral effects of early exposure to methylphenidate in rats. Biol. Psychiatry 2003, 54:1330-1337.
13. Carmack S.A., Wood S.C., Anagnostaras S.G. Amphetamine and extinction of cued fear. Neurosci. Lett. 2010, 468:18-22.
14. Dalla C., Shors T.J. Sex differences in learning processes of classical and operant conditioning. Physiol. Behav. 2009, 97:229-238.
15. Deacon R.M.J. Housing, husbandry and handling of rodents for behavioral experiments. Nat. Protoc. 2006, 1:936-946.
16. Fanselow M.S. The postshock activity burst. Anim. Learn. Behav. 1982, 10:448-454.
17. Gerasimov M.R., Franceschi M., Volkow N.D., Gifford A., Gatley S.J., Marsteller D., Molina P.E., Dewey S.L. Comparison between intraperitoneal and oral methylphenidate administration: a microdialysis and locomotor activity study. J. Pharmacol. Exp. Ther. 2000, 295:51-57.
18. Giedd J.N., Castellanos F.X., Rajapakse J.C., Vaituzis A.C., Rapaport J.L. Sexual dimorphism of the developing human brain. Prog. Neuropsychopharmacol. Biol. Psychiatry 1997, 21:1185-1201.
19. Giedd J.N., Rosenthal M.A., Blythe R.A., Blumenthal J.D., Molloy E., Dopp R.R., Clasen L.S., Fridberg D.J., Gogtay N. Brain development in healthy children and adolescents: magnetic resonance imaging studies. Neurodevelopment and Schizophrenia 2004, 35-44. University Press, New York. M.S. Keshavan, J.L. Kennedy, R.M. Murray (Eds.).
20. Gray J.D., Punsoni M., Tabori N.E., Melton J.T., Fanslow V., Ward M.J., Zupan B., Menzer D., Rice J., Drake C.T., Romeo R.D., Brake W.G., Torres-Reveron A., Milner T. Methylphenidate administration to juvenile rats alters brain areas involved in cognition, motivated behaviors, appetite, and stress. J. Neurosci. 2007, 27:7196-7207.
21. Heyser C.J., Pelletier M., Ferris J.S. The effects of methylphenidate on novel object exploration in weanling and periadolescent rats. Ann. N.Y. Acad. Sci. 2004, 1021:465-469.
22. Kelly S.J., Ostrowski N.L., Wilson M.A. Gender differences in brain and behavior: hormonal and neural bases. Pharm. Biochem. Behav. 1999, 64:655-664.
23. Kuczenski R., Segal D.S. Stimulant actions in rodents: implications for attention-deficit hyperactivity disorder treatment and potential for substance abuse. Biol. Psychiatry 2005, 57:1391-1396.
24. LeBlanc-Duchin D., Taukulis H.K. Chronic oral methylphenidate administration to peri-adolescent rats yields prolonged impairment of memory for objects. Neurobiol. Learn. Mem. 2007, 88:312-320.
25. Maren S., De Oca B., Fanselow M.S. Sex differences in hippocampal long-term potentiation (LTP) and Pavlovian fear conditioning in rats: positive correlation between LTP and contextual learning. Brain Res. 1994, 661:25-34.
26. McFadyen M.P., Brown R.E., Carrey N. Subchronic methylphenidate administration has no effect on locomotion, emotional behavior, or water maze learning in prepubertal mice. Dev. Psychobiol. 2002, 41:123-132.
27. Milad M.R., Igoe S.A., Lebron-Milad K., Novales J.E. Estrous cycle phase and gonadal hormones influence conditioned fear extinction. Neuroscience 2009, 164:887-895.
28. Moll G.H., Hause S., Rüther E., Rothenberger A., Huether G. Early methylphenidate administration to young rats causes a persistent reduction in the density of striatal dopamine transporters. J. Child Adol. Psychopharmacol. 2001, 11:15-24.
29. Prut L., Belzung C. The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review. Eur. J. Pharmacol. 2003, 463:3-33.
30. Pryce C.R., Lehmann J., Feldon J. Effect of sex on fear conditioning is similar for context and discrete CS in Wistar, Lewis and Fischer rat strains. Pharm. Biochem. Behav. 1999, 64:753-759.
31. Quinn P.O. Treating adolescent girls and women with ADHD: gender-specific issues. J. Clin. Psychol. 2005, 61:579-587.
32. Rosso I.M., Young A.D., Femia L.A., Yurgelun-Todd D.A. Cognitive and emotional components of frontal lobe functioning in childhood and adolescence. Ann. N.Y. Acad. Sci. 2004, 1021:355-362.
33. Scheffler R.M., Hinshaw S.P., Modrek S., Levine P. The global market for ADHD medications. Health Aff. 2007, 26:450-457.
34. Spear L.P. The adolescent brain and age-related behavioral manifestations. Neurosci. Biobehav. Rev. 2000, 24:417-463.
35. Swanson J.M., Volkow N.D. Serum and brain concentrations of methylphenidate: implications for use and abuse. Neurosci. Biobehav. Rev. 2003, 27:615-621.
36. Vaughan B.S., Wetzel M.W., Kratochvil C.J. Beyond the 'typical' patient: treating attention-deficit/hyperactivity disorders in preschoolers and adults. Int. Rev. Psychiatry 2008, 20:143-149.
37. Walf A.A., Koonce C., Manley K., Frye C.A. Proestrous compared to diestrous wildtype, but not estrogen receptor beta knockout, mice have better performance in the spontaneous alternation and object recognition tasks and reduced anxiety-like behavior in the elevated plus and mirror maze. Behav. Brain Res. 2009, 196:254-260.
38. Walker Q.D., Ray R., Kuhn C.M. Sex differences in neurochemical effects of dopaminergic drugs in rat striatum. Neuropsychopharmacology 2005, 3:1193-1202.
39. Wiley M.D., Poveromo L.B., Antapasis J., Herrera C.M., Bolaños Guzmán C.A. Kappa-opioid system regulates the long-lasting behavioral adaptations induced by early-life exposure to methylphenidate. Neuropsychopharmacology 2009, 34:1339-1350.
40. Wong D.F., Broussolle E.P., Wand G., Villemagne V., Danals R.F., Links J.M., Zacur H.A., Harris J., Naidu S., Braestrup C. In vivo measurement of dopamine receptors in human brain by positron emission tomography: age and sex differences. Ann. N.Y. Acad. Sci. 1988, 515:203-214.
41. Wooters T.E., Dwoskin L.P., Bardo M.T. Age and sex differences in the locomotor effect of repeated methylphenidate in rats classified as high or low novelty responders. Psychopharmacology 2006, 188:18-27.
42. Zhu N., Weedon J., Dow-Edwards D.L. The multifaceted effects of oral administration of methylphenidate in juvenile rats: anxiety, activity, and attention. Eur. Neuropsychopharmacol. 2010, 20:236-244.
43. Zito J.M., Safer D.J., de Jong-van den Berg L.T.W., Janhsen K., Fegert J.M., Gardner J.F., Glaeske G., valluri S.C. A three-country comparison of psychotropic medication prevalence in youth. Child Adolesc. Psychiatry Ment. Health 2008, 2:24.