The multifaceted effects of oral administration of methylphenidate in juvenile rats: Anxiety, activity, and attention

European Neuropsychopharmacology

Volumn 20, Issue 4, 2010, Pages 236-244

  Zhu, Ning ^a   Weedon, Jeremy ^a   Dow Edwards, Diana L ^a  

^a SUNY DOWNSTATE MEDICAL CENTER   (United States)

Author keywords

Attention; Elevated plus maze; Individual differences; Locomotor activity; Oral administration; Ritalin

Indexed keywords

METHYLPHENIDATE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANXIETY; ARTICLE; ATTENTION; CONTROLLED STUDY; DRUG ACTIVITY; ELEVATED PLUS MAZE; FEMALE; JUVENILE; LOCOMOTION; MALE; MAZE TEST; NONHUMAN; PRIORITY JOURNAL; RAT; REACTION TIME; SEX DIFFERENCE; SPRAGUE DAWLEY RAT; TASK PERFORMANCE; TRANQUILIZING ACTIVITY;

ADMINISTRATION, ORAL; AGE FACTORS; ANIMALS; ANXIETY; ATTENTION; FEMALE; MALE; MAZE LEARNING; METHYLPHENIDATE; MOTOR ACTIVITY; RATS; RATS, SPRAGUE-DAWLEY;

EID: 77349083916     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.euroneuro.2009.12.004     Document Type: Article

References (51)

1. Albrechet-Souza L., de Carvalho M.C., Franci C.R., and Bradao M.L. Increases in plasma corticosterone and stretched-attend postures in rats naive and previously exposed to the elevated plus-maze are sensitive to the anxiolytic-like effects of midazolam. Hormones and Behavior 53 (2007) 267-273
2. Andersen S.L., Dumont N.L., and Teicher M.H. Developmental differences in dopamine synthesis inhibition by (+/-)-7-OH-DPAT. Naunyn-Schmiedeberg's Archives of Pharmacology 356 (1997) 173-181
3. Aoyama T., Kotaki H., and Iga T. Dose-dependent kinetics of methylphenidate enantiomers after oral administration of racemic methylphenidate to rats. Journal of Pharmacobio-dynamics 13 (1990) 647-652
4. Asan E. The catecholaminergic innervation of the rat amygdala. Advances in Anatomy, Embryology, and Cell Biology 142 (1998) L1-118L
5. Barrickman L.L., Perry P.J., Allen A.J., Kuperman S., Arndt S.V., Herrmann K.J., and Schumacher E. Bupropion versus methylphenidate in the treatment of attention-deficit hyperactivity disorder. Journal of the American Academy of Child and Adolescent Psychiatry 34 (1995) 649-657
6. Bethancourt J.A., Camarena Z.Z., and Britton G.B. Exposure to oral methylphenidate from adolescence through young adulthood produces transient effects on hippocampal-sensitive memory in rats. Behavioral Brain Research 202 (2009) 50-57
7. Bevins R.A., and Peterson J.L. Individual differences in rats' reactivity to novelty and the unconditioned and conditioned locomotor effects of methamphetamine. Pharmacology, Biochemistry and Behavior 79 (2004) 65-74
8. Bouffard R., Hechtman L., Minde K., and Iaboni-Kassab F. The efficacy of 2 different dosages of methylphenidate in treating adults with attention-deficit hyperactivity disorder. Canadian Journal of Psychiatry 48 (2003) 546-554
9. Britton G.B., and Bethancourt J.A. Characterization of anxiety-related responses in male rats following prolonged exposure to therapeutic doses of oral methylphenidate. Pharmacology Biochemistry and Behavior 93 (2009) 451-459
10. Brown R.M., and Goldman P.S. Catecholamines in neocortex of rhesus monkeys: regional distribution and ontogenetic development. Brain Research 124 (1977) 576-580
11. Bunsey M., Kramer D., Kesler M., and Strupp B.J. A vasopressin metabolite increases attentional selectivity. Behavioral Neuroscience 104 (1990) 277-287
12. Challman T.D., and Lipsky J.J. Methylphenidate: its pharmacology and uses. Mayo Clinic Proceedings 75 (2000) 711-721
13. Chambers R.A., Moore J., McEvoy J.P., and Levin E.D. Cognitive effects of neonatal hippocampal lesions in a rat model of schizophrenia. Neuropsychopharmacology 15 (1996) 587-594
14. Doremus T.L., Varlinskaya E.I., and Spear L.P. Factor analysis of elevated plus-maze behavior in adolescent and adult rats. Pharmacology, Biochemistry and Behavior 83 (2006) 570-577
15. Dow-Edwards D.L., Weedon J.C., and Hellmann E. Methylphenidate improves performance on the radial arm maze in periadolescent rats. Neurotoxicology and Teratology 30 (2008) 419-427
16. Eals M., and Silverman I. The hunter-gather theory of spatial sex differences: proximate factors mediating the female advantage in recall of object arrays. Ethology and Sociobiology 15 (1994) 95-105
17. Else-Quest N., Hyde J., Goldsmith H.H., and Van Hulle C.A. Gender differences in temperament: a meta-analysis. Psychological Bulletin 132 (2009) 33-72
18. Fernandes C., and File S.E. The influence of open arm ledges and maze experience in the elevated plus-maze. Pharmacology, Biochemistry and Behavior 54 (1996) 31-40
19. Galef Jr., B.G., 1981. The ecology of weaning: parasitism and the achievement of independence by altricial mammals. In: Gubernick, D.J., Klopfer, P.H. (Eds.), Parental care in mammals. Plenum Press, New York, USA, pp. 211-241.
20. Goldman-Rakic P.S., and Brown R.M. Postnatal development of monoamine content and synthesis in the cerebral cortex of rhesus monkeys. Developmental Brain Research 4 (1982) 339-349
21. Gray J.R., and Kagan J. The challenge of predicting which children with ADHD will respond positively to methylphenidate. Journal of Applied Developmental Psychology 21 (2000) 471-489
22. Greenhill L., Kollins S., Abikoff H., McCracken J., Riddle M., Swanson J., McGough J., Wigal S., Wigal T., Vitiello B., Skrobala A., Posner K., Ghuman J., Cunningham C., Davies M., Chuang S., and Cooper T. Efficacy and safety of immediate-release methylphenidate treatment for preschoolers with ADHD. Journal of the American Academy of Child and Adolescent Psychiatry 45 (2006) 1284-1293
23. Horsley R.R., and Cassaday H.J. Methylphenidate can reduce selectivity in associative learning in an aversive trace conditioning task. Journal of Psychopharmacology 25 (2007) 492-500
24. Klebaur J.E., Bevins R.A., Segar T.M., and Bardo M.T. Individual differences in behavioral responses to novelty and amphetamine self-administration in male and female rats. Behavioural Pharmacology 12 (2001) 267-275
25. Konkol R.J., Bendeich E.G., and Breese G.R. A biochemical and morphological study of the altered growth pattern of central catecholamine neurons following 6-hydroxydopamine. Brain Research 140 (1978) 125-135
26. Koob G.F., and Swerdlow N.R. The functional output of the mesolimbic dopamine system. Annuals New York Academy of Sciences 537 (1988) 216-227
27. Kuczenski R., and Segal D.S. Exposure of adolescent rats to oral methylphenidate: preferential effects on extracellular norepinephrine and absence of sensitization and cross-sensitization to methamphetamine. Journal of Neuroscience 22 (2002) 7264-7271 8-15
28. Kudielka B.M., Buske-Kirschbaum A., Hellhammer D.H., and Kirschbaum C. Differential heart rate reactivity and recovery after psychosocial stress (TSST) in healthy children, younger adults, and elderly adults: the impact of age and gender. International Journal of Behavioral Medicine 11 (2004) 116-121
29. Levitt P. Structural and functional maturation of the developing primate brain. The Journal of Pediatrics 143 (2003) S35-S45
30. Loizou L.A., and Salt P. Regional changes in monoamines of the rat brain during postnatal development. Brain Research 20 (1970) 467-470
31. Maggiore V.D., and Ralph M.R. The effect of amphetamine on locomotion depends on the motor device utilized: the open field vs. the running wheel. Pharmacology Biochemistry and Behavior 65 (2000) 585-590
32. Markowitz J.S., DeVane C.L., Pestreich L.K., Patrick K.S., and Muniz R. A comprehensive in vitro screening of d-, l-, and dl-threo-methylphenidate: an exploratory study. Journal of Child and Adolescent Psychopharmacology 16 (2006) 687-698
33. Mcgivern R.F., Huston J.P., Byrd D., King T., Siegle G.J., and Reilly J. Sex differences in visual recognition memory: support for a sex-related difference in attention in adults and children. Brain and Cognition 34 (1997) 323-336
34. Morris M.J., Dausse J.P., Devynck M.A., and Meyer P. Ontogeny of a1 and a2-adrenoceptors in rat brain. Brain Research 190 (1980) 268-271
35. Olton D.S., and Samuelson R.J. Remembrance of places. passed: spatial memory in rats. Journal of Experimental Psychology: Animal Behavior Processes 2 (1976) 97-116
36. Olton D.S., Collison C., and Werz M.A. Spatial memory and radial arm maze performance of rats. Learning and Motivation 8 (1977) 289-314
37. Quinn P.O. Treating adolescent girls and women with ADHD: gender-specific issues. Journal of Clinical Psychology 61 (2005) 579-587
38. Rapport M.D., Quinn S.O., DuPaul G.J., Quinn E.P., and Kelly K.L. Attention deficit disorder with hyperactivity and methylphenidate: the effects of dose and mastery level on children's learning performance. Journal of Abnormal Child Psychology 17 (1989) 669-689
39. Robison L.M., Sclar D.A., Skaer T.L., and Galin R.S. National trends in the prevalence of attention-deficit/hyperactivity disorder and the prescribing of methylphenidate among school-age children: 1990-1995. Clinical Pediatrics 38 (1999) 209-217
40. Rodgers R.J., and Cole J.C. An ethological analysis of chlordiazepoxide and bretazenil (Ro 16-6028) in the murine elevated plus-maze. Behavioural Pharmacology 4 (1993) 573-580
41. Rodgers R.J., Haller J., Holmes A., Halasz J., Walton T.J., and Brain P.F. Corticosterone response to the plus-maze: high correlation with risk assessment in rats and mice. Physiology & Behavior 68 (1999) 47-53
42. Safer D.J., Zito J.M., and Fine E.M. Increased methylphenidate usage for attention deficit disorder in the 1990s. Pediatrics 98 (1996) 1084-1088
43. Schildkraut J.J. The catecholamine hypothesis of affective disorders. A review of supporting evidence. International Journal of Psychiatry 4 (1967) 203-217
44. Sonuga-barke E.J., Coghill D., Markowitz J.S., Swanson J.M., Vandenberghe M., and Hatch S.J. Sex differences in the response of children with ADHD to once-daily formulations of methylphenidate. Journal of the American Academy of Child and Adolescent Psychiatry 46 (2007) 701-710
45. Spear L., Shalaby I.A., and Brick J. Chronic administration of haloperidol during development: behavioral and psychopharmacological effects. Psychopharmacology 70 (1980) 47-58
46. Swanson J.M., and Volkow N.D. Pharmacokinetic and pharmacodynamic properties of stimulants: implications for the design of new treatments for ADHD. Behavioural Brain Research 130 (2002) 73-78
47. Treit, D. and Fundytus, M. Thigmotaxis as a test for anxiolytic activity in rats. Pharmacology, Biochemistry and Behavior 31 (1989) 959-962
48. Weiss S.M., Wadsworth G., Fletcher A., and Dourish C.T. Utility of ethological analysis to overcome locomotor confounds in elevated maze models of anxiety. Neuroscience and Biobehavioral Reviews 23 (1998) 265-271
49. Yang P.B., Amini B., Swann A.C., and Dafny N. Strain differences in the behavioral responses of male rats to chronically administered methylphenidate. Brain Research 971 (2003) 139-152
50. Yang P.B., Swann A.C., and Dafny N. Acute and chronic methylphenidate dose-response assessment on three adolescent male rat strains. Brain Research Bulletin 71 (2006) 301-310
51. Zhu N., Weedon J., and Dow-Edwards D.L. Oral methylphenidate improves spatial learning and memory in pre- and periadolescent rats. Behavioral Neuroscience 121 (2007) 1272-1279