Early exposure to methylphenidate increases fear responses in an aversive context in adult rats

Developmental Psychobiology

Volumn 49, Issue 3, 2007, Pages 265-275

  Britton, Gabrielle B ^a   Segan, Andrew T ^b   Sejour, Jeffrey ^b   Mancebo, Silvia E ^b  

^a Tecnología e innovación   (Panama)

^b LAFAYETTE COLLEGE   (United States)

Author keywords

Conditioning; Emotion; Fear; Memory; Psychostimulant; Ritalin

Indexed keywords

METHYLPHENIDATE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANXIETY; ARTICLE; AVERSION; AVERSIVE BEHAVIOR; BODY WEIGHT; CONDITIONING; CONTROLLED STUDY; FEAR; MALE; NONHUMAN; PRENATAL EXPOSURE; RAT;

AGE FACTORS; ANIMALS; AROUSAL; ASSOCIATION LEARNING; AVOIDANCE LEARNING; CENTRAL NERVOUS SYSTEM STIMULANTS; CONDITIONING, CLASSICAL; ELECTROSHOCK; HABITUATION, PSYCHOPHYSIOLOGIC; MALE; METHYLPHENIDATE; RATS; RATS, SPRAGUE-DAWLEY; RETENTION (PSYCHOLOGY); SOCIAL ENVIRONMENT;

ANIMALIA; RATTUS;

EID: 34247388458     PISSN: 00121630     EISSN: 10982302     Source Type: Journal    
DOI: 10.1002/dev.20213     Document Type: Article

References (46)

1. Anderson, J. C., Williams, S., McGee, R., & Silva, P. A. (1987). DSM III disorders in preadolescent children. Prevalence in a large sample from the general population. Archives of General Psychiatry, 44, 69-76.
2. Blanchard, R. J., & Blanchard, D. C. (1969). Crouching as an index of fear. Journal of Comparative and Physiological Psychology, 67, 370-375.
3. Bolanos, C. A., Barrot, M., Berton, O., Wallace-Black, D., & Nestler, E. J. (2003). Methylphenidate treatment during pre- and periadolescence alters behavioral responses to emotional stimuli at adulthood. Biological Psychiatry, 54, 1317-1329.
4. Bouton, M. E., & Bolles, R. C. (1980). Conditioned fear assessed by freezing and by the suppression of three different baselines. Animal Learning and Behavior, 8(3), 429-434.
5. Brandon, C. L., Marinelli, M., & White, F. J. (2003). Adolescent exposure to methylphenidate alters activity of rat midbrain dopamine neurons. Biological Psychiatry, 54, 1338-1344.
6. Carlezon, W. A., Mague, S. D., & Andersen, S. L. (2003). Enduring behavioral effects of early exposure to methylphenidate in rats. Biological Psychiatry, 54, 1330-1337.
7. Coco, M. L., Kuhn, C. M., Ely, T. D., & Kilts, C. D. (1992). Selective activation of mesoamygdaloid dopamine neurons by conditioned stress: Attenuation by diazepam. Brain Research, 590, 39-47.
8. Davis, M. (2000). The role of the amygdala in conditioned and unconditioned fear and anxiety. In J. P. Aggleton (Eds.), The amygdala (pp. 213-288). New York: Oxford University Press.
9. Deutch, A. Y., & Roth, R. H. (1990). The determinants of stress-induced activation of the prefrontal cortical dopamine system. In H. B. M. Uylings, C. G. Van Eden, J. P. C. De Bruin, M. A. Corner, & M. G. P. Feenstra (Eds.), Progress in brain research (Vol. 85, pp. 367-403). Amsterdam: Elsevier.
10. Deutch, A. Y., Tam, S. Y., & Roth, R. H. (1985). Footshock and conditioned stress increase 3, 4 dihydroxyphenylacetic acid (DOPAC) in the ventral tegmental area but not substantia nigra. Brain Research, 333, 143-146.
11. Fanselow, M. S. (1980a). Signaled shock-free periods and preference for signaled shock. Journal of Experimental Psychology, Animal Behavior Processes, 6(1), 65-80.
12. Fanselow, M. S. (1980b). Conditional and unconditional components of post-shock freezing. Pavlovian Journal of Biological Science, 15, 177-182.
13. Fanselow, M. S. (1990). Factors governing one trial context conditioning. Animal Learning and Behavior, 18, 264-270.
14. Giedd, J. N., Rosenthal, M. A., Blythe, R. A., Blumenthal, J. D., Molloy, E., Dopp, R. R., Clasen, L. S., Fridberg, D. J., & Gogtay, N. (2004). Brain development in healthy children and adolescents: Magnetic resonance imaging studies. In M. S. Keshavan, J. L. Kennedy, & R. M. Murray (Eds.), Neurodevelopment and schizophrenia (pp. 35-44). NY: University Press.
15. Goldman, L. S., Genel, M., Bezman, R. J., & Slanetz, P. J. (1998). Diagnosis and treatment of attention-deficit/hyperactivity disorder in children and adolescents. Journal of the American Medical Association, 279, 110-1107.
16. Guarraci, F. A., & Kapp, B. S. (1999). An electrophysiological characterization of ventral tegmental area dopaminergic neurons during differential Pavlovian fear conditioning in the awake rabbit. Behavioral Brain Research, 99, 169-179.
17. Halliday, M. S. (1966). Exploration and fear in the rat. Symposia of the Zoological Society of London, 18, 45-59.
18. Harmer, C. J., & Phillips, G. D. (1999). Enhanced dopamine efflux in the amygdala by a predictive, but not a non-predictive, stimulus: Facilitation by prior repeated D-amphetamine. Neuroscience, 90, 119-130.
19. Holson, R. R. (1986a). Mesial prefrontal cortical lesions and timidity in rats: I. Reactivity to aversive stimuli. Physiology and Behavior, 37, 221-230.
20. Holson, R. R. (1986b). Mesial prefrontal cortical lesions and timidity in rats: II. Reactivity to novel stimuli. Physiology and Behavior, 37, 231-238.
21. Jinks, A. L., & McGregor, I. S. (1997). Modulation of anxiety-related behaviours following lesions of the prelimbic or infralimbic cortex in the rat. Brain Research, 772, 181-190.
22. Killcross, S., Robbins, T. W., & Evereitt, B. J. (1997). Different types of conditioned fear behavior mediated by different nuclei within the amygdala. Nature, 388, 377-380.
23. Kim, J. J., & Fanselow, M. S. (1992). Modality-specific retrograde amnesia of fear. Science, 256, 675-677.
24. LeDoux, J. E. (1992). Emotion and the amygdala. In J. P. Aggleton (Ed.), The amygdala: Neurobiological aspects of emotion, memory, and mental dysfunction (pp. 339-351). NY: Wiley-Liss.
25. LeDoux, J. E. (1996). The emotional brain. NY: Simon & Schuster.
26. LeDoux, J. E. (2000). Emotion circuits in the brain. Annual Review of Neuroscience, 23, 155-184.
27. LeDoux, J. E., Cicchetti, P., Xagoraris, A., & Romanski, L. M. (1990). The lateral amygdaloid nucleus: Sensory interface of the amygdala in fear conditioning. Journal of Neuroscience, 10, 1062-1069.
28. Maes, J. H., Fidler, T. L., & LoLordo, V. M. (1996). Contextual fear after signalled versus unsignalled shocks: Effect of extent of prior experience with context and signal. The Quarterly Journal of Experimental Psychology, 49B(2), 148-173.
29. Moll, G. H., Hause, S., Rüther, E., Rothenberger, A., & Huether, G. (2001). Early methylphenidate administration to young rats causes a persistent reduction in the density of striatal dopamine transporters. Journal of Child and Adolescent Psychopharmacology, 11, 15-24.
30. Phillips, R. G., & LeDoux, J. E. (1992). Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behavioral Neuroscience, 106, 274-285.
31. Puglisi-Allegra, S., Imperato, A., Angelucci, L., & Cabib, S. (1991). Acute stress induced time-dependent responses in dopamine mesolimbic system. Brain Research, 554, 217-222.
32. Rescorla, R. A., & Wagner, A. R. (1972). A theory of Pavlovian conditioning: Variations in the effectiveness of reinforcement and nonreinforcement. In A. H. Black & W. F. Prokasy (Eds.), Classical conditioning II: Current theory and research (pp. 105-132). New York: Appleton-Century-Crofts.
33. Romanski, L. M., & LeDoux, J. E. (1992). Equipotentiality of the thalamo-amygdala and thalamo-cortico-amygdala circuits in auditory fear conditioning. Journal of Neuroscience, 12, 4501-4509.
34. Rudy, J. W. (1993). Contextual conditioning and auditory cue conditioning dissociate during development. Behavioral Neuroscience, 107, 887-891.
35. Shors, T. (2006). Stressful experience and learning across the lifespan. Annual Review of Psychology, 57, 55-85.
36. Solanto, M. V. (1998). Neuropsychopharmacological mechanisms of stimulant drug action in attention-deficit hyperactivity disorder: A review and integration. Behavioral Brain Research, 94, 127-152.
37. Spear, L. P. (2000). The adolescent brain and age-related behavioral manifestations. Neuroscience and Biobehavioral Reviews, 24, 417-463.
38. Spencer, T., Biederman, J., Wilens, T., Harding, M., O'Donnell, D., & Griffin, S. (1996). Pharmacotherapy of attention-deficit hyperactivity disorder across the life cycle. Journal of the American Academy of Child and Adolescent Psychiatry, 35, 409-432.
39. Sproson, E. J., Chantrey, J., Hollis, C., Marsden, C. A., & Fone, K. C. F. (2001). Effect of repeated methylphenidate administration on presynaptic dopamine and behaviour in young adult rats. Journal of Psychopharmacology, 15, 67-75.
40. Steen, R. G., Ogg, R. J., Reddick, W. E., & Kingsley, P. B. (1997). Age-related changes in the pediatric brain: Quantitative MR evidence of maturational changes during adolescence. American Journal of Neuroradiology, 18, 819-828.
41. Tsuda, A., Ida, Y., Satoh, H., Tsujimaru, S., & Tanaka, M. (1989). Stressor predictability and rat brain noradrenaline metabolism. Pharmacology, Biochemistry, and Behavior, 32(2), 569-572.
42. Vazdarjanova, A., & McGaugh, J. L. (1998). Basolateral amygdala is not critical for cognitive memory of contextual fear conditioning. Proceedings of the National Academy of Science U.S.A., 95, 15003-15007.
43. Volkow, N. D., Wang, G., Fowler, J. S., Logan, J., Gerasimov, M., Maynard, L., Ding, Y., Gatley, S. J., Gifford, A., & Franceschi, D. (2001). Therapeutic doses of oral methylphenidate significantly increase extracellular dopamine in the human brain. Journal of Neuroscience, 21, RC121.
44. Whimbey, A. E., & Denenberg, V. H. (1967). Two independent behavioural dimensions in open field performance. Journal of Comparative and Physiological Psychology, 63, 500-504.
45. Wolraich, M. L., Lindgren, S., Stormquist, A., Milich, R., Davis, C., & Watson, D. (1990). Stimulant medication use by primary care physicians in the treatment of attention-deficit hyperactivity disorder. Pediatrics, 86, 95-100.
46. Zito, J. M., Safer, D. J., dosReis, S., Gardner, J. F., Boles, M., & Lynch, F. (2000). Trends in the prescribing of psychotropic medications to preschoolers. Journal of the American Medical Association, 283, 1025-1030.