Synthesis of N-substituted 2-[(1E)-alkenyl]-4-(1H)-quinolone derivatives as antimycobacterial agents against non-tubercular mycobacteria

European Journal of Medicinal Chemistry

Volumn 46, Issue 6, 2011, Pages 2091-2101

  Wube, Abraham A ^a   Bucar, Franz ^a   Hochfellner, Christina ^a   Blunder, Martina ^a   Bauer, Rudolf ^a   Hüfner, Antje ^a  

^a UNIVERSITY OF GRAZ   (Austria)

Author keywords

Antimycobacterial; Lipophilicity; N Substituted 2 (1E) alkenyl 4 (1H) quinolone; Structure activity relationship

Indexed keywords

1 (2 PROPENYL) 2 (DECENYL) 4 (1H) QUINOLONE; 1 (2 PROPENYL) 2 (NONENYL) 4 (1H) QUINOLONE; 1 (2 PROPENYL) 2 (UNDECENYL) 4 (1H) QUINOLONE; 1 (2 PROPYNYL) 2 (DECENYL) 4 (1H) QUINOLONE; 1 (2 PROPYNYL) 2 (NONENYL) 4 (1H) QUINOLONE; 1 BUTYL 2 (DECENYL) 4 (1H) QUINOLONE; 1 BUTYL 2 (NONENYL) 4 (1H) QUINOLINONE; 1 BUTYL 2 (UNDECENYL) 4 (1H) QUINOLONE; 1 ETHYL 2 (DECENYL) 4 (1H) QUINOLONE; 1 ETHYL 2 (NONENYL) 4 (1H) QUINOLONE; 1 ETHYL 2 (UNDECENYL) 4 (1H) QUINOLONE; 1 PENTYL 2 (DECENYL) 4 (1H) QUINOLONE; 1 PROPYL 2 (DECENYL) 4 (1H) QUINOLONE; 1 PROPYL 2 (NONENYL) 4 (1H) QUINOLONE; 1 PROPYL 2 (UNDECENYL) 4 (1H) QUINOLONE; 3 HEXADECEN 2 ONE; 3 PENTADECEN 2 ONE; 3 TETRADECEN 2 ONE; 3 TRIDECEN 2 ONE; ANTIMYCOBACTERIAL AGENT; ETHAMBUTOL; ISONIAZID; N 2 PROPENYL ISATOIC ACID ANHYDRIDE; N 2 PROPYNYL ISATOIC ACID ANHYDRIDE; N BUTYL ISATOIC ACID ANHYDRIDE; N ETHYL ISATOIC ACID ANHYDRIDE; N PENTYL ISATOIC ACID ANHYDRIDE; N PROPYL ISATOIC ACID ANHYDRIDE; QUINOLONE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO SELECTION; LIPOPHILICITY; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM FORTUITUM; MYCOBACTERIUM PHLEI; MYCOBACTERIUM SMEGMATIS; NONHUMAN;

ANTI-BACTERIAL AGENTS; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; MYCOBACTERIUM; QUINOLONES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79955612465     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.02.062     Document Type: Article

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