-
1
-
-
0025882895
-
Recent developments in the field of quinolone antibacterial agents
-
Chu, D. T. W., and P. B. Fernandes. 1991. Recent developments in the field of quinolone antibacterial agents. Adv. Drug Res. 21:39-144.
-
(1991)
Adv. Drug Res.
, vol.21
, pp. 39-144
-
-
Chu, D.T.W.1
Fernandes, P.B.2
-
2
-
-
0028316927
-
Structure-activity and structure-side-effect relationships for quinolone antibacterials
-
Domagala, J. M. 1994. Structure-activity and structure-side-effect relationships for quinolone antibacterials. J. Antimicrob. Chemother. 33:685-706.
-
(1994)
J. Antimicrob. Chemother.
, vol.33
, pp. 685-706
-
-
Domagala, J.M.1
-
3
-
-
0025906086
-
Synthesis and biological activity of 5-amino and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship
-
Domagala, J. M., A. J. Bridges, T. P. Culbertson, L. Gambino, S. E. Hagen, G. Karrick, K. Porter, J. P. Sanchez, J. A. Sesnie, F. G. Spense, D. Szotek, and J. Wemple. 1991. Synthesis and biological activity of 5-amino and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship. J. Med. Chem. 34: 1142-1154.
-
(1991)
J. Med. Chem.
, vol.34
, pp. 1142-1154
-
-
Domagala, J.M.1
Bridges, A.J.2
Culbertson, T.P.3
Gambino, L.4
Hagen, S.E.5
Karrick, G.6
Porter, K.7
Sanchez, J.P.8
Sesnie, J.A.9
Spense, F.G.10
Szotek, D.11
Wemple, J.12
-
4
-
-
0027462143
-
Quinolone antibacterials containing the new 7-[3-(1-aminoethyl)-1-pyrrolidinyl] side chain: The effects of the 1-aminoethyl moiety and its stereochemical configurations on potency and in vivo efficacy
-
Domagala, J. M., S. E. Hagen, T. Joannides, J. S. Kiely, E. Labordo, and M. C. Schroeder. 1993. Quinolone antibacterials containing the new 7-[3-(1-aminoethyl)-1-pyrrolidinyl] side chain: the effects of the 1-aminoethyl moiety and its stereochemical configurations on potency and in vivo efficacy. J. Med. Chem. 36:871-882.
-
(1993)
J. Med. Chem.
, vol.36
, pp. 871-882
-
-
Domagala, J.M.1
Hagen, S.E.2
Joannides, T.3
Kiely, J.S.4
Labordo, E.5
Schroeder, M.C.6
-
5
-
-
0022633174
-
New structure-activity relationships of the quinolone antibacterials using the target enzyme. The development and application of a DNA gyrase assay
-
Domagala, J. M., L. D. Hanna, C. L. Heifetz, M. P. Hutt, T. F. Mich, J. P. Sanchez, and M. Solomon. 1986. New structure-activity relationships of the quinolone antibacterials using the target enzyme. The development and application of a DNA gyrase assay. J. Med. Chem. 29:394-404.
-
(1986)
J. Med. Chem.
, vol.29
, pp. 394-404
-
-
Domagala, J.M.1
Hanna, L.D.2
Heifetz, C.L.3
Hutt, M.P.4
Mich, T.F.5
Sanchez, J.P.6
Solomon, M.7
-
6
-
-
0023885198
-
1-Substituted 7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4-dihydto-4-oxo-3- quinolinecarboxylic acids. New quantitative structure-activity relationships at N1 for the quinolone antibacterials
-
Domagala, J. M., C. L. Heifetz, M. P. Hutt, T. F. Mich, J. B. Nichols, M. Solomon, and D. F. Worth. 1988. 1-Substituted 7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4-dihydto-4-oxo-3- quinolinecarboxylic acids. New quantitative structure-activity relationships at N1 for the quinolone antibacterials. J. Med. Chem. 31:991-1001.
-
(1988)
J. Med. Chem.
, vol.31
, pp. 991-1001
-
-
Domagala, J.M.1
Heifetz, C.L.2
Hutt, M.P.3
Mich, T.F.4
Nichols, J.B.5
Solomon, M.6
Worth, D.F.7
-
7
-
-
0025726861
-
Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-carboxylic acids
-
Hagen, S. E., J. M. Domagala, C. L. Heifetz, and J. Johnson. 1991. Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-carboxylic acids. J. Med. Chem. 34:1155-1161.
-
(1991)
J. Med. Chem.
, vol.34
, pp. 1155-1161
-
-
Hagen, S.E.1
Domagala, J.M.2
Heifetz, C.L.3
Johnson, J.4
-
8
-
-
0025057986
-
New quinolone antibacterial agents. Synthesis and biological activity of 7-(3,3- Or 3,4-disubstituted-1-pyrrolidyl)quinoline-3-carboxylic acid
-
Hagen, S. E., J. M. Domagala, C. L. Heifetz, J. P. Sanchez, and M. Solomon. 1990. New quinolone antibacterial agents. Synthesis and biological activity of 7-(3,3- or 3,4-disubstituted-1-pyrrolidyl)quinoline-3-carboxylic acid. J. Med. Chem. 33:849-854.
-
(1990)
J. Med. Chem.
, vol.33
, pp. 849-854
-
-
Hagen, S.E.1
Domagala, J.M.2
Heifetz, C.L.3
Sanchez, J.P.4
Solomon, M.5
-
9
-
-
0021529312
-
Artificial intelligence approach to structure-activity studies. Computer automated structure evaluation of biological activity of organic molecules
-
Klopman, G. 1984. Artificial intelligence approach to structure-activity studies. Computer automated structure evaluation of biological activity of organic molecules. J. Am. Chem. Soc. 106:7315-7321.
-
(1984)
J. Am. Chem. Soc.
, vol.106
, pp. 7315-7321
-
-
Klopman, G.1
-
10
-
-
0026778110
-
MULTICASE: A hierarchical computer automated structure evaluation program
-
Klopman, G. 1992. MULTICASE: a hierarchical computer automated structure evaluation program. Quant. Struct.-Act. Relat. 11:176-184.
-
(1992)
Quant. Struct.-Act. Relat.
, vol.11
, pp. 176-184
-
-
Klopman, G.1
-
11
-
-
0029880891
-
Antimycobacterial quinolones: A comparative analysis of structure-activity and structure-cytotoxicity relationships
-
Klopman, G., D. Fercu, J.-Y. Li, H. S. Rosenkranz, and M. R. Jacobs. 1996. Antimycobacterial quinolones: a comparative analysis of structure-activity and structure-cytotoxicity relationships. Res. Microbiol. 147:86-96.
-
(1996)
Res. Microbiol.
, vol.147
, pp. 86-96
-
-
Klopman, G.1
Fercu, D.2
Li, J.-Y.3
Rosenkranz, H.S.4
Jacobs, M.R.5
-
12
-
-
0028043351
-
In vitro anti-Mycobacterium avium activities of quinolones: Predicted active structures and mechanistic considerations
-
Klopman, G., J.-Y. Li, S. Wang, A. J. Pearson, K. Chang, M. R. Jacobs, S. Bajaksouzian, and J. J. Elmer. 1994. In vitro anti-Mycobacterium avium activities of quinolones: predicted active structures and mechanistic considerations. Antimicrob. Agents Chemother. 38:1794-1802.
-
(1994)
Antimicrob. Agents Chemother.
, vol.38
, pp. 1794-1802
-
-
Klopman, G.1
Li, J.-Y.2
Wang, S.3
Pearson, A.J.4
Chang, K.5
Jacobs, M.R.6
Bajaksouzian, S.7
Elmer, J.J.8
-
13
-
-
0023203618
-
Computer automated structure evaluation of quinolone antibacterial agents
-
Klopman, G., O. T. Macina, M. E. Levinson, and H. S. Rosenkranz. 1987. Computer automated structure evaluation of quinolone antibacterial agents. Antimicrob. Agents Chemother. 31:1831-1840.
-
(1987)
Antimicrob. Agents Chemother.
, vol.31
, pp. 1831-1840
-
-
Klopman, G.1
Macina, O.T.2
Levinson, M.E.3
Rosenkranz, H.S.4
-
14
-
-
0027244484
-
Anti-Mycobacterium avium activity of quinolones: In vitro activities
-
Klopman, G., S. Wang, M. R. Jacobs, S. Bajaksouzian, K. Edmonds, and J. J. Ellner. 1993. Anti-Mycobacterium avium activity of quinolones: in vitro activities. Antimicrob. Agents Chemother. 37:1799-1806.
-
(1993)
Antimicrob. Agents Chemother.
, vol.37
, pp. 1799-1806
-
-
Klopman, G.1
Wang, S.2
Jacobs, M.R.3
Bajaksouzian, S.4
Edmonds, K.5
Ellner, J.J.6
-
15
-
-
0027254969
-
Anti-Mycobacterium avium activity of quinolones: Structure-activity relationship studies
-
Klopman, G., S. Wang, M. R. Jacobs, and J. J. Ellner. 1993. Anti-Mycobacterium avium activity of quinolones: structure-activity relationship studies. Antimicrob. Agents Chemother. 37:1807-1815.
-
(1993)
Antimicrob. Agents Chemother.
, vol.37
, pp. 1807-1815
-
-
Klopman, G.1
Wang, S.2
Jacobs, M.R.3
Ellner, J.J.4
-
17
-
-
0027162938
-
Penetration of lipophilic agents with multiple protonation sites into bacterial cells: Tetracyclines and fluoroquinolones as examples
-
Nikaido, H., and D. G. Thanassi. 1993. Penetration of lipophilic agents with multiple protonation sites into bacterial cells: tetracyclines and fluoroquinolones as examples. Antimicrob. Agents Chemother. 37:1393-1399.
-
(1993)
Antimicrob. Agents Chemother.
, vol.37
, pp. 1393-1399
-
-
Nikaido, H.1
Thanassi, D.G.2
-
18
-
-
0030041117
-
Structure-activity relationships of the quinolone antibacterials against mycobacteria: Effect of structural changes at N-1 and C-7
-
Renau, T. E., J. P. Sanchez, J. W. Gage, J. A. Denver, M. A. Shapiro, S. J. Gracheck, and J. M. Domagala. 1996. Structure-activity relationships of the quinolone antibacterials against mycobacteria: effect of structural changes at N-1 and C-7. J. Med. Chem. 39:729-735.
-
(1996)
J. Med. Chem.
, vol.39
, pp. 729-735
-
-
Renau, T.E.1
Sanchez, J.P.2
Gage, J.W.3
Denver, J.A.4
Shapiro, M.A.5
Gracheck, S.J.6
Domagala, J.M.7
-
19
-
-
0029097023
-
Effect of lipophilicity at N-1 on activity of fluoroquinolones against mycobacteria
-
Renau, T. E., J. P. Sanchez, M. A. Shapiro, J. A. Dever, S. J. Gracheck, and J. M. Domagala. 1995. Effect of lipophilicity at N-1 on activity of fluoroquinolones against mycobacteria. J. Med. Chem. 38:2974-2977.
-
(1995)
J. Med. Chem.
, vol.38
, pp. 2974-2977
-
-
Renau, T.E.1
Sanchez, J.P.2
Shapiro, M.A.3
Dever, J.A.4
Gracheck, S.J.5
Domagala, J.M.6
-
20
-
-
0028693339
-
Molecular mechanisms of DNA gyrase inhibition by quinolone antibacterials
-
Shen, L. L. 1994. Molecular mechanisms of DNA gyrase inhibition by quinolone antibacterials. Adv. Pharmacol. 29A:285-304.
-
(1994)
Adv. Pharmacol.
, vol.29 A
, pp. 285-304
-
-
Shen, L.L.1
-
21
-
-
0021669296
-
Inactivation of cytochrome P-450 and monoamine oxidase by cyclopropylamine
-
Tullman, R. H., and R. P. Hanzlik. 1984. Inactivation of cytochrome P-450 and monoamine oxidase by cyclopropylamine. Drug Metab. Rev. 15:1163-1182.
-
(1984)
Drug Metab. Rev.
, vol.15
, pp. 1163-1182
-
-
Tullman, R.H.1
Hanzlik, R.P.2
-
22
-
-
0023231360
-
Broth microdilution testing of susceptibilities to 30 antimicrobial agents of Mycobacterium avium strains from patients with acquired immune deficiency syndrome
-
Yajko, D. M., P. S. Nassos, and W. K. Hadley. 1987. Broth microdilution testing of susceptibilities to 30 antimicrobial agents of Mycobacterium avium strains from patients with acquired immune deficiency syndrome. Antimicrob. Agents Chemother. 31:1579-1584.
-
(1987)
Antimicrob. Agents Chemother.
, vol.31
, pp. 1579-1584
-
-
Yajko, D.M.1
Nassos, P.S.2
Hadley, W.K.3
|