Aphrodisiacs from plant and animal sources-A review of current scientific literature

Food Research International

Volumn 44, Issue 4, 2011, Pages 840-850

  Melnyk, John P ^a   Marcone, Massimo F ^a  

^a UNIVERSITY OF GUELPH   (Canada)

Author keywords

Aphrodisiac; Corpus cavernosum smooth muscle; Erection; Libido; Sexual enhancement; Sildenafil; Traditional medicine

Indexed keywords

APHRODISIAC; CORPUS CAVERNOSUM; ERECTION; LIBIDO; SEXUAL ENHANCEMENT; SILDENAFIL; TRADITIONAL MEDICINE;

EXPERIMENTS; MEDICAL APPLICATIONS; MUSCLE;

ANIMALS;

ANIMALIA; ANURA; BUFO; CAPRA HIRCUS; MYRISTICA FRAGRANS; PANAX GINSENG; THEOBROMA CACAO; TRIBULUS TERRESTRIS;

EID: 79955603034     PISSN: 09639969     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.foodres.2011.02.043     Document Type: Review

References (76)

1. Abdel-Rahman M.A., Ahmed S.H., Nabil Z.I. In vitro cardiotoxicity and mechanism of action of the Egyptian green toad Bufo viridis skin secretions. Toxicology in Vitro 2010, 24(2):480-485.
2. Afoakwa E.O. Cocoa and chocolate consumption-Are there aphrodisiac and other benefits for human health?. South African Journal of Clinical Nutrition 2008, 21(3):107-113.
3. Ang H.H., Sim M.K. Eurycoma longifolia Jack enhances libido in sexually experienced male rats. Experimental Animals 1997, 46(4):287-290.
4. Antunes E., Gordo W.M., de Oliveira J.F., Teixeira C.E., Hyslop S., De Nucci G. The relaxation of isolated rabbit corpus cavernosum by the herbal medicine Catuama (R) and its constituents. Phytotherapy Research 2001, 15(5):416-421.
5. Bick R.J., Poindexter B.J., Sweney R.R., Dasgupta A. Effects of Chan Su, a traditional Chinese medicine, on the calcium transients of isolated cardiomyocytes: Cardiotoxicity due to more than Na, K-ATPase blocking. Life Sciences 2002, 72(6):699-709.
6. Brooks N.A., Wilcox G., Walker K.Z., Ashton J.F., Cox M.B., Stojanovska L. Beneficial effects of Lepidium meyenii (Maca) on psychological symptoms and measures of sexual dysfunction in postmenopausal women are not related to estrogen or androgen content. Menopause-the Journal of the North American Menopause Society 2008, 15(6):1157-1162.
7. Chauhan N.S., Rao C.V., Dixit V.K. Effect of Curculigo orchioides rhizomes on sexual behaviour of male rats. Fitoterapia 2007, 78(7-8):530-534.
8. Cheng J.Y.W., Ng E.M.L., Chen R.Y.L., Ko J.S.N. Alcohol consumption and erectile dysfunction: Meta-analysis of population-based studies. International Journal of Impotence Research 2007, 19(4):343-352.
9. Chew K.K. Alcohol consumption and male erectile dysfunction: An unfounded reputation for risk?. The Journal of Sexual Medicine 2009, 6(8):2340.
10. Choi H.K., Choi Y.D., Adaikan P.G., Jiang Y. Effectiveness of Korean red ginseng in erectile dysfunction-Multi-national approach. Journal of Ginseng Research 1999, 23(4):247-256.
11. Choi H.K., Choi Y.J. Evaluation of clinical efficacy of Korean red ginseng for erectile dysfunction by international index of erectile function (IIEF). Journal of Ginseng Research 2001, 25(3):112-117.
12. Cicero A.F.G., Bandieri E., Arletti R. Lepidium meyenii Walp. improves sexual behaviour in male rats independently from its action on spontaneous locomotor activity. Journal of Ethnopharmacology 2001, 75(2-3):225-229.
13. Cicero A.F.G., Piacente S., Plaza A., Sala E., Arletti R., Pizza C. Hexanic Maca extract improves rat sexual performance more effectively than methanolic and chloroformic Maca extracts. Andrologia 2002, 34(3):177-179.
14. de Andrade E., de Mesquita A.A., Claro J.D., de Andrade P.M., Ortiz V., Paranhos M., et al. Study of the efficacy of Korean Red Ginseng in the treatment of erectile dysfunction. Asian Journal of Andrology 2007, 9(2):241-244.
15. Dording C.M., Fisher L., Papakostas G., Farabaugh A., Sonawalla S., Fava M., et al. A double-blind, randomized, pilot dose-finding study of maca root (L. meyenii) for the management of SSRI-Induced sexual dysfunction. CNS Neuroscience & Therapeutics 2008, 14(3):182-191.
16. Elferink J.G.R. Aphrodisiac use in pre-Columbian Aztec and Inca cultures. Journal of the History of Sexuality 2000, 9(1-2):25-36.
17. Ernst E., Pittler M.H. Yohimbine for erectile dysfunction: A systematic review and meta-analysis of randomized clinical trials. The Journal of Urology 1998, 159(2):433-436.
18. Filippi S., Luconi M., Granchi S., Natali A., Tozzi P., Forti G., et al. Endothelium-dependency of yohimbine-induced corpus cavernosum relaxation. International Journal of Impotence Research 2002, 14(4):295-307.
19. Freitas F.C., Nascimento N.R.F., Cerqueira J.B.G., Morais M.E.A., Regadas R.P., Gonzaga-Silva L.F. Yohimbine relaxes the human corpus cavernosum through a non-adrenergic mechanism involving the activation of K+ATP-dependent channels. International Journal of Impotence Research 2009, 21(6):356-361.
20. Gauthaman K., Adaikan P.G., Prasad R.N.V. Aphrodisiac properties of Tribulus terrestris extract (Protodioscin) in normal and castrated rats. Life Sciences 2002, 71(12):1385-1396.
21. Gauthaman K., Ganesan A.P. The hormonal effects of Tribulus terrestris and its role in the management of male erectile dysfunction-An evaluation using primates, rabbit and rat. Phytomedicine 2008, 15(1-2):44-54.
22. Gauthaman K., Ganesan A.P., Prasad R.N.V. Sexual effects of puncturevine (Tribulus terrestris) extract (protodioscin): An evaluation using a rat model. Journal of Alternative and Complementary Medicine 2003, 9(2):257-265.
23. Gonzales G.F., Cordova A., Vega K., Chung A., Villena A., Gonez C., et al. Effect of Lepidium meyenii (MACA) on sexual desire and its absent relationship with serum testosterone levels in adult healthy men. Andrologia 2002, 34(6):367-372.
24. Guay A.T., Spark R.F., Jacobson J., Murray F.T., Geisser M.E. Yohimbine treatment of organic erectile dysfunction in a dose-escalation trial. International Journal of Impotence Research 2002, 14(1):25-31.
25. Helmrick L., Reiser C. Aphrodisiac properties of Turnera diffusa. Journal of Undergraduate Research 2000, 3:109-113.
26. Hong B., Ji Y.H., Hong J.H., Nam K.Y., Ahn T.Y. A double-blind crossover study evaluating the efficacy of Korean red ginseng in patients with erectile dysfunction: A preliminary report. The Journal of Urology 2002, 168(5):2070-2073.
27. Hosseinzadeh H., Ziaee T., Sadeghi A. The effect of saffron, Crocus sativus stigma, extract and its constituents, safranal and crocin on sexual behaviors in normal male rats. Phytomedicine 2008, 15(6-7):491-495.
28. Islam M.W., Tariq M., Ageel A.M., Alsaid M.S., Alyhya A.M. Effect of Salvia haematodes on sexual-behavior of male-rats. Journal of Ethnopharmacology 1991, 33(1-2):67-72.
29. Jang D.J., Lee M.S., Shin B.C., Lee Y.C., Ernst E. Red ginseng for treating erectile dysfunction: A systematic review. British Journal of Clinical Pharmacology 2008, 66(4):444-450.
30. Jiang Z., Hu B., Wang J., Tang Q., Tan Y., Xiang J., et al. Effect of icariin on cyclic GMP levels and on the mRNA expression of cGMP-binding cGMP-specific phosphodiesterase (PDE5) in penile cavernosum. Journal of Huazhong University of Science and Technology 2006, 26(4):460-462.
31. Kamtchouing P., Mbongue G.Y.F., Dimo T., Watcho P., Jatsa H.B., Sokeng S.D. Effects of Aframomum melegueta and Piper guineense on sexual behaviour of male rats. Behavioural Pharmacology 2002, 13(3):243-247.
32. Karras D.J., Farrell S.E., Harrigan R.A., Henretig F.M., Gealt L. Poisoning from "Spanish fly" (cantharidin). The American Journal of Emergency Medicine 1996, 14(5):478-483.
33. Kim H.J., Woo D.S., Lee G., Kim J.J. The relaxation effects of ginseng saponin in rabbit corporal smooth muscle: Is it a nitric oxide donor?. British Journal of Urology 1998, 82(5):744-748.
34. Krychman M.L., Gubili J., Pereira L., Holstein L., Cassileth B. Female sexual enhancers and neutraceuticals. Current Sexual Health Reports 2007, 4:177-182.
35. Leavitt F.I. Drug-induced modifications in sexual behavior and open field locomotion of male rats. Physiology & Behavior 1969, 4(5):677-683.
36. Liu W.J., Xin Z.C., Xin H., Yuan Y.M., Tian L., Guo Y.L. Effects of icariin on erectile function and expression of nitric oxide synthase isoforms in castrated rats. Asian Journal of Andrology 2005, 7(4):381-388.
37. Makarova M.N., Pozharitskaya O.N., Shikov A.N., Tesakova S.V., Makarov V.G., Tikhonov V.P. Effect of lipid-based suspension of Epimedium koreanum Nakai extract on sexual behavior in rats. Journal of Ethnopharmacology 2007, 114(3):412-416.
38. Mann K., Klingler T., Noe S., Roschke J., Muller S., Benkert O. Effects of yohimbine on sexual experiences and nocturnal penile tumescence and rigidity in erectile dysfunction. Archives of Sexual Behavior 1996, 25(1):1-16.
39. Melnyk J.P., Wang S.N., Marcone M.F. Chemical and biological properties of the world's most expensive spice Saffron. Food Research International 2010, 43(8):1981-1989.
40. Miller R.A. The magical and ritual use of aphrodisiacs 1985, Inner Traditions-Bear & Company, Rochester, (Chapter 16).
41. Montorsi F., Strambi L.F., Guazzoni G., Galli L., Barbieri L., Rigatti P., et al. Effect of yohimbine-trazodone on psychogenic impotence-A randomized, double-blind, placebo-controlled Study. Urology 1994, 44(5):732-736.
42. Morales A., Condra M., Owen J.A., Surridge D.H., Fenemore J., Harris C. Is yohimbine effective in the treatment of organic impotence-Results of a controlled trial. The Journal of Urology 1987, 137(6):1168-1172.
43. Neychev V.K., Mitev V.I. The aphrodisiac herb Tribulus terrestris does not influence the androgen production in young men. Journal of Ethnopharmacology 2005, 101(1-3):319-323.
44. O'Farrell T.J., Kleinke C.L., Cutter H.S.G. Sexual adjustment of male alcoholics: Changes from before to after receiving alcoholism counseling with and without marital therapy. Addictive Behaviors 1998, 23(3):419-425.
45. Oh K.J., Chae M.J., Lee H.S., Hong H.D., Park K. Effects of Korean red ginseng on sexual arousal in menopausal women: Placebo-controlled, double-blind crossover clinical study. The Journal of Sexual Medicine 2010, 7(4):1469-1477.
46. Peugh J., Belenko S. Alcohol, drugs and sexual function: A review. Journal of Psychoactive Drugs 2001, 33(3):223-232.
47. Ratnasooriya W.D., Dharmasiri M.G. Effects of Terminalia catappa seeds on sexual behaviour and fertility of male rats. Asian Journal of Andrology 2000, 2(3):213-219.
48. Ratnasooriya W.D., Fernando T.S.P. Effect of black tea brew of Camellia sinensis on sexual competence of male rats. Journal of Ethnopharmacology 2008, 118(3):373-377.
49. Reid K., Surridge D.H.C., Morales A., Condra M., Harris C., Owen J., et al. Double-blind trial of yohimbine in treatment of psychogenic impotence. Lancet 1987, 2(8556):421-423.
50. Safarinejad M.R., Shafiei N., Safarinejad S. An open label, randomized, fixed-dose, crossover study comparing efficacy and safety of sildenafil citrate and saffron (Crocus sativus Linn.) for treating erectile dysfunction in men naive to treatment. International Journal of Impotence Research 2010, 22(4):240-250.
51. Salonia A., Fabbri F., Zanni G., Scavini M., Fantini G.V., Briganti A., et al. Chocolate and women's sexual health: An intriguing correlation. The Journal of Sexual Medicine 2006, 3(3):476-482.
52. Sandroni P. Aphrodisiacs past and present: A historical review. Clinical Autonomic Research 2001, 11(5):303-307.
53. Shah J. Erectile dysfunction through the ages. BJU International 2002, 90(4):433-441.
54. Shamloul R. Natural aphrodisiacs. The Journal of Sexual Medicine 2010, 7(1):39-49.
55. Shamsa A., Hosseinzadeh H., Molaei M., Shakeri M.T., Rajabi O. Evaluation of Crocus sativus L. (saffron) on male erectile dysfunction: A pilot study. Phytomedicine 2009, 16(8):690-693.
56. Shin B.C., Lee M.S., Yang E.J., Lim H.S., Ernst E. Maca (L. meyenii) for improving sexual function: A systematic review. BMC Complementary and Alternative Medicine 2010, 10.
57. Shindel A.W., Xin Z.C., Lin G.T., Fandel T.M., Huang Y.C., Banie L., et al. Erectogenic and neurotrophic effects of icariin, a purified extract of horny goat weed (Epimedium spp.) in vitro and in vivo. The Journal of Sexual Medicine 2010, 7(4):1518-1528.
58. Stone M., Ibarra A., Roller M., Zangara A., Stevenson E. A pilot investigation into the effect of maca supplementation on physical activity and sexual desire in sportsmen. Journal of Ethnopharmacology 2009, 126(3):574-576.
59. Suresh S., Prithiviraj E., Prakash S. Dose- and time-dependent effects of ethanolic extract of Mucuna pruriens Linn. seed on sexual behaviour of normal male rats. Journal of Ethnopharmacology 2009, 122(3):497-501.
60. Tagwireyi D., Ball D.E., Loga P.J., Moyo S. Cantharidin poisoning due to "Blister beetle" ingestion. Toxicon 2000, 38(12):1865-1869.
61. Taha S.A., Islam M.W., Ageel A.M. Effect of ambrein, a major constituent of ambergris, on masculine sexual-behavior in rats. Archives Internationales de Pharmacodynamie et de Thérapie 1995, 329(2):283-294.
62. Taha S.A., Raza M., El-Khawad I.E. Effect of ambrein on smooth muscle responses to various agonists. Journal of Ethnopharmacology 1998, 60(1):19-26.
63. Tajuddin, Ahmad S., Latif A., Qasmi I.A. Aphrodisiac activity of 50% ethanolic extracts of Myristica fragrans Houtt. (nutmeg) and Syzygium aromaticum (L) Merr. & Perry. (clove) in male mice: A comparative study. BMC Complementary and Alternative Medicine 2003, 3:6.
64. Tajuddin, Ahmad S., Latif A., Qasmi I.A., Amin K.M.Y. An experimental study of sexual function improving effect of Myristica fragrans Houtt. (nutmeg). BMC Complementary and Alternative Medicine 2005, 5:16.
65. Teloken C., Rhoden E.L., Sogari P., Dambros M., Souto C.A.V. Therapeutic effects of high dose yohimbine hydrochloride on organic erectile dysfunction. The Journal of Urology 1998, 159(1):122-124.
66. Vogt H.J., Brandl P., Kockott G., Schmitz J.R., Wiegand M.H., Schadrack J., et al. Double-blind, placebo-controlled safety and efficacy trial with yohimbine hydrochloride in the treatment of nonorganic erectile dysfunction. International Journal of Impotence Research 1997, 9(3):155-161.
67. Waddell T.G., Jones H., Keith A.L. Legendary chemical aphrodisiacs. Indian Journal of Pharmaceutical Sciences 1981, 43(1):1-5.
68. Waynberg J. Yohimbine versus muira puama in the treatment of sexual dysfunctions. American Journal of Natural Medicine 1994, 1:8-9.
69. Waynberg J., Brewer S. Effects of herbal vX on libido and sexual activity in premenopausal and postmenopausal women. Advances in Therapy 2000, 17(5):255-262.
70. Xin Z.C., Kim E.Y., Tian Z.J., Lin G.T., Guo Y.L. Icariin on relaxation effect of corpus cavernosum smooth muscle. Chinese Science Bulletin 2001, 46(14):1186-1191.
71. Yakubu M.T., Akanji M.A., Oladiji A.T. Male sexual dysfunction and methods used in assessing medicinal plants with aphrodisiac potentials. Pharmacognosy Reviews 2007, 1(1):49-56.
72. Zamble A., Martin-Nizard F., Sahpaz S., Reynaert M.L., Staels B., Bordet R., et al. Effects of Microdesmis keayana alkaloids on vascular parameters of erectile dysfunction. Phytotherapy Research 2009, 23(6):892-895.
73. Zamble A., Sahpaz S., Brunet C., Bailleul F. Effects of Microdesmis keayana roots on sexual behavior of male rats. Phytomedicine 2008, 15(8):625-629.
74. Zanoli P., Rivasi M., Zavatti M., Brusiani F., Vezzalini F., Baraldi M. Activity of single components of Ferula hermonis on male rat sexual behavior. International Journal of Impotence Research 2005, 17:513-518.
75. Zenico T., Cicero A.F.G., Valmorri L., Mercuriali M., Bercovich E. Subjective effects of Lepidium meyenii (Maca) extract on well-being and sexual performances in patients with mild erectile dysfunction: A randomised, double-blind clinical trial. Andrologia 2009, 41(2):95-99.
76. Zheng B.L., He K., Kim C.H., Rogers L., Shao Y., Huang Z.Y., et al. Effect of a lipidic extract from Lepidium meyenii on sexual behavior in mice and rats. Urology 2000, 55(4):598-602.