Degeneration of the mouse retina upon dysregulated activity of serum response factor

Molecular Vision

Volumn 17, Issue , 2011, Pages 1110-1127

  Sandström, Jenny ^a   Heiduschka, Peter ^b,e   Beck, Susanne C ^c   Philippar, Ulrike ^a,d   Seeliger, Matthias W ^c   Schraermeyer, Ulrich ^b   Nordheim, Alfred ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b University Eye Hospital Tuebingen   (Germany)

^c UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^d Merck Research Laboratories Boston   (United States)

^e UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; SERUM RESPONSE FACTOR; SERUM RESPONSE FACTOR VP16; UNCLASSIFIED DRUG;

ADULT ANIMAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTRORETINOGRAPHY; EMBRYONIC STEM CELL; GENE EXPRESSION; GENE LOCUS; HETEROZYGOSITY; HOMOLOGOUS RECOMBINATION; HOMOZYGOSITY; MOUSE; NONHUMAN; OPHTHALMOSCOPY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; RETINA CELL; RETINA DEGENERATION; RETINA NERVE CELL; TRANSGENE; WILD TYPE;

ANIMALS; DISEASE MODELS, ANIMAL; ELECTRORETINOGRAPHY; EMBRYONIC STEM CELLS; EOSINE YELLOWISH-(YS); GENE DOSAGE; GENE EXPRESSION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEMATOXYLIN; HERPES SIMPLEX VIRUS PROTEIN VMW65; MICE; MICE, MUTANT STRAINS; RECOMBINANT FUSION PROTEINS; RETINA; RETINAL DEGENERATION; SERUM RESPONSE FACTOR; TRANSFECTION; TRANSGENES;

EID: 79955594257     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Graw J. Genetic aspects of embryonic eye development in vertebrates. Dev Genet 1996; 18:181-197. [PMID: 8631154]
2. Jean D, Ewan K, Gruss P. Molecular regulators involved in vertebrate eye development. Mech Dev 1998; 76:3-18. [PMID: 9767078]
3. Rossant J, Tam PPL, editors. Mouse development: Patterning, morphogenesis, and organogenesis. 1st edition. San Diego: Academic Press; 2002.
4. Alberti S, Krause SM, Kretz O, Philippar U, Lemberger T, Casanova E, Wiebel FF, Schwarz H, Frotscher M, Schütz G, Nordheim A. Neuronal migration in the murine rostral migratory stream requires serum response factor. Proc Natl Acad Sci USA 2005; 102:6148-6153. [PMID: 15837932]
5. Etkin A, Alarcón JM, Weisberg SP, Touzani K, Huang YY, Nordheim A, Kandel ER. A role in learning for SRF: deletion in the adult forebrain disrupts LTD and the formation of an immediate memory of a novel context. Neuron 2006; 50:127-143. [PMID: 16600861]
6. Knöll B, Kretz O, Fiedler C, Alberti S, Schütz G, Frotscher M, Nordheim A. Serum response factor controls neuronal circuit assembly in the hippocampus. Nat Neurosci 2006;9:195-204. [PMID: 16415869]
7. Schratt G, Philippar U, Berger J, Schwarz H, Heidenreich O, Nordheim A. Serum response factor is crucial for actin cytoskeletal organization and focal adhesion assembly in embryonic stem cells. J Cell Biol 2002; 156:737-750. [PMID: 11839767]
8. Stern S, Debre E, Stritt C, Berger J, Posern G, Knoll B. A nuclear actin function regulates neuronal motility by serum response factor-dependent gene transcription. J Neurosci 2009; 29:4512-4518. [PMID: 19357276]
9. Mohun T, Garrett N, Treisman R. Xenopus cytoskeletal actin and human c-fos gene promoters share a conserved proteinbinding site. EMBO J 1987; 6:667-673. [PMID: 3582369]
10. Treisman R. Identification and purification of a polypeptide that binds to the c-fos serum response element. EMBO J 1987; 6:2711-2717. [PMID: 3119326]
11. Perez-Albuerne ED, Schatteman G, Sanders LK, Nathans D. Transcriptional regulatory elements downstream of the JunB gene. Proc Natl Acad Sci USA 1993; 90:11960-11964. [PMID: 8265655]
12. Qureshi SA, Rim M, Bruder J, Kolch W, Rapp U, Sukhatme VP, Foster DA. An inhibitory mutant of c-Raf-1 blocks v-Srcinduced activation of the Egr-1 promoter. J Biol Chem 1991; 266:20594-20597. [PMID: 1939108]
13. Schratt G, Weinhold B, Lundberg AS, Schuck S, Berger J, Schwarz H, Weinberg RA, Rüther U, Nordheim A. Serum response factor is required for immediate-early gene activation yet is dispensable for proliferation of embryonic stem cells. Mol Cell Biol 2001; 21:2933-2943. [PMID: 11283270]
14. Spencer JA, Misra RP. Expression of the serum response factor gene is regulated by serum response factor binding sites. J Biol Chem 1996; 271:16535-16543. [PMID: 8663310]
15. Moiseyeva EP, Weller PA, Zhidkova NI, Corben EB, Patel B, Jasinska I, Koteliansky VE, Critchley DR. Organization of the human gene encoding the cytoskeletal protein vinculin and the sequence of the vinculin promoter. J Biol Chem 1993; 268:4318-4325. [PMID: 8440716]
16. Ng SY, Gunning P, Liu SH, Leavitt J, Kedes L. Regulation of the human beta-actin promoter by upstream and intron domains. Nucleic Acids Res 1989; 17:601-615. [PMID: 2915924]
17. Olson EN, Nordheim A. Linking actin dynamics and gene transcription to drive cellular motile functions. Nat Rev Mol Cell Biol 2010; 11:353-365. [PMID: 20414257]
18. Miano JM. Role of serum response factor in the pathogenesis of disease. Lab Invest 2010; 90:1274-1284. [PMID: 20498652]
19. Kumar MS, Owens GK. Combinatorial control of smooth muscle-specific gene expression. Arterioscler Thromb Vasc Biol 2003; 23:737-747. [PMID: 12740224]
20. Stritt C, Stern S, Harting K, Manke T, Sinske D, Schwarz H, Vingron M, Nordheim A, Knöll B. Paracrine control of oligodendrocyte differentiation by SRF-directed neuronal gene expression. Nat Neurosci 2009; 12:418-427. [PMID: 19270689]
21. Dalton S, Treisman R. Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element. Cell 1992; 68:597-612. [PMID: 1339307]
22. Tuveson DA, Shaw AT, Willis NA, Silver DP, Jackson EL, Chang S, Mercer KL, Grochow R, Hock H, Crowley D, Hingorani SR, Zaks T, King C, Jacobetz MA, Wang L, Bronson RT, Orkin SH, DePinho RA, Jacks T. Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. Cancer Cell 2004; 5:375-387. [PMID: 15093544]
23. Soriano P. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet 1999; 21:70-71. [PMID: 9916792]
24. Mao X, Fujiwara Y, Orkin SH. Improved reporter strain for monitoring Cre recombinase-mediated DNA excisions in mice. Proc Natl Acad Sci USA 1999; 96:5037-5042. [PMID: 10220414]
25. Seeliger MW, Beck SC, Pereyra-Muñoz N, Dangel S, Tsai JY, Luhmann UF, van de Pavert SA, Wijnholds J, Samardzija M, Wenzel A, Zrenner E, Narfström K, Fahl E, Tanimoto N, Acar N, Tonagel F. In vivo confocal imaging of the retina in animal models using scanning laser ophthalmoscopy. Vision Res 2005; 45:3512-3519. [PMID: 16188288]
26. Casanova E, Fehsenfeld S, Mantamadiotis T, Lemberger T, Greiner E, Stewart AF, Schütz GA. CamKIIalpha iCre BAC allows brain-specific gene inactivation. Genesis 2001; 31:37-42. [PMID: 11668676]
27. Ouvrard-Pascaud A, Puttini S, Sainte-Marie Y, Athman R, Fontaine V, Cluzeaud F, Farman N, Rafestin-Oblin ME, Blot-Chabaud M, Jaisser F. Conditional gene expression in renal collecting duct epithelial cells: use of the inducible Cre-lox system. Am J Physiol Renal Physiol 2004; 286:F180-F187. [PMID: 12928315]
28. Nishijo K, Hosoyama T, Bjornson CR, Schaffer BS, Prajapati SI, Bahadur AN, Hansen MS, Blandford MC, McCleish AT, Rubin BP, Epstein JA, Rando TA, Capecchi MR, Keller C. Biomarker system for studying muscle, stem cells, and cancer in vivo. FASEB J 2009; 23:2681-2690. [PMID: 19332644]
29. Kaczmarczyk SJ, Green JE. A single vector containing modified cre recombinase and LOX recombination sequences for inducible tissue-specific amplification of gene expression. Nucleic Acids Res 2001; 29:E56-E56. [PMID: 11410679]
30. Treisman R, Ammerer G. The SRF and MCM1 transcription factors. Curr Opin Genet Dev 1992; 2:221-226. [PMID: 1638115]
31. Johansen FE, Prywes R. Two pathways for serum regulation of the c-fos serum response element require specific sequence elements and a minimal domain of serum response factor. Mol Cell Biol 1994; 14:5920-5928. [PMID: 8065325]
32. Hines WA, Thorburn J, Thorburn A. A low-affinity serum response element allows other transcription factors to activate inducible gene expression in cardiac myocytes. Mol Cell Biol 1999; 19:1841-1852. [PMID: 10022871]
33. Stritt C, Knoll B. Serum response factor regulates hippocampal lamination and dendrite development and is connected with reelin signaling. Mol Cell Biol 2010; 30:1828-1837. [PMID: 20123976]
34. Ramanan N, Shen Y, Sarsfield S, Lemberger T, Schütz G, Linden DJ, Ginty DD. SRF mediates activity-induced gene expression and synaptic plasticity but not neuronal viability. Nat Neurosci 2005; 8:759-767. [PMID: 15880109]
35. Lindecke A, Korte M, Zagrebelsky M, Horejschi V, Elvers M, Widera D, Prüllage M, Pfeiffer J, Kaltschmidt B, Kaltschmidt C. Long-term depression activates transcription of immediate early transcription factor genes: involvement of serum response factor/Elk-1. Eur J Neurosci 2006; 24:555-563. [PMID: 16903857]
36. Tulvatana W, Adamian M, Berson EL, Dryja TP. Photoreceptor rosettes in autosomal dominant retinitis pigmentosa with reduced penetrance. Arch Ophthalmol 1999; 117:399-402. [PMID: 10088824]
37. Mears AJ, Kondo M, Swain PK, Takada Y, Bush RA, Saunders TL, Sieving PA, Swaroop A. Nrl is required for rod photoreceptor development. Nat Genet 2001; 29:447-452. [PMID: 11694879]
38. Farjo R, Fliesler SJ, Naash MI. Effect of Rds abundance on cone outer segment morphogenesis, photoreceptor gene expression, and outer limiting membrane integrity. J Comp Neurol 2007; 504:619-630. [PMID: 17722028]
39. Schmitz-Valckenberg S, Holz FG, Bird AC, Spaide RF. Fundus autofluorescence imaging: review and perspectives. Retina 2008; 28:385-409. [PMID: 18327131]
40. Vickers ER, Kasza A, Kurnaz IA, Seifert A, Zeef LA. O'donnell A, Hayes A, Sharrocks AD. Ternary complex factor-serum response factor complex-regulated gene activity is required for cellular proliferation and inhibition of apoptotic cell death. Mol Cell Biol 2004; 24:10340-10351. [PMID: 15542842]
41. Schratt G, Philippar U, Hockemeyer D, Schwarz H, Alberti S, Nordheim A. SRF regulates Bcl-2 expression and promotes cell survival during murine embryonic development. EMBO J 2004; 23:1834-1844. [PMID: 15057274]
42. Townsend KJ, Zhou P, Qian L, Bieszczad CK, Lowrey CH, Yen A, Craig RW. Regulation of MCL1 through a serum response factor/Elk-1-mediated mechanism links expression of a viability-promoting member of the BCL2 family to the induction of hematopoietic cell differentiation. J Biol Chem 1999; 274:1801-1813. [PMID: 9880563]
43. Chang SH, Poser S, Xia Z. A novel role for serum response factor in neuronal survival. J Neurosci 2004; 24:2277-2285. [PMID: 14999078]
44. Hafezi F, Steinbach JP, Marti A, Munz K, Wang ZQ, Wagner EF, Aguzzi A, Remé CE. The absence of c-fos prevents lightinduced apoptotic cell death of photoreceptors in retinal degeneration in vivo. Nat Med 1997; 3:346-349. [PMID: 9055866]
45. Kueng-Hitz N, Grimm C, Lansel N, Hafezi F, He L, Fox DA, Remé CE, Niemeyer G, Wenzel A. The retina of c-fos-/-mice: electrophysiologic, morphologic and biochemical aspects. Invest Ophthalmol Vis Sci 2000; 41:909-916. [PMID: 10711713]
46. Verdoni AM, Aoyama N, Ikeda A, Ikeda S. Effect of destrin mutations on the gene expression profile in vivo. Physiol Genomics 2008; 34:9-21. [PMID: 18381839]
47. Verdoni AM, Schuster KJ, Cole BS, Ikeda A, Kao WW, Ikeda S. A pathogenic relationship between a regulator of the actin cytoskeleton and serum response factor. Genetics 2010; 186:147-157. [PMID: 20610412]