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Volumn 91, Issue 10, 2011, Pages 1057-1064

Novel strategies in immunosuppression: Issues in perspective

Author keywords

Biologics; Immunosuppression; Tolerance

Indexed keywords

ABATACEPT; ALEFACEPT; ASKP 1240; ATACICEPT; B7 ANTIGEN; BELATACEPT; BELIMUMAB; BORTEZOMIB; CALCINEURIN INHIBITOR; CD28 ANTIGEN; CD40 ANTIGEN; CD40 LIGAND; CHI 220; ECULIZUMAB; EFALIZUMAB; IMMUNOGLOBULIN; JANUS KINASE INHIBITOR; LUCATUMUMAB; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY HU5C8; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PG 102; PLACEBO; PRO 64553; RAPAMYCIN; RITUXIMAB; STEROID; THYMOCYTE ANTIBODY; TOFACITINIB; UNCLASSIFIED DRUG;

EID: 79955590004     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3182145306     Document Type: Review
Times cited : (71)

References (83)
  • 1
    • 1442338509 scopus 로고    scopus 로고
    • Lack of improvement in renal allograft survival despite a marked decrease in acute rejection rates over the most recent era
    • Meier-Kriesche HU, Schold JD, Srinivas TR, et al. Lack of improvement in renal allograft survival despite a marked decrease in acute rejection rates over the most recent era. Am J Transplant 2004; 4: 378.
    • (2004) Am J Transplant , vol.4 , pp. 378
    • Meier-Kriesche, H.U.1    Schold, J.D.2    Srinivas, T.R.3
  • 2
    • 0344666767 scopus 로고    scopus 로고
    • The natural history of chronic allograft nephropathy
    • Nankivell BJ, Borrows RJ, Fung CL, et al. The natural history of chronic allograft nephropathy. N Engl J Med 2003; 349: 2326.
    • (2003) N Engl J Med , vol.349 , pp. 2326
    • Nankivell, B.J.1    Borrows, R.J.2    Fung, C.L.3
  • 3
    • 75149136028 scopus 로고    scopus 로고
    • Pathological and clinical characterization of the "troubled transplant": Data from the DeKAF study
    • Gourishankar S, Leduc R, Connett J, et al. Pathological and clinical characterization of the "troubled transplant": Data from the DeKAF study. Am J Transplant 2010; 10: 324.
    • (2010) Am J Transplant , vol.10 , pp. 324
    • Gourishankar, S.1    Leduc, R.2    Connett, J.3
  • 4
    • 75149147570 scopus 로고    scopus 로고
    • Histopathologic clusters differentiate subgroups within the nonspecific diagnoses of CANor CR: Preliminary data from the DeKAF study
    • Matas AJ, Leduc R, Rush D, et al. Histopathologic clusters differentiate subgroups within the nonspecific diagnoses ofCANor CR: Preliminary data from the DeKAF study. Am J Transplant 2010; 10: 315.
    • (2010) Am J Transplant , vol.10 , pp. 315
    • Matas, A.J.1    Leduc, R.2    Rush, D.3
  • 5
    • 77954623148 scopus 로고    scopus 로고
    • Evidence for antibodymediated injury as a major determinant of late kidney allograft failure
    • Gaston RS, Cecka JM, Kasiske BL, et al. Evidence for antibodymediated injury as a major determinant of late kidney allograft failure. Transplantation 2010; 90: 68.
    • (2010) Transplantation , vol.90 , pp. 68
    • Gaston, R.S.1    Cecka, J.M.2    Kasiske, B.L.3
  • 6
    • 77949784071 scopus 로고    scopus 로고
    • Antibody-mediated microcirculation injury is the major cause of late kidney transplant failure: Response to Dr. Loupy et al
    • Einecke G, Halloran PF. Antibody-mediated microcirculation injury is the major cause of late kidney transplant failure: Response to Dr. Loupy et al. Am J Transplant 2010; 10: 953.
    • (2010) Am J Transplant , vol.10 , pp. 953
    • Einecke, G.1    Halloran, P.F.2
  • 7
    • 70350131763 scopus 로고    scopus 로고
    • De novo donor-specific antibody at the time of kidney transplant biopsy associates with microvascular pathology and late graft failure
    • Hidalgo LG, Campbell PM, Sis B, et al. De novo donor-specific antibody at the time of kidney transplant biopsy associates with microvascular pathology and late graft failure. Am J Transplant 2009; 9: 2532.
    • (2009) Am J Transplant , vol.9 , pp. 2532
    • Hidalgo, L.G.1    Campbell, P.M.2    Sis, B.3
  • 8
    • 65249160252 scopus 로고    scopus 로고
    • Reducing de novo donor-specific antibody levels during acute rejection diminishes renal allograft loss
    • Everly MJ, Everly JJ, Arend LJ, et al. Reducing de novo donor-specific antibody levels during acute rejection diminishes renal allograft loss. Am J Transplant 2009; 9: 1063.
    • (2009) Am J Transplant , vol.9 , pp. 1063
    • Everly, M.J.1    Everly, J.J.2    Arend, L.J.3
  • 9
    • 67649574165 scopus 로고    scopus 로고
    • Anti-human leukocyte antigen and donor-specific antibodies detected by luminex posttransplant serve as biomarkers for chronic rejection of renal allografts
    • Lachmann N, Terasaki PI, Budde K, et al. Anti-human leukocyte antigen and donor-specific antibodies detected by luminex posttransplant serve as biomarkers for chronic rejection of renal allografts. Transplantation 2009; 87: 1505.
    • (2009) Transplantation , vol.87 , pp. 1505
    • Lachmann, N.1    Terasaki, P.I.2    Budde, K.3
  • 10
    • 65549141734 scopus 로고    scopus 로고
    • Influence of immunosuppressive regimens on graft survival and secondary outcomes after kidney transplantation
    • Opelz G, Dohler B. Influence of immunosuppressive regimens on graft survival and secondary outcomes after kidney transplantation. Transplantation 2009; 87: 795.
    • (2009) Transplantation , vol.87 , pp. 795
    • Opelz, G.1    Dohler, B.2
  • 11
    • 0028206578 scopus 로고
    • Hypertension following kidney transplantation
    • Curtis JJ. Hypertension following kidney transplantation. Am J Kidney Dis 1994; 23: 471.
    • (1994) Am J Kidney Dis , vol.23 , pp. 471
    • Curtis, J.J.1
  • 12
    • 0036782790 scopus 로고    scopus 로고
    • Hypertensinogenic mechanism of the calcineurin inhibitors
    • Curtis JJ. Hypertensinogenic mechanism of the calcineurin inhibitors. Curr Hypertens Rep 2002; 4: 377.
    • (2002) Curr Hypertens Rep , vol.4 , pp. 377
    • Curtis, J.J.1
  • 13
    • 0031016349 scopus 로고    scopus 로고
    • Hyperlipidemia in solid organ transplantation
    • Kobashigawa JA, Kasiske BL. Hyperlipidemia in solid organ transplantation. Transplantation 1997; 63: 331.
    • (1997) Transplantation , vol.63 , pp. 331
    • Kobashigawa, J.A.1    Kasiske, B.L.2
  • 14
    • 0025854069 scopus 로고
    • Mechanism of cyclosporine-induced hypertension
    • Luke RG. Mechanism of cyclosporine-induced hypertension. Am J Hypertens 1991; 4(5 Pt 1): 468.
    • (1991) Am J Hypertens , vol.4 , Issue.5 PART 1 , pp. 468
    • Luke, R.G.1
  • 15
    • 27744527131 scopus 로고    scopus 로고
    • Cyclosporine withdrawal from a mycophenolate mofetil-containing immunosuppressive regimen: Results of a five-year, prospective, randomized study
    • Abramowicz D, Del Carmen Rial M, Vitko S, et al. Cyclosporine withdrawal from a mycophenolate mofetil-containing immunosuppressive regimen: Results of a five-year, prospective, randomized study. J Am Soc Nephrol 2005; 16: 2234.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 2234
    • Abramowicz, D.1    Del Carmen Rial, M.2    Vitko, S.3
  • 16
    • 14044252180 scopus 로고    scopus 로고
    • Mycophenolate mofetil substitution for cyclosporine a in renal transplant recipients with chronic progressive allograft dysfunction: The "creeping creatinine" study
    • Dudley C, Pohanka E, Riad H, et al. Mycophenolate mofetil substitution for cyclosporine a in renal transplant recipients with chronic progressive allograft dysfunction: The "creeping creatinine" study. Transplantation 2005; 79: 466.
    • (2005) Transplantation , vol.79 , pp. 466
    • Dudley, C.1    Pohanka, E.2    Riad, H.3
  • 17
    • 37349034394 scopus 로고    scopus 로고
    • Reduced exposure to calcineurin inhibitors in renal transplantation
    • Ekberg H, Tedesco-Silva H, Demirbas A, et al. Reduced exposure to calcineurin inhibitors in renal transplantation. N Engl J Med 2007; 357: 2562.
    • (2007) N Engl J Med , vol.357 , pp. 2562
    • Ekberg, H.1    Tedesco-Silva, H.2    Demirbas, A.3
  • 18
    • 59649126728 scopus 로고    scopus 로고
    • Conversion from calcineurin inhibitors to sirolimus maintenance therapy in renal allograft recipients: 24-month efficacy and safety results from the CONVERT trial
    • Schena FP, Pascoe MD, Alberu J, et al. Conversion from calcineurin inhibitors to sirolimus maintenance therapy in renal allograft recipients: 24-month efficacy and safety results from the CONVERT trial. Transplantation 2009; 87: 233.
    • (2009) Transplantation , vol.87 , pp. 233
    • Schena, F.P.1    Pascoe, M.D.2    Alberu, J.3
  • 19
    • 0035872742 scopus 로고    scopus 로고
    • Multicenter trial exploring calcineurin inhibitors avoidance in renal transplantation
    • Vincenti F, Ramos E, Brattstrom C, et al. Multicenter trial exploring calcineurin inhibitors avoidance in renal transplantation. Transplantation 2001; 71: 1282.
    • (2001) Transplantation , vol.71 , pp. 1282
    • Vincenti, F.1    Ramos, E.2    Brattstrom, C.3
  • 20
    • 0037184316 scopus 로고    scopus 로고
    • Kidney transplantation without calcineurin inhibitor drugs: A prospective, randomized trial of sirolimus versus cyclosporine
    • Flechner SM, Goldfarb D, Modlin C, et al. Kidney transplantation without calcineurin inhibitor drugs: A prospective, randomized trial of sirolimus versus cyclosporine. Transplantation 2002; 74: 1070.
    • (2002) Transplantation , vol.74 , pp. 1070
    • Flechner, S.M.1    Goldfarb, D.2    Modlin, C.3
  • 21
    • 33644889043 scopus 로고    scopus 로고
    • Complete avoidance of calcineurin inhibitors in renal transplantation: A randomized trial comparing sirolimus and tacrolimus
    • Larson TS, Dean PG, Stegall MD, et al. Complete avoidance of calcineurin inhibitors in renal transplantation: A randomized trial comparing sirolimus and tacrolimus. Am J Transplant 2006; 6: 514.
    • (2006) Am J Transplant , vol.6 , pp. 514
    • Larson, T.S.1    Dean, P.G.2    Stegall, M.D.3
  • 22
    • 56049108213 scopus 로고    scopus 로고
    • An MMF based regimen in combination with sirolimus after CNI withdrawal in renal transplant recipients: Final results of the Spare the Nephron Trial. [Abstract]
    • Pearson Tea. An MMF based regimen in combination with sirolimus after CNI withdrawal in renal transplant recipients: Final results of the Spare the Nephron Trial. [Abstract]. Am J Transplant 2008; 8: 213.
    • (2008) Am J Transplant , vol.8 , pp. 213
    • Pearson, T.E.A.1
  • 23
    • 72449205113 scopus 로고    scopus 로고
    • The success of continued steroid avoidance after kidney transplantation in the US
    • Schold JD, Santos A, Rehman S, et al. The success of continued steroid avoidance after kidney transplantation in the US. Am J Transplant 2009; 9: 2768.
    • (2009) Am J Transplant , vol.9 , pp. 2768
    • Schold, J.D.1    Santos, A.2    Rehman, S.3
  • 24
    • 55449124588 scopus 로고    scopus 로고
    • A prospective, randomized, double-blind, placebo-controlled multicenter trial comparing early (7 day) corticosteroid cessation versus long-term, low-dose corticosteroid therapy
    • Woodle ES, First MR, Pirsch J, et al. A prospective, randomized, double-blind, placebo-controlled multicenter trial comparing early (7 day) corticosteroid cessation versus long-term, low-dose corticosteroid therapy. Ann Surg 2008; 248: 564.
    • (2008) Ann Surg , vol.248 , pp. 564
    • Woodle, E.S.1    First, M.R.2    Pirsch, J.3
  • 25
    • 74549170957 scopus 로고    scopus 로고
    • Steroid avoidance or withdrawal after renal transplantation increases the risk of acute rejection but decreases cardiovascular risk
    • Knight SR, Morris PJ. Steroid avoidance or withdrawal after renal transplantation increases the risk of acute rejection but decreases cardiovascular risk. A meta-analysis. Transplantation 2010; 89: 1.
    • (2010) A Meta-analysis. Transplantation , vol.89 , pp. 1
    • Knight, S.R.1    Morris, P.J.2
  • 26
    • 33644677802 scopus 로고    scopus 로고
    • Predicting subsequent decline in kidney allograft function from early surveillance biopsies
    • Cosio FG, Grande JP, Wadei H, et al. Predicting subsequent decline in kidney allograft function from early surveillance biopsies. Am J Transplant 2005; 5: 2464.
    • (2005) Am J Transplant , vol.5 , pp. 2464
    • Cosio, F.G.1    Grande, J.P.2    Wadei, H.3
  • 27
    • 72449183621 scopus 로고    scopus 로고
    • The impact of c4d pattern and donor-specific antibody on graft survival in recipients requiring indication renal allograft biopsy
    • Haririan A, Kiangkitiwan B, Kukuruga D, et al. The impact of c4d pattern and donor-specific antibody on graft survival in recipients requiring indication renal allograft biopsy. Am J Transplant 2009; 9: 2758.
    • (2009) Am J Transplant , vol.9 , pp. 2758
    • Haririan, A.1    Kiangkitiwan, B.2    Kukuruga, D.3
  • 28
    • 70349196778 scopus 로고    scopus 로고
    • Endothelial gene expression in kidney transplants with alloantibody indicates antibody-mediated damage despite lack of C4d staining
    • Sis B, Jhangri GS, Bunnag S, et al. Endothelial gene expression in kidney transplants with alloantibody indicates antibody-mediated damage despite lack of C4d staining. Am J Transplant 2009; 9: 2312.
    • (2009) Am J Transplant , vol.9 , pp. 2312
    • Sis, B.1    Jhangri, G.S.2    Bunnag, S.3
  • 29
    • 33644885700 scopus 로고    scopus 로고
    • A comparison of plasmapheresis versus high-dose IVIG desensitization in renal allograft recipients with high levels of donor specific alloantibody
    • Stegall MD, Gloor J, Winters JL, et al. A comparison of plasmapheresis versus high-dose IVIG desensitization in renal allograft recipients with high levels of donor specific alloantibody. Am J Transplant 2006; 6: 346.
    • (2006) Am J Transplant , vol.6 , pp. 346
    • Stegall, M.D.1    Gloor, J.2    Winters, J.L.3
  • 30
    • 47549105407 scopus 로고    scopus 로고
    • Rituximab and intravenous immune globulin for desensitization during renal transplantation
    • Vo AA, Lukovsky M, Toyoda M, et al. Rituximab and intravenous immune globulin for desensitization during renal transplantation. N Engl J Med 2008; 359: 242.
    • (2008) N Engl J Med , vol.359 , pp. 242
    • Vo, A.A.1    Lukovsky, M.2    Toyoda, M.3
  • 31
    • 67651027514 scopus 로고    scopus 로고
    • Intravenous immunoglobulin a natural regulator of immunity and inflammation
    • Jordan SC, Toyoda M, Vo AA. Intravenous immunoglobulin a natural regulator of immunity and inflammation. Transplantation 2009; 88: 1.
    • (2009) Transplantation , vol.88 , pp. 1
    • Jordan, S.C.1    Toyoda, M.2    Vo, A.A.3
  • 32
    • 2942568020 scopus 로고    scopus 로고
    • Rituximab as treatment for refractory kidney transplant rejection
    • Becker YT, Becker BN, Pirsch JD, et al. Rituximab as treatment for refractory kidney transplant rejection. Am J Transplant 2004; 4: 996.
    • (2004) Am J Transplant , vol.4 , pp. 996
    • Becker, Y.T.1    Becker, B.N.2    Pirsch, J.D.3
  • 33
    • 34547850861 scopus 로고    scopus 로고
    • Transplant glomerulopathy: Subclinical incidence and association with alloantibody
    • Gloor JM, Sethi S, Stegall MD, et al. Transplant glomerulopathy: Subclinical incidence and association with alloantibody. Am J Transplant 2007; 7: 2124.
    • (2007) Am J Transplant , vol.7 , pp. 2124
    • Gloor, J.M.1    Sethi, S.2    Stegall, M.D.3
  • 34
    • 37549061830 scopus 로고    scopus 로고
    • Two novel assays of alloantibody-secreting cells demonstrating resistance to desensitization with IVIG and rATG
    • Perry DK, Pollinger HS, Burns JM, et al. Two novel assays of alloantibody-secreting cells demonstrating resistance to desensitization with IVIG and rATG. Am J Transplant 2008; 8: 133.
    • (2008) Am J Transplant , vol.8 , pp. 133
    • Perry, D.K.1    Pollinger, H.S.2    Burns, J.M.3
  • 35
    • 33747837100 scopus 로고    scopus 로고
    • BAFF, APRIL and their receptors: Structure, function and signaling
    • Bossen C, Schneider P. BAFF, APRIL and their receptors: Structure, function and signaling. Semin Immunol 2006; 18: 263.
    • (2006) Semin Immunol , vol.18 , pp. 263
    • Bossen, C.1    Schneider, P.2
  • 36
    • 0034972257 scopus 로고    scopus 로고
    • Elevated serum B lymphocyte stimulator levels in patients with systemic immune-based rheumatic diseases
    • Cheema GS, Roschke V, Hilbert DM, et al. Elevated serum B lymphocyte stimulator levels in patients with systemic immune-based rheumatic diseases. Arthritis Rheum 2001; 44: 1313.
    • (2001) Arthritis Rheum , vol.44 , pp. 1313
    • Cheema, G.S.1    Roschke, V.2    Hilbert, D.M.3
  • 37
    • 49449092839 scopus 로고    scopus 로고
    • Association of plasma B lymphocyte stimulator levels and disease activity in systemic lupus erythematosus
    • Petri M, Stohl W, Chatham W, et al. Association of plasma B lymphocyte stimulator levels and disease activity in systemic lupus erythematosus. Arthritis Rheum 2008; 58: 2453.
    • (2008) Arthritis Rheum , vol.58 , pp. 2453
    • Petri, M.1    Stohl, W.2    Chatham, W.3
  • 38
    • 0035167632 scopus 로고    scopus 로고
    • Cutting edge: A role for B lymphocyte stimulator in systemic lupus erythematosus
    • Zhang J, Roschke V, Baker KP, et al. Cutting edge: A role for B lymphocyte stimulator in systemic lupus erythematosus. J Immunol 2001; 166: 6.
    • (2001) J Immunol , vol.166 , pp. 6
    • Zhang, J.1    Roschke, V.2    Baker, K.P.3
  • 39
    • 33644660402 scopus 로고    scopus 로고
    • Similarities and differences between selective and nonselective BAFF blockade in murine SLE
    • Ramanujam M, Wang X, Huang W, et al. Similarities and differences between selective and nonselective BAFF blockade in murine SLE. J Clin Invest 2006; 116: 724.
    • (2006) J Clin Invest , vol.116 , pp. 724
    • Ramanujam, M.1    Wang, X.2    Huang, W.3
  • 40
    • 37149032474 scopus 로고    scopus 로고
    • Reduced B lymphocyte and immunoglobulin levels after atacicept treatment in patients with systemic lupus erythematosus: Results of a multicenter, phase Ib, doubleblind, placebo-controlled, dose-escalating trial
    • Dall'Era M, Chakravarty E, Wallace D, et al. Reduced B lymphocyte and immunoglobulin levels after atacicept treatment in patients with systemic lupus erythematosus: Results of a multicenter, phase Ib, doubleblind, placebo-controlled, dose-escalating trial. Arthritis Rheum 2007; 56: 4142.
    • (2007) Arthritis Rheum , vol.56 , pp. 4142
    • Dall'Era, M.1    Chakravarty, E.2    Wallace, D.3
  • 41
    • 58049200722 scopus 로고    scopus 로고
    • Proteasome inhibition causes apoptosis of normal human plasma cells preventing alloantibody production
    • Perry DK, Burns JM, Pollinger HS, et al. Proteasome inhibition causes apoptosis of normal human plasma cells preventing alloantibody production. Am J Transplant 2009; 9: 201.
    • (2009) Am J Transplant , vol.9 , pp. 201
    • Perry, D.K.1    Burns, J.M.2    Pollinger, H.S.3
  • 43
    • 76649086359 scopus 로고    scopus 로고
    • Proteasome inhibitor-based primary therapy for antibody-mediated renal allograft rejection
    • Walsh RC, Everly JJ, Brailey P, et al. Proteasome inhibitor-based primary therapy for antibody-mediated renal allograft rejection. Transplantation 2010; 89: 277.
    • (2010) Transplantation , vol.89 , pp. 277
    • Walsh, R.C.1    Everly, J.J.2    Brailey, P.3
  • 44
    • 76949099011 scopus 로고    scopus 로고
    • Bortezomib as the sole post-renal transplantation desensitization agent does not decrease donor-specific anti-HLA antibodies
    • Sberro-Soussan R, Zuber J, Suberbielle-Boissel C, et al. Bortezomib as the sole post-renal transplantation desensitization agent does not decrease donor-specific anti-HLA antibodies. Am J Transplant 2010; 10: 681.
    • (2010) Am J Transplant , vol.10 , pp. 681
    • Sberro-Soussan, R.1    Zuber, J.2    Suberbielle-Boissel, C.3
  • 45
    • 77956133521 scopus 로고    scopus 로고
    • Eculizumab, bortezomib and kidney paired donation facilitate transplantation of a highly sensitized patient without vascular access
    • Lonze BE, Dagher NN, Simpkins CE, et al. Eculizumab, bortezomib and kidney paired donation facilitate transplantation of a highly sensitized patient without vascular access. Am J Transplant 2010; 10: 2154.
    • (2010) Am J Transplant , vol.10 , pp. 2154
    • Lonze, B.E.1    Dagher, N.N.2    Simpkins, C.E.3
  • 46
    • 77953362636 scopus 로고    scopus 로고
    • Effect of the proteasome inhibitor bortezomib on humoral immunity in two presensitized renal transplant candidates
    • Wahrmann M, Haidinger M, Kormoczi GF, et al. Effect of the proteasome inhibitor bortezomib on humoral immunity in two presensitized renal transplant candidates. Transplantation 2010; 89: 1385.
    • (2010) Transplantation , vol.89 , pp. 1385
    • Wahrmann, M.1    Haidinger, M.2    Kormoczi, G.F.3
  • 47
    • 35948959015 scopus 로고    scopus 로고
    • Discovery and development of the complement inhibitor eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria
    • Rother RP, Rollins SA, Mojcik CF, et al. Discovery and development of the complement inhibitor eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria. Nat Biotechnol 2007; 25: 1256.
    • (2007) Nat Biotechnol , vol.25 , pp. 1256
    • Rother, R.P.1    Rollins, S.A.2    Mojcik, C.F.3
  • 48
    • 70350130833 scopus 로고    scopus 로고
    • Safety and longterm efficacy of eculizumab in a renal transplant patient with recurrent atypical hemolytic-uremic syndrome
    • Chatelet V, Fremeaux-Bacchi V, Lobbedez T, et al. Safety and longterm efficacy of eculizumab in a renal transplant patient with recurrent atypical hemolytic-uremic syndrome. Am J Transplant 2009; 9: 2644.
    • (2009) Am J Transplant , vol.9 , pp. 2644
    • Chatelet, V.1    Fremeaux-Bacchi, V.2    Lobbedez, T.3
  • 49
    • 77949570344 scopus 로고    scopus 로고
    • Maintenance of kidney function following treatment with eculizumab and discontinuation of plasma exchange after a third kidney transplant for atypical hemolytic uremic syndrome associated with a CFH mutation
    • Davin JC, Gracchi V, Bouts A, et al. Maintenance of kidney function following treatment with eculizumab and discontinuation of plasma exchange after a third kidney transplant for atypical hemolytic uremic syndrome associated with a CFH mutation. Am J Kidney Dis 2010; 55: 708.
    • (2010) Am J Kidney Dis , vol.55 , pp. 708
    • Davin, J.C.1    Gracchi, V.2    Bouts, A.3
  • 50
    • 59449107473 scopus 로고    scopus 로고
    • Eculizumab for atypical hemolytic-uremic syndrome
    • Nurnberger J, Philipp T, Witzke O, et al. Eculizumab for atypical hemolytic-uremic syndrome. N Engl J Med 2009; 360: 542.
    • (2009) N Engl J Med , vol.360 , pp. 542
    • Nurnberger, J.1    Philipp, T.2    Witzke, O.3
  • 51
    • 77951876953 scopus 로고    scopus 로고
    • Prophylactic eculizumab after renal transplantation in atypical hemolytic-uremic syndrome
    • Zimmerhackl LB, Hofer J, Cortina G, et al. Prophylactic eculizumab after renal transplantation in atypical hemolytic-uremic syndrome. N Engl J Med 2010; 362: 1746.
    • (2010) N Engl J Med , vol.362 , pp. 1746
    • Zimmerhackl, L.B.1    Hofer, J.2    Cortina, G.3
  • 52
    • 79955604617 scopus 로고    scopus 로고
    • Complement inhibitors for treatment of antibody-mediated renal allograft injury [Abstract]
    • Lonze BE, Dagher NN, Locke JE, et al. Complement inhibitors for treatment of antibody-mediated renal allograft injury [Abstract]. Am J Transplant 2010; 10: 564.
    • (2010) Am J Transplant , vol.10 , pp. 564
    • Lonze, B.E.1    Dagher, N.N.2    Locke, J.E.3
  • 53
    • 78649638480 scopus 로고    scopus 로고
    • Terminal complement inhibition decreases early acute humoral rejection in sensitized renal transplant recipients [Abstract]
    • Stegall MD, Diwan TS, Cornell LD, et al. Terminal complement inhibition decreases early acute humoral rejection in sensitized renal transplant recipients [Abstract]. Am J Transplant 2010; 10: 39.
    • (2010) Am J Transplant , vol.10 , pp. 39
    • Stegall, M.D.1    Diwan, T.S.2    Cornell, L.D.3
  • 54
    • 79955555797 scopus 로고    scopus 로고
    • Chronic humoral rejection despite C5 inhibition after positive-crossmatch kidney transplantation [Abstract]
    • Cornell LD, Gloor JD, Nasr SH, et al. Chronic humoral rejection despite C5 inhibition after positive-crossmatch kidney transplantation [Abstract]. Am J Transplant 2010; 10: 125.
    • (2010) Am J Transplant , vol.10 , pp. 125
    • Cornell, L.D.1    Gloor, J.D.2    Nasr, S.H.3
  • 55
    • 76949090842 scopus 로고    scopus 로고
    • A phase III study of belatacept versus cyclosporine in kidney transplants from extended criteria donors (BENEFIT-EXT study)
    • Durrbach A, Pestana JM, Pearson T, et al. A phase III study of belatacept versus cyclosporine in kidney transplants from extended criteria donors (BENEFIT-EXT study). Am J Transplant 2010; 10: 547.
    • (2010) Am J Transplant , vol.10 , pp. 547
    • Durrbach, A.1    Pestana, J.M.2    Pearson, T.3
  • 56
    • 16544365874 scopus 로고    scopus 로고
    • Chronic induction. What's new in the pipeline
    • Vincenti F. Chronic induction. What's new in the pipeline. Contrib Nephrol 2005; 146: 22.
    • (2005) Contrib Nephrol , vol.146 , pp. 22
    • Vincenti, F.1
  • 57
    • 77956528156 scopus 로고    scopus 로고
    • Five-year safety and efficacy of belatacept in renal transplantation
    • Vincenti F, Blancho G, Durrbach A, et al. Five-year safety and efficacy of belatacept in renal transplantation. J AmSoc Nephrol 2010; 21: 1587.
    • (2010) J AmSoc Nephrol , vol.21 , pp. 1587
    • Vincenti, F.1    Blancho, G.2    Durrbach, A.3
  • 58
    • 76949101581 scopus 로고    scopus 로고
    • A phase III study of belatacept-based immunosuppression regimens versus cyclosporine in renal transplant recipients (BENEFIT study)
    • Vincenti F, Charpentier B, Vanrenterghem Y, et al. A phase III study of belatacept-based immunosuppression regimens versus cyclosporine in renal transplant recipients (BENEFIT study). Am J Transplant 2010; 10: 535.
    • (2010) Am J Transplant , vol.10 , pp. 535
    • Vincenti, F.1    Charpentier, B.2    Vanrenterghem, Y.3
  • 59
    • 23944502334 scopus 로고    scopus 로고
    • Costimulation blockade with belatacept in renal transplantation
    • Vincenti F, Larsen C, Durrbach A, et al. Costimulation blockade with belatacept in renal transplantation. N Engl J Med 2005; 353: 770.
    • (2005) N Engl J Med , vol.353 , pp. 770
    • Vincenti, F.1    Larsen, C.2    Durrbach, A.3
  • 60
    • 79954462757 scopus 로고    scopus 로고
    • A phase 2B study of CNI-free immunosuppression with the JAK inhibitor CP-690-550 in de novo kidney transplant patients: 6-month interim analysis [Abstract]
    • Vincenti F, Silva HT, Busque S, et al. A phase 2B study of CNI-free immunosuppression with the JAK inhibitor CP-690-550 in de novo kidney transplant patients: 6-month interim analysis [Abstract]. Am J Transplant 2010; 10: 211.
    • (2010) Am J Transplant , vol.10 , pp. 211
    • Vincenti, F.1    Silva, H.T.2    Busque, S.3
  • 61
    • 67650938638 scopus 로고    scopus 로고
    • Calcineurin-inhibitor-free immunosuppression based on the JAK inhibitor CP-690, 550: A pilot study in de novo kidney allograft recipients
    • Busque S, Leventhal J, Brennan DC, et al. Calcineurin-inhibitor-free immunosuppression based on the JAK inhibitor CP-690,550: A pilot study in de novo kidney allograft recipients. Am J Transplant 2009; 9: 1936.
    • (2009) Am J Transplant , vol.9 , pp. 1936
    • Busque, S.1    Leventhal, J.2    Brennan, D.C.3
  • 63
    • 0000203537 scopus 로고    scopus 로고
    • Preliminary results of the use of humanized anti-CD 154 in human renal allotransplantation [Abstract]
    • Kirk AD, Knechtle SJ, Sollinger HE, et al. Preliminary results of the use of humanized anti-CD 154 in human renal allotransplantation [Abstract]. Am J Transplant 2001; 1(suppl 1): 191.
    • (2001) Am J Transplant , vol.1 , Issue.SUPPL. 1 , pp. 191
    • Kirk, A.D.1    Knechtle, S.J.2    Sollinger, H.E.3
  • 64
    • 0036130828 scopus 로고    scopus 로고
    • CD40L stabilizes arterial thrombi by a beta3 integrin-dependent mechanism
    • Andre P, Prasad KS, Denis CV, et al. CD40L stabilizes arterial thrombi by a beta3 integrin-dependent mechanism. Nat Med 2002; 8: 247.
    • (2002) Nat Med , vol.8 , pp. 247
    • Andre, P.1    Prasad, K.S.2    Denis, C.V.3
  • 65
    • 2942711587 scopus 로고    scopus 로고
    • Lessons learned from anti-CD40L treatment in systemic lupus erythematosus patients
    • Sidiropoulos PI, Boumpas DT. Lessons learned from anti-CD40L treatment in systemic lupus erythematosus patients. Lupus 2004; 13: 391.
    • (2004) Lupus , vol.13 , pp. 391
    • Sidiropoulos, P.I.1    Boumpas, D.T.2
  • 66
    • 12644262358 scopus 로고    scopus 로고
    • CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates
    • Kirk AD, Harlan DM, Armstrong NN, et al. CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates. Proc Natl Acad Sci USA 1997; 94: 8789.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 8789
    • Kirk, A.D.1    Harlan, D.M.2    Armstrong, N.N.3
  • 67
    • 15844404353 scopus 로고    scopus 로고
    • Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways
    • Larsen CP, Elwood ET, Alexander DZ, et al. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature 1996; 381: 434.
    • (1996) Nature , vol.381 , pp. 434
    • Larsen, C.P.1    Elwood, E.T.2    Alexander, D.Z.3
  • 68
    • 33644872811 scopus 로고    scopus 로고
    • LFA-1 (CD11a) as a therapeutic target
    • Nicolls MR, Gill RG. LFA-1 (CD11a) as a therapeutic target. Am J Transplant 2006; 6: 27.
    • (2006) Am J Transplant , vol.6 , pp. 27
    • Nicolls, M.R.1    Gill, R.G.2
  • 69
    • 0037359334 scopus 로고    scopus 로고
    • Alefacept-induced decreases in circulating blood lymphocyte counts correlate with clinical response in patients with chronic plaque psoriasis
    • Ortonne JP, Lebwohl M, Em Griffiths C. Alefacept-induced decreases in circulating blood lymphocyte counts correlate with clinical response in patients with chronic plaque psoriasis. Eur J Dermatol 2003; 13: 117.
    • (2003) Eur J Dermatol , vol.13 , pp. 117
    • Ortonne, J.P.1    Lebwohl, M.2    Em Griffiths, C.3
  • 70
    • 79955642066 scopus 로고    scopus 로고
    • Targeting of costimulation blockade resistant T effector memory (TEM) cells in non-human primate renal transplantation with LFA-3-Ig (alefacept) prolongs allograft survival [Abstract]
    • Kirk A, Weaver T, Charafeddine A, et al. Targeting of costimulation blockade resistant T effector memory (TEM) cells in non-human primate renal transplantation with LFA-3-Ig (alefacept) prolongs allograft survival [Abstract]. Am J Transplant 2008; 8(suppl 2): 204.
    • (2008) Am J Transplant , vol.8 , Issue.SUPPL. 2 , pp. 204
    • Kirk, A.1    Weaver, T.2    Charafeddine, A.3
  • 71
    • 0042532322 scopus 로고    scopus 로고
    • Heterologous immunity provides a potent barrier to transplantation tolerance
    • Adams AB, Williams MA, Jones TR, et al. Heterologous immunity provides a potent barrier to transplantation tolerance. J Clin Invest 2003; 111: 1887.
    • (2003) J Clin Invest , vol.111 , pp. 1887
    • Adams, A.B.1    Williams, M.A.2    Jones, T.R.3
  • 72
    • 22844438322 scopus 로고    scopus 로고
    • Pre-transplant IFN-gamma ELISPOTs are associated with post-transplant renal function in African American renal transplant recipients
    • Augustine JJ, Siu DS, Clemente MJ, et al. Pre-transplant IFN-gamma ELISPOTs are associated with post-transplant renal function in African American renal transplant recipients. Am J Transplant 2005; 5: 1971.
    • (2005) Am J Transplant , vol.5 , pp. 1971
    • Augustine, J.J.1    Siu, D.S.2    Clemente, M.J.3
  • 73
    • 0033566737 scopus 로고    scopus 로고
    • Pretransplant frequency of donor-specific, IFN-gamma-producing lymphocytes is a manifestation of immunologic memory and correlates with the risk of posttransplant rejection episodes
    • Heeger PS, Greenspan NS, Kuhlenschmidt S, et al. Pretransplant frequency of donor-specific, IFN-gamma-producing lymphocytes is a manifestation of immunologic memory and correlates with the risk of posttransplant rejection episodes. J Immunol 1999; 163: 2267.
    • (1999) J Immunol , vol.163 , pp. 2267
    • Heeger, P.S.1    Greenspan, N.S.2    Kuhlenschmidt, S.3
  • 74
    • 33751522625 scopus 로고    scopus 로고
    • Controlling the generation and function of human CD8 memory T cells in vitro with immunosuppressants
    • Jones DL, Sacks SH, Wong W. Controlling the generation and function of human CD8 memory T cells in vitro with immunosuppressants. Transplantation 2006; 82: 1352.
    • (2006) Transplantation , vol.82 , pp. 1352
    • Jones, D.L.1    Sacks, S.H.2    Wong, W.3
  • 75
    • 0035954670 scopus 로고    scopus 로고
    • Treatment of chronic plaque psoriasis by selective targeting of memory effector T lymphocytes
    • Ellis CN, Krueger GG. Treatment of chronic plaque psoriasis by selective targeting of memory effector T lymphocytes. N Engl J Med 2001; 345: 248.
    • (2001) N Engl J Med , vol.345 , pp. 248
    • Ellis, C.N.1    Krueger, G.G.2
  • 76
    • 79955630090 scopus 로고    scopus 로고
    • Immunosuppression with a belatacept-based, CNI avoiding and steroid-avoiding regimen vs tacrolimus-based, steroid avoiding regimen in kidney transplant patients: Results of a 1-year, randomized study
    • Feguson R, Vincenti F, Kaufman DB, et al. Immunosuppression with a belatacept-based, CNI avoiding and steroid-avoiding regimen vs tacrolimus-based, steroid avoiding regimen in kidney transplant patients: Results of a 1-year, randomized study. Am J Transplant. 2011; 11: 76.
    • (2011) Am J Transplant , vol.11 , pp. 76
    • Feguson, R.1    Vincenti, F.2    Kaufman, D.B.3
  • 77
    • 38549088096 scopus 로고    scopus 로고
    • HLA-mismatched renal transplantation without maintenance immunosuppression
    • Kawai T, Cosimi AB, Spitzer TR, et al. HLA-mismatched renal transplantation without maintenance immunosuppression. N Engl J Med 2008; 358: 353.
    • (2008) N Engl J Med , vol.358 , pp. 353
    • Kawai, T.1    Cosimi, A.B.2    Spitzer, T.R.3
  • 78
    • 38549134052 scopus 로고    scopus 로고
    • Tolerance and chimerism after renal and hematopoietic-cell transplantation
    • Scandling JD, Busque S, Dejbakhsh-Jones S, et al. Tolerance and chimerism after renal and hematopoietic-cell transplantation. N Engl J Med 2008; 358: 362.
    • (2008) N Engl J Med , vol.358 , pp. 362
    • Scandling, J.D.1    Busque, S.2    Dejbakhsh-Jones, S.3
  • 79
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006; 126: 663.
    • (2006) Cell , vol.126 , pp. 663
    • Takahashi, K.1    Yamanaka, S.2
  • 80
    • 77954904503 scopus 로고    scopus 로고
    • Clonal deletion with bortezomib followed by low or no maintenance immunosuppression in renal allograft recipients
    • Trivedi HL, Terasaki PI, Feroz A, et al. Clonal deletion with bortezomib followed by low or no maintenance immunosuppression in renal allograft recipients. Transplantation 2010; 90: 221.
    • (2010) Transplantation , vol.90 , pp. 221
    • Trivedi, H.L.1    Terasaki, P.I.2    Feroz, A.3
  • 81
    • 38949168818 scopus 로고    scopus 로고
    • Perfusion-decellularized matrix: Using nature's platform to engineer a bioartificial heart
    • Ott HC, Matthiesen TS, Goh SK, et al. Perfusion-decellularized matrix: Using nature's platform to engineer a bioartificial heart. Nat Med 2008; 14: 213.
    • (2008) Nat Med , vol.14 , pp. 213
    • Ott, H.C.1    Matthiesen, T.S.2    Goh, S.K.3
  • 82
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi K, Tanabe K, Ohnuki M, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007; 131: 861.
    • (2007) Cell , vol.131 , pp. 861
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3
  • 83
    • 36749043230 scopus 로고    scopus 로고
    • Induced pluripotent stem cell lines derived from human somatic cells
    • Yu J, Vodyanik MA, Smuga-Otto K, et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 2007; 318: 1917.
    • (2007) Science , vol.318 , pp. 1917
    • Yu, J.1    Vodyanik, M.A.2    Smuga-Otto, K.3


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