Sequential co-immobilization of thrombomodulin and endothelial protein C receptor on polyurethane: Activation of protein C

Acta Biomaterialia

Volumn 7, Issue 6, 2011, Pages 2508-2517

  Kador, K E ^a,b   Mamedov, T G ^a,c   Schneider, M ^a   Subramanian, A ^a  

^a UNIVERSITY OF NEBRASKA LINCOLN   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^c Fraunhofer Center for Molecular Biotechnology   (United States)

Author keywords

EPCR; Immobilization; Protein C; Thromboelastograph; Thrombomodulin

Indexed keywords

ENZYMES; POLYURETHANES;

BIOMATERIAL SURFACES; CLOT FORMATION; ENDOTHELIAL PROTEIN C RECEPTOR; ENDOTHELIAL PROTEINS; IMMOBILISATION; NATURAL COFACTORS; PROTEIN-C; SURFACE DENSITY; THROMBOELASTOGRAPH; THROMBOMODULIN;

CHEMICAL ACTIVATION;

ACTIVATED PROTEIN C; ENDOTHELIAL PROTEIN C RECEPTOR; POLYURETHAN; THROMBOMODULIN;

ARTICLE; BINDING AFFINITY; BLOOD CLOTTING; ENDOTHELIUM; PRIORITY JOURNAL; PROTEIN IMMOBILIZATION; THROMBOCYTE POOR PLASMA; THROMBOELASTOGRAPHY;

EID: 79955583141     PISSN: 17427061     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actbio.2011.03.015     Document Type: Article

References (47)

1. Wilson FJ, Yeger H, Klement P, Lee JM, Courtmant DW. Acellular matrix allograft small caliber vascular prostheses. ASAIO Trans 1990;36:M340-3.
2. Ratner BD. Blood compatibility, a perspective. J Biomater Sci, Polym Ed 2000;11:1107-19.
3. Gorbet MB, Sefton MV. Biomaterial-associated thrombosis: roles of coagulation factors, complement, platelets and leukocytes. Biomaterials 2004;25:5681-703. (Pubitemid 38624449)
4. Castner DG, Ratner BD. Biomedical surface science: foundations to frontiers. Surf Sci 2002;500:28-60. (Pubitemid 34228498)
5. Ishihara K, Iwasaki Y. Reduced protein adsorption on novel phospholipid polymers. J Biomater Appl 1998;13:111-27. (Pubitemid 128615742)
6. Wu B, Gerlitz B, Grinnell BW, Meyerhoff ME. Polymeric coatings that mimic the endothelium: combining nitric oxide release with surface-bound active thrombomodulin and heparin. Biomaterials 2007;2007:4047-55. (Pubitemid 47048384)
7. Tseng PY, Rele SS, Sun XL, Chaikof EL. Membrane-mimetic films containing thrombomodulin and heparin inhibit tissue factor-induced thrombin generation in a flow model. Biomaterials 2006;27:2637-50. (Pubitemid 43113288)
8. Liaw PCY, Mather T, Oganesyan N, Ferrell GL, Esmon CT. Identification of the protein C/activated protein C binding sites on the endothelial cell protein C receptor. Implications for a novel mode of ligand recognition by a major histocompatibility complex class 1-type receptor. J Biol Chem 2001;276:8364-70.
9. Esmon CT. Structure and functions of the endothelial cell protein C receptor. Crit Care Med 2004;32:S298-301.
10. Dahlbaeck B, Villoutreix BO. The anticoagulant protein C pathway. FEBS Lett 2005;579:3310-6. (Pubitemid 40804679)
11. Wu K, Thiagarajan P. Role of endothelium in thrombosis and hemostasis. Annu Rev 1996;47:315-31. (Pubitemid 26138894)
12. Esmon N, DeBault L, Esmon C. Proteolytic formation and properties of γ-carboxyglutamic acid-domainless protein C. J Biol Chem 1983;258:5548-53.
13. Liaw PCY, Neuenschwander PF, Smirnow MD, Esmon CT. Mechanisms by which soluble endothelial cell protein C receptor modulates protein C and activated protein C function. J Biol Chem 2000;275:5447-52. (Pubitemid 30115177)
14. Fukudome K, Ye X, Tsuneyoshi N, Tokunaga O, Sugawara K, Mizokami H, et al. Activation mechanism of anticoagulant protein C in large blood vessels involving the endothelial cell protein C receptor. J Exp Med 1998;187: 1029-35. (Pubitemid 28176403)
15. Stearns-Kurosawa D, Kurosawa S, Mollica J, Ferrell G, Esmon C. The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex. Cell Biol 1996;93:10212-6. (Pubitemid 26314601)
16. Tseng PY, Jordan SW, Sun X, Chaikof EL. Catalytic efficiency of a thrombomodulin-functionalized membrane-mimetic film in a flow model. Biomaterials 2006;27:2768-75. (Pubitemid 43122082)
17. Han HS, Yang SL, Yeh HY, Lin JC, Wu HL, Shi GY. Studies of a novel thrombomodulin immobilized substrate: surface characterization and anticoagulation activity evaluation. J Biomater Sci, Polym Ed 2001;12: 1075-89.
18. Kishida A, Ueno Y, Fukudome N, Yashima E, Maruyama I, Akashi M. Immobilization of human thrombomodulin onto poly(ether urethane urea) for developing antithrombogenic blood-contacting materials. Biomaterials 1994;15:848-52. (Pubitemid 24252004)
19. Li J-m, Singh MJ, Nelson PR, Hendricks GM, Itani M, Rohrer MJ, et al. Immobilization of human thrombomodulin to expanded polytetrafluoroethylene. J Surg Res 2002;105:200-8. (Pubitemid 34765328)
20. Sperling C, Salchert K, Streller U, Werner C. Covalently immobilized thrombomodulin inhibits coagulation and complement activation of artificial surfaces in vitro. Biomaterials 2004;25:5101-13. (Pubitemid 38510396)
21. Yeh HY, Lin JC. Bioactivity and platelet adhesion study of a human thrombomodulin-immobilized nitinol surface. J Biomater Sci 2009;20:807-19.
22. Weber N, Wendel HP, Ziemer G. Quality assessment of heparin coatings by their binding capacities of coagulation and complement enzymes. J Biomater Appl 2000;15:8-22.
23. Weber N, Wendel HP, Ziemer G. Hemocompatability of heparin-coated surfaces and the role of selective plasma protein adsorption. Biomaterials 2002;23:429-30.
24. Li J-M, Singh MJ, Nelson PR, Hendricks GM, Itani M, Rohrer MJ, et al. Immobilization of human thrombomodulin to expanded olytetrafluoroethylene. Journal of surgical research 2002;105:200-8. (Pubitemid 34765328)
25. Kim AY, Walinshy PL, Kilidgie FD, Bian C, Sperry JL, Deming CB, et al. Early loss of thrombomodulin expression impairs vein graft thromboresistance. Implications for vein graft failure. Circ Res 2002;90:205-12. (Pubitemid 34627090)
26. Feng J, Tseng P, Faucher K, Orban J, Sun X, Chaikof E. Functional reconstitution of thrombomodulin within a substrate-supported membrane-mimetic polymer Film. Langmuir 2002;18:9907-13.
27. Mamedov TG, Padhye NV, Viljoen H, Subramanian A. Rational de novo gene synthesis by rapid polymerase chain assembly (PCA) and expression of endothelial protein-C and thrombin receptor genes. J Biotechnol 2007;131:379-87. (Pubitemid 47464096)
28. Regan LM, Stearns-Kurosawa DJ, Kurosawa S, Mollica J, Fukudome K, Esmon CT. The endothelial cell protein C receptor. Inhibition of activated protein C anticoagulant function without modulation of reaction with proteinase inhibitors. J Biol Chem 1996;271:17499-503. (Pubitemid 26244317)
29. Mamedov TG, Schneider M, Pattanayak A, Subramanian A. Human Protein C binding affinities of endothelial protein c receptor (EPCR) and its variants upon surface immobilization. Appl Biochem Biotechnol, Submitted for publication.
30. Ye X, Fukudome K, Tsuneyoshi N, Satoh T, Tokunaga O, Sugawara K, et al. The endothelial cell protein C receptor (EPCR) functions as a primary receptor for protein C activation on endothelial cells in arteries, veins, and capillaries. Biochem Biophys Res Commun 1999;259:671-7. (Pubitemid 29335592)
31. Preston RJ, Villegas-Mendez A, Sun YH, Hermida J, Simioni P, Philippou H, et al. Selective modulation of protein C affinity for EPCR and phospholipids by Gla domain mutation. FEBS J 2005;272:97-108. (Pubitemid 40083070)
32. Castilho LR, Anspach FB, Deckwer WD. Comparison of affinity membranes for the purification of immunoglobulins. J Membr Sci 2002;207: 253-64. (Pubitemid 34712046)
33. Xu J, Esmon NL, Esmon CT. Reconstitution of the human endothelial cell protein C receptor with thrombomodulin in phosphatidylcholine vesicles enhances protein c activation. J Biol Chem 1999;274:6704-10. (Pubitemid 29111091)
34. Subramanian A, Velander WH. Effect of antibody orientation on immunosorbent performance. J Mol Recognit 1996;9:528-35. (Pubitemid 126447005)
35. Kador KE. Synthesis of an endothelial cell mimicking surface containing thrombomodulin and endothelial protein C receptor. Lincoln: University of Nebraska; 2010.
36. Preston RJS, Villegas-Mendez A, Sun YH, Hermida J, Simioni P, Philippou H, et al. Selective modulation of protein C affinity for EPCR and phospholipids by Gla domain mutation. FEBS J 2005;272:97-108. (Pubitemid 40083070)
37. Nojiri C, Okano T, Park K, Kim S. Suppression mechanisms for thrombus formation on heparin-immobilized segmented polyurethane-ureas. ASAIO Transactions 1988;34:386-98.
38. Oshita K, Az-ma T, Osawa Y, Yuge O. Quantitative measurement of thromboelastography as a function of platelet count. Anesth Analg 1999;89:296-9. (Pubitemid 29367702)
39. Taylor FB, Peer GT, Lockhart MS, Ferrell G, Esmon C. Endothelial cell protein C receptor plays an important role in protein C activation in vivo. Blood 2001;97:1685-8. (Pubitemid 32217234)
40. Pérez-Casal M, Downey C, Fukudome K, Marx G, Toh CH. Activated protein C induces the release of microparticle-associated endothelial protein C receptor. Blood 2005;105:1515-22. (Pubitemid 40223668)
41. Pemawansa KP, Heisler MD, L BS, Cymes L, Mahalak KL, Kraus MA. An advanced affinity membrane for covalent binding of amino ligands. Biotechniques 1990;9:3.
42. Fu Z, Liu H, Ju H. Flow-through multianalyte chemiluminescent immunosensing system with designed substrate zone-resolved technique for sequential detection of tumor markers. Anal Chem 2006;78:6999-7005. (Pubitemid 44522554)
43. Villoutreix BO, Blom AM, Dahlbäck B. Structural prediction and analysis of endothelial cell protein C/activated protein C receptor. Protein Eng 1999;12:833-40. (Pubitemid 29533107)
44. Kurosawa S, Stearns-Kurosawa DJ, Hidari N, Esmon C. Identification of functional endothelial protein C receptor in human plasma. J Clin Invest 1997;100:411-8. (Pubitemid 27349089)
45. Dahlback B, Villouteix BO. Regulation of blood coagulation by the protein C anticoagulant pathway. Arterioscler Thromb Vasc Biol 2005;25:1311-20.
46. Mason RG, Shermer RW, Zucker WH. Effects of certain purified plasma proteins on the compatibility of glass with blood. Am J Pathol 1973;73:183-200.
47. Mulvihill JN, Faradji A, Oberling F, Cazenave JP. Surface passivation by human albumin of plasmapheresis circuits reduces platelet accumulation and thrombus formation. Experimental and clinical studies. J Biomed Mater Res A 1990;24:155-63. (Pubitemid 20123720)